{"id":"https://openalex.org/W1973976973","doi":"https://doi.org/10.1016/j.tibs.2012.04.001","title":"Staying on message: ensuring fidelity in pre-mRNA splicing","display_name":"Staying on message: ensuring fidelity in pre-mRNA splicing","publication_year":2012,"publication_date":"2012-05-06","ids":{"openalex":"https://openalex.org/W1973976973","doi":"https://doi.org/10.1016/j.tibs.2012.04.001","mag":"1973976973","pmid":"https://pubmed.ncbi.nlm.nih.gov/22564363","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3735133"},"language":"en","primary_location":{"id":"doi:10.1016/j.tibs.2012.04.001","doi":"https://doi.org/10.1016/j.tibs.2012.04.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tibs.2012.04.001","pdf_url":"http://www.cell.com/article/S0968000412000485/pdf","source":{"id":"https://openalex.org/S136233269","display_name":"Trends in Biochemical Sciences","issn_l":"0968-0004","issn":["0968-0004","1362-4326"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Biochemical Sciences","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S0968000412000485/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040646015","display_name":"Daniel R. Semlow","orcid":"https://orcid.org/0000-0001-6538-9713","observed_orcids":["https://orcid.org/0000-0001-6538-9713"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel R. Semlow","raw_affiliation_strings":["Graduate Program in Cell and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Program in Cell and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088442568","display_name":"Jonathan P. Staley","orcid":"https://orcid.org/0000-0002-4469-9509","observed_orcids":["https://orcid.org/0000-0002-4469-9509"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jonathan P. Staley","raw_affiliation_strings":["Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL 60637, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5088442568"],"corresponding_institution_ids":["https://openalex.org/I40347166"],"apc_list":{"value":7030,"currency":"USD","value_usd":7030},"apc_paid":null,"fwci":1.0155,"has_fulltext":true,"cited_by_count":137,"citation_normalized_percentile":{"value":0.71477343,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"37","issue":"7","first_page":"263","last_page":"273"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pre-mrna-splicing","display_name":"pre-mRNA splicing","score":0.9810000061988831},{"id":"https://openalex.org/keywords/splicing-fidelity","display_name":"splicing fidelity","score":0.9850000143051147},{"id":"https://openalex.org/keywords/spliceosome","display_name":"spliceosome","score":0.8790000081062317},{"id":"https://openalex.org/keywords/splice-site-selection","display_name":"splice site selection","score":0.7009999752044678},{"id":"https://openalex.org/keywords/intron-excision","display_name":"intron excision","score":0.9110000133514404},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.7179999947547913}],"concepts":[{"id":"https://openalex.org/C40000846","wikidata":"https://www.wikidata.org/wiki/Q915868","display_name":"Spliceosome","level":5,"score":0.9440748691558838},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.8181750774383545},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6633663773536682},{"id":"https://openalex.org/C94671646","wikidata":"https://www.wikidata.org/wiki/Q207551","display_name":"Intron","level":3,"score":0.6521291136741638},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5906014442443848},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5856425762176514},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5671831369400024},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.49561870098114014},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.42003703117370605},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.35096317529678345},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.27039632201194763}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007438","descriptor_name":"Introns","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012326","descriptor_name":"RNA Splicing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053487","descriptor_name":"DEAD-box RNA Helicases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053487","descriptor_name":"DEAD-box RNA Helicases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.tibs.2012.04.001","doi":"https://doi.org/10.1016/j.tibs.2012.04.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tibs.2012.04.001","pdf_url":"http://www.cell.com/article/S0968000412000485/pdf","source":{"id":"https://openalex.org/S136233269","display_name":"Trends in Biochemical Sciences","issn_l":"0968-0004","issn":["0968-0004","1362-4326"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Biochemical Sciences","raw_type":"journal-article"},{"id":"pmid:22564363","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22564363","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in biochemical sciences","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2728349","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3735133","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3735133","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3735133/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Trends Biochem Sci","raw_type":"Text"},{"id":"pmh:oai:authors.library.caltech.edu:104549","doi":null,"is_oa":false,"landing_page_url":"https://authors.library.caltech.edu/104549/","pdf_url":null,"source":{"id":"https://openalex.org/S4306402161","display_name":"CaltechAUTHORS (California Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122411786","host_organization_name":"California Institute of Technology","host_organization_lineage":["https://openalex.org/I122411786"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1016/j.tibs.2012.04.001","doi":"https://doi.org/10.1016/j.tibs.2012.04.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tibs.2012.04.001","pdf_url":"http://www.cell.com/article/S0968000412000485/pdf","source":{"id":"https://openalex.org/S136233269","display_name":"Trends in Biochemical Sciences","issn_l":"0968-0004","issn":["0968-0004","1362-4326"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Biochemical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5666530682","display_name":"Mechanisms for Rearranging RNA during Pre-mRNA Splicing  - Renewal 01","funder_award_id":"R01GM062264","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7100900607","display_name":"Genetics and Regulation","funder_award_id":"T32GM007197","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1973976973.pdf","grobid_xml":"https://content.openalex.org/works/W1973976973.grobid-xml"},"referenced_works_count":88,"referenced_works":["https://openalex.org/W133794913","https://openalex.org/W1498170184","https://openalex.org/W1967919168","https://openalex.org/W1976367392","https://openalex.org/W1976678081","https://openalex.org/W1977658792","https://openalex.org/W1983668342","https://openalex.org/W1983924599","https://openalex.org/W1983954245","https://openalex.org/W1984962092","https://openalex.org/W1989429196","https://openalex.org/W1992433724","https://openalex.org/W1993987952","https://openalex.org/W1996645650","https://openalex.org/W1999078233","https://openalex.org/W2002336825","https://openalex.org/W2003564334","https://openalex.org/W2004838350","https://openalex.org/W2007165715","https://openalex.org/W2007526989","https://openalex.org/W2007781782","https://openalex.org/W2008065215","https://openalex.org/W2011227394","https://openalex.org/W2015670742","https://openalex.org/W2020662133","https://openalex.org/W2021987221","https://openalex.org/W2027455260","https://openalex.org/W2033725512","https://openalex.org/W2034085554","https://openalex.org/W2034490095","https://openalex.org/W2035350840","https://openalex.org/W2036867693","https://openalex.org/W2037339623","https://openalex.org/W2037576800","https://openalex.org/W2038280179","https://openalex.org/W2038872813","https://openalex.org/W2039162233","https://openalex.org/W2039347057","https://openalex.org/W2041034033","https://openalex.org/W2042973755","https://openalex.org/W2045952340","https://openalex.org/W2049415064","https://openalex.org/W2054448059","https://openalex.org/W2056431625","https://openalex.org/W2057990302","https://openalex.org/W2064517080","https://openalex.org/W2067000354","https://openalex.org/W2073928054","https://openalex.org/W2074018982","https://openalex.org/W2074026981","https://openalex.org/W2074616759","https://openalex.org/W2075387685","https://openalex.org/W2082337556","https://openalex.org/W2082998335","https://openalex.org/W2087847877","https://openalex.org/W2088264444","https://openalex.org/W2090850551","https://openalex.org/W2091328421","https://openalex.org/W2091746054","https://openalex.org/W2093132137","https://openalex.org/W2097966611","https://openalex.org/W2098122641","https://openalex.org/W2098906256","https://openalex.org/W2101536272","https://openalex.org/W2106422996","https://openalex.org/W2107933976","https://openalex.org/W2110082176","https://openalex.org/W2116876551","https://openalex.org/W2120740701","https://openalex.org/W2124444021","https://openalex.org/W2126548874","https://openalex.org/W2129963496","https://openalex.org/W2132505931","https://openalex.org/W2136942244","https://openalex.org/W2137117646","https://openalex.org/W2137970552","https://openalex.org/W2140031156","https://openalex.org/W2143350291","https://openalex.org/W2145473270","https://openalex.org/W2148890785","https://openalex.org/W2153405631","https://openalex.org/W2153849837","https://openalex.org/W2162079209","https://openalex.org/W2163686989","https://openalex.org/W2164731955","https://openalex.org/W2165906337","https://openalex.org/W2166288313","https://openalex.org/W2174994538"],"related_works":["https://openalex.org/W3168475178","https://openalex.org/W2063295008","https://openalex.org/W6976851373","https://openalex.org/W2035350840","https://openalex.org/W1968105284","https://openalex.org/W2110082176","https://openalex.org/W1977183414","https://openalex.org/W2034085554","https://openalex.org/W1884725878","https://openalex.org/W4394936167"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
