{"id":"https://openalex.org/W1973530641","doi":"https://doi.org/10.1111/j.1365-2826.2006.01449.x","title":"Alteration in Hypothalamic Neuropeptide Y (NPY) Secretion May Underlie Female Reproductive Ageing: Induction of Steroid\u2010Induced Luteinising Hormone Surge by NPY in Ovariectomised Aged Rats","display_name":"Alteration in Hypothalamic Neuropeptide Y (NPY) Secretion May Underlie Female Reproductive Ageing: Induction of Steroid\u2010Induced Luteinising Hormone Surge by NPY in Ovariectomised Aged Rats","publication_year":2006,"publication_date":"2006-06-15","ids":{"openalex":"https://openalex.org/W1973530641","doi":"https://doi.org/10.1111/j.1365-2826.2006.01449.x","mag":"1973530641","pmid":"https://pubmed.ncbi.nlm.nih.gov/16867179"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2826.2006.01449.x","doi":"https://doi.org/10.1111/j.1365-2826.2006.01449.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2826.2006.01449.x","pdf_url":null,"source":{"id":"https://openalex.org/S100175869","display_name":"Journal of Neuroendocrinology","issn_l":"0953-8194","issn":["0953-8194","1365-2826"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroendocrinology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1973530641"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101592276","display_name":"Abhijit Sahu","orcid":"https://orcid.org/0009-0004-9034-6538","observed_orcids":["https://orcid.org/0009-0004-9034-6538"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"A. Sahu","raw_affiliation_strings":["Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. asahu@pitt.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. asahu@pitt.edu","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101592276"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":{"value":4550,"currency":"USD","value_usd":4550},"apc_paid":null,"fwci":0.2372,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.57172746,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"18","issue":"8","first_page":"584","last_page":"593"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuropeptide-y","display_name":"neuropeptide Y","score":0.9800000190734863},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.7239999771118164},{"id":"https://openalex.org/keywords/luteinizing-hormone-surge","display_name":"luteinizing hormone surge","score":0.9950000047683716},{"id":"https://openalex.org/keywords/median-eminence","display_name":"median eminence","score":0.8169999718666077},{"id":"https://openalex.org/keywords/arcuate-nucleus","display_name":"arcuate nucleus","score":0.9940000176429749},{"id":"https://openalex.org/keywords/ovariectomy","display_name":"ovariectomy","score":0.847000002861023},{"id":"https://openalex.org/keywords/progesterone","display_name":"progesterone","score":0.8730000257492065},{"id":"https://openalex.org/keywords/estrogen","display_name":"estrogen","score":0.7720000147819519},{"id":"https://openalex.org/keywords/intracerebroventricular-injection","display_name":"intracerebroventricular administration","score":0.8960000276565552},{"id":"https://openalex.org/keywords/middle-aged-rats","display_name":"middle-aged rats","score":0.5830000042915344},{"id":"https://openalex.org/keywords/aged-rats","display_name":"aged rats","score":0.4729999899864197}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.9262211918830872},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.9228860139846802},{"id":"https://openalex.org/C93984277","wikidata":"https://www.wikidata.org/wiki/Q24782073","display_name":"Neuropeptide Y receptor","level":4,"score":0.8163032531738281},{"id":"https://openalex.org/C2778458369","wikidata":"https://www.wikidata.org/wiki/Q253246","display_name":"Arcuate nucleus","level":3,"score":0.5885512828826904},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.5637825727462769},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4337961673736572},{"id":"https://openalex.org/C2779067335","wikidata":"https://www.wikidata.org/wiki/Q1337712","display_name":"Median eminence","level":3,"score":0.41826826333999634},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.3479517996311188},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2676645517349243},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1402980387210846}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001111","descriptor_name":"Arcuate Nucleus of Hypothalamus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008473","descriptor_name":"Median Eminence","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009478","descriptor_name":"Neuropeptide Y","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009478","descriptor_name":"Neuropeptide Y","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010052","descriptor_name":"Ovariectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030762","descriptor_name":"Estrous Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-2826.2006.01449.x","doi":"https://doi.org/10.1111/j.1365-2826.2006.01449.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2826.2006.01449.x","pdf_url":null,"source":{"id":"https://openalex.org/S100175869","display_name":"Journal of Neuroendocrinology","issn_l":"0953-8194","issn":["0953-8194","1365-2826"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroendocrinology","raw_type":"journal-article"},{"id":"pmid:16867179","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16867179","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuroendocrinology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7846669922","display_name":"HYPOTHALAMIC NEUROPEPTIDE Y AND REPRODUCTIVE AGING","funder_award_id":"R01AG010868","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":80,"referenced_works":["https://openalex.org/W30257253","https://openalex.org/W586218165","https://openalex.org/W597289951","https://openalex.org/W659326369","https://openalex.org/W1543958106","https://openalex.org/W1834687907","https://openalex.org/W1964639026","https://openalex.org/W1967501438","https://openalex.org/W1968650788","https://openalex.org/W1970460118","https://openalex.org/W1971607526","https://openalex.org/W1971650902","https://openalex.org/W1972185899","https://openalex.org/W1976631136","https://openalex.org/W1976946227","https://openalex.org/W1983834933","https://openalex.org/W1988497879","https://openalex.org/W1989835151","https://openalex.org/W1990257364","https://openalex.org/W1994079967","https://openalex.org/W1995833639","https://openalex.org/W1996713062","https://openalex.org/W1998372148","https://openalex.org/W1998909712","https://openalex.org/W2000005190","https://openalex.org/W2004042726","https://openalex.org/W2004222158","https://openalex.org/W2004668225","https://openalex.org/W2005099683","https://openalex.org/W2006595910","https://openalex.org/W2008660628","https://openalex.org/W2009059114","https://openalex.org/W2014711623","https://openalex.org/W2016226609","https://openalex.org/W2017828692","https://openalex.org/W2017989931","https://openalex.org/W2018622017","https://openalex.org/W2018822787","https://openalex.org/W2031850503","https://openalex.org/W2035923958","https://openalex.org/W2038972984","https://openalex.org/W2044431563","https://openalex.org/W2046628195","https://openalex.org/W2053187221","https://openalex.org/W2053807193","https://openalex.org/W2061819194","https://openalex.org/W2062202511","https://openalex.org/W2062608519","https://openalex.org/W2065210194","https://openalex.org/W2070069967","https://openalex.org/W2070766330","https://openalex.org/W2075019242","https://openalex.org/W2075100913","https://openalex.org/W2075434024","https://openalex.org/W2076615684","https://openalex.org/W2079737602","https://openalex.org/W2080250188","https://openalex.org/W2085955084","https://openalex.org/W2087062933","https://openalex.org/W2088269503","https://openalex.org/W2089683663","https://openalex.org/W2091572103","https://openalex.org/W2095105006","https://openalex.org/W2097033041","https://openalex.org/W2097974216","https://openalex.org/W2107984282","https://openalex.org/W2112004170","https://openalex.org/W2115301017","https://openalex.org/W2116654602","https://openalex.org/W2118109447","https://openalex.org/W2133212833","https://openalex.org/W2137191809","https://openalex.org/W2151252423","https://openalex.org/W2157461071","https://openalex.org/W2161814182","https://openalex.org/W2171584675","https://openalex.org/W2172235474","https://openalex.org/W2484478694","https://openalex.org/W2485228882","https://openalex.org/W6722478159"],"related_works":["https://openalex.org/W2000005190","https://openalex.org/W1543958106","https://openalex.org/W2161814182","https://openalex.org/W1990257364","https://openalex.org/W2054579612","https://openalex.org/W2065210194","https://openalex.org/W2004222158","https://openalex.org/W2016226609","https://openalex.org/W1971650902","https://openalex.org/W2004668225"],"abstract_inverted_index":{"A":[0],"large":[1],"body":[2],"of":[3,18,245],"evidence":[4],"suggests":[5],"that":[6,28,217],"a":[7,148],"defect":[8],"in":[9,21,34,48,54,73,86,117,129,133,139,145,165,185,189,210,219,234,241,249],"the":[10,15,69,91,97,103,113,155,206,213,223,228,242,246],"hypothalamic":[11,35,63,198],"function":[12],"may":[13,238],"be":[14,239],"primary":[16],"cause":[17],"reproductive":[19],"ageing":[20],"female":[22],"rats.":[23,57,89,195,251],"We":[24],"have":[25],"previously":[26],"shown":[27],"luteinising":[29],"hormone":[30],"(LH)-surge":[31],"associated":[32],"changes":[33],"neuropeptide":[36],"Y":[37],"(NPY)":[38],"gene":[39],"expression":[40],"and":[41,78,111,150,181,201,230,237],"median":[42],"eminence":[43],"(ME)":[44],"NPY":[45,64,81,94,130,174,199,220],"levels":[46],"seen":[47,132],"young":[49,121,134,211],"rats":[50,122,135,141,169,236],"do":[51],"not":[52,137],"occur":[53],"middle-aged":[55],"(MA)":[56],"The":[58],"present":[59,214],"study":[60],"examined":[61],"whether":[62,79],"release":[65,95,131,202,221],"is":[66,203],"altered":[67],"during":[68,112],"steroid-induced":[70,83],"LH":[71,84,115,152,163,186,208,232,247],"surge":[72,85,116,187],"ovariectomised":[74,120,167,193],"(OVX)":[75],"MA":[76,140,235],"rats,":[77,212],"exogenous":[80],"initiates":[82],"OVX":[87],"old":[88,168,194,250],"In":[90,154],"first":[92],"study,":[93,157],"from":[96,222],"ME-arcuate":[98,224],"nucleus,":[99],"as":[100],"assessed":[101],"by":[102],"push-pull":[104],"cannula":[105],"technique,":[106],"was":[107,136],"significantly":[108],"increased":[109,197],"before":[110],"progesterone-induced":[114],"oestrogen":[118],"(E(2))-primed":[119],"(2-3":[123],"months":[124,143,171],"old).":[125],"This":[126],"antecedent":[127],"increase":[128],"apparent":[138],"(11-13":[142],"old)":[144],"association":[146],"with":[147],"delayed":[149,229],"attenuated":[151],"surge.":[153],"second":[156],"whereas":[158],"progesterone":[159],"failed":[160],"to":[161,227],"induce":[162],"surges":[164,233,248],"E(2)-primed":[166],"(23-25":[170],"old),":[172],"intracerebroventricular":[173],"(0.1-0.5":[175],"microg)":[176],"injections":[177],"at":[178],"1100,":[179],"1200":[180],"13.00":[182],"h":[183],"resulted":[184],"induction":[188],"E(2)":[190],"+":[191],"progesterone-primed":[192],"Because":[196],"synthesis":[200],"obligatory":[204],"for":[205],"preovulatory":[207],"discharge":[209],"findings":[215],"suggest":[216],"alteration":[218],"nucleus":[225],"contributes":[226],"reduced":[231],"involved":[240],"subsequent":[243],"loss":[244]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}