{"id":"https://openalex.org/W1973704397","doi":"https://doi.org/10.1046/j.1365-2141.1997.2353052.x","title":"The prothrombin gene G20210A variant: prevalence in a U.K. anticoagulant clinic population","display_name":"The prothrombin gene G20210A variant: prevalence in a U.K. anticoagulant clinic population","publication_year":1997,"publication_date":"1997-08-01","ids":{"openalex":"https://openalex.org/W1973704397","doi":"https://doi.org/10.1046/j.1365-2141.1997.2353052.x","mag":"1973704397","pmid":"https://pubmed.ncbi.nlm.nih.gov/9266933"},"language":"en","primary_location":{"id":"doi:10.1046/j.1365-2141.1997.2353052.x","doi":"https://doi.org/10.1046/j.1365-2141.1997.2353052.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1365-2141.1997.2353052.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-2141.1997.2353052.x","source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-2141.1997.2353052.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110352747","display_name":"Anthony M. Cumming","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801926401","display_name":"Manchester Royal Infirmary","ror":"https://ror.org/03kr30n36","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801926401","https://openalex.org/I4210092852"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"A. M. CUMMING","raw_affiliation_strings":["University Department of Haematology, Royal Infirmary, Manchester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Department of Haematology, Royal Infirmary, Manchester","institution_ids":["https://openalex.org/I2801926401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111502468","display_name":"Stephen Keeney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801926401","display_name":"Manchester Royal Infirmary","ror":"https://ror.org/03kr30n36","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801926401","https://openalex.org/I4210092852"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S. KEENEY","raw_affiliation_strings":["University Department of Haematology, Royal Infirmary, Manchester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Department of Haematology, Royal Infirmary, Manchester","institution_ids":["https://openalex.org/I2801926401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039812589","display_name":"A. Salden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801926401","display_name":"Manchester Royal Infirmary","ror":"https://ror.org/03kr30n36","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801926401","https://openalex.org/I4210092852"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. SALDEN","raw_affiliation_strings":["University Department of Haematology, Royal Infirmary, Manchester"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Department of Haematology, Royal Infirmary, Manchester","institution_ids":["https://openalex.org/I2801926401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032335601","display_name":"Manju Bhavnani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125418","display_name":"Royal Albert Edward Infirmary","ror":"https://ror.org/02v0mj573","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210125418"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M. BHAVNANI","raw_affiliation_strings":["Department of Haematology, Royal Albert Edward Infirmary, Wigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Royal Albert Edward Infirmary, Wigan","institution_ids":["https://openalex.org/I4210125418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017313929","display_name":"K. H. Shwe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125418","display_name":"Royal Albert Edward Infirmary","ror":"https://ror.org/02v0mj573","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210125418"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"K. H. SHWE","raw_affiliation_strings":["Department of Haematology, Royal Albert Edward Infirmary, Wigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Royal Albert Edward Infirmary, Wigan","institution_ids":["https://openalex.org/I4210125418"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036282387","display_name":"Charles R. M. Hay","orcid":"https://orcid.org/0000-0002-0162-6828","observed_orcids":["https://orcid.org/0000-0002-0162-6828"]},"institutions":[{"id":"https://openalex.org/I2801926401","display_name":"Manchester Royal Infirmary","ror":"https://ror.org/03kr30n36","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801926401","https://openalex.org/I4210092852"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C. R. M. HAY","raw_affiliation_strings":["0","Manchester Haemostasis and Thrombosis Centre, Department of Haematology, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"0","institution_ids":[]},{"raw_affiliation_string":"Manchester Haemostasis and Thrombosis Centre, Department of Haematology, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL","institution_ids":["https://openalex.org/I2801926401"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110352747"],"corresponding_institution_ids":["https://openalex.org/I2801926401"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":null,"fwci":15.3783,"has_fulltext":true,"cited_by_count":166,"citation_normalized_percentile":{"value":0.99418114,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"98","issue":"2","first_page":"353","last_page":"355"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/venous-thrombosis","display_name":"venous thrombosis","score":0.890999972820282},{"id":"https://openalex.org/keywords/thrombophilia","display_name":"thrombophilia","score":0.9409999847412109},{"id":"https://openalex.org/keywords/genetic-risk-factors","display_name":"genetic risk factors","score":0.878000020980835},{"id":"https://openalex.org/keywords/allele-frequency","display_name":"allele frequency","score":0.7710000276565552},{"id":"https://openalex.org/keywords/inherited-thrombophilia","display_name":"inherited thrombophilia","score":0.7149999737739563},{"id":"https://openalex.org/keywords/factor-v-leiden","display_name":"factor V Leiden","score":0.6840000152587891},{"id":"https://openalex.org/keywords/antithrombin-deficiency","display_name":"antithrombin deficiency","score":0.9100000262260437},{"id":"https://openalex.org/keywords/protein-c-deficiency","display_name":"protein C deficiency","score":0.9559999704360962},{"id":"https://openalex.org/keywords/protein-s-deficiency","display_name":"protein S deficiency","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C2777175894","wikidata":"https://www.wikidata.org/wiki/Q185986","display_name":"Factor V Leiden","level":4,"score":0.7499954700469971},{"id":"https://openalex.org/C2780842393","wikidata":"https://www.wikidata.org/wiki/Q1570013","display_name":"Thrombophilia","level":3,"score":0.6725369095802307},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.6718320846557617},{"id":"https://openalex.org/C2779026020","wikidata":"https://www.wikidata.org/wiki/Q416336","display_name":"Antithrombin","level":3,"score":0.6469794511795044},{"id":"https://openalex.org/C2777872019","wikidata":"https://www.wikidata.org/wiki/Q2113626","display_name":"Prothrombin G20210A","level":5,"score":0.6429088115692139},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6079509854316711},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5970364809036255},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5793413519859314},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5479325652122498},{"id":"https://openalex.org/C2780011451","wikidata":"https://www.wikidata.org/wiki/Q2751330","display_name":"Venous thrombosis","level":3,"score":0.5285519361495972},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.5001852512359619},{"id":"https://openalex.org/C2781287897","wikidata":"https://www.wikidata.org/wiki/Q412810","display_name":"Protein C","level":2,"score":0.4492076337337494},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4374655783176422},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.42592817544937134},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.4181886613368988},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2904302477836609},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2138270139694214},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16625896096229553},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.11246636509895325},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004739","descriptor_name":"England","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011516","descriptor_name":"Prothrombin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013924","descriptor_name":"Thrombophlebitis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013924","descriptor_name":"Thrombophlebitis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1365-2141.1997.2353052.x","doi":"https://doi.org/10.1046/j.1365-2141.1997.2353052.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1365-2141.1997.2353052.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-2141.1997.2353052.x","source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},{"id":"pmid:9266933","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9266933","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of haematology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1046/j.1365-2141.1997.2353052.x","doi":"https://doi.org/10.1046/j.1365-2141.1997.2353052.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1365-2141.1997.2353052.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-2141.1997.2353052.x","source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320291","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1973704397.pdf","grobid_xml":"https://content.openalex.org/works/W1973704397.grobid-xml"},"referenced_works_count":8,"referenced_works":["https://openalex.org/W112842645","https://openalex.org/W1531281563","https://openalex.org/W1543904568","https://openalex.org/W1965958910","https://openalex.org/W1995474189","https://openalex.org/W2269290009","https://openalex.org/W2328547014","https://openalex.org/W2399373446"],"related_works":["https://openalex.org/W1969138367","https://openalex.org/W2126744674","https://openalex.org/W1618204641","https://openalex.org/W2462261788","https://openalex.org/W2410590026","https://openalex.org/W2163474339","https://openalex.org/W1885843860","https://openalex.org/W191575290","https://openalex.org/W2443885663","https://openalex.org/W92365771"],"abstract_inverted_index":{"We":[0],"have":[1],"investigated":[2],"the":[3,12,36,42,87,94,116],"prevalence":[4],"of":[5,23,35,41,48,78,118],"a":[6,46,63],"recently":[7],"reported":[8],"genetic":[9,120],"variation":[10,112],"in":[11,16,45],"prothrombin":[13,109],"gene":[14,110],"(G20210A)":[15],"patients":[17,27,61],"with":[18,62],"an":[19],"objectively":[20],"confirmed":[21],"history":[22],"venous":[24,70,97],"thrombosis,":[25],"12/219":[26],"(5.5%)":[28],"were":[29,85],"found":[30,91],"to":[31,92,115],"be":[32],"heterozygous":[33],"carriers":[34],"20210A":[37,43],"allele.":[38],"The":[39],"incidence":[40],"allele":[44],"group":[47],"164":[49],"healthy":[50],"controls":[51],"was":[52,90],"1.2%":[53],"(allele":[54],"frequency":[55],"0.61%,":[56],"95%":[57,105],"CI":[58,106],"0.08-2.19).":[59],"When":[60],"known":[64],"alternative":[65],"hereditary":[66],"risk":[67,95,121],"factor":[68],"for":[69,96,123],"thrombosis":[71,98],"(factor":[72],"V":[73],"Leiden":[74],"mutation":[75],"or":[76,82],"deficiency":[77],"antithrombin,":[79],"protein":[80,83],"C":[81],"S)":[84],"excluded,":[86],"G20210A":[88],"variant":[89],"increase":[93],"by":[99],"approximately":[100],"5-fold":[101],"(odds":[102],"ratio":[103],"5.4,":[104],"1.16-25.0).":[107],"This":[108],"sequence":[111],"adds":[113],"further":[114],"list":[117],"recognized":[119],"factors":[122],"thrombophilia.":[124]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}