{"id":"https://openalex.org/W1973808708","doi":"https://doi.org/10.1097/ppo.0b013e3181be1b90","title":"Other Paradigms: Growth Rate Constants and Tumor Burden Determined Using Computed Tomography Data Correlate Strongly With the Overall Survival of Patients With Renal Cell Carcinoma","display_name":"Other Paradigms: Growth Rate Constants and Tumor Burden Determined Using Computed Tomography Data Correlate Strongly With the Overall Survival of Patients With Renal Cell Carcinoma","publication_year":2009,"publication_date":"2009-09-01","ids":{"openalex":"https://openalex.org/W1973808708","doi":"https://doi.org/10.1097/ppo.0b013e3181be1b90","mag":"1973808708","pmid":"https://pubmed.ncbi.nlm.nih.gov/19826366","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3667552"},"language":"en","primary_location":{"id":"doi:10.1097/ppo.0b013e3181be1b90","doi":"https://doi.org/10.1097/ppo.0b013e3181be1b90","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ppo.0b013e3181be1b90","pdf_url":null,"source":{"id":"https://openalex.org/S4210176243","display_name":"The Cancer Journal","issn_l":"1528-9117","issn":["1528-9117","1540-336X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Cancer Journal","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3667552","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048530943","display_name":"Wilfred Donald Stein","orcid":"https://orcid.org/0000-0003-3557-6854","observed_orcids":["https://orcid.org/0000-0003-3557-6854"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wilfred D. Stein","raw_affiliation_strings":["Medical Oncology Branch, National Cancer Institute, NIH, Bethesda, MD20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Branch, National Cancer Institute, NIH, Bethesda, MD20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049136567","display_name":"Hui Huang","orcid":"https://orcid.org/0000-0002-2279-8418","observed_orcids":["https://orcid.org/0000-0002-2279-8418"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hui Huang","raw_affiliation_strings":["Medical Oncology Branch, National Cancer Institute, NIH, Bethesda, MD","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Branch, National Cancer Institute, NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066423217","display_name":"Michael E. Menefee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Menefee","raw_affiliation_strings":["Division of Hematology and Oncology, Mayo Clinic, San Pablo Road, Jacksonville, FL","Hematology / Oncology / Cancer Center / Breast Clinic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology and Oncology, Mayo Clinic, San Pablo Road, Jacksonville, FL","institution_ids":["https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Hematology / Oncology / Cancer Center / Breast Clinic","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008898573","display_name":"Maureen Edgerly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Maureen Edgerly","raw_affiliation_strings":["Medical Oncology Branch, National Cancer Institute, NIH, Bethesda, MD","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Branch, National Cancer Institute, NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110266399","display_name":"Herbert L. Kotz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Herb Kotz","raw_affiliation_strings":["Medical Oncology Branch, National Cancer Institute, NIH, Bethesda, MD","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Branch, National Cancer Institute, NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033298715","display_name":"Andrew A. Dwyer","orcid":"https://orcid.org/0000-0002-7023-6794","observed_orcids":["https://orcid.org/0000-0002-7023-6794"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Dwyer","raw_affiliation_strings":["Department of Imaging Sciences, and \u00b6Surgical Oncology Branch, National Institutes of Health, Bethesda, MD","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Imaging Sciences, and \u00b6Surgical Oncology Branch, National Institutes of Health, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055074037","display_name":"James Chih\u2010Hsin Yang","orcid":"https://orcid.org/0000-0002-5586-5138","observed_orcids":["https://orcid.org/0000-0002-5586-5138"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Yang","raw_affiliation_strings":["\u00b6Surgical Oncology Branch, National Institutes of Health, Bethesda, MD","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00b6Surgical Oncology Branch, National Institutes of Health, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013592290","display_name":"Susan Elaine Bates","orcid":"https://orcid.org/0000-0001-6708-0330","observed_orcids":["https://orcid.org/0000-0001-6708-0330"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Susan E. Bates","raw_affiliation_strings":["Medical Oncology Branch, National Cancer Institute, NIH, Bethesda, MD","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Branch, National Cancer Institute, NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5008898573","https://openalex.org/A5013592290","https://openalex.org/A5048530943","https://openalex.org/A5049136567","https://openalex.org/A5110266399"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"],"apc_list":null,"apc_paid":null,"fwci":0.2976,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.25956567,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"15","issue":"5","first_page":"441","last_page":"447"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.42579999566078186,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.42579999566078186,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.4189000129699707,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.10490000247955322,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":0.9670000076293945},{"id":"https://openalex.org/keywords/ixabepilone","display_name":"ixabepilone","score":0.9480000138282776},{"id":"https://openalex.org/keywords/growth-rate-constant","display_name":"growth rate constant","score":0.8180000185966492},{"id":"https://openalex.org/keywords/tumor-burden","display_name":"tumor burden","score":0.7670000195503235},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.5450000166893005},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6330000162124634},{"id":"https://openalex.org/keywords/computed-tomography","display_name":"computed tomography","score":0.6890000104904175},{"id":"https://openalex.org/keywords/mathematical-tumor-growth-model","display_name":"mathematical tumor growth model","score":0.7450000047683716},{"id":"https://openalex.org/keywords/metastatic-renal-cell-carcinoma","display_name":"metastatic renal cell carcinoma","score":0.6970000267028809},{"id":"https://openalex.org/keywords/epothilone-b-analog","display_name":"epothilone B analog","score":0.7609999775886536},{"id":"https://openalex.org/keywords/surrogate-endpoints","display_name":"surrogate endpoints","score":0.47699999809265137},{"id":"https://openalex.org/keywords/treatment-efficacy-evaluation","display_name":"treatment efficacy assessment","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.8294400572776794},{"id":"https://openalex.org/C2779194965","wikidata":"https://www.wikidata.org/wiki/Q11711607","display_name":"Ixabepilone","level":5,"score":0.6822860240936279},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6563711762428284},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.4793201684951782},{"id":"https://openalex.org/C141341695","wikidata":"https://www.wikidata.org/wiki/Q2368661","display_name":"Surrogate endpoint","level":2,"score":0.44484972953796387},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40416383743286133},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.37363606691360474},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3657090663909912},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3259166479110718},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19402381777763367},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017322","descriptor_name":"Clinical Trials, Phase II as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D034261","descriptor_name":"Epothilones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1097/ppo.0b013e3181be1b90","doi":"https://doi.org/10.1097/ppo.0b013e3181be1b90","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ppo.0b013e3181be1b90","pdf_url":null,"source":{"id":"https://openalex.org/S4210176243","display_name":"The Cancer Journal","issn_l":"1528-9117","issn":["1528-9117","1540-336X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Cancer Journal","raw_type":"journal-article"},{"id":"pmid:19826366","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19826366","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer journal (Sudbury, Mass.)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2662465","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3667552","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3667552","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3667552","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer J","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2662465","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3667552","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000881388","display_name":"Paul Calabresi Program in Clinical/Translational Research at Mayo Clinic","funder_award_id":"K12CA090628","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W71294735","https://openalex.org/W1880480189","https://openalex.org/W1991283648","https://openalex.org/W1999966467","https://openalex.org/W2002362358","https://openalex.org/W2007883847","https://openalex.org/W2012681221","https://openalex.org/W2017810579","https://openalex.org/W2018998854","https://openalex.org/W2021592757","https://openalex.org/W2035828101","https://openalex.org/W2041881143","https://openalex.org/W2046507292","https://openalex.org/W2057864075","https://openalex.org/W2081084899","https://openalex.org/W2099243119","https://openalex.org/W2101995865","https://openalex.org/W2123914905","https://openalex.org/W2135636495","https://openalex.org/W2139248078","https://openalex.org/W2141577422","https://openalex.org/W2144390074","https://openalex.org/W2147051864","https://openalex.org/W2149026055","https://openalex.org/W2149456801","https://openalex.org/W2151716382","https://openalex.org/W2152251876","https://openalex.org/W2153867442","https://openalex.org/W2158749015","https://openalex.org/W2162383970","https://openalex.org/W2171469612","https://openalex.org/W2227568616","https://openalex.org/W2259820675","https://openalex.org/W2322553446","https://openalex.org/W2334694951","https://openalex.org/W2620176919","https://openalex.org/W6683284789"],"related_works":["https://openalex.org/W3036176660","https://openalex.org/W124217592","https://openalex.org/W2135636495","https://openalex.org/W2561343955","https://openalex.org/W2560417961","https://openalex.org/W2213533241","https://openalex.org/W4415502915","https://openalex.org/W2891953603","https://openalex.org/W3090398150","https://openalex.org/W2601669178"],"abstract_inverted_index":{"In":[0],"solid":[1],"tumors,":[2],"where":[3],"curative":[4],"therapies":[5,19,221],"still":[6],"elude":[7],"oncologists,":[8],"novel":[9,55],"paradigms":[10],"are":[11],"needed":[12],"to":[13,49,64,187,204],"assess":[14],"the":[15,43,61,66,84,88,149,154,166,171,199,214,226],"efficacy":[16],"of":[17,42,69,90,115,128,216,219,230],"new":[18],"and":[20,72,75,153,158,170,222],"those":[21,127],"already":[22],"approved.":[23],"We":[24],"used":[25,60],"radiologic":[26,62],"measurements":[27,63,101],"obtained":[28,102],"in":[29,37,130,135,213,224],"patients":[30,80,131],"with":[31,120,126,142,195],"metastatic":[32],"renal":[33,116],"cell":[34,117],"carcinoma":[35],"enrolled":[36,82,108],"a":[38,54,105,136,140,206],"phase":[39],"II":[40],"study":[41],"epothilone":[44],"B":[45],"analog,":[46],"ixabepilone":[47,85,121],"(Ixempra),":[48],"address":[50],"this":[51,91,159],"issue.":[52],"Using":[53],"2-phase":[56],"mathematical":[57,180],"equation,":[58],"we":[59],"estimate":[65],"concomitant":[67],"rates":[68],"tumor":[70,156,173,189],"regression":[71],"growth":[73,76,112,150,167,200],"(regression":[74],"rate":[77,94,113,151,168,201],"constants).":[78],"Eighty-one":[79],"were":[81,96,122,175],"on":[83,109],"trial":[86],"at":[87],"time":[89],"analysis.":[92],"Growth":[93],"constants":[95,114],"determined":[97],"using":[98],"computed":[99],"tomography":[100],"exclusively":[103],"while":[104],"patient":[106],"was":[107,145,161],"study.":[110],"The":[111,177],"carcinomas":[118],"treated":[119],"significantly":[123],"reduced":[124],"compared":[125],"tumors":[129],"who":[132],"received":[133],"placebo":[134],"previous":[137],"trial.":[138],"Furthermore,":[139],"correlation":[141,160],"overall":[143],"survival":[144],"found":[146],"for":[147,208],"both":[148,165],"constant":[152,169,202],"initial":[155,172],"burden;":[157],"even":[162],"stronger":[163],"when":[164],"burden":[174],"combined.":[176],"readily":[178],"amenable":[179],"model":[181],"described":[182],"herein":[183],"has":[184],"potential":[185,227],"applications":[186],"many":[188],"types":[190],"that":[191],"can":[192],"be":[193,205],"assessed":[194],"imaging":[196],"modalities.":[197],"Because":[198],"seems":[203],"surrogate":[207],"survival,":[209],"assessment":[210],"could":[211],"aid":[212],"evaluation":[215],"relative":[217],"efficacies":[218],"different":[220],"perhaps":[223],"assessing":[225],"individual":[228],"benefit":[229],"an":[231],"experimental":[232],"therapy.":[233]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}