{"id":"https://openalex.org/W1973873084","doi":"https://doi.org/10.1179/016164106x116836","title":"Convection-enhanced delivery in the treatment of malignant glioma","display_name":"Convection-enhanced delivery in the treatment of malignant glioma","publication_year":2006,"publication_date":"2006-06-22","ids":{"openalex":"https://openalex.org/W1973873084","doi":"https://doi.org/10.1179/016164106x116836","mag":"1973873084","pmid":"https://pubmed.ncbi.nlm.nih.gov/16808887"},"language":"en","primary_location":{"id":"doi:10.1179/016164106x116836","doi":"https://doi.org/10.1179/016164106x116836","is_oa":false,"landing_page_url":"https://doi.org/10.1179/016164106x116836","pdf_url":null,"source":{"id":"https://openalex.org/S187584928","display_name":"Neurological Research","issn_l":"0161-6412","issn":["0161-6412","1743-1328"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurological Research","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004094441","display_name":"Kim A. Lopez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kim A. Lopez","raw_affiliation_strings":["Gabriele Bartoli Brain Tumor Laboratory, Department of Neurological Surgery, Columbia University Medical Center, New York, NY 10032, USA","Gabriele Bartoli Brain Tumor LaboratoryDepartment of Neurological Surgery, Columbia University Medical Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gabriele Bartoli Brain Tumor Laboratory, Department of Neurological Surgery, Columbia University Medical Center, New York, NY 10032, USA","institution_ids":["https://openalex.org/I2799503643"]},{"raw_affiliation_string":"Gabriele Bartoli Brain Tumor LaboratoryDepartment of Neurological Surgery, Columbia University Medical Center, New York, NY, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056395131","display_name":"Allen E. Waziri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allen E. Waziri","raw_affiliation_strings":["Gabriele Bartoli Brain Tumor LaboratoryDepartment of Neurological Surgery, Columbia University Medical Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gabriele Bartoli Brain Tumor LaboratoryDepartment of Neurological Surgery, Columbia University Medical Center, New York, NY, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046673359","display_name":"Peter Canoll","orcid":"https://orcid.org/0000-0002-7001-0226","observed_orcids":["https://orcid.org/0000-0002-7001-0226"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter D. Canoll","raw_affiliation_strings":["Department of Pathology and Center for Neurobiology and BehaviorColumbia University Medical Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Center for Neurobiology and BehaviorColumbia University Medical Center, New York, NY, USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055848888","display_name":"Jeffrey N. Bruce","orcid":"https://orcid.org/0000-0002-6844-0286","observed_orcids":["https://orcid.org/0000-0002-6844-0286"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey N. Bruce","raw_affiliation_strings":["Gabriele Bartoli Brain Tumor LaboratoryDepartment of Neurological Surgery, Columbia University Medical Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gabriele Bartoli Brain Tumor LaboratoryDepartment of Neurological Surgery, Columbia University Medical Center, New York, NY, USA","institution_ids":["https://openalex.org/I2799503643"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2325,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.7311828,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"28","issue":"5","first_page":"542","last_page":"548"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/convection-enhanced-delivery","display_name":"convection-enhanced delivery","score":0.996999979019165},{"id":"https://openalex.org/keywords/high-grade-glioma","display_name":"high-grade glioma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/topotecan","display_name":"topotecan","score":0.7319999933242798},{"id":"https://openalex.org/keywords/regional-drug-delivery","display_name":"regional drug delivery","score":0.6399999856948853},{"id":"https://openalex.org/keywords/recurrent-glioma","display_name":"recurrent glioma","score":0.7020000219345093},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.7670000195503235}],"concepts":[{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.8051007986068726},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7483420372009277},{"id":"https://openalex.org/C2781209748","wikidata":"https://www.wikidata.org/wiki/Q419953","display_name":"Topotecan","level":3,"score":0.6226930618286133},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.6033305525779724},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5248406529426575},{"id":"https://openalex.org/C110121322","wikidata":"https://www.wikidata.org/wiki/Q865811","display_name":"Distribution (mathematics)","level":2,"score":0.49375399947166443},{"id":"https://openalex.org/C2778074680","wikidata":"https://www.wikidata.org/wiki/Q2125439","display_name":"Cannula","level":2,"score":0.4825843870639801},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38819214701652527},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3583473563194275},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.31998568773269653},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.30447715520858765},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23759961128234863},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.13947850465774536},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.08920332789421082},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1179/016164106x116836","doi":"https://doi.org/10.1179/016164106x116836","is_oa":false,"landing_page_url":"https://doi.org/10.1179/016164106x116836","pdf_url":null,"source":{"id":"https://openalex.org/S187584928","display_name":"Neurological Research","issn_l":"0161-6412","issn":["0161-6412","1743-1328"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurological Research","raw_type":"journal-article"},{"id":"pmid:16808887","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16808887","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurological research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4199931036","display_name":"TOPOTECAN BY INTRACEREBRAL CLYSIS FOR BRAIN TUMORS","funder_award_id":"R01CA089395","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W129044252","https://openalex.org/W1521872585","https://openalex.org/W1975473840","https://openalex.org/W1976858458","https://openalex.org/W1978062879","https://openalex.org/W1979848970","https://openalex.org/W1982152660","https://openalex.org/W1985664084","https://openalex.org/W1987408132","https://openalex.org/W1990408233","https://openalex.org/W1997712655","https://openalex.org/W2006104156","https://openalex.org/W2007719782","https://openalex.org/W2016044792","https://openalex.org/W2021517358","https://openalex.org/W2026873511","https://openalex.org/W2027024102","https://openalex.org/W2030608887","https://openalex.org/W2039227150","https://openalex.org/W2039816707","https://openalex.org/W2040520928","https://openalex.org/W2055475004","https://openalex.org/W2065301357","https://openalex.org/W2082933755","https://openalex.org/W2090881363","https://openalex.org/W2091114855","https://openalex.org/W2125514745","https://openalex.org/W2132024010","https://openalex.org/W2135062838","https://openalex.org/W2137020659","https://openalex.org/W2145206602","https://openalex.org/W2149791952","https://openalex.org/W2150696320","https://openalex.org/W2153388538","https://openalex.org/W2169103384","https://openalex.org/W2171791693","https://openalex.org/W2176801482","https://openalex.org/W2181569653","https://openalex.org/W2275952213","https://openalex.org/W2434926675","https://openalex.org/W2816627810"],"related_works":["https://openalex.org/W2275903432","https://openalex.org/W2563858628","https://openalex.org/W2097128649","https://openalex.org/W2016541971","https://openalex.org/W2042975893","https://openalex.org/W1993725418","https://openalex.org/W1701333584","https://openalex.org/W2510737262","https://openalex.org/W2491545850","https://openalex.org/W4391141121"],"abstract_inverted_index":{"Despite":[0],"advancements":[1],"in":[2,96],"glioma":[3,78,100,144],"therapy,":[4],"median":[5],"survival":[6],"remains":[7],"low":[8],"because":[9],"of":[10,17,38,75,129,140,150,157],"rapid":[11],"post-resection":[12],"recurrence.":[13],"A":[14],"regional":[15],"method":[16],"drug":[18],"delivery":[19,29],"to":[20,154],"address":[21],"local":[22],"invasion":[23],"may":[24],"improve":[25],"clinical":[26,125],"outcomes.":[27],"Convection-enhanced":[28],"(CED)":[30],"is":[31],"a":[32,97,141],"novel":[33,130],"therapy":[34],"that":[35,54,79,133],"allows":[36],"distribution":[37,156],"substances":[39,86],"throughout":[40],"the":[41,52],"interstitium":[42],"via":[43],"positive-pressure":[44],"infusion.":[45],"Studies":[46],"using":[47,84,94],"various":[48],"agents":[49,132,159],"have":[50,80,111],"investigated":[51],"parameters":[53],"affect":[55],"CED":[56,109],"including":[57],"infusion":[58,62],"rate,":[59],"cannula":[60],"size,":[61],"volume,":[63],"extracellular":[64],"space,":[65],"particle":[66],"characteristics":[67],"and":[68,116,127,160],"tumor":[69],"tissue":[70],"structure.":[71],"We":[72,102],"review":[73,104],"models":[74],"small":[76],"animal":[77,143],"been":[81],"successfully":[82],"treated":[83],"different":[85],"administered":[87],"through":[88],"CED,":[89],"particularly":[90],"our":[91],"favorable":[92],"results":[93],"topotecan":[95],"C6":[98],"rat":[99],"model.":[101],"also":[103],"Phase":[105],"I/II":[106],"trials":[107,126],"utilizing":[108],"which":[110],"shown":[112],"promising":[113],"response":[114,163],"rates":[115],"acceptable":[117],"safety":[118],"profiles.":[119],"Future":[120],"studies":[121],"should":[122,164],"include":[123],"prospective":[124],"investigation":[128,149],"antitumor":[131],"are":[134],"ineffective":[135],"with":[136],"systemic":[137],"delivery.":[138],"Development":[139],"large":[142],"model":[145],"would":[146],"enhance":[147],"pre-clinical":[148],"CED.":[151],"Clinically,":[152],"methods":[153],"monitor":[155],"therapeutic":[158],"real-time":[161],"patient":[162],"likewise":[165],"be":[166],"explored.":[167]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}