{"id":"https://openalex.org/W1973705388","doi":"https://doi.org/10.3892/ijmm.15.3.519","title":"Fish soluble Toll-like receptor 5 (TLR5S) is an acute-phase protein with integral flagellin-recognition activity","display_name":"Fish soluble Toll-like receptor 5 (TLR5S) is an acute-phase protein with integral flagellin-recognition activity","publication_year":2005,"publication_date":"2005-03-01","ids":{"openalex":"https://openalex.org/W1973705388","doi":"https://doi.org/10.3892/ijmm.15.3.519","mag":"1973705388","pmid":"https://pubmed.ncbi.nlm.nih.gov/15702248"},"language":"en","primary_location":{"id":"doi:10.3892/ijmm.15.3.519","doi":"https://doi.org/10.3892/ijmm.15.3.519","is_oa":false,"landing_page_url":"https://doi.org/10.3892/ijmm.15.3.519","pdf_url":null,"source":{"id":"https://openalex.org/S192722082","display_name":"International Journal of Molecular Medicine","issn_l":"1107-3756","issn":["1107-3756","1791-244X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076259754","display_name":"Hironobu Tsukada","orcid":"https://orcid.org/0009-0009-8039-7194","observed_orcids":["https://orcid.org/0009-0009-8039-7194"]},"institutions":[{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hironobu Tsukada","raw_affiliation_strings":["Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari-ku, Osaka 537-8511, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari-ku, Osaka 537-8511, Japan","institution_ids":["https://openalex.org/I4210151107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113759936","display_name":"A Fukui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405282797","display_name":"Osaka Prefectural Hospital Organization","ror":"https://ror.org/00fb90w44","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405282797"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Aya Fukui","raw_affiliation_strings":["Osaka Prefectural Hospital Organization"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Osaka Prefectural Hospital Organization","institution_ids":["https://openalex.org/I4405282797"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009095158","display_name":"Tadayuki Tsujita","orcid":"https://orcid.org/0000-0002-7189-0376","observed_orcids":["https://orcid.org/0000-0002-7189-0376"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tadayuki Tsujita","raw_affiliation_strings":["MED - Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MED - Medical Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071402791","display_name":"Misako Matsumoto","orcid":"https://orcid.org/0000-0002-4333-5260","observed_orcids":["https://orcid.org/0000-0002-4333-5260"]},"institutions":[{"id":"https://openalex.org/I4405282797","display_name":"Osaka Prefectural Hospital Organization","ror":"https://ror.org/00fb90w44","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405282797"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Misako Matsumoto","raw_affiliation_strings":["Osaka Prefectural Hospital Organization"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Osaka Prefectural Hospital Organization","institution_ids":["https://openalex.org/I4405282797"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110340198","display_name":"Takaji Iida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405282797","display_name":"Osaka Prefectural Hospital Organization","ror":"https://ror.org/00fb90w44","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405282797"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takaji Iida","raw_affiliation_strings":["Osaka Prefectural Hospital Organization"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Osaka Prefectural Hospital Organization","institution_ids":["https://openalex.org/I4405282797"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089860635","display_name":"Tsukasa Seya","orcid":"https://orcid.org/0000-0002-0808-5710","observed_orcids":["https://orcid.org/0000-0002-0808-5710"]},"institutions":[{"id":"https://openalex.org/I4405282797","display_name":"Osaka Prefectural Hospital Organization","ror":"https://ror.org/00fb90w44","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405282797"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsukasa Seya","raw_affiliation_strings":["Osaka Prefectural Hospital Organization"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Osaka Prefectural Hospital Organization","institution_ids":["https://openalex.org/I4405282797"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9102,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.71130185,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"15","issue":"3","first_page":"519","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.8657000064849854,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.8657000064849854,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10506","display_name":"Aquaculture disease management and microbiota","score":0.13199999928474426,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rainbow-trout","display_name":"rainbow trout","score":0.9509999752044678},{"id":"https://openalex.org/keywords/flagellin-recognition","display_name":"flagellin recognition","score":0.878000020980835},{"id":"https://openalex.org/keywords/acute-phase-proteins","display_name":"acute phase proteins","score":0.9380000233650208},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.9369999766349792},{"id":"https://openalex.org/keywords/vibrio-anguillarum","display_name":"Vibrio anguillarum","score":0.8930000066757202},{"id":"https://openalex.org/keywords/leucine-rich-repeats","display_name":"leucine-rich repeats","score":0.8450000286102295},{"id":"https://openalex.org/keywords/liver-expression","display_name":"liver expression","score":0.41100001335144043},{"id":"https://openalex.org/keywords/bacterial-infection","display_name":"bacterial infection","score":0.5509999990463257},{"id":"https://openalex.org/keywords/fish-innate-immunity","display_name":"fish innate immunity","score":0.7440000176429749}],"concepts":[{"id":"https://openalex.org/C38117629","wikidata":"https://www.wikidata.org/wiki/Q24788421","display_name":"Flagellin","level":3,"score":0.9539093971252441},{"id":"https://openalex.org/C2777338127","wikidata":"https://www.wikidata.org/wiki/Q14914085","display_name":"TLR5","level":5,"score":0.8596310615539551},{"id":"https://openalex.org/C2781348184","wikidata":"https://www.wikidata.org/wiki/Q7924678","display_name":"Vibrio anguillarum","level":4,"score":0.8251738548278809},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7886561155319214},{"id":"https://openalex.org/C2778873838","wikidata":"https://www.wikidata.org/wiki/Q134385","display_name":"Fugu","level":4,"score":0.5311485528945923},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.49459001421928406},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.486901193857193},{"id":"https://openalex.org/C2779282177","wikidata":"https://www.wikidata.org/wiki/Q217329","display_name":"Turbot","level":3,"score":0.45739731192588806},{"id":"https://openalex.org/C2994167347","wikidata":"https://www.wikidata.org/wiki/Q187986","display_name":"Rainbow trout","level":3,"score":0.43393486738204956},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.3712937831878662},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.37031546235084534},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.3658265471458435},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3331751823425293},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.305691659450531},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2846183776855469},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2512965798377991},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1546945571899414},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.1268480122089386},{"id":"https://openalex.org/C2776154503","wikidata":"https://www.wikidata.org/wiki/Q753490","display_name":"Vibrio","level":3,"score":0.11268627643585205},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.07473266124725342},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000209","descriptor_name":"Acute-Phase Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000209","descriptor_name":"Acute-Phase Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000209","descriptor_name":"Acute-Phase Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005408","descriptor_name":"Flagellin","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D005408","descriptor_name":"Flagellin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014733","descriptor_name":"Vibrio","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015723","descriptor_name":"Gene Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017686","descriptor_name":"Oncorhynchus mykiss","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017686","descriptor_name":"Oncorhynchus mykiss","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051198","descriptor_name":"Toll-Like Receptor 5","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3892/ijmm.15.3.519","doi":"https://doi.org/10.3892/ijmm.15.3.519","is_oa":false,"landing_page_url":"https://doi.org/10.3892/ijmm.15.3.519","pdf_url":null,"source":{"id":"https://openalex.org/S192722082","display_name":"International Journal of Molecular Medicine","issn_l":"1107-3756","issn":["1107-3756","1791-244X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Medicine","raw_type":"journal-article"},{"id":"pmid:15702248","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15702248","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320338075","display_name":"Core Research for Evolutional Science and Technology","ror":"https://ror.org/00097mb19"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2157129863","https://openalex.org/W1976972606","https://openalex.org/W2979466636","https://openalex.org/W4307658985","https://openalex.org/W2077503388","https://openalex.org/W4223483667","https://openalex.org/W2034265657","https://openalex.org/W7133307041","https://openalex.org/W4380758525","https://openalex.org/W4405748862"],"abstract_inverted_index":{"From":[0],"an":[1,174],"EST":[2],"fragment":[3],"of":[4,26,48,61,70,76,85,99,111,160,182,185],"the":[5,18,35,45,73,83,105,112,157,161,170,204],"rainbow":[6,113],"trout":[7,114],"that":[8,116,167],"was":[9,40,101],"predicted":[10],"to":[11,44,59,118,121,126,151,188,198],"contain":[12],"leucine-rich":[13],"repeats":[14],"(LRR),":[15],"we":[16],"cloned":[17],"whole":[19],"cDNA":[20],"and":[21,37,51,72,88,192],"identified":[22],"a":[23,183],"soluble":[24,171],"form":[25],"TLR5":[27,172],"ortholog":[28],"(rtTLR5S),":[29],"which":[30],"does":[31],"not":[32],"exist":[33],"in":[34,94,104,124,142,149,168,203],"mouse":[36,52,65],"human.":[38],"rtTLR5S":[39,55,71,100,123],"about":[41],"38%":[42],"homologous":[43,58],"extracellular":[46],"domains":[47],"human":[49,63],"(hu)":[50],"(mo)TLR5,":[53],"while":[54],"showed":[56],"<25%":[57],"those":[60],"other":[62],"or":[64,129],"TLRs.":[66],"A":[67,87],"chimera":[68],"constructed":[69],"intra-cellular":[74],"TIR":[75],"huTLR5":[77,141],"expressed":[78],"on":[79],"HeLa":[80,143],"cells":[81],"signaled":[82],"presence":[84],"flagellin":[86,132],"C":[89],"from":[90,200],"V.":[91,127],"anguillarum,":[92],"resulting":[93],"NF-kappaB":[95,147,190],"activation.":[96],"The":[97,107],"mRNA":[98],"predominantly":[102],"detected":[103],"liver.":[106],"hepatoma":[108],"cell":[109],"line":[110],"RTH149":[115],"responded":[117],"flagellin,":[119],"allowed":[120],"up-regulate":[122],"response":[125,150],"anguillarum":[128],"its":[130],"purified":[131],"within":[133],"8":[134],"h.":[135],"rtTLR5S,":[136],"when":[137],"co-expressed":[138],"with":[139,156],"membrane":[140],"cells,":[144],"augmented":[145],"huTLR5-mediated":[146],"activation":[148],"flagellin.":[152],"These":[153],"results,":[154],"together":[155],"genome":[158],"information":[159],"pufferfish":[162],"Fugu":[163],"(Fugu":[164],"rubripes),":[165],"suggest":[166],"fish":[169,197],"is":[173],"acute-phase":[175],"protein":[176],"sensing":[177],"bacterial":[178,186,201],"infection":[179,202],"via":[180],"recognition":[181],"variety":[184],"flagellins":[187],"augment":[189],"activation,":[191],"may":[193],"be":[194],"important":[195],"for":[196],"survive":[199],"water.":[205]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
