{"id":"https://openalex.org/W1973649607","doi":"https://doi.org/10.1186/1471-2180-12-284","title":"Putative SF2 helicases of the early-branching eukaryote Giardia lamblia are involved in antigenic variation and parasite differentiation into cysts","display_name":"Putative SF2 helicases of the early-branching eukaryote Giardia lamblia are involved in antigenic variation and parasite differentiation into cysts","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W1973649607","doi":"https://doi.org/10.1186/1471-2180-12-284","mag":"1973649607","pmid":"https://pubmed.ncbi.nlm.nih.gov/23190735","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3566956"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2180-12-284","doi":"https://doi.org/10.1186/1471-2180-12-284","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2180-12-284","pdf_url":"https://bmcmicrobiol.biomedcentral.com/counter/pdf/10.1186/1471-2180-12-284","source":{"id":"https://openalex.org/S128543880","display_name":"BMC Microbiology","issn_l":"1471-2180","issn":["1471-2180"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcmicrobiol.biomedcentral.com/counter/pdf/10.1186/1471-2180-12-284","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084886479","display_name":"Pablo Rub\u00e9n Gargantini","orcid":"https://orcid.org/0000-0001-5884-8387","observed_orcids":["https://orcid.org/0000-0001-5884-8387"]},"institutions":[{"id":"https://openalex.org/I130054616","display_name":"Universidad Cat\u00f3lica de C\u00f3rdoba","ror":"https://ror.org/04hehwn14","country_code":"AR","type":"education","lineage":["https://openalex.org/I130054616"]}],"countries":["AR"],"is_corresponding":true,"raw_author_name":"Pablo R Gargantini","raw_affiliation_strings":["Laboratory of Biochemistry and Molecular Biology, School of Medicine, Catholic University of C\u00f3rdoba, C\u00f3rdoba X5004ASK, Argentina. gargantini@ucc.edu.ar","Laboratory of Biochemistry and Molecular Biology, School of Medicine, Catholic University of Cordoba, Cordoba, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biochemistry and Molecular Biology, School of Medicine, Catholic University of C\u00f3rdoba, C\u00f3rdoba X5004ASK, Argentina. gargantini@ucc.edu.ar","institution_ids":["https://openalex.org/I130054616"]},{"raw_affiliation_string":"Laboratory of Biochemistry and Molecular Biology, School of Medicine, Catholic University of Cordoba, Cordoba, Argentina","institution_ids":["https://openalex.org/I130054616"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Marianela C Serradell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130054616","display_name":"Universidad Cat\u00f3lica de C\u00f3rdoba","ror":"https://ror.org/04hehwn14","country_code":"AR","type":"education","lineage":["https://openalex.org/I130054616"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Marianela C Serradell","raw_affiliation_strings":["Laboratory of Biochemistry and Molecular Biology, School of Medicine, Catholic University of C\u00f3rdoba, C\u00f3rdoba, X5004ASK, Argentina","Laboratory of Biochemistry and Molecular Biology, School of Medicine, Catholic University of Cordoba, Cordoba, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biochemistry and Molecular Biology, School of Medicine, Catholic University of C\u00f3rdoba, C\u00f3rdoba, X5004ASK, Argentina","institution_ids":["https://openalex.org/I130054616"]},{"raw_affiliation_string":"Laboratory of Biochemistry and Molecular Biology, School of Medicine, Catholic University of Cordoba, Cordoba, Argentina","institution_ids":["https://openalex.org/I130054616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084159335","display_name":"Alessandro Torri","orcid":"https://orcid.org/0000-0001-6340-5572","observed_orcids":["https://orcid.org/0000-0001-6340-5572","https://orcid.org/0000-0001-8318-6346"]},"institutions":[{"id":"https://openalex.org/I130054616","display_name":"Universidad Cat\u00f3lica de C\u00f3rdoba","ror":"https://ror.org/04hehwn14","country_code":"AR","type":"education","lineage":["https://openalex.org/I130054616"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Alessandro Torri","raw_affiliation_strings":["Laboratory of Biochemistry and Molecular Biology, School of Medicine, Catholic University of C\u00f3rdoba, C\u00f3rdoba, X5004ASK, Argentina","Laboratory of Biochemistry and Molecular Biology, School of Medicine, Catholic University of Cordoba, Cordoba, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biochemistry and Molecular Biology, School of Medicine, Catholic University of C\u00f3rdoba, C\u00f3rdoba, X5004ASK, Argentina","institution_ids":["https://openalex.org/I130054616"]},{"raw_affiliation_string":"Laboratory of Biochemistry and Molecular Biology, School of Medicine, Catholic University of Cordoba, Cordoba, Argentina","institution_ids":["https://openalex.org/I130054616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086191612","display_name":"Hugo Daniel Luj\u00e1n","orcid":"https://orcid.org/0000-0002-3797-8315","observed_orcids":["https://orcid.org/0000-0002-3797-8315"]},"institutions":[{"id":"https://openalex.org/I130054616","display_name":"Universidad Cat\u00f3lica de C\u00f3rdoba","ror":"https://ror.org/04hehwn14","country_code":"AR","type":"education","lineage":["https://openalex.org/I130054616"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Hugo D Lujan","raw_affiliation_strings":["Laboratory of Biochemistry and Molecular Biology, School of Medicine, Catholic University of C\u00f3rdoba, C\u00f3rdoba, X5004ASK, Argentina","Laboratory of Biochemistry and Molecular Biology, School of Medicine, Catholic University of Cordoba, Cordoba, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biochemistry and Molecular Biology, School of Medicine, Catholic University of C\u00f3rdoba, C\u00f3rdoba, X5004ASK, Argentina","institution_ids":["https://openalex.org/I130054616"]},{"raw_affiliation_string":"Laboratory of Biochemistry and Molecular Biology, School of Medicine, Catholic University of Cordoba, Cordoba, Argentina","institution_ids":["https://openalex.org/I130054616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5084886479"],"corresponding_institution_ids":["https://openalex.org/I130054616"],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":{"value":2990,"currency":"USD","value_usd":2990},"fwci":1.0222,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.7029302,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"12","issue":"1","first_page":"284","last_page":"284"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11086","display_name":"Parasitic Infections and Diagnostics","score":0.4779999852180481,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11086","display_name":"Parasitic Infections and Diagnostics","score":0.4779999852180481,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.08309999853372574,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.05660000070929527,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/giardia-duodenalis","display_name":"Giardia lamblia","score":0.996999979019165},{"id":"https://openalex.org/keywords/antigenic-variation","display_name":"antigenic variation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/cyst-formation","display_name":"cyst formation","score":0.906000018119812},{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.7369999885559082},{"id":"https://openalex.org/keywords/dicer","display_name":"Dicer","score":0.7929999828338623},{"id":"https://openalex.org/keywords/dead-box-rna-helicase","display_name":"DEAD-box RNA helicase","score":0.9760000109672546},{"id":"https://openalex.org/keywords/deah-box-helicase","display_name":"DEAH-box helicase","score":0.9890000224113464},{"id":"https://openalex.org/keywords/recq-helicase","display_name":"RecQ helicase","score":0.8870000243186951},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.7260000109672546},{"id":"https://openalex.org/keywords/cyst-differentiation","display_name":"cyst differentiation","score":0.4620000123977661}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8933762311935425},{"id":"https://openalex.org/C161223559","wikidata":"https://www.wikidata.org/wiki/Q138864","display_name":"Helicase","level":4,"score":0.8024380803108215},{"id":"https://openalex.org/C2779867133","wikidata":"https://www.wikidata.org/wiki/Q21111297","display_name":"Dicer","level":5,"score":0.7330065369606018},{"id":"https://openalex.org/C68592252","wikidata":"https://www.wikidata.org/wiki/Q17913854","display_name":"RNA Helicase A","level":5,"score":0.63405442237854},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5845898985862732},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5594858527183533},{"id":"https://openalex.org/C2780626423","wikidata":"https://www.wikidata.org/wiki/Q155630","display_name":"Giardia lamblia","level":2,"score":0.5223325490951538},{"id":"https://openalex.org/C191942190","wikidata":"https://www.wikidata.org/wiki/Q4774739","display_name":"Antigenic variation","level":3,"score":0.43570196628570557},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.3728793263435364},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2010546326637268}],"mesh":[{"descriptor_ui":"D000940","descriptor_name":"Antigenic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004265","descriptor_name":"DNA Helicases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004265","descriptor_name":"DNA Helicases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016829","descriptor_name":"Giardia lamblia","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D016829","descriptor_name":"Giardia lamblia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016829","descriptor_name":"Giardia lamblia","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D018503","descriptor_name":"Genome, Protozoan","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020365","descriptor_name":"RNA Helicases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020365","descriptor_name":"RNA Helicases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D033761","descriptor_name":"Spores, Protozoan","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D033761","descriptor_name":"Spores, Protozoan","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1186/1471-2180-12-284","doi":"https://doi.org/10.1186/1471-2180-12-284","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2180-12-284","pdf_url":"https://bmcmicrobiol.biomedcentral.com/counter/pdf/10.1186/1471-2180-12-284","source":{"id":"https://openalex.org/S128543880","display_name":"BMC Microbiology","issn_l":"1471-2180","issn":["1471-2180"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2569236","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3566956","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:23190735","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23190735","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3566956","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3566956/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Microbiol","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.783.7061","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.783.7061","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/a6/e2/1471-2180-12-284.PMC3566956.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:78e15156541440778c1864c850280b80","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/78e15156541440778c1864c850280b80","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Microbiology, Vol 12, Iss 1, p 284 (2012)","raw_type":"article"},{"id":"doi:10.60692/eshbf-c3447","doi":"https://doi.org/10.60692/eshbf-c3447","is_oa":true,"landing_page_url":"https://doi.org/10.60692/eshbf-c3447","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/kx5ac-pcb05","doi":"https://doi.org/10.60692/kx5ac-pcb05","is_oa":true,"landing_page_url":"https://doi.org/10.60692/kx5ac-pcb05","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1186/1471-2180-12-284","doi":"https://doi.org/10.1186/1471-2180-12-284","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2180-12-284","pdf_url":"https://bmcmicrobiol.biomedcentral.com/counter/pdf/10.1186/1471-2180-12-284","source":{"id":"https://openalex.org/S128543880","display_name":"BMC Microbiology","issn_l":"1471-2180","issn":["1471-2180"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7378882120","display_name":null,"funder_award_id":"CONICET","funder_id":"https://openalex.org/F4320334832","funder_display_name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica"}],"funders":[{"id":"https://openalex.org/F4320311002","display_name":"Universidad Cat\u00f3lica de C\u00f3rdoba","ror":"https://ror.org/04hehwn14"},{"id":"https://openalex.org/F4320321594","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59"},{"id":"https://openalex.org/F4320334832","display_name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","ror":"https://ror.org/03stxzb56"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1973649607.pdf","grobid_xml":"https://content.openalex.org/works/W1973649607.grobid-xml"},"referenced_works_count":93,"referenced_works":["https://openalex.org/W249486536","https://openalex.org/W1526634362","https://openalex.org/W1534924434","https://openalex.org/W1577060935","https://openalex.org/W1943240551","https://openalex.org/W1962379686","https://openalex.org/W1964434157","https://openalex.org/W1965005292","https://openalex.org/W1969296875","https://openalex.org/W1970101934","https://openalex.org/W1977922844","https://openalex.org/W1978570354","https://openalex.org/W1981910011","https://openalex.org/W1989030559","https://openalex.org/W1993374643","https://openalex.org/W1995223052","https://openalex.org/W1997192898","https://openalex.org/W2002863315","https://openalex.org/W2004445056","https://openalex.org/W2006285635","https://openalex.org/W2009395178","https://openalex.org/W2010201702","https://openalex.org/W2013721931","https://openalex.org/W2016537573","https://openalex.org/W2017099333","https://openalex.org/W2017866593","https://openalex.org/W2021007708","https://openalex.org/W2023116310","https://openalex.org/W2024316824","https://openalex.org/W2024725357","https://openalex.org/W2028333546","https://openalex.org/W2030823707","https://openalex.org/W2032780343","https://openalex.org/W2032991899","https://openalex.org/W2037978116","https://openalex.org/W2039885485","https://openalex.org/W2041877620","https://openalex.org/W2043428681","https://openalex.org/W2045193818","https://openalex.org/W2047179560","https://openalex.org/W2051848082","https://openalex.org/W2056154236","https://openalex.org/W2060677669","https://openalex.org/W2072690167","https://openalex.org/W2072861322","https://openalex.org/W2079690613","https://openalex.org/W2085519695","https://openalex.org/W2086145483","https://openalex.org/W2086188781","https://openalex.org/W2087514066","https://openalex.org/W2088831160","https://openalex.org/W2090441795","https://openalex.org/W2092144038","https://openalex.org/W2095296709","https://openalex.org/W2096365000","https://openalex.org/W2098870800","https://openalex.org/W2099249565","https://openalex.org/W2102524090","https://openalex.org/W2103546861","https://openalex.org/W2104507084","https://openalex.org/W2105439835","https://openalex.org/W2109292252","https://openalex.org/W2114084606","https://openalex.org/W2117991391","https://openalex.org/W2118030557","https://openalex.org/W2121090724","https://openalex.org/W2121883063","https://openalex.org/W2122663168","https://openalex.org/W2123023172","https://openalex.org/W2123774768","https://openalex.org/W2123957786","https://openalex.org/W2129929437","https://openalex.org/W2132748660","https://openalex.org/W2132926880","https://openalex.org/W2137015675","https://openalex.org/W2144717644","https://openalex.org/W2146455029","https://openalex.org/W2149531726","https://openalex.org/W2152977880","https://openalex.org/W2155687954","https://openalex.org/W2155744824","https://openalex.org/W2158676715","https://openalex.org/W2158846481","https://openalex.org/W2164278290","https://openalex.org/W2168514491","https://openalex.org/W2169999342","https://openalex.org/W2286018835","https://openalex.org/W2765633603","https://openalex.org/W3097849217","https://openalex.org/W4205246014","https://openalex.org/W4241179589","https://openalex.org/W4298355645","https://openalex.org/W6719529052"],"related_works":["https://openalex.org/W7098621236","https://openalex.org/W2079690613","https://openalex.org/W2043428681","https://openalex.org/W2102524090","https://openalex.org/W7051939821","https://openalex.org/W4220788690","https://openalex.org/W2535931453","https://openalex.org/W1984553344","https://openalex.org/W6947855689","https://openalex.org/W9955048"],"abstract_inverted_index":{"BACKGROUND:":[0],"Regulation":[1],"of":[2,42,79,118,122,143,149,199,217,232,257],"surface":[3],"antigenic":[4,63,161,223],"variation":[5,162,224],"in":[6,34,46,50,62,76,246,260],"Giardia":[7,69,81,129],"lamblia":[8],"is":[9,194],"controlled":[10],"post-transcriptionally":[11],"by":[12,163],"an":[13],"RNA-interference":[14],"(RNAi)":[15],"pathway":[16],"that":[17,56,91,186],"includes":[18],"a":[19,147],"Dicer-like":[20],"bidentate":[21],"RNase":[22],"III":[23],"(gDicer).":[24],"This":[25,193],"enzyme,":[26],"however,":[27],"lacks":[28],"the":[29,80,95,139,195,200,206,229,254],"RNA":[30,44,57,89,97,115,140,154,219,241],"helicase":[31,98,131,141],"domain":[32,142],"present":[33],"Dicer":[35,144],"enzymes":[36,234,259],"from":[37,125,176,205],"higher":[38,126],"eukaryotes.":[39],"The":[40,212,239],"participation":[41,231],"several":[43],"helicases":[45,58,90,124,155,175,204,220,244],"practically":[47],"all":[48,94],"organisms":[49],"which":[51,119],"RNAi":[52],"was":[53,132],"studied":[54],"suggests":[55],"are":[59,120],"potentially":[60],"involved":[61],"variation,":[64],"as":[65,67],"well":[66],"during":[68,158,221,235],"differentiation":[70],"into":[71,107],"cysts.":[72],"RESULTS:":[73],"An":[74],"extensive":[75],"silico":[77],"analysis":[78,104,198],"genome":[82],"identified":[83,245],"32":[84],"putative":[85,130,153,174],"Super":[86,201],"Family":[87,202],"2":[88,203],"contain":[92],"almost":[93],"conserved":[96],"motifs.":[99],"Phylogenetic":[100],"studies":[101],"and":[102,112,151,160,183,214,225,242,263],"sequence":[103],"separated":[105],"them":[106],"22":[108],"DEAD-box,":[109],"6":[110],"DEAH-box":[111],"4":[113],"Ski2p-box":[114],"helicases,":[116],"some":[117],"homologs":[121],"well-characterized":[123],"organisms.":[127],"No":[128],"found":[133,157],"to":[134,138,170],"have":[135],"significant":[136],"homology":[137],"enzymes.":[145],"Additionally":[146],"series":[148],"up-":[150],"down-regulated":[152],"were":[156,168],"encystation":[159,226],"qPCR":[164],"experiments.":[165],"Finally,":[166],"we":[167],"able":[169],"recognize":[171],"14":[172],"additional":[173],"three":[177],"different":[178],"families":[179],"(RecQ":[180],"family,":[181],"Swi2/Snf2":[182],"Rad3":[184],"family)":[185],"could":[187],"be":[188],"considered":[189],"DNA":[190,243],"helicases.":[191],"CONCLUSIONS:":[192],"first":[196],"comprehensive":[197],"human":[207],"intestinal":[208],"parasite":[209],"G.":[210],"lamblia.":[211],"relative":[213],"variable":[215],"expression":[216],"particular":[218],"both":[222,236],"agrees":[227],"with":[228],"proposed":[230],"these":[233,258],"adaptive":[237],"processes.":[238],"putatives":[240],"this":[247],"early-branching":[248],"eukaryote":[249],"provide":[250],"initial":[251],"information":[252],"regarding":[253],"biological":[255],"role":[256],"cell":[261],"adaptation":[262],"differentiation.":[264]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}