{"id":"https://openalex.org/W1973707149","doi":"https://doi.org/10.1089/ars.2007.1677","title":"On the Biologic Role of the Reaction of NO with Oxidized Cytochrome c Oxidase","display_name":"On the Biologic Role of the Reaction of NO with Oxidized Cytochrome c Oxidase","publication_year":2007,"publication_date":"2007-07-31","ids":{"openalex":"https://openalex.org/W1973707149","doi":"https://doi.org/10.1089/ars.2007.1677","mag":"1973707149","pmid":"https://pubmed.ncbi.nlm.nih.gov/17665969"},"language":"en","primary_location":{"id":"doi:10.1089/ars.2007.1677","doi":"https://doi.org/10.1089/ars.2007.1677","is_oa":false,"landing_page_url":"https://doi.org/10.1089/ars.2007.1677","pdf_url":null,"source":{"id":"https://openalex.org/S88052261","display_name":"Antioxidants and Redox Signaling","issn_l":"1523-0864","issn":["1523-0864","1557-7716"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants &amp; Redox Signaling","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015138948","display_name":"Fernando Antunes","orcid":"https://orcid.org/0000-0002-4192-2840","observed_orcids":["https://orcid.org/0000-0002-4192-2840"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Fernando Antunes","raw_affiliation_strings":["Grupo de Bioqu\u00edmica dos Oxidantes e Antioxidantes, Centro de Qu\u00edmica e Bioqu\u00edmica and Departamento de Qu\u00edmica e Bioqu\u00edmica, Faculdade de Ci\u00eancias da Universidade de Lisboa, P-1250\u2013047 Lisboa, Portugal","Instituto de Investiga\u00e7\u00e3o Cient\u00edfica Bento da Rocha Cabral, P-1250\u2013047 Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grupo de Bioqu\u00edmica dos Oxidantes e Antioxidantes, Centro de Qu\u00edmica e Bioqu\u00edmica and Departamento de Qu\u00edmica e Bioqu\u00edmica, Faculdade de Ci\u00eancias da Universidade de Lisboa, P-1250\u2013047 Lisboa, Portugal","institution_ids":["https://openalex.org/I141596103"]},{"raw_affiliation_string":"Instituto de Investiga\u00e7\u00e3o Cient\u00edfica Bento da Rocha Cabral, P-1250\u2013047 Lisboa, Portugal","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110338653","display_name":"Alberto Boveris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Alberto Boveris","raw_affiliation_strings":["Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry University of Buenos Aires, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry University of Buenos Aires, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110386441","display_name":"Enrique Cadenas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Enrique Cadenas","raw_affiliation_strings":["Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6321,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.8175267,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"9","issue":"10","first_page":"1569","last_page":"1580"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.875,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.875,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.09080000221729279,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cytochrome-c-oxidase","display_name":"cytochrome c oxidase","score":0.9900000095367432},{"id":"https://openalex.org/keywords/competitive-inhibition","display_name":"competitive inhibition","score":0.9290000200271606},{"id":"https://openalex.org/keywords/uncompetitive-inhibition","display_name":"uncompetitive inhibition","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mitochondrial-respiration","display_name":"mitochondrial respiration","score":0.7440000176429749},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.7480000257492065},{"id":"https://openalex.org/keywords/adp-o-ratio","display_name":"ADP/O ratio","score":0.9039999842643738},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.9900000095367432},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.6620000004768372},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.7265438437461853},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6514462232589722},{"id":"https://openalex.org/C123249941","wikidata":"https://www.wikidata.org/wiki/Q306116","display_name":"Cytochrome c oxidase","level":3,"score":0.639346718788147},{"id":"https://openalex.org/C38485361","wikidata":"https://www.wikidata.org/wiki/Q576379","display_name":"Oxidase test","level":3,"score":0.5413768887519836},{"id":"https://openalex.org/C55904794","wikidata":"https://www.wikidata.org/wiki/Q82682","display_name":"Redox","level":2,"score":0.5367833971977234},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5181359052658081},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5128265023231506},{"id":"https://openalex.org/C8171440","wikidata":"https://www.wikidata.org/wiki/Q903414","display_name":"Steady state (chemistry)","level":2,"score":0.5088053345680237},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5026803016662598},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.49089866876602173},{"id":"https://openalex.org/C2780768313","wikidata":"https://www.wikidata.org/wiki/Q408068","display_name":"Cytochrome","level":3,"score":0.47829824686050415},{"id":"https://openalex.org/C29311851","wikidata":"https://www.wikidata.org/wiki/Q408223","display_name":"Cytochrome c","level":3,"score":0.4739927053451538},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.4505980610847473},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.43691202998161316},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.43265342712402344},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1953120231628418},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07278496026992798},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003576","descriptor_name":"Electron Transport Complex IV","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014451","descriptor_name":"Ubiquinone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014451","descriptor_name":"Ubiquinone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/ars.2007.1677","doi":"https://doi.org/10.1089/ars.2007.1677","is_oa":false,"landing_page_url":"https://doi.org/10.1089/ars.2007.1677","pdf_url":null,"source":{"id":"https://openalex.org/S88052261","display_name":"Antioxidants and Redox Signaling","issn_l":"1523-0864","issn":["1523-0864","1557-7716"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants &amp; Redox Signaling","raw_type":"journal-article"},{"id":"pmid:17665969","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17665969","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antioxidants & redox signaling","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.428600013256073,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4050948601","display_name":"Oxidative Stress, Mitochondrial Dysfunction and Aging","funder_award_id":"R01AG016718","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5942510344","display_name":"Mitochondrial oxidative damage in dopaminergic cells","funder_award_id":"R01ES011342","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1542438435","https://openalex.org/W1589229976","https://openalex.org/W1750720387","https://openalex.org/W1916285502","https://openalex.org/W1967162316","https://openalex.org/W1971692939","https://openalex.org/W1973159051","https://openalex.org/W1974794685","https://openalex.org/W1976995270","https://openalex.org/W1977290021","https://openalex.org/W1984560727","https://openalex.org/W1985977889","https://openalex.org/W1998998834","https://openalex.org/W2008624998","https://openalex.org/W2009052965","https://openalex.org/W2009905368","https://openalex.org/W2015221597","https://openalex.org/W2016788057","https://openalex.org/W2018740639","https://openalex.org/W2028837923","https://openalex.org/W2034744093","https://openalex.org/W2035671239","https://openalex.org/W2036573181","https://openalex.org/W2041124801","https://openalex.org/W2047219072","https://openalex.org/W2057622179","https://openalex.org/W2058062846","https://openalex.org/W2058454177","https://openalex.org/W2059418292","https://openalex.org/W2063146732","https://openalex.org/W2063219876","https://openalex.org/W2065784898","https://openalex.org/W2071292197","https://openalex.org/W2071348092","https://openalex.org/W2071632687","https://openalex.org/W2074507716","https://openalex.org/W2075710075","https://openalex.org/W2076333641","https://openalex.org/W2077103811","https://openalex.org/W2079811417","https://openalex.org/W2080128777","https://openalex.org/W2082244214","https://openalex.org/W2083600400","https://openalex.org/W2087203246","https://openalex.org/W2109893157","https://openalex.org/W2116642215","https://openalex.org/W2132826785","https://openalex.org/W2135822356","https://openalex.org/W2141123131","https://openalex.org/W2143445854","https://openalex.org/W2147080431","https://openalex.org/W2147649093","https://openalex.org/W2151339067","https://openalex.org/W2764818464","https://openalex.org/W4238744171","https://openalex.org/W4239329060"],"related_works":["https://openalex.org/W2008624998","https://openalex.org/W2096901494","https://openalex.org/W2018205667","https://openalex.org/W101073623","https://openalex.org/W2065784898","https://openalex.org/W2166291947","https://openalex.org/W2042263904","https://openalex.org/W1993829914","https://openalex.org/W2056966959","https://openalex.org/W1976995270"],"abstract_inverted_index":{"The":[0,23,113],"inhibition":[1,46,57,76,89],"of":[2,37,63,74,87,94,104,117,146,151,163,171,180,192],"cytochrome":[3],"c":[4],"oxidase":[5],"(CcOX)":[6],"by":[7,108,183],"nitric":[8],"oxide":[9],"(NO)":[10],"is":[11,125,153],"analyzed":[12],"with":[13,97],"a":[14,100],"mathematical":[15],"model":[16],"that":[17,39,142,167],"simulates":[18],"the":[19,27,35,60,70,92,118,143,178,185,189],"metabolism":[20],"in":[21,47,80,155,174,194,196],"vivo.":[22],"main":[24,114],"results":[25],"were":[26],"following:":[28],"(a)":[29],"We":[30],"derived":[31],"novel":[32],"equations":[33],"for":[34,50],"catalysis":[36],"CcOX":[38,45,75,96,124,152],"can":[40],"be":[41],"used":[42],"to":[43,65,126],"predict":[44],"any":[48,51],"tissue":[49],"[NO]":[52],"or":[53],"[O(2)];":[54,110],"(b)":[55],"Competitive":[56],"(resulting":[58,90],"from":[59,91],"reversible":[61],"binding":[62],"NO":[64,121,147,193],"reduced":[66],"CcOX)":[67],"emerges":[68],"has":[69],"sole":[71],"relevant":[72],"component":[73],"under":[77],"state":[78,84,156,175],"3":[79],"vivo;":[81],"(c)":[82],"In":[83],"4,":[85,157],"contribution":[86],"uncompetitive":[88],"reaction":[93,119,133],"oxidized":[95,123],"NO)":[98],"represents":[99],"significant":[101],"nonmajority":[102],"fraction":[103],"inhibition,":[105],"being":[106],"favored":[107],"high":[109],"and":[111,122,173],"(d)":[112],"biologic":[115,144],"role":[116,145],"between":[120],"consume":[127],"NO.":[128],"By":[129],"reducing":[130],"[NO],":[131],"this":[132],"stimulates,":[134],"rather":[135],"than":[136],"inhibits,":[137],"respiration.":[138],"Finally,":[139],"we":[140],"propose":[141],"as":[148],"an":[149,160],"inhibitor":[150],"twofold:":[154],"it":[158],"avoids":[159],"excessive":[161],"buildup":[162],"mitochondrial":[164],"membrane":[165],"potential":[166],"triggers":[168],"rapid":[169],"production":[170],"oxidants,":[172],"3,":[176],"increases":[177],"efficiency":[179],"oxidative":[181],"phosphorylation":[182],"increasing":[184],"ADP/O":[186],"ratio,":[187],"supporting":[188],"therapeutic":[190],"use":[191],"situations":[195],"which":[197],"mitochondria":[198],"are":[199],"dysfunctional.":[200]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
