{"id":"https://openalex.org/W1973666076","doi":"https://doi.org/10.1016/j.ygyno.2006.09.011","title":"In vitro and in vivo histone deacetylase inhibitor therapy with suberoylanilide hydroxamic acid (SAHA) and paclitaxel in ovarian cancer","display_name":"In vitro and in vivo histone deacetylase inhibitor therapy with suberoylanilide hydroxamic acid (SAHA) and paclitaxel in ovarian cancer","publication_year":2006,"publication_date":"2006-10-18","ids":{"openalex":"https://openalex.org/W1973666076","doi":"https://doi.org/10.1016/j.ygyno.2006.09.011","mag":"1973666076","pmid":"https://pubmed.ncbi.nlm.nih.gov/17049973"},"language":"en","primary_location":{"id":"doi:10.1016/j.ygyno.2006.09.011","doi":"https://doi.org/10.1016/j.ygyno.2006.09.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ygyno.2006.09.011","pdf_url":null,"source":{"id":"https://openalex.org/S2574783","display_name":"Gynecologic Oncology","issn_l":"0090-8258","issn":["0090-8258","1095-6859"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gynecologic Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005756677","display_name":"Amy L. Cooper","orcid":"https://orcid.org/0000-0002-9786-2496","observed_orcids":["https://orcid.org/0000-0002-9786-2496"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I2801012209","display_name":"Albert B. Chandler Hospital","ror":"https://ror.org/03r8nx235","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285210727","https://openalex.org/I143302722","https://openalex.org/I2801012209"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy L. Cooper","raw_affiliation_strings":["Division of Gynecologic Oncology, University of Kentucky Chandler Medical Center, Lexington, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gynecologic Oncology, University of Kentucky Chandler Medical Center, Lexington, KY, USA","institution_ids":["https://openalex.org/I143302722","https://openalex.org/I2801012209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017425124","display_name":"Victoria L. Greenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victoria L. Greenberg","raw_affiliation_strings":["Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086060425","display_name":"Pamela S. Lancaster","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pamela S. Lancaster","raw_affiliation_strings":["Department of Statistics; University of Kentucky; Lexington; KY; USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics; University of Kentucky; Lexington; KY; USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111784794","display_name":"John Rensselaer van Nagell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I2801012209","display_name":"Albert B. Chandler Hospital","ror":"https://ror.org/03r8nx235","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285210727","https://openalex.org/I143302722","https://openalex.org/I2801012209"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John R. van Nagell","raw_affiliation_strings":["Division of Gynecologic Oncology, University of Kentucky Chandler Medical Center, Lexington, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gynecologic Oncology, University of Kentucky Chandler Medical Center, Lexington, KY, USA","institution_ids":["https://openalex.org/I143302722","https://openalex.org/I2801012209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106402466","display_name":"Stephen G. Zimmer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen G. Zimmer","raw_affiliation_strings":["Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024756890","display_name":"Susan C. Modesitt","orcid":"https://orcid.org/0000-0003-2499-8672","observed_orcids":["https://orcid.org/0000-0003-2499-8672"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan C. Modesitt","raw_affiliation_strings":["Division of Gynecologic Oncology, University of Virginia, Charlottesville, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gynecologic Oncology, University of Virginia, Charlottesville, VA, USA","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4380,"currency":"USD","value_usd":4380},"apc_paid":null,"fwci":1.3579,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.76921676,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"104","issue":"3","first_page":"596","last_page":"601"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.5131999850273132,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.5131999850273132,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.4821999967098236,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vorinostat","display_name":"vorinostat","score":0.949999988079071},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.8679999709129333},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.902999997138977},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.9670000076293945},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.9449999928474426},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6029999852180481},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.8220000267028809},{"id":"https://openalex.org/keywords/treatment-sequencing","display_name":"treatment sequencing","score":0.7609999775886536},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.47699999809265137},{"id":"https://openalex.org/keywords/nude-mouse-xenograft","display_name":"nude mouse xenograft","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.961676836013794},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6745476722717285},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5762932896614075},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.5738775730133057},{"id":"https://openalex.org/C2776262904","wikidata":"https://www.wikidata.org/wiki/Q905901","display_name":"Vorinostat","level":5,"score":0.5675422549247742},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5366100668907166},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5022525787353516},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4806719720363617},{"id":"https://openalex.org/C2776202225","wikidata":"https://www.wikidata.org/wiki/Q3569101","display_name":"Histone deacetylase inhibitor","level":5,"score":0.41195547580718994},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.39635953307151794},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3576994240283966},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35001814365386963},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.2015422284603119},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1662972867488861},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.08012029528617859},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.04520541429519653},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077337","descriptor_name":"Vorinostat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006877","descriptor_name":"Hydroxamic Acids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ygyno.2006.09.011","doi":"https://doi.org/10.1016/j.ygyno.2006.09.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ygyno.2006.09.011","pdf_url":null,"source":{"id":"https://openalex.org/S2574783","display_name":"Gynecologic Oncology","issn_l":"0090-8258","issn":["0090-8258","1095-6859"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gynecologic Oncology","raw_type":"journal-article"},{"id":"pmid:17049973","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17049973","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gynecologic oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8100000023841858}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3711620236","display_name":"BUILDING INTERDISCIPLINARY RESEARCH CAREERS IN WOMEN'S HEALTH IN KENTUCKY","funder_award_id":"K12DA014040","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G5534006824","display_name":null,"funder_award_id":"2 K12 DA14040-06","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W75975850","https://openalex.org/W1504303645","https://openalex.org/W1514623505","https://openalex.org/W1585151515","https://openalex.org/W1812576394","https://openalex.org/W1820010991","https://openalex.org/W1895939501","https://openalex.org/W1899454014","https://openalex.org/W1935102817","https://openalex.org/W1949165922","https://openalex.org/W1960984881","https://openalex.org/W1963592300","https://openalex.org/W1971621147","https://openalex.org/W1973899902","https://openalex.org/W1982619775","https://openalex.org/W2010631526","https://openalex.org/W2022285476","https://openalex.org/W2030822086","https://openalex.org/W2032025865","https://openalex.org/W2034420402","https://openalex.org/W2039278049","https://openalex.org/W2044303805","https://openalex.org/W2044945060","https://openalex.org/W2052181006","https://openalex.org/W2070437897","https://openalex.org/W2077187292","https://openalex.org/W2088783750","https://openalex.org/W2097105130","https://openalex.org/W2099440961","https://openalex.org/W2101704140","https://openalex.org/W2102371219","https://openalex.org/W2108230631","https://openalex.org/W2123245958","https://openalex.org/W2132440338","https://openalex.org/W2135085078","https://openalex.org/W2135830745","https://openalex.org/W2135994759","https://openalex.org/W2147220700","https://openalex.org/W2151139309","https://openalex.org/W2151164110","https://openalex.org/W2160173183","https://openalex.org/W2161363609","https://openalex.org/W2166103065","https://openalex.org/W2167118090","https://openalex.org/W2169508075","https://openalex.org/W2285047382","https://openalex.org/W2318410985","https://openalex.org/W2339601781","https://openalex.org/W2345727187","https://openalex.org/W3151948122","https://openalex.org/W4242138200","https://openalex.org/W6640659826","https://openalex.org/W6640747794","https://openalex.org/W6696053835","https://openalex.org/W6703762880"],"related_works":["https://openalex.org/W1899454014","https://openalex.org/W1983587751","https://openalex.org/W2163225870","https://openalex.org/W2086245480","https://openalex.org/W2027321070","https://openalex.org/W7095684729","https://openalex.org/W2329147662","https://openalex.org/W2383441101","https://openalex.org/W2085138654","https://openalex.org/W2067419747"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
