{"id":"https://openalex.org/W1973898211","doi":"https://doi.org/10.1111/j.1600-0773.1996.tb00231.x","title":"Chronic Effect of Aluminium Ingestion on Bone in Calcium\u2010Deficient Rats","display_name":"Chronic Effect of Aluminium Ingestion on Bone in Calcium\u2010Deficient Rats","publication_year":1996,"publication_date":"1996-06-01","ids":{"openalex":"https://openalex.org/W1973898211","doi":"https://doi.org/10.1111/j.1600-0773.1996.tb00231.x","mag":"1973898211","pmid":"https://pubmed.ncbi.nlm.nih.gov/8829206"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-0773.1996.tb00231.x","doi":"https://doi.org/10.1111/j.1600-0773.1996.tb00231.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0773.1996.tb00231.x","pdf_url":null,"source":{"id":"https://openalex.org/S62051601","display_name":"Pharmacology & Toxicology","issn_l":"0901-9928","issn":["0901-9928","1600-0773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology &amp; Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086543543","display_name":"Yuko Konishi","orcid":"https://orcid.org/0000-0002-5086-0856","observed_orcids":["https://orcid.org/0000-0002-5086-0856"]},"institutions":[{"id":"https://openalex.org/I4210088960","display_name":"Kochi Medical School Hospital","ror":"https://ror.org/013rvtk45","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210088960"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yuko Konishi","raw_affiliation_strings":["Medical Research laboratory, Kochi Medical School, Japan","Medical Research Laboratory, Kochi Medical School, Kochi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research laboratory, Kochi Medical School, Japan","institution_ids":["https://openalex.org/I4210088960"]},{"raw_affiliation_string":"Medical Research Laboratory, Kochi Medical School, Kochi","institution_ids":["https://openalex.org/I4210088960"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kenichi Yagyu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088960","display_name":"Kochi Medical School Hospital","ror":"https://ror.org/013rvtk45","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210088960"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenichi Yagyu","raw_affiliation_strings":["Medical Research Laboratory, Kochi Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Laboratory, Kochi Medical School","institution_ids":["https://openalex.org/I4210088960"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111372256","display_name":"Hideo Kinebuchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088960","display_name":"Kochi Medical School Hospital","ror":"https://ror.org/013rvtk45","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210088960"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideo Kinebuchi","raw_affiliation_strings":["Department of Environmental and Occupational Health, Kochi Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Occupational Health, Kochi Medical School","institution_ids":["https://openalex.org/I4210088960"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111375395","display_name":"Noboru Saito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I77063589","display_name":"K\u014dchi University","ror":"https://ror.org/01xxp6985","country_code":"JP","type":"education","lineage":["https://openalex.org/I77063589"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Noboru Saito","raw_affiliation_strings":["Department of Geriatrics, Kochi Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatrics, Kochi Medical School","institution_ids":["https://openalex.org/I77063589"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061608163","display_name":"Takuya Yamaguchi","orcid":"https://orcid.org/0000-0002-1776-2197","observed_orcids":["https://orcid.org/0000-0002-1776-2197"]},"institutions":[{"id":"https://openalex.org/I4210088960","display_name":"Kochi Medical School Hospital","ror":"https://ror.org/013rvtk45","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210088960"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuya Yamaguchi","raw_affiliation_strings":["Department of Pathology, Kochi Medical School, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Kochi Medical School, and","institution_ids":["https://openalex.org/I4210088960"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013908034","display_name":"And Yuji Ohtsuki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088960","display_name":"Kochi Medical School Hospital","ror":"https://ror.org/013rvtk45","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210088960"]},{"id":"https://openalex.org/I77063589","display_name":"K\u014dchi University","ror":"https://ror.org/01xxp6985","country_code":"JP","type":"education","lineage":["https://openalex.org/I77063589"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"And Yuji Ohtsuki","raw_affiliation_strings":["Department of Pathology, Kochi Medical School, Kochi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Kochi Medical School, Kochi, Japan","institution_ids":["https://openalex.org/I4210088960","https://openalex.org/I77063589"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5086543543"],"corresponding_institution_ids":["https://openalex.org/I4210088960"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.24215865,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"78","issue":"6","first_page":"429","last_page":"434"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12211","display_name":"Aluminum toxicity and tolerance in plants and animals","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12211","display_name":"Aluminum toxicity and tolerance in plants and animals","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcium-deficiency","display_name":"calcium deficiency","score":0.8389999866485596},{"id":"https://openalex.org/keywords/bone-histopathology","display_name":"bone histopathology","score":0.8090000152587891},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.8460000157356262},{"id":"https://openalex.org/keywords/iron-accumulation","display_name":"iron accumulation","score":0.7590000033378601},{"id":"https://openalex.org/keywords/aluminum-deposition","display_name":"aluminum deposition","score":0.9739999771118164},{"id":"https://openalex.org/keywords/trabecular-bone","display_name":"trabecular bone","score":0.7139999866485596},{"id":"https://openalex.org/keywords/serum-parathyroid-hormone","display_name":"serum parathyroid hormone","score":0.847000002861023}],"concepts":[{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.8104389309883118},{"id":"https://openalex.org/C513153333","wikidata":"https://www.wikidata.org/wiki/Q663","display_name":"Aluminium","level":2,"score":0.7213020920753479},{"id":"https://openalex.org/C2780309369","wikidata":"https://www.wikidata.org/wiki/Q933382","display_name":"Calcification","level":2,"score":0.7057632207870483},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5417599678039551},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4884707033634186},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4822474420070648},{"id":"https://openalex.org/C2778606738","wikidata":"https://www.wikidata.org/wiki/Q265868","display_name":"Bone tissue","level":2,"score":0.45695921778678894},{"id":"https://openalex.org/C2781294515","wikidata":"https://www.wikidata.org/wiki/Q2733470","display_name":"Stain","level":3,"score":0.45433738827705383},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.31781092286109924},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3102872967720032},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2196274995803833},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000535","descriptor_name":"Aluminum","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000535","descriptor_name":"Aluminum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000535","descriptor_name":"Aluminum","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001846","descriptor_name":"Bone Development","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010281","descriptor_name":"Parathyroid Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013977","descriptor_name":"Tibia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013977","descriptor_name":"Tibia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015430","descriptor_name":"Weight Gain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1600-0773.1996.tb00231.x","doi":"https://doi.org/10.1111/j.1600-0773.1996.tb00231.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0773.1996.tb00231.x","pdf_url":null,"source":{"id":"https://openalex.org/S62051601","display_name":"Pharmacology & Toxicology","issn_l":"0901-9928","issn":["0901-9928","1600-0773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology &amp; Toxicology","raw_type":"journal-article"},{"id":"pmid:8829206","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8829206","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology & toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8199999928474426,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1539264794","https://openalex.org/W1985223815","https://openalex.org/W1988766553","https://openalex.org/W1998206849","https://openalex.org/W2004508245","https://openalex.org/W2009094435","https://openalex.org/W2010723616","https://openalex.org/W2012306041","https://openalex.org/W2023457594","https://openalex.org/W2028375549","https://openalex.org/W2035511117","https://openalex.org/W2037660591","https://openalex.org/W2038854239","https://openalex.org/W2045751162","https://openalex.org/W2053524560","https://openalex.org/W2064558188","https://openalex.org/W2077367838","https://openalex.org/W2077404802","https://openalex.org/W2088327372","https://openalex.org/W2115891408","https://openalex.org/W2134528758","https://openalex.org/W2262557680","https://openalex.org/W2326377922","https://openalex.org/W2331517609","https://openalex.org/W2401819744","https://openalex.org/W2411695834","https://openalex.org/W2411924536","https://openalex.org/W4245115771"],"related_works":["https://openalex.org/W2028449869","https://openalex.org/W2316842838","https://openalex.org/W2128638272","https://openalex.org/W2068800940","https://openalex.org/W2051140518","https://openalex.org/W2434082108","https://openalex.org/W200769873","https://openalex.org/W2030341919","https://openalex.org/W2025975775","https://openalex.org/W2418378822"],"abstract_inverted_index":{"In":[0],"order":[1],"to":[2,57],"elucidate":[3],"the":[4,15,40,59,88,106,125,129,173,177,180,186],"relationship":[5],"of":[6,18,28,42,61,64,87,169,176,182],"osteogenesis":[7],"with":[8,26,141,145,150],"aluminum":[9],"and":[10,31,35,38,76,98,128,166],"iron":[11,32,146],"deposition,":[12],"we":[13],"investigated":[14],"histopathological":[16],"findings":[17],"bone":[19,36,108,112,178],"in":[20,33,91,113,117,133],"calcium":[21,99,183],"and/or":[22],"aluminium-deficient":[23],"rats,":[24],"together":[25,144],"levels":[27],"calcium,":[29,170],"aluminium":[30,103,142,165],"sera":[34],"tissues,":[37],"also":[39],"level":[41],"serum":[43],"parathyroid":[44],"hormone.":[45],"Four":[46],"week":[47],"old":[48],"male":[49],"STD-Wistar":[50],"rats":[51,70],"were":[52],"divided":[53],"into":[54,110],"four":[55,62],"groups":[56],"examine":[58],"effects":[60],"kinds":[63],"diets":[65],"for":[66],"ten":[67],"weeks.":[68],"The":[69],"on":[71,172],"normal":[72,77,187],"diet":[73,94,101],"(Group":[74,79,96,104],"I)":[75],"diet+aluminum":[78],"II)":[80],"did":[81],"not":[82],"show":[83],"any":[84],"pathological":[85],"changes":[86],"bones,":[89],"but":[90],"both":[92],"calcium-deficient":[93],"group":[95],"III)":[97],"deficient":[100],"added":[102],"IV),":[105],"compact":[107],"converted":[109],"spongy":[111],"varying":[114],"degrees,":[115],"particularly":[116],"Group":[118,134],"IV.":[119],"Aluminium":[120],"deposition":[121,147],"was":[122,161],"demonstrated":[123],"at":[124],"calcification":[126,174],"fronts":[127],"cement":[130],"lines":[131,140],"only":[132],"IV":[135],"as":[136,148,158],"red":[137],"or":[138],"violet-red":[139],"stain,":[143,153],"revealed":[149],"Berlin":[151],"blue":[152],"showing":[154],"similar":[155],"distribution":[156],"pattern":[157],"aluminum.":[159],"It":[160],"clearly":[162],"indicated":[163],"that":[164],"iron,":[167],"instead":[168],"deposited":[171],"front":[175],"under":[179],"condition":[181],"deficiency,":[184],"inhibiting":[185],"osteogenesis.":[188]},"counts_by_year":[{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
