{"id":"https://openalex.org/W1973459975","doi":"https://doi.org/10.1111/j.1471-4159.2009.05889.x","title":"Cultured astrocytes derived from corpus callosum or cortical grey matter show distinct glutamate handling properties","display_name":"Cultured astrocytes derived from corpus callosum or cortical grey matter show distinct glutamate handling properties","publication_year":2009,"publication_date":"2009-02-13","ids":{"openalex":"https://openalex.org/W1973459975","doi":"https://doi.org/10.1111/j.1471-4159.2009.05889.x","mag":"1973459975","pmid":"https://pubmed.ncbi.nlm.nih.gov/19222709"},"language":"en","primary_location":{"id":"doi:10.1111/j.1471-4159.2009.05889.x","doi":"https://doi.org/10.1111/j.1471-4159.2009.05889.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.2009.05889.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1471-4159.2009.05889.x","source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1471-4159.2009.05889.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044658587","display_name":"St\u00e9phanie Goursaud","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"St\u00e9phanie Goursaud","raw_affiliation_strings":["Laboratoire de Pharmacologie Exp\u00e9rimentale, Universit\u00e9 Catholique de Louvain, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Pharmacologie Exp\u00e9rimentale, Universit\u00e9 Catholique de Louvain, Brussels, Belgium","institution_ids":["https://openalex.org/I95674353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091093243","display_name":"Elena N. Kozlova","orcid":"https://orcid.org/0000-0002-2234-0079","observed_orcids":["https://orcid.org/0000-0002-2234-0079"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Elena N. Kozlova","raw_affiliation_strings":["Neuroanatomy, Department of Neuroscience, Biomedical Center, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroanatomy, Department of Neuroscience, Biomedical Center, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110865773","display_name":"Jean\u2010Marie Maloteaux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jean\u2010Marie Maloteaux","raw_affiliation_strings":["Laboratoire de Pharmacologie Expe\u0301rimentale, Universite\u0301 catholique de Louvain, Brussels, Belgium","Laboratoire de Pharmacologie Exp\u00e9rimentale, Universit\u00e9 Catholique de Louvain, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Pharmacologie Expe\u0301rimentale, Universite\u0301 catholique de Louvain, Brussels, Belgium","institution_ids":["https://openalex.org/I95674353"]},{"raw_affiliation_string":"Laboratoire de Pharmacologie Exp\u00e9rimentale, Universit\u00e9 Catholique de Louvain, Brussels, Belgium","institution_ids":["https://openalex.org/I95674353"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018248529","display_name":"Emmanuel Hermans","orcid":"https://orcid.org/0000-0002-8589-3279","observed_orcids":["https://orcid.org/0000-0002-8589-3279"]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Emmanuel Hermans","raw_affiliation_strings":["Laboratoire de Pharmacologie Expe\u0301rimentale, Universite\u0301 catholique de Louvain, Brussels, Belgium","Laboratoire de Pharmacologie Exp\u00e9rimentale, Universit\u00e9 Catholique de Louvain, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Pharmacologie Expe\u0301rimentale, Universite\u0301 catholique de Louvain, Brussels, Belgium","institution_ids":["https://openalex.org/I95674353"]},{"raw_affiliation_string":"Laboratoire de Pharmacologie Exp\u00e9rimentale, Universit\u00e9 Catholique de Louvain, Brussels, Belgium","institution_ids":["https://openalex.org/I95674353"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5018248529"],"corresponding_institution_ids":["https://openalex.org/I95674353"],"apc_list":{"value":5330,"currency":"USD","value_usd":5330},"apc_paid":null,"fwci":0.8283,"has_fulltext":true,"cited_by_count":69,"citation_normalized_percentile":{"value":0.65888202,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"108","issue":"6","first_page":"1442","last_page":"1452"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.9010000228881836},{"id":"https://openalex.org/keywords/corpus-callosum","display_name":"corpus callosum","score":0.9179999828338623},{"id":"https://openalex.org/keywords/white-matter","display_name":"white matter","score":0.7129999995231628},{"id":"https://openalex.org/keywords/cortical-gray-matter","display_name":"cortical gray matter","score":0.8650000095367432},{"id":"https://openalex.org/keywords/glt-1","display_name":"GLT-1","score":0.824999988079071},{"id":"https://openalex.org/keywords/glast","display_name":"GLAST","score":0.9240000247955322},{"id":"https://openalex.org/keywords/glutamine-synthetase","display_name":"glutamine synthetase","score":0.9929999709129333},{"id":"https://openalex.org/keywords/metabotropic-glutamate-receptor-5","display_name":"metabotropic glutamate receptor 5","score":0.8759999871253967},{"id":"https://openalex.org/keywords/intracellular-calcium-release","display_name":"intracellular calcium release","score":0.7409999966621399},{"id":"https://openalex.org/keywords/glial-fibrillary-acidic-protein","display_name":"glial fibrillary acidic protein","score":0.9129999876022339},{"id":"https://openalex.org/keywords/vimentin","display_name":"vimentin","score":0.8960000276565552},{"id":"https://openalex.org/keywords/nestin","display_name":"nestin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/glial-activation","display_name":"glial activation","score":0.6970000267028809},{"id":"https://openalex.org/keywords/excitotoxicity","display_name":"excitotoxicity","score":0.9279999732971191}],"concepts":[{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.771823525428772},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.7373408675193787},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.6933579444885254},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6075972318649292},{"id":"https://openalex.org/C2778013878","wikidata":"https://www.wikidata.org/wiki/Q646150","display_name":"Grey matter","level":4,"score":0.6000123620033264},{"id":"https://openalex.org/C2779289688","wikidata":"https://www.wikidata.org/wiki/Q418306","display_name":"Glutamine synthetase","level":4,"score":0.5183578133583069},{"id":"https://openalex.org/C2780648746","wikidata":"https://www.wikidata.org/wiki/Q28208871","display_name":"Glutamatergic","level":4,"score":0.4981400966644287},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.4426499009132385},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43542978167533875},{"id":"https://openalex.org/C49051014","wikidata":"https://www.wikidata.org/wiki/Q2033959","display_name":"Metabotropic glutamate receptor","level":4,"score":0.41009974479675293},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.36714887619018555},{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.365959107875824},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26841580867767334},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.17612764239311218},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12933355569839478},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.09518641233444214},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.05767074227333069},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001224","descriptor_name":"Aspartic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D003337","descriptor_name":"Corpus Callosum","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005904","descriptor_name":"Glial Fibrillary Acidic Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007381","descriptor_name":"Intermediate Filament Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014746","descriptor_name":"Vimentin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018094","descriptor_name":"Receptors, Metabotropic Glutamate","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D026905","descriptor_name":"Amino Acid Transport Systems","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048429","descriptor_name":"Cell Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064231","descriptor_name":"Nestin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064529","descriptor_name":"Receptor, Metabotropic Glutamate 5","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1471-4159.2009.05889.x","doi":"https://doi.org/10.1111/j.1471-4159.2009.05889.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.2009.05889.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1471-4159.2009.05889.x","source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},{"id":"pmid:19222709","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19222709","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurochemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1471-4159.2009.05889.x","doi":"https://doi.org/10.1111/j.1471-4159.2009.05889.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.2009.05889.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1471-4159.2009.05889.x","source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8747590069","display_name":null,"funder_award_id":"20716","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"}],"funders":[{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1973459975.pdf","grobid_xml":"https://content.openalex.org/works/W1973459975.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W10453469","https://openalex.org/W204348490","https://openalex.org/W1519351707","https://openalex.org/W1526030258","https://openalex.org/W1629378997","https://openalex.org/W1861156630","https://openalex.org/W1916120989","https://openalex.org/W1939198520","https://openalex.org/W1969305530","https://openalex.org/W1971279713","https://openalex.org/W1973939587","https://openalex.org/W1973953770","https://openalex.org/W1976400860","https://openalex.org/W1978969328","https://openalex.org/W1979031928","https://openalex.org/W1983836947","https://openalex.org/W1988424282","https://openalex.org/W1995731471","https://openalex.org/W1999658678","https://openalex.org/W2012597496","https://openalex.org/W2012893265","https://openalex.org/W2015556961","https://openalex.org/W2026688064","https://openalex.org/W2028900541","https://openalex.org/W2034003277","https://openalex.org/W2040611959","https://openalex.org/W2041340250","https://openalex.org/W2070030037","https://openalex.org/W2070081929","https://openalex.org/W2073880845","https://openalex.org/W2083398714","https://openalex.org/W2091341053","https://openalex.org/W2093950888","https://openalex.org/W2094902133","https://openalex.org/W2094996078","https://openalex.org/W2102089332","https://openalex.org/W2116447221","https://openalex.org/W2123016546","https://openalex.org/W2131601310","https://openalex.org/W2132704608","https://openalex.org/W2156061695","https://openalex.org/W2157486029","https://openalex.org/W2157853053","https://openalex.org/W2160935383","https://openalex.org/W2168078141"],"related_works":["https://openalex.org/W2103456224","https://openalex.org/W29706529","https://openalex.org/W2993166982","https://openalex.org/W2063272984","https://openalex.org/W1983163651","https://openalex.org/W2031486344","https://openalex.org/W2058702798","https://openalex.org/W2933470892","https://openalex.org/W4386493266","https://openalex.org/W1976819383"],"abstract_inverted_index":{"While":[0],"the":[1,18,77,131,171,220,225,230],"astrocytic":[2],"control":[3,231],"of":[4,20,56,76,133,140,157,178,203,224,232],"extracellular":[5],"glutamate":[6,21,37,92,141,161],"concentration":[7],"at":[8,104],"synaptic":[9],"contacts":[10],"is":[11,15],"well":[12,95],"characterized,":[13],"little":[14],"known":[16],"regarding":[17],"clearance":[19],"along":[22],"axon":[23],"tracts,":[24],"even":[25],"though":[26],"local":[27],"excitotoxic":[28,217],"damage":[29],"has":[30],"been":[31],"reported.":[32],"Therefore,":[33],"we":[34],"have":[35],"compared":[36,110],"handling":[38],"in":[39,107,126,166,182,229],"astrocyte":[40,184],"cultures":[41,185],"derived":[42,206],"from":[43,207],"white":[44,70,108,127,167,208],"matter":[45,50,71,109,113,128,146,168,209],"(corpus":[46],"callosum)":[47],"and":[48,86,91,130,222],"grey":[49,112,145],"tissues":[51],"(cortical":[52],"structures).":[53],"These":[54],"populations":[55],"astrocytes":[57,72,169,205],"showed":[58,73],"clearly":[59],"distinct":[60],"phenotypes,":[61],"adopting":[62],"stellate":[63],"or":[64],"protoplasmic":[65],"morphologies":[66],"respectively.":[67],"In":[68,154],"addition,":[69,155],"high":[74],"densities":[75],"intermediate":[78],"filament":[79],"proteins":[80],"glial":[81,196],"fibrillary":[82],"acidic":[83],"protein,":[84],"vimentin":[85],"nestin.":[87],"The":[88],"glutamate-aspartate":[89],"transporter":[90,150],"transporter-1,":[93,142],"as":[94,96],"glutamine":[97],"synthetase,":[98],"were":[99,186],"found":[100],"to":[101,123,191,215],"be":[102],"expressed":[103],"higher":[105,125,165],"levels":[106],"with":[111,116,144],"astrocytes.":[114],"Consistent":[115],"this":[117,149],"aspartate":[118],"uptake":[119],"capacity":[120],"was":[121,163],"three":[122],"fourfold":[124],"cells,":[129],"use":[132],"specific":[134],"inhibitors":[135],"revealed":[136],"a":[137,175,245],"substantial":[138],"activity":[139,223],"contrasting":[143],"cells":[147,239],"where":[148,170],"appeared":[151],"poorly":[152],"functional.":[153],"expression":[156,221],"type":[158],"5":[159],"metabotropic":[160],"receptors":[162],"considerably":[164],"agonist":[172],"(S)-3,5-dihydroxyphenylglycine":[173],"triggered":[174],"large":[176],"release":[177],"intracellular":[179],"calcium.":[180],"Differences":[181],"these":[183,238],"also":[187],"observed":[188],"when":[189,237],"exposed":[190],"experimental":[192],"conditions":[193,243],"that":[194],"trigger":[195],"activation.":[197],"This":[198],"study":[199],"highlights":[200],"typical":[201],"features":[202],"cultured":[204],"tissues,":[210],"which":[211],"appear":[212],"constitutively":[213],"adapted":[214],"handle":[216],"insults.":[218],"Moreover,":[219],"astroglial":[226],"components":[227],"involved":[228],"glutamatergic":[233],"transmission":[234],"are":[235,240],"reinforced":[236],"maintained":[241],"under":[242],"mimicking":[244],"gliotic":[246],"environment.":[247]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}