{"id":"https://openalex.org/W1973456959","doi":"https://doi.org/10.2298/mpns1502035g","title":"Reasons for and frequency of off - label drug use","display_name":"Reasons for and frequency of off - label drug use","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W1973456959","doi":"https://doi.org/10.2298/mpns1502035g","mag":"1973456959","pmid":"https://pubmed.ncbi.nlm.nih.gov/26012242"},"language":"en","primary_location":{"id":"doi:10.2298/mpns1502035g","doi":"https://doi.org/10.2298/mpns1502035g","is_oa":true,"landing_page_url":"https://doi.org/10.2298/mpns1502035g","pdf_url":"http://www.doiserbia.nb.rs/ft.aspx?id=0025-81051502035G","source":{"id":"https://openalex.org/S121341522","display_name":"Medicinski pregled","issn_l":"0025-8105","issn":["0025-8105","1820-7383"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20"],"host_organization":"https://openalex.org/P4310322539","host_organization_name":"Serbian Medical Society","host_organization_lineage":["https://openalex.org/P4310322539"],"host_organization_lineage_names":["Serbian Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicinski pregled","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.doiserbia.nb.rs/ft.aspx?id=0025-81051502035G","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019432013","display_name":"Svetlana Golo\u010dorbin-Kon","orcid":"https://orcid.org/0000-0002-9257-8074","observed_orcids":["https://orcid.org/0000-0002-9257-8074"]},"institutions":[{"id":"https://openalex.org/I170726198","display_name":"University of Novi Sad","ror":"https://ror.org/00xa57a59","country_code":"RS","type":"education","lineage":["https://openalex.org/I170726198"]},{"id":"https://openalex.org/I5936373","display_name":"University of Montenegro","ror":"https://ror.org/02drrjp49","country_code":"ME","type":"education","lineage":["https://openalex.org/I5936373"]}],"countries":["ME","RS"],"is_corresponding":false,"raw_author_name":"Svetlana Golocorbin-Kon","raw_affiliation_strings":["Faculty of Medicine, Department of Pharmacy, Novi Sad + University of Montenegro, Faculty of Pharmacy, Podgorica, Montenegro"],"raw_orcid":"https://orcid.org/0000-0002-9257-8074","affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Pharmacy, Novi Sad + University of Montenegro, Faculty of Pharmacy, Podgorica, Montenegro","institution_ids":["https://openalex.org/I170726198","https://openalex.org/I5936373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047611203","display_name":"Ivana M. Ili\u010dkovi\u0107","orcid":"https://orcid.org/0000-0002-7960-0724","observed_orcids":["https://orcid.org/0000-0002-7960-0724"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ivana Ilickovic","raw_affiliation_strings":["Farmegra Podgorica, Montenegro UDK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Farmegra Podgorica, Montenegro UDK","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026540507","display_name":"Momir Mikov","orcid":"https://orcid.org/0000-0002-2804-0624","observed_orcids":["https://orcid.org/0000-0002-2804-0624"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Momir Mikov","raw_affiliation_strings":["Toxicology and Clinical Pharmacology, Novi Sad"],"raw_orcid":"https://orcid.org/0000-0002-2804-0624","affiliations":[{"raw_affiliation_string":"Toxicology and Clinical Pharmacology, Novi Sad","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2937,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.8732872,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"68","issue":"1-2","first_page":"35","last_page":"40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11649","display_name":"Pharmaceutical industry and healthcare","score":0.014000000432133675,"subfield":{"id":"https://openalex.org/subfields/2910","display_name":"Issues, ethics and legal aspects"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11792","display_name":"Pharmaceutical Economics and Policy","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/off-label-drug-use","display_name":"off-label drug use","score":1.0},{"id":"https://openalex.org/keywords/prescribing-patterns","display_name":"prescribing patterns","score":0.6800000071525574},{"id":"https://openalex.org/keywords/pediatric-prescribing","display_name":"pediatric prescribing","score":0.5619999766349792},{"id":"https://openalex.org/keywords/geriatric-prescribing","display_name":"geriatric prescribing","score":0.9860000014305115},{"id":"https://openalex.org/keywords/oncology-prescribing","display_name":"oncology prescribing","score":0.796999990940094}],"concepts":[{"id":"https://openalex.org/C188313352","wikidata":"https://www.wikidata.org/wiki/Q119697","display_name":"Off-label use","level":2,"score":0.8877333998680115},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8741503953933716},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6758966445922852},{"id":"https://openalex.org/C108759981","wikidata":"https://www.wikidata.org/wiki/Q788590","display_name":"Authorization","level":2,"score":0.5477156639099121},{"id":"https://openalex.org/C3018890749","wikidata":"https://www.wikidata.org/wiki/Q204711","display_name":"Food and drug administration","level":2,"score":0.5238338112831116},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.49510112404823303},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.472986102104187},{"id":"https://openalex.org/C2777589142","wikidata":"https://www.wikidata.org/wiki/Q6770899","display_name":"Marketing authorization","level":2,"score":0.42159390449523926},{"id":"https://openalex.org/C2909938333","wikidata":"https://www.wikidata.org/wiki/Q96376653","display_name":"Drug labeling","level":3,"score":0.4122757017612457},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39731618762016296},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.09139379858970642},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005062","descriptor_name":"European Union","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006113","descriptor_name":"United Kingdom","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010818","descriptor_name":"Practice Patterns, Physicians'","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055771","descriptor_name":"Serbia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056687","descriptor_name":"Off-Label Use","qualifier_ui":"Q000331","qualifier_name":"legislation & jurisprudence","is_major_topic":true},{"descriptor_ui":"D056687","descriptor_name":"Off-Label Use","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.2298/mpns1502035g","doi":"https://doi.org/10.2298/mpns1502035g","is_oa":true,"landing_page_url":"https://doi.org/10.2298/mpns1502035g","pdf_url":"http://www.doiserbia.nb.rs/ft.aspx?id=0025-81051502035G","source":{"id":"https://openalex.org/S121341522","display_name":"Medicinski pregled","issn_l":"0025-8105","issn":["0025-8105","1820-7383"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20"],"host_organization":"https://openalex.org/P4310322539","host_organization_name":"Serbian Medical Society","host_organization_lineage":["https://openalex.org/P4310322539"],"host_organization_lineage_names":["Serbian Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicinski pregled","raw_type":"journal-article"},{"id":"pmid:26012242","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26012242","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicinski pregled","raw_type":"Journal Article"},{"id":"mag:2463109915","doi":null,"is_oa":false,"landing_page_url":"http://www.doiserbia.nb.rs/ft.aspx?id=0025-81051502035G","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.2298/mpns1502035g","doi":"https://doi.org/10.2298/mpns1502035g","is_oa":true,"landing_page_url":"https://doi.org/10.2298/mpns1502035g","pdf_url":"http://www.doiserbia.nb.rs/ft.aspx?id=0025-81051502035G","source":{"id":"https://openalex.org/S121341522","display_name":"Medicinski pregled","issn_l":"0025-8105","issn":["0025-8105","1820-7383"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20"],"host_organization":"https://openalex.org/P4310322539","host_organization_name":"Serbian Medical Society","host_organization_lineage":["https://openalex.org/P4310322539"],"host_organization_lineage_names":["Serbian Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicinski pregled","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1330770582","display_name":null,"funder_award_id":"41012","funder_id":"https://openalex.org/F4320322729","funder_display_name":"Ministarstvo Prosvete, Nauke i Tehnolo\u0161kog Razvoja"}],"funders":[{"id":"https://openalex.org/F4320322349","display_name":"Ministry of Education, Science and Technology","ror":"https://ror.org/01p262204"},{"id":"https://openalex.org/F4320322729","display_name":"Ministarstvo Prosvete, Nauke i Tehnolo\u0161kog Razvoja","ror":"https://ror.org/01znas443"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1973456959.pdf","grobid_xml":"https://content.openalex.org/works/W1973456959.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1609679782","https://openalex.org/W1966204708","https://openalex.org/W2005431370","https://openalex.org/W2019050521","https://openalex.org/W2019079008","https://openalex.org/W2047220243","https://openalex.org/W2049535074","https://openalex.org/W2064940595","https://openalex.org/W2100092136","https://openalex.org/W2105085055","https://openalex.org/W2106952837","https://openalex.org/W2121487587","https://openalex.org/W2134824076","https://openalex.org/W2144462910","https://openalex.org/W2158887619","https://openalex.org/W2158941494","https://openalex.org/W2407881306","https://openalex.org/W2422135076","https://openalex.org/W2467971609","https://openalex.org/W2487234606"],"related_works":["https://openalex.org/W2463109915","https://openalex.org/W2182972274","https://openalex.org/W3204211831","https://openalex.org/W7219324027","https://openalex.org/W2737540953","https://openalex.org/W2797177153","https://openalex.org/W4230236942","https://openalex.org/W2195261462","https://openalex.org/W3011367056","https://openalex.org/W1973211972"],"abstract_inverted_index":{"INTRODUCTION:":[0],"The":[1,79,113,136],"application":[2,32],"of":[3,33,69,81,98,108,115,130,151,191,247,250],"drugs":[4,34,71,146,152,170,192],"in":[5,26,57,88,92,121,212,227,256],"accordance":[6],"with":[7,42,214],"the":[8,13,31,82,96,105,127,149,194,236,248],"marketing":[9],"authorization":[10],"issued":[11],"by":[12,235,240],"regulatory":[14,99,131,206],"authority":[15],"is":[16,84,184,243,254,263],"considered":[17],"on-label":[18],"use,":[19],"while":[20],"off-label":[21,55,70,89,106,145,173,189,209,270],"drug":[22,56,90,210,222,271],"use":[23,91,107,174,190,211,223,253],"frequently":[24,52],"occurs":[25],"medical":[27,237],"practice.":[28],"It":[29],"includes":[30],"beyond":[35],"approved":[36],"indications;":[37],"for":[38,74,153,159,171,269],"unapproved":[39],"age":[40,162],"group,":[41],"different":[43,47],"dosage":[44],"regimens":[45],"or":[46,157,179,196],"administration":[48],"route.":[49],"Medical":[50],"specialists":[51],"prescribe":[53,144,169],"an":[54,172],"pediatrics,":[58],"neonatology,":[59],"geriatrics,":[60],"psychiatry":[61],"and":[62,72,77,101,124,201,205,217,229,239,259,261],"oncology.":[63],"Some":[64],"countries":[65],"have":[66],"established":[67],"registers":[68],"guidelines":[73],"their":[75,165,177],"prescribing":[76],"administration.":[78],"aim":[80],"paper":[83],"to":[85,94,143,265],"review":[86],"practices":[87],"order":[93],"satisfy":[95],"attitude":[97],"bodies":[100,207],"professional":[102],"associations":[103,204],"regarding":[104],"drugs.":[109],"MATERIAL":[110],"AND":[111,134],"METHODS:":[112],"sources":[114],"information":[116,125],"used":[117],"are":[118,147],"articles":[119],"published":[120],"scientific":[122,216],"journals":[123],"from":[126],"official":[128],"websites":[129],"agencies.":[132],"RESULTS":[133],"DISCUSSION:":[135],"most":[137],"common":[138,255],"reasons":[139],"why":[140],"physicians":[141],"decide":[142],"primarily":[148],"absence":[150],"a":[154,160,245,267],"particular":[155,161],"indication":[156],"those":[158],"group.":[163],"In":[164],"daily":[166],"work,":[167],"doctors":[168],"based":[175],"on":[176,188],"own":[178],"other":[180],"colleague's":[181],"experience.":[182],"There":[183],"no":[185],"general":[186],"agreement":[187],"at":[193],"national":[195],"international":[197],"level,":[198],"but":[199],"more":[200,202],"doctors'":[203],"approve":[208],"compliance":[213],"certain":[215],"legal":[218],"requirements.":[219],"CONCLUSION:":[220],"Off-label":[221,252],"has":[224,231],"its":[225],"place":[226],"practice":[228],"it":[230,242,262],"been":[232],"widely":[233],"accepted":[234],"community":[238],"itself":[241],"not":[244],"violation":[246],"standards":[249],"healthcare.":[251],"our":[257],"country":[258],"worldwide,":[260],"necessary":[264],"establish":[266],"registry":[268],"use.":[272]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}