{"id":"https://openalex.org/W1974027787","doi":"https://doi.org/10.1016/s0003-2670(00)82075-9","title":"Subcellular pharmacokinetics and quantitative structure / time / activity relationships","display_name":"Subcellular pharmacokinetics and quantitative structure / time / activity relationships","publication_year":1990,"publication_date":"1990-01-01","ids":{"openalex":"https://openalex.org/W1974027787","doi":"https://doi.org/10.1016/s0003-2670(00)82075-9","mag":"1974027787"},"language":"en","primary_location":{"id":"doi:10.1016/s0003-2670(00)82075-9","doi":"https://doi.org/10.1016/s0003-2670(00)82075-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0003-2670(00)82075-9","pdf_url":null,"source":{"id":"https://openalex.org/S192559872","display_name":"Analytica Chimica Acta","issn_l":"0003-2670","issn":["0003-2670","1873-4324"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytica Chimica Acta","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089020337","display_name":"\u0160tefan Bal\u00e1\u017e","orcid":"https://orcid.org/0000-0003-4378-8945","observed_orcids":["https://orcid.org/0000-0003-4378-8945"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u0160tefan Bal\u00e1\u017e","raw_affiliation_strings":["Department of Medicinal and Pharmaceutical Chemistry, Institute for Experimental Biology and Medicine, D-2061 Borstel F.R.G"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal and Pharmaceutical Chemistry, Institute for Experimental Biology and Medicine, D-2061 Borstel F.R.G","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael Wiese","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Wiese","raw_affiliation_strings":["Department of Medicinal and Pharmaceutical Chemistry, Institute for Experimental Biology and Medicine, D-2061 Borstel F.R.G"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal and Pharmaceutical Chemistry, Institute for Experimental Biology and Medicine, D-2061 Borstel F.R.G","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110057075","display_name":"H. Chi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Han-Lin Chi","raw_affiliation_strings":["Department of Medicinal and Pharmaceutical Chemistry, Institute for Experimental Biology and Medicine, D-2061 Borstel F.R.G"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal and Pharmaceutical Chemistry, Institute for Experimental Biology and Medicine, D-2061 Borstel F.R.G","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110175818","display_name":"Joachim Karl Seydel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joachim K. Seydel","raw_affiliation_strings":["Department of Medicinal and Pharmaceutical Chemistry, Institute for Experimental Biology and Medicine, D-2061 Borstel F.R.G"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal and Pharmaceutical Chemistry, Institute for Experimental Biology and Medicine, D-2061 Borstel F.R.G","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4270,"currency":"USD","value_usd":4270},"apc_paid":null,"fwci":1.4184,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.78153616,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"235","issue":null,"first_page":"195","last_page":"207"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.8335000276565552,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.8335000276565552,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.07109999656677246,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0494999997317791,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/subcellular-localization","display_name":"subcellular localization","score":0.7699999809265137},{"id":"https://openalex.org/keywords/hydrophobicity","display_name":"hydrophobicity","score":0.8939999938011169},{"id":"https://openalex.org/keywords/acid-base-properties","display_name":"acid-base properties","score":0.9539999961853027},{"id":"https://openalex.org/keywords/protein-binding","display_name":"protein binding","score":0.7440000176429749},{"id":"https://openalex.org/keywords/elimination-rate","display_name":"elimination rate","score":0.4830000102519989},{"id":"https://openalex.org/keywords/microbial-degradation","display_name":"microbial degradation","score":0.7979999780654907},{"id":"https://openalex.org/keywords/time-hierarchy","display_name":"time hierarchy","score":0.8009999990463257},{"id":"https://openalex.org/keywords/lipophilicity","display_name":"lipophilicity","score":0.7160000205039978},{"id":"https://openalex.org/keywords/bioactivity","display_name":"biological activity","score":0.7749999761581421},{"id":"https://openalex.org/keywords/fentanyl-derivatives","display_name":"fentanyl derivatives","score":0.9359999895095825},{"id":"https://openalex.org/keywords/analgesic-effect","display_name":"analgesic effect","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9638389348983765},{"id":"https://openalex.org/C201399114","wikidata":"https://www.wikidata.org/wiki/Q898401","display_name":"Lipophilicity","level":2,"score":0.8035940527915955},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.4742159843444824},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4500097930431366},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.42103472352027893},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.3874981701374054},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.32038944959640503},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.27962827682495117},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0003-2670(00)82075-9","doi":"https://doi.org/10.1016/s0003-2670(00)82075-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0003-2670(00)82075-9","pdf_url":null,"source":{"id":"https://openalex.org/S192559872","display_name":"Analytica Chimica Acta","issn_l":"0003-2670","issn":["0003-2670","1873-4324"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytica Chimica Acta","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W4425695","https://openalex.org/W5460352","https://openalex.org/W1964397336","https://openalex.org/W1978102442","https://openalex.org/W1991461962","https://openalex.org/W1996222937","https://openalex.org/W1996759407","https://openalex.org/W2002512466","https://openalex.org/W2010002181","https://openalex.org/W2030823283","https://openalex.org/W2034977865","https://openalex.org/W2045005550","https://openalex.org/W2046602210","https://openalex.org/W2049775325","https://openalex.org/W2051185147","https://openalex.org/W2052226480","https://openalex.org/W2055173808","https://openalex.org/W2063071207","https://openalex.org/W2064856251","https://openalex.org/W2064857091","https://openalex.org/W2066092828","https://openalex.org/W2071438703","https://openalex.org/W2071462174","https://openalex.org/W2074568090","https://openalex.org/W2080717770","https://openalex.org/W2088988437","https://openalex.org/W2089195672","https://openalex.org/W2090870808","https://openalex.org/W2091310030","https://openalex.org/W2092313806","https://openalex.org/W2095125411","https://openalex.org/W2142998435","https://openalex.org/W2145026983","https://openalex.org/W2168703963","https://openalex.org/W2184491303","https://openalex.org/W2328945358","https://openalex.org/W2407183484","https://openalex.org/W2414843923","https://openalex.org/W2423210039","https://openalex.org/W2473215285","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1984362713","https://openalex.org/W2000848847","https://openalex.org/W1999669808","https://openalex.org/W2055868308","https://openalex.org/W2030449924","https://openalex.org/W2090113806","https://openalex.org/W2167919546","https://openalex.org/W2004009564","https://openalex.org/W2003512894","https://openalex.org/W2124562222"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}