{"id":"https://openalex.org/W1973536626","doi":"https://doi.org/10.1253/jcj.53.1185","title":"Application of thrombin-antithrombin III complex for detecting a latent hypercoagulable state in patients with coronary artery disease.","display_name":"Application of thrombin-antithrombin III complex for detecting a latent hypercoagulable state in patients with coronary artery disease.","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W1973536626","doi":"https://doi.org/10.1253/jcj.53.1185","mag":"1973536626","pmid":"https://pubmed.ncbi.nlm.nih.gov/2693750"},"language":"en","primary_location":{"id":"doi:10.1253/jcj.53.1185","doi":"https://doi.org/10.1253/jcj.53.1185","is_oa":true,"landing_page_url":"https://doi.org/10.1253/jcj.53.1185","pdf_url":"https://www.jstage.jst.go.jp/article/circj1960/53/10/53_10_1185/_pdf","source":{"id":"https://openalex.org/S150042853","display_name":"Japanese Circulation Journal-english Edition","issn_l":"0047-1828","issn":["0047-1828","1347-4839"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313287","host_organization_name":"Japanese Circulation Society","host_organization_lineage":["https://openalex.org/P4310313287"],"host_organization_lineage_names":["Japanese Circulation Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Circulation Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/circj1960/53/10/53_10_1185/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111542639","display_name":"Masashi Uno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"MASASHI UNO","raw_affiliation_strings":["Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan","Second Dept of Medicine, Kyoto Prefectural University of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan","institution_ids":["https://openalex.org/I40677808"]},{"raw_affiliation_string":"Second Dept of Medicine, Kyoto Prefectural University of Medicine, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070645906","display_name":"Hajime Tsuji","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"HAJIME TSUJI","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110895758","display_name":"Masahiko Watanabe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MASAHIKO WATANABE","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064762030","display_name":"Osamu Takada","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"OSAMU TAKADA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086974310","display_name":"Kyoichiro KOBAYASHI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"KYOICHIRO KOBAYASHI","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017412069","display_name":"Hiroaki Takabuchi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"HIROAKI TAKABUCHI","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"KAORI SHIRAI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"KAORI SHIRAI","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112165055","display_name":"Shohei Sawada","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"SHOHEI SAWADA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112064964","display_name":"Takeo TOYODA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"TAKEO TOYODA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103263360","display_name":"Katsumi Yamamoto","orcid":"https://orcid.org/0000-0003-2503-4170","observed_orcids":["https://orcid.org/0000-0003-2503-4170"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"KATSUMI YAMAMOTO","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051768020","display_name":"Kazuharu Katoh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"KAZUHARU KATOH","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5047706524","display_name":"Masao Nakagawa","orcid":"https://orcid.org/0000-0002-8602-6054","observed_orcids":["https://orcid.org/0000-0002-8602-6054"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MASAO NAKAGAWA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2522,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.51007621,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"53","issue":"10","first_page":"1185","last_page":"1191"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thrombin-antithrombin-complex","display_name":"thrombin-antithrombin complex","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hypercoagulability","display_name":"hypercoagulability","score":0.8930000066757202},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/thrombin-generation","display_name":"thrombin generation","score":0.9350000023841858},{"id":"https://openalex.org/keywords/submaximal-exercise-test","display_name":"submaximal exercise testing","score":0.7749999761581421},{"id":"https://openalex.org/keywords/coagulation-activation","display_name":"coagulation activation","score":0.8730000257492065},{"id":"https://openalex.org/keywords/coagulation-markers","display_name":"coagulation markers","score":0.8069999814033508},{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":0.75},{"id":"https://openalex.org/keywords/fibrin-degradation-products","display_name":"fibrin degradation products","score":0.8830000162124634}],"concepts":[{"id":"https://openalex.org/C2779026020","wikidata":"https://www.wikidata.org/wiki/Q416336","display_name":"Antithrombin","level":3,"score":0.7484925389289856},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.7323384284973145},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6610772609710693},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6355074644088745},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.6099491715431213},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5546921491622925},{"id":"https://openalex.org/C3018972837","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin generation","level":4,"score":0.42707371711730957},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4180281162261963},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.07651284337043762},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.06847560405731201}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000990","descriptor_name":"Antithrombin III","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001780","descriptor_name":"Blood Coagulation Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005080","descriptor_name":"Exercise Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010447","descriptor_name":"Peptide Hydrolases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1253/jcj.53.1185","doi":"https://doi.org/10.1253/jcj.53.1185","is_oa":true,"landing_page_url":"https://doi.org/10.1253/jcj.53.1185","pdf_url":"https://www.jstage.jst.go.jp/article/circj1960/53/10/53_10_1185/_pdf","source":{"id":"https://openalex.org/S150042853","display_name":"Japanese Circulation Journal-english Edition","issn_l":"0047-1828","issn":["0047-1828","1347-4839"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313287","host_organization_name":"Japanese Circulation Society","host_organization_lineage":["https://openalex.org/P4310313287"],"host_organization_lineage_names":["Japanese Circulation Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Circulation Journal","raw_type":"journal-article"},{"id":"pmid:2693750","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2693750","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese circulation journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1253/jcj.53.1185","doi":"https://doi.org/10.1253/jcj.53.1185","is_oa":true,"landing_page_url":"https://doi.org/10.1253/jcj.53.1185","pdf_url":"https://www.jstage.jst.go.jp/article/circj1960/53/10/53_10_1185/_pdf","source":{"id":"https://openalex.org/S150042853","display_name":"Japanese Circulation Journal-english Edition","issn_l":"0047-1828","issn":["0047-1828","1347-4839"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313287","host_organization_name":"Japanese Circulation Society","host_organization_lineage":["https://openalex.org/P4310313287"],"host_organization_lineage_names":["Japanese Circulation Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Circulation Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1973536626.pdf","grobid_xml":"https://content.openalex.org/works/W1973536626.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W21802224","https://openalex.org/W83185956","https://openalex.org/W1510327059","https://openalex.org/W1524888592","https://openalex.org/W1531305061","https://openalex.org/W1963856902","https://openalex.org/W1983674418","https://openalex.org/W1984643311","https://openalex.org/W2012231773","https://openalex.org/W2031570202","https://openalex.org/W2040092130","https://openalex.org/W2070395968","https://openalex.org/W2075083432","https://openalex.org/W2166432182","https://openalex.org/W2306967068","https://openalex.org/W2323692584","https://openalex.org/W2326400675","https://openalex.org/W2327467387","https://openalex.org/W2336267479","https://openalex.org/W2407936953","https://openalex.org/W2530163185","https://openalex.org/W2889082042"],"related_works":["https://openalex.org/W2397717934","https://openalex.org/W2577878882","https://openalex.org/W2375254652","https://openalex.org/W2021275671","https://openalex.org/W3112424003","https://openalex.org/W2414566956","https://openalex.org/W2414405841","https://openalex.org/W2064798096","https://openalex.org/W2036317585","https://openalex.org/W2043347142"],"abstract_inverted_index":{"It":[0],"is":[1],"thought":[2],"that":[3,118,164,181,188],"a":[4,39,52,170,194],"hypercoagulable":[5,196],"state":[6],"contributes":[7],"to":[8,95],"the":[9,25,28,31,75,82,104,108,112,120,126,135,138,182],"pathogenesis":[10],"of":[11,34,42,71,176,184],"coronary":[12],"artery":[13],"disease":[14],"(CAD),":[15],"but":[16],"few":[17],"sensitive":[18,171],"markers":[19],"have":[20],"been":[21],"available":[22],"for":[23,173],"detecting":[24],"state.":[26,197],"In":[27],"present":[29],"study":[30],"plasma":[32,72,165],"level":[33,93,167],"thrombin-antithrombin":[35],"III":[36],"complex":[37],"(TAT),":[38],"specific":[40],"indicator":[41],"thrombin":[43],"generation":[44],"in":[45,56,62,81,89,111,119,137,193],"blood,":[46],"was":[47,77,115,162],"investigated":[48],"before":[49,74,123],"and":[50,61,85,91,99,124,155,179],"after":[51,103,125],"submaximal":[53],"exercise":[54,76],"test":[55],"18":[57],"patients":[58,189],"with":[59,190],"CAD":[60,191],"12":[63],"healthy":[64],"controls.":[65],"The":[66],"mean":[67],"(+/-":[68],"SEM)":[69],"value":[70,110],"TAT":[73,109,166],"3.30":[78],"(0.81)":[79],"ng/ml":[80,88,98,102],"patient":[83,113],"group":[84,114],"1.49":[86],"(0.08)":[87],"controls,":[90],"its":[92],"increased":[94],"29.22":[96],"(5.74)":[97],"12.07":[100],"(2.89)":[101],"exercise,":[105],"respectively.":[106],"Thus,":[107],"higher":[116],"than":[117],"controls":[121],"both":[122],"exercise.":[127],"However,":[128],"no":[129],"differences":[130],"could":[131,168],"be":[132,169],"found":[133],"between":[134],"groups":[136],"following":[139],"parameters;":[140],"prothrombin":[141],"time,":[142,146],"activated":[143],"partial":[144],"thromboplastin":[145],"antithrombin":[147],"III,":[148],"fibrinogen,":[149],"FDP,":[150],"plasminogen,":[151],"alpha":[152,156],"2-plasmin":[153],"inhibitor,":[154],"2-macroglobulin.":[157],"Through":[158],"these":[159,185],"results":[160,183],"it":[161],"concluded":[163],"marker":[172],"latent":[174,195],"activation":[175],"blood":[177],"coagulation,":[178],"also":[180],"experiments":[186],"showed":[187],"were":[192]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
