{"id":"https://openalex.org/W1973457451","doi":"https://doi.org/10.1517/14728222.2014.925882","title":"PAR-4: a possible new target for age-related disease","display_name":"PAR-4: a possible new target for age-related disease","publication_year":2014,"publication_date":"2014-06-03","ids":{"openalex":"https://openalex.org/W1973457451","doi":"https://doi.org/10.1517/14728222.2014.925882","mag":"1973457451","pmid":"https://pubmed.ncbi.nlm.nih.gov/24890982"},"language":"en","primary_location":{"id":"doi:10.1517/14728222.2014.925882","doi":"https://doi.org/10.1517/14728222.2014.925882","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14728222.2014.925882","pdf_url":null,"source":{"id":"https://openalex.org/S149756942","display_name":"Expert Opinion on Therapeutic Targets","issn_l":"1472-8222","issn":["1472-8222","1744-7631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Therapeutic Targets","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101817335","display_name":"Qinan Wu","orcid":"https://orcid.org/0000-0002-8733-9191","observed_orcids":["https://orcid.org/0000-0002-8733-9191","https://orcid.org/0009-0000-7001-4836"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wu Qinan","raw_affiliation_strings":["The First Affiliated Hospital of the Third Military Medical University, Endocrine Department , Post number: 400038, Chongqing , China chenbingxnyy@126.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of the Third Military Medical University, Endocrine Department , Post number: 400038, Chongqing , China chenbingxnyy@126.com","institution_ids":["https://openalex.org/I151075929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100450751","display_name":"Ling Zhang","orcid":"https://orcid.org/0000-0002-8369-3927","observed_orcids":["https://orcid.org/0000-0002-8369-3927"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhang Ling","raw_affiliation_strings":["The First Affiliated Hospital of the Third Military Medical University, Outpatient Department, Post number: 400038, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of the Third Military Medical University, Outpatient Department, Post number: 400038, Chongqing, China","institution_ids":["https://openalex.org/I151075929"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100443087","display_name":"Bing Chen","orcid":"https://orcid.org/0000-0001-8102-7333","observed_orcids":["https://orcid.org/0000-0001-8102-7333"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Bing","raw_affiliation_strings":["The First Affiliated Hospital of the Third Military Medical University, Endocrine Department, Post number: 400038, Chongqing, China chenbingxnyy@126.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of the Third Military Medical University, Endocrine Department, Post number: 400038, Chongqing, China chenbingxnyy@126.com","institution_ids":["https://openalex.org/I151075929"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I151075929"],"apc_list":null,"apc_paid":null,"fwci":0.1499,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.09508776,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"18","issue":"8","first_page":"917","last_page":"927"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/par-4","display_name":"Par-4","score":0.9279999732971191},{"id":"https://openalex.org/keywords/prostate-apoptosis-response-4","display_name":"prostate apoptosis response-4","score":0.9589999914169312},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7580000162124634},{"id":"https://openalex.org/keywords/age-related-diseases","display_name":"age-related diseases","score":0.9330000281333923},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6489999890327454},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9049999713897705},{"id":"https://openalex.org/keywords/dopamine-d2-receptor","display_name":"dopamine D2 receptor","score":0.8450000286102295},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.8259999752044678},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9909999966621399},{"id":"https://openalex.org/keywords/tumor-cell-apoptosis","display_name":"tumor cell apoptosis","score":0.5870000123977661},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.762843906879425},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6723327040672302},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.594209611415863},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5059084296226501},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.48506656289100647},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.46704477071762085},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44836047291755676},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42412757873535156},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4240246117115021},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38385915756225586},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34028542041778564},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2185664176940918},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20766127109527588},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.140103280544281}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059865","descriptor_name":"Endoplasmic Reticulum Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1517/14728222.2014.925882","doi":"https://doi.org/10.1517/14728222.2014.925882","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14728222.2014.925882","pdf_url":null,"source":{"id":"https://openalex.org/S149756942","display_name":"Expert Opinion on Therapeutic Targets","issn_l":"1472-8222","issn":["1472-8222","1744-7631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Therapeutic Targets","raw_type":"journal-article"},{"id":"pmid:24890982","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24890982","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on therapeutic targets","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":90,"referenced_works":["https://openalex.org/W66185305","https://openalex.org/W1508744139","https://openalex.org/W1517407659","https://openalex.org/W1572960859","https://openalex.org/W1604513214","https://openalex.org/W1622978237","https://openalex.org/W1955419087","https://openalex.org/W1964345901","https://openalex.org/W1966027561","https://openalex.org/W1968677381","https://openalex.org/W1974552235","https://openalex.org/W1977603207","https://openalex.org/W1979415253","https://openalex.org/W1982273641","https://openalex.org/W1987097693","https://openalex.org/W1987162834","https://openalex.org/W1988279611","https://openalex.org/W1988557685","https://openalex.org/W1988572431","https://openalex.org/W1988644010","https://openalex.org/W1991204646","https://openalex.org/W2000888772","https://openalex.org/W2001323503","https://openalex.org/W2001536936","https://openalex.org/W2003392393","https://openalex.org/W2006681165","https://openalex.org/W2007078899","https://openalex.org/W2009190474","https://openalex.org/W2010397777","https://openalex.org/W2011447745","https://openalex.org/W2013048175","https://openalex.org/W2017044887","https://openalex.org/W2024705093","https://openalex.org/W2024992738","https://openalex.org/W2025587382","https://openalex.org/W2027923201","https://openalex.org/W2029059784","https://openalex.org/W2029604570","https://openalex.org/W2032577354","https://openalex.org/W2036876722","https://openalex.org/W2037232360","https://openalex.org/W2040193443","https://openalex.org/W2040518666","https://openalex.org/W2047761494","https://openalex.org/W2047946890","https://openalex.org/W2049591771","https://openalex.org/W2049978396","https://openalex.org/W2050643539","https://openalex.org/W2051073953","https://openalex.org/W2053274595","https://openalex.org/W2054354127","https://openalex.org/W2055492712","https://openalex.org/W2056993355","https://openalex.org/W2058511356","https://openalex.org/W2061362388","https://openalex.org/W2061876807","https://openalex.org/W2073826397","https://openalex.org/W2075055448","https://openalex.org/W2075511251","https://openalex.org/W2075581908","https://openalex.org/W2078818685","https://openalex.org/W2079786457","https://openalex.org/W2079933639","https://openalex.org/W2086679989","https://openalex.org/W2087699981","https://openalex.org/W2090565894","https://openalex.org/W2092423273","https://openalex.org/W2095361286","https://openalex.org/W2101884233","https://openalex.org/W2103173512","https://openalex.org/W2103631479","https://openalex.org/W2112601240","https://openalex.org/W2113468873","https://openalex.org/W2113544353","https://openalex.org/W2120420203","https://openalex.org/W2122620029","https://openalex.org/W2123496677","https://openalex.org/W2124252726","https://openalex.org/W2133335227","https://openalex.org/W2134020800","https://openalex.org/W2141515497","https://openalex.org/W2152203644","https://openalex.org/W2155989642","https://openalex.org/W2161334764","https://openalex.org/W2161542744","https://openalex.org/W2161655114","https://openalex.org/W2162738751","https://openalex.org/W2162925265","https://openalex.org/W2170045907","https://openalex.org/W4256495376"],"related_works":["https://openalex.org/W1561612353","https://openalex.org/W2039885900","https://openalex.org/W2102800489","https://openalex.org/W2069377495","https://openalex.org/W2130317887","https://openalex.org/W3119069247","https://openalex.org/W2008254819","https://openalex.org/W2434537502","https://openalex.org/W4238140162","https://openalex.org/W126084106"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Apoptosis":[1],"plays":[2,30],"an":[3,31],"important":[4,32],"role":[5,33,55,102],"in":[6,22,34,61,83,95,103,133,150],"age-related":[7,39,62,84,96,117],"disease,":[8],"and":[9,48,80,111,142,146,168,172],"prostate":[10],"apoptosis":[11,21,132],"response-4":[12],"(PAR-4)":[13],"is":[14,137,148],"a":[15,50,57,124],"novel":[16],"apoptosis-inducing":[17],"factor":[18],"that":[19,28,114,128],"regulates":[20],"most":[23],"cells.":[24,135],"Recent":[25],"studies":[26],"suggest":[27],"PAR-4":[29,47,79,94,121,161,170],"the":[35,44,69,72,91,151,154],"progression":[36],"of":[37,46,93,153,160],"many":[38],"diseases.":[40],"This":[41,66],"review":[42,67],"highlights":[43],"significance":[45,82,92],"builds":[49],"strong":[51],"case":[52],"supporting":[53],"its":[54,81,101],"as":[56,98,100],"possible":[58],"therapeutic":[59,126],"target":[60,127],"disease.":[63,85,118],"AREAS":[64],"COVERED:":[65],"covers":[68],"advancements":[70],"over":[71],"last":[73],"15":[74],"years":[75],"with":[76,165],"respect":[77],"to":[78],"Additionally,":[86],"it":[87,147],"provides":[88],"knowledge":[89],"regarding":[90],"disease":[97,167],"well":[99],"apoptotic":[104],"signaling":[105],"pathways,":[106],"endoplasmic":[107],"reticulum":[108],"(ER)":[109],"stress,":[110,145],"other":[112],"mechanisms":[113],"may":[115,122,162],"induce":[116],"EXPERT":[119],"OPINION:":[120],"be":[123,163,175],"potential":[125],"can":[129,180],"trigger":[130],"selective":[131],"cancer":[134],"It":[136],"induced":[138],"by":[139],"ER":[140,144],"stress":[141],"increased":[143],"involved":[149],"activity":[152],"dopamine":[155],"D2":[156],"receptor.":[157],"Abnormal":[158],"expression":[159],"associated":[164],"cardiovascular":[166],"diabetes.":[169],"agonists":[171],"inhibitors":[173],"must":[174],"identified":[176],"before":[177],"gene":[178],"therapy":[179],"commence.":[181]},"counts_by_year":[{"year":2021,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
