{"id":"https://openalex.org/W1973876085","doi":"https://doi.org/10.1210/jc.81.10.3607","title":"Cytogenetic and microsatellite alterations in tumors from patients with the syndrome of myxomas, spotty skin pigmentation, and endocrine overactivity (Carney complex)","display_name":"Cytogenetic and microsatellite alterations in tumors from patients with the syndrome of myxomas, spotty skin pigmentation, and endocrine overactivity (Carney complex)","publication_year":1996,"publication_date":"1996-10-01","ids":{"openalex":"https://openalex.org/W1973876085","doi":"https://doi.org/10.1210/jc.81.10.3607","mag":"1973876085","pmid":"https://pubmed.ncbi.nlm.nih.gov/8855810"},"language":"en","primary_location":{"id":"doi:10.1210/jc.81.10.3607","doi":"https://doi.org/10.1210/jc.81.10.3607","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.81.10.3607","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/jcem/article-pdf/81/10/3607/10506242/jcem3607.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031897654","display_name":"Constantine A. Stratakis","orcid":"https://orcid.org/0000-0002-4058-5520","observed_orcids":["https://orcid.org/0000-0002-4058-5520"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C A Stratakis","raw_affiliation_strings":["Section on Pediatric Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1862, USA. stratakc@cc1.nichd.nih.gov","Section on Pediatric Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1862, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section on Pediatric Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1862, USA. stratakc@cc1.nichd.nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]},{"raw_affiliation_string":"Section on Pediatric Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1862, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060720802","display_name":"Robert Brian Jenkins","orcid":"https://orcid.org/0000-0002-4049-694X","observed_orcids":["https://orcid.org/0000-0002-4049-694X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R B Jenkins","raw_affiliation_strings":["Section on Pediatric Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1862, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section on Pediatric Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1862, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084615582","display_name":"Eran Pras","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E Pras","raw_affiliation_strings":["Section on Pediatric Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1862, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section on Pediatric Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1862, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060072091","display_name":"Constantine S. Mitsiadis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C S Mitsiadis","raw_affiliation_strings":["Section on Pediatric Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1862, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section on Pediatric Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1862, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044949176","display_name":"Sandra B. Raff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S B Raff","raw_affiliation_strings":["Section on Pediatric Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1862, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section on Pediatric Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1862, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026109294","display_name":"Paul G. Stalboerger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P G Stalboerger","raw_affiliation_strings":["Section on Pediatric Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1862, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section on Pediatric Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1862, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109929990","display_name":"C. Tsigos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Tsigos","raw_affiliation_strings":["Section on Pediatric Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1862, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section on Pediatric Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1862, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108197434","display_name":"J A Carney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J A Carney","raw_affiliation_strings":["Section on Pediatric Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1862, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section on Pediatric Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1862, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046164327","display_name":"George Panagiotis Chrousos","orcid":"https://orcid.org/0000-0002-3098-5264","observed_orcids":["https://orcid.org/0000-0002-3098-5264"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G P Chrousos","raw_affiliation_strings":["Section on Pediatric Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1862, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section on Pediatric Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1862, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":{"value":3750,"currency":"USD","value_usd":3750},"fwci":5.3104,"has_fulltext":true,"cited_by_count":92,"citation_normalized_percentile":{"value":0.95686983,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"81","issue":"10","first_page":"3607","last_page":"3614"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.7939000129699707,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.7939000129699707,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11638","display_name":"Cardiac tumors and thrombi","score":0.04820000007748604,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.04149999842047691,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carney-complex","display_name":"Carney complex","score":0.9829999804496765},{"id":"https://openalex.org/keywords/myxoma","display_name":"myxoma","score":0.593999981880188},{"id":"https://openalex.org/keywords/primary-pigmented-nodular-adrenocortical-disease","display_name":"primary pigmented nodular adrenocortical disease","score":0.9100000262260437},{"id":"https://openalex.org/keywords/acromegaly","display_name":"acromegaly","score":0.8960000276565552},{"id":"https://openalex.org/keywords/loss-of-heterozygosity","display_name":"loss of heterozygosity","score":0.8619999885559082},{"id":"https://openalex.org/keywords/telomeric-associations","display_name":"telomeric associations","score":0.7919999957084656},{"id":"https://openalex.org/keywords/msh2","display_name":"MSH2","score":0.7839999794960022},{"id":"https://openalex.org/keywords/msh6","display_name":"MSH6","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dna-mismatch-repair","display_name":"DNA mismatch repair","score":0.6439999938011169},{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.41999998688697815},{"id":"https://openalex.org/keywords/lentiginosis","display_name":"lentiginosis","score":0.7139999866485596},{"id":"https://openalex.org/keywords/cushing-s-syndrome","display_name":"Cushing's syndrome","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C2777108446","wikidata":"https://www.wikidata.org/wiki/Q1044007","display_name":"Carney complex","level":3,"score":0.8519096374511719},{"id":"https://openalex.org/C2777542379","wikidata":"https://www.wikidata.org/wiki/Q589612","display_name":"Myxoma","level":2,"score":0.7046414613723755},{"id":"https://openalex.org/C143589142","wikidata":"https://www.wikidata.org/wiki/Q2617554","display_name":"Loss of heterozygosity","level":4,"score":0.6754637956619263},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6031420230865479},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5533626675605774},{"id":"https://openalex.org/C2778674399","wikidata":"https://www.wikidata.org/wiki/Q4684749","display_name":"Adrenocortical adenoma","level":3,"score":0.5274285078048706},{"id":"https://openalex.org/C2777433750","wikidata":"https://www.wikidata.org/wiki/Q189580","display_name":"Acromegaly","level":4,"score":0.4840826094150543},{"id":"https://openalex.org/C61320498","wikidata":"https://www.wikidata.org/wiki/Q265193","display_name":"Microsatellite","level":4,"score":0.4751053750514984},{"id":"https://openalex.org/C2780103800","wikidata":"https://www.wikidata.org/wiki/Q1553018","display_name":"Multiple endocrine neoplasia","level":3,"score":0.4272282123565674},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.4251245856285095},{"id":"https://openalex.org/C2777428134","wikidata":"https://www.wikidata.org/wiki/Q272741","display_name":"Adenoma","level":2,"score":0.3902107775211334},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33289340138435364},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.26878976821899414},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26272302865982056},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23363274335861206},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2297191321849823},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18065807223320007},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10822898149490356},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.0},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000172","descriptor_name":"Acromegaly","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000310","descriptor_name":"Adrenal Gland Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002889","descriptor_name":"Chromosomes, Human, Pair 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003480","descriptor_name":"Cushing Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004701","descriptor_name":"Endocrine Gland Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007621","descriptor_name":"Karyotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007911","descriptor_name":"Lentigo","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009232","descriptor_name":"Myxoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009386","descriptor_name":"Neoplastic Syndromes, Hereditary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018895","descriptor_name":"Microsatellite Repeats","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1210/jc.81.10.3607","doi":"https://doi.org/10.1210/jc.81.10.3607","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.81.10.3607","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},{"id":"doi:10.1210/jcem.81.10.8855810","doi":"https://doi.org/10.1210/jcem.81.10.8855810","is_oa":true,"landing_page_url":"https://doi.org/10.1210/jcem.81.10.8855810","pdf_url":"https://academic.oup.com/jcem/article-pdf/81/10/3607/10506242/jcem3607.pdf","source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},{"id":"pmid:8855810","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8855810","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1210/jcem.81.10.8855810","doi":"https://doi.org/10.1210/jcem.81.10.8855810","is_oa":true,"landing_page_url":"https://doi.org/10.1210/jcem.81.10.8855810","pdf_url":"https://academic.oup.com/jcem/article-pdf/81/10/3607/10506242/jcem3607.pdf","source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1973876085.pdf","grobid_xml":"https://content.openalex.org/works/W1973876085.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W36127973","https://openalex.org/W53984696","https://openalex.org/W120968873","https://openalex.org/W1486632619","https://openalex.org/W1525223081","https://openalex.org/W1770076830","https://openalex.org/W1776863503","https://openalex.org/W1925484557","https://openalex.org/W1975299549","https://openalex.org/W1978871519","https://openalex.org/W1979329276","https://openalex.org/W1980685048","https://openalex.org/W1998947396","https://openalex.org/W2005065014","https://openalex.org/W2008227227","https://openalex.org/W2012867725","https://openalex.org/W2030150908","https://openalex.org/W2032948663","https://openalex.org/W2034609335","https://openalex.org/W2038074792","https://openalex.org/W2038638342","https://openalex.org/W2046136844","https://openalex.org/W2046513019","https://openalex.org/W2048552527","https://openalex.org/W2052271835","https://openalex.org/W2064533401","https://openalex.org/W2065727657","https://openalex.org/W2067795112","https://openalex.org/W2072341672","https://openalex.org/W2088440260","https://openalex.org/W2088950661","https://openalex.org/W2091080694","https://openalex.org/W2091805323","https://openalex.org/W2098034673","https://openalex.org/W2102636415","https://openalex.org/W2103764985","https://openalex.org/W2104309134","https://openalex.org/W2116045011","https://openalex.org/W2125995528","https://openalex.org/W2127247808","https://openalex.org/W2139964075","https://openalex.org/W2150746480","https://openalex.org/W2155077707","https://openalex.org/W2165014853","https://openalex.org/W2172067843","https://openalex.org/W2334487286","https://openalex.org/W2336816837","https://openalex.org/W2414258783","https://openalex.org/W2415288250","https://openalex.org/W2469233951"],"related_works":["https://openalex.org/W2064533401","https://openalex.org/W4247852132","https://openalex.org/W2118545928","https://openalex.org/W7050646851","https://openalex.org/W2095669888","https://openalex.org/W3095771537","https://openalex.org/W2047597784","https://openalex.org/W4237201962","https://openalex.org/W2047101422","https://openalex.org/W7098392900"],"abstract_inverted_index":{"Carney":[0],"complex":[1],"(CC)":[2],"is":[3,18,358],"a":[4,181],"familial":[5,21],"multiple":[6,172],"neoplasia":[7],"and":[8,25,29,42,77,81,106,137,147,167,206,211,225,227,238,243,246,255,261,281,301,320,335,363,366],"lentiginosis":[9],"syndrome,":[10],"transmitted":[11],"in":[12,70,87,289,380,389,395],"an":[13],"autosomal":[14],"dominant":[15],"manner.":[16],"It":[17],"the":[19,79,88,99,163,191,264,293,352,361,381,391,399,402],"only":[20,310],"form":[22],"of":[23,90,94,162,240,250,292,317,325,383,386,393,401],"cardiac":[24],"skin":[26],"myxomas":[27,72],"known":[28],"includes":[30],"endocrine":[31],"neoplasms":[32],"causing":[33],"Cushing's":[34],"syndrome":[35],"[primary":[36],"pigmented":[37],"nodular":[38],"adrenocortical":[39,178],"disease":[40],"(PPNAD)]":[41],"acromegaly":[43],"(GH-producing":[44],"adenoma).":[45],"The":[46,176,233,315],"molecular":[47],"defect":[48],"leading":[49],"to":[50,58,213,377],"CC":[51,76,114,342,353],"remains":[52],"unknown,":[53],"but":[54,346],"was":[55,155,198],"recently":[56],"mapped":[57],"chromosome":[59,231,307,356],"2p16":[60,357],"by":[61,157],"linkage":[62],"analysis.":[63],"This":[64,374],"region":[65],"has":[66,367],"exhibited":[67],"cytogenetic":[68,159],"aberrations":[69],"atrial":[71],"from":[73,110,180,200,218,339,360],"patients":[74,112,340],"with":[75,113,183,216,268,341],"harbors":[78],"hMSH2":[80,362],"hMSH6":[82,364],"genes,":[83],"which":[84],"are":[85],"involved":[86,379],"preservation":[89],"microsatellite":[91,220,256,311,348],"length":[92,257,312],"stability":[93,385],"replicating":[95,396],"human":[96],"cells.":[97],"In":[98],"present":[100],"study,":[101],"we":[102],"examined":[103],"15":[104],"tumor":[105,203,326,336],"normal":[107,131,177],"tissue":[108,179,194],"specimens":[109,170],"13":[111],"[GH-producing":[115],"adenoma":[116],"(n":[117,128,134,144,150],"=":[118,124,129,135,145,151],"1),":[119,130],"adrenal":[120,132],"tumors":[121,334],"(PPNAD,":[122],"n":[123],"8),":[125],"thyroid":[126],"cancer":[127],"gland":[133],"1)]":[136],"4":[138],"cultured":[139],"cell":[140,165,204,337],"lines":[141,166,338],"[heart":[142],"myxoma":[143,149,164],"3)":[146],"eyelid":[148],"1)].":[152],"Chromosome":[153],"analysis":[154],"obtained":[156],"standard":[158],"techniques.":[160],"One":[161],"3":[168],"PPNAD":[169,184,193],"contained":[171,185],"telomeric":[173,269],"associations":[174],"(tas).":[175],"patient":[182],"no":[186],"apparent":[187],"chromosomal":[188],"anomalies,":[189],"whereas":[190,304],"neighboring":[192],"demonstrated":[195,283],"tas.":[196],"DNA":[197],"extracted":[199],"peripheral":[201],"blood,":[202],"lines,":[205],"frozen":[207],"or":[208,287],"paraffin-embedded":[209],"tissues":[210],"subjected":[212],"PCR":[214],"amplification":[215],"primers":[217],"64":[219],"locations":[221],"covering":[222,230],"chromosomes":[223,397],"1":[224],"3-22":[226],"14":[228],"loci":[229,295],"2.":[232],"alterations":[234],"detected":[235],"were":[236,263,323],"loss":[237],"gain":[239],"heterozygosity":[241],"(LOH":[242],"GOH;":[244],"49%":[245],"26%,":[247],"respectively),":[248,303],"deletions":[249],"both":[251],"alleles":[252],"(DEL;":[253],"10%),":[254],"instability":[258,313,319],"(15%).":[259],"GOH":[260],"LOH":[262],"most":[265],"frequent":[266],"changes,":[267],"markers":[270,305],"significantly":[271],"over-represented":[272],"(P":[273,328],"<":[274],"0.05).":[275],"Chromosomes":[276],"6,":[277],"11,":[278],"22,":[279],"10,":[280],"19":[282],"mostly":[284],"LOH,":[285],"GOH,":[286],"DEL":[288],"over":[290],"40%":[291],"informative":[294],"tested":[296],"(73%,":[297],"59%,":[298],"47%,":[299],"46%,":[300],"44%,":[302],"on":[306,355],"2":[308],"showed":[309],"(10%).":[314],"degree":[316],"genomic":[318,384],"its":[321],"type":[322,327],"independent":[324],">":[329],"0.1).":[330],"We":[331],"conclude":[332],"that":[333],"demonstrate":[343],"significant":[344],"genomic,":[345],"not":[347],"length,":[349],"instability.":[350],"Thus,":[351],"gene(s)":[354,375],"different":[359],"genes":[365],"dominant,":[368],"rather":[369],"than":[370],"recessive,":[371],"tumorigenic":[372],"function.":[373],"appears":[376],"be":[378],"regulation":[382],"dividing":[387],"cells,":[388],"particular":[390],"structure":[392],"telomeres":[394],"and/or":[398],"function":[400],"mitotic":[403],"apparatus.":[404]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}