{"id":"https://openalex.org/W1973687792","doi":"https://doi.org/10.1016/s0168-1605(00)00307-x","title":"Permeability barrier of the Gram-negative bacterial outer membrane with special reference to nisin","display_name":"Permeability barrier of the Gram-negative bacterial outer membrane with special reference to nisin","publication_year":2000,"publication_date":"2000-09-01","ids":{"openalex":"https://openalex.org/W1973687792","doi":"https://doi.org/10.1016/s0168-1605(00)00307-x","mag":"1973687792","pmid":"https://pubmed.ncbi.nlm.nih.gov/11016605"},"language":"en","primary_location":{"id":"doi:10.1016/s0168-1605(00)00307-x","doi":"https://doi.org/10.1016/s0168-1605(00)00307-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0168-1605(00)00307-x","pdf_url":null,"source":{"id":"https://openalex.org/S132626406","display_name":"International Journal of Food Microbiology","issn_l":"0168-1605","issn":["0168-1605","1879-3460"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Food Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089621896","display_name":"Ilkka M. Helander","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87653560","display_name":"VTT Technical Research Centre of Finland","ror":"https://ror.org/04b181w54","country_code":"FI","type":"nonprofit","lineage":["https://openalex.org/I4210089493","https://openalex.org/I87653560"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Ilkka M Helander","raw_affiliation_strings":["VTT Biotechnology, Espoo, Finland. ilkka.helander@vtt.fi","VTT Biotechnology, Tietotie 2, FIN-02044 VTT, Espoo, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VTT Biotechnology, Espoo, Finland. ilkka.helander@vtt.fi","institution_ids":["https://openalex.org/I87653560"]},{"raw_affiliation_string":"VTT Biotechnology, Tietotie 2, FIN-02044 VTT, Espoo, Finland","institution_ids":["https://openalex.org/I87653560"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101459913","display_name":"Tiina Mattila","orcid":"https://orcid.org/0000-0001-8466-985X","observed_orcids":["https://orcid.org/0000-0001-8466-985X"]},"institutions":[{"id":"https://openalex.org/I87653560","display_name":"VTT Technical Research Centre of Finland","ror":"https://ror.org/04b181w54","country_code":"FI","type":"nonprofit","lineage":["https://openalex.org/I4210089493","https://openalex.org/I87653560"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Tiina Mattila-Sandholm","raw_affiliation_strings":["VTT Biotechnology, Tietotie 2, FIN-02044 VTT, Espoo, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VTT Biotechnology, Tietotie 2, FIN-02044 VTT, Espoo, Finland","institution_ids":["https://openalex.org/I87653560"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I87653560"],"apc_list":{"value":4090,"currency":"USD","value_usd":4090},"apc_paid":null,"fwci":1.2729,"has_fulltext":false,"cited_by_count":167,"citation_normalized_percentile":{"value":0.77677294,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"60","issue":"2-3","first_page":"153","last_page":"161"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.92330002784729,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.92330002784729,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.02459999918937683,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.02250000089406967,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nisin","display_name":"nisin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/outer-membrane-permeability","display_name":"outer membrane permeability","score":0.796999990940094},{"id":"https://openalex.org/keywords/gram-negative-bacteria","display_name":"Gram-negative bacteria","score":0.9589999914169312},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8299999833106995},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pseudomonas-marginalis","display_name":"Pseudomonas marginalis","score":0.9129999876022339},{"id":"https://openalex.org/keywords/salmonella-typhimurium","display_name":"Salmonella typhimurium","score":0.9660000205039978},{"id":"https://openalex.org/keywords/edta","display_name":"EDTA","score":0.75},{"id":"https://openalex.org/keywords/cell-surface-charge","display_name":"cell surface charge","score":0.8989999890327454},{"id":"https://openalex.org/keywords/electrostatic-interactions","display_name":"electrostatic interactions","score":0.9020000100135803},{"id":"https://openalex.org/keywords/acid-tolerance","display_name":"acid resistance","score":0.4449999928474426}],"concepts":[{"id":"https://openalex.org/C2778457984","wikidata":"https://www.wikidata.org/wiki/Q415798","display_name":"Nisin","level":3,"score":0.9608481526374817},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.6513104438781738},{"id":"https://openalex.org/C146587185","wikidata":"https://www.wikidata.org/wiki/Q258248","display_name":"Bacterial outer membrane","level":4,"score":0.5544016361236572},{"id":"https://openalex.org/C2775920511","wikidata":"https://www.wikidata.org/wiki/Q161249","display_name":"Lactic acid","level":3,"score":0.5429101586341858},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.52875155210495},{"id":"https://openalex.org/C2992270614","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Membrane permeability","level":3,"score":0.48963648080825806},{"id":"https://openalex.org/C2779032678","wikidata":"https://www.wikidata.org/wiki/Q159683","display_name":"Citric acid","level":2,"score":0.48532694578170776},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.4830544590950012},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.45758122205734253},{"id":"https://openalex.org/C2779607309","wikidata":"https://www.wikidata.org/wiki/Q2264864","display_name":"Salmonella enterica","level":4,"score":0.45440784096717834},{"id":"https://openalex.org/C2776051709","wikidata":"https://www.wikidata.org/wiki/Q632006","display_name":"Gram-negative bacteria","level":4,"score":0.424605131149292},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3538993000984192},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.3158359229564667},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3118184208869934},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002614","descriptor_name":"Chelating Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004492","descriptor_name":"Edetic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005470","descriptor_name":"Fluorometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005503","descriptor_name":"Food Additives","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005519","descriptor_name":"Food Preservation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006090","descriptor_name":"Gram-Negative Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006090","descriptor_name":"Gram-Negative Bacteria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009561","descriptor_name":"Nisin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019343","descriptor_name":"Citric Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0168-1605(00)00307-x","doi":"https://doi.org/10.1016/s0168-1605(00)00307-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0168-1605(00)00307-x","pdf_url":null,"source":{"id":"https://openalex.org/S132626406","display_name":"International Journal of Food Microbiology","issn_l":"0168-1605","issn":["0168-1605","1879-3460"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Food Microbiology","raw_type":"journal-article"},{"id":"pmid:11016605","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11016605","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of food microbiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W148792610","https://openalex.org/W1509938542","https://openalex.org/W1512810258","https://openalex.org/W1571045414","https://openalex.org/W1606754555","https://openalex.org/W1895129045","https://openalex.org/W1939235968","https://openalex.org/W1963494339","https://openalex.org/W1966478139","https://openalex.org/W1989824871","https://openalex.org/W2023330867","https://openalex.org/W2039983258","https://openalex.org/W2046030834","https://openalex.org/W2052833935","https://openalex.org/W2076107714","https://openalex.org/W2079080788","https://openalex.org/W2082267818","https://openalex.org/W2090664858","https://openalex.org/W2098795566","https://openalex.org/W2104928358","https://openalex.org/W2105326324","https://openalex.org/W2111827000","https://openalex.org/W2120738727","https://openalex.org/W2127206088","https://openalex.org/W2137404895","https://openalex.org/W2139441606","https://openalex.org/W2147161211","https://openalex.org/W2164858928","https://openalex.org/W2275855731","https://openalex.org/W2331346527","https://openalex.org/W2494271032","https://openalex.org/W2724247512","https://openalex.org/W6689572705","https://openalex.org/W6814802264"],"related_works":["https://openalex.org/W2000237019","https://openalex.org/W1989824871","https://openalex.org/W2039983258","https://openalex.org/W1966478139","https://openalex.org/W2014701586","https://openalex.org/W2014918156","https://openalex.org/W2120738727","https://openalex.org/W2147161211","https://openalex.org/W2894692585","https://openalex.org/W2046945009"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}