{"id":"https://openalex.org/W1973604653","doi":"https://doi.org/10.1097/00007890-199805131-00405","title":"IMMEDIATE POST-TRANSPLANT MYOCYTE NECROSIS DETECTED BY ELEVATED SERUM LEVELS OF TROPONIN I IS ASSOCIATED WITH AN ADVERSE LONG TERM GRAFTOUTCOME.","display_name":"IMMEDIATE POST-TRANSPLANT MYOCYTE NECROSIS DETECTED BY ELEVATED SERUM LEVELS OF TROPONIN I IS ASSOCIATED WITH AN ADVERSE LONG TERM GRAFTOUTCOME.","publication_year":1998,"publication_date":"1998-05-01","ids":{"openalex":"https://openalex.org/W1973604653","doi":"https://doi.org/10.1097/00007890-199805131-00405","mag":"1973604653"},"language":"en","primary_location":{"id":"doi:10.1097/00007890-199805131-00405","doi":"https://doi.org/10.1097/00007890-199805131-00405","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-199805131-00405","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054364960","display_name":"Steven R. Steinhubl","orcid":"https://orcid.org/0000-0002-9256-7914","observed_orcids":["https://orcid.org/0000-0002-9256-7914"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven. R. Steinhubl","raw_affiliation_strings":["Cleveland Clinic Founsdation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Founsdation","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030690893","display_name":"Frederick Van Lente","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederick Van Lente","raw_affiliation_strings":["Cleveland Clinic Founsdation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Founsdation","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068839295","display_name":"Nancy Anzlovar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy Anzlovar","raw_affiliation_strings":["Cleveland Clinic Founsdation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Founsdation","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006688566","display_name":"James B. Young","orcid":"https://orcid.org/0000-0003-2785-1617","observed_orcids":["https://orcid.org/0000-0003-2785-1617"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James B. Young","raw_affiliation_strings":["Cleveland Clinic Founsdation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Founsdation","institution_ids":["https://openalex.org/I1316902750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1316902750"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"65","issue":"Supplement","first_page":"180","last_page":"180"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-transplantation","display_name":"heart transplantation","score":0.9430000185966492},{"id":"https://openalex.org/keywords/troponin-i","display_name":"troponin I","score":0.9760000109672546},{"id":"https://openalex.org/keywords/myocyte-necrosis","display_name":"myocyte necrosis","score":0.8669999837875366},{"id":"https://openalex.org/keywords/long-term-graft-outcomes","display_name":"long-term graft outcomes","score":0.7269999980926514},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.8830000162124634},{"id":"https://openalex.org/keywords/left-ventricular-systolic-dysfunction","display_name":"left ventricular systolic dysfunction","score":0.972000002861023},{"id":"https://openalex.org/keywords/cardiac-rejection","display_name":"cardiac rejection","score":0.4320000112056732},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6570000052452087},{"id":"https://openalex.org/keywords/coronary-angiography","display_name":"coronary angiography","score":0.5630000233650208},{"id":"https://openalex.org/keywords/ventriculography","display_name":"ventriculography","score":0.9739999771118164}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8182195425033569},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7508577108383179},{"id":"https://openalex.org/C36036425","wikidata":"https://www.wikidata.org/wiki/Q7846262","display_name":"Troponin","level":3,"score":0.7388433814048767},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7110838294029236},{"id":"https://openalex.org/C115725540","wikidata":"https://www.wikidata.org/wiki/Q7846263","display_name":"Troponin I","level":3,"score":0.5561500787734985},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.5414379835128784},{"id":"https://openalex.org/C144469398","wikidata":"https://www.wikidata.org/wiki/Q24785650","display_name":"Troponin T","level":3,"score":0.5296611189842224},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.512313723564148},{"id":"https://openalex.org/C2778849806","wikidata":"https://www.wikidata.org/wiki/Q643396","display_name":"Heart transplantation","level":3,"score":0.4464961290359497},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.33907535672187805}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/00007890-199805131-00405","doi":"https://doi.org/10.1097/00007890-199805131-00405","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-199805131-00405","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.47999998927116394,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2011389308","https://openalex.org/W2183490517","https://openalex.org/W2062603374","https://openalex.org/W2330001204","https://openalex.org/W2006756330","https://openalex.org/W7134425444","https://openalex.org/W2109882410","https://openalex.org/W2094585733","https://openalex.org/W2551261533","https://openalex.org/W2099937200"],"abstract_inverted_index":{"407":[0],"Early":[1,298,318],"following":[2,285,322],"cardiac":[3,93,286],"transplantation":[4,287,323],"a":[5,10,19,92,135,272,309,326],"characteristic":[6],"early":[7,47],"peak,":[8],"then":[9,110],"gradual":[11],"decline":[12],"in":[13,88,181,246,288,338,344],"serum":[14,59],"levels":[15,85,321],"of":[16,21,46,61,99,138,163,171,183,248,255,261,271,301,313,341],"troponin":[17,62,71,83,195,219,240,251,279,320],"I,":[18,63],"marker":[20],"myocyte":[22],"necrosis":[23,270],"is":[24,282,292,300,306],"seen.":[25],"This":[26],"elevation":[27,299],"has":[28],"been":[29],"shown":[30],"not":[31,293],"to":[32,115,296],"be":[33,44,325],"associated":[34,76,307],"with":[35,77,250,263,308],"cellular":[36],"rejection,":[37],"but":[38,305],"we":[39],"postulated":[40],"that":[41],"it":[42],"may":[43,324],"indicative":[45],"immunologically-":[48],"mediated":[49],"small":[50],"vessel":[51],"injury.":[52],"We":[53],"therefore":[54],"evaluated":[55,122],"whether":[56],"the":[57,67,70,105,148,184,189,192,214,218,339,345],"peak":[58,194],"level":[60,197],"as":[64,66,276,335,337],"well":[65,336],"area":[68,216],"under":[69,217],"versus":[72],"time":[73,222,238,253],"curve,":[74],"were":[75,86,102,121],"long":[78,314,332],"term":[79,119,315,333],"graft":[80],"performance.":[81],"Serum":[82],"I":[84,196,205,220,280],"determined":[87],"18":[89,185],"patients":[90,143,186,249,290],"receiving":[91],"transplant":[94],"between":[95,234],"January":[96],"and":[97,109,128,132,158,213,239,258,291],"August":[98],"1994.":[100],"Specimens":[101],"obtained":[103],"on":[104],"initial":[106],"post-operative":[107],"day":[108],"daily":[111],"thereafter":[112],"until":[113],"return":[114],"undetectable":[116,207],"levels.":[117,241],"Long":[118],"outcomes":[120],"through":[123,278],"routine":[124],"clinical":[125],"follow":[126],"up":[127],"yearly":[129],"coronary":[130,153,173],"angiography":[131,157],"ventriculography.":[133],"At":[134],"mean":[136,193,215],"follow-up":[137],"37":[139],"months":[140],"post-transplantation,":[141],"15":[142],"(83%)":[144],"had":[145,152,160,179],"survived.":[146],"Among":[147],"surviving":[149],"patients,":[150],"26%":[151],"artery":[154,174],"disease":[155],"by":[156,208],"20%":[159],"some":[161],"degree":[162],"left":[164],"ventricular":[165,177],"systolic":[166],"dysfunction.":[167],"The":[168,242],"combined":[169,243],"endpoint":[170,244],"death,":[172],"disease,":[175],"or":[176],"dysfunction":[178],"occurred":[180,245],"44%":[182],"studied.":[187],"For":[188],"entire":[190],"group":[191],"was":[198,206,224,231],"11.7":[199],"(range":[200,226],"2.8":[201],"-":[202,210,228],"50).":[203],"Troponin":[204],"9":[209],"25":[211],"days,":[212],"vs.":[221,252],"curve":[223],"31.9":[225],"7.1":[227],"112.6).":[229],"There":[230],"no":[232],"correlation":[233],"donor":[235],"heart":[236],"ischemia":[237],"83%":[247],"areas":[254],">":[256],"30,":[257],"only":[259],"25%":[260],"those":[262],"values":[264],"<30":[265],"(P=":[266],"0.045).":[267],"Conclusion:":[268],"Myocardial":[269],"strikingly":[273],"variable":[274],"degree,":[275],"detected":[277],"elevations,":[281],"found":[283],"immediately":[284],"all":[289],"necessarily":[294],"related":[295],"rejection.":[297],"an":[302],"unknown":[303],"ctiology,":[304],"significantly":[310],"increased":[311],"incidence":[312],"adverse":[316],"outcomes.":[317],"serial":[319],"useful":[327],"tool":[328],"for":[329],"helping":[330],"predict":[331],"outcome":[334],"evaluation":[340],"new":[342],"therapies":[343],"peri-transplant":[346],"period.":[347]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}