{"id":"https://openalex.org/W1973408153","doi":"https://doi.org/10.1111/j.1539-6924.1994.tb00276.x","title":"Modeling Fetal Death and Malformation in Developmental Toxicity Studies","display_name":"Modeling Fetal Death and Malformation in Developmental Toxicity Studies","publication_year":1994,"publication_date":"1994-08-01","ids":{"openalex":"https://openalex.org/W1973408153","doi":"https://doi.org/10.1111/j.1539-6924.1994.tb00276.x","mag":"1973408153","pmid":"https://pubmed.ncbi.nlm.nih.gov/7972963"},"language":"en","primary_location":{"id":"doi:10.1111/j.1539-6924.1994.tb00276.x","doi":"https://doi.org/10.1111/j.1539-6924.1994.tb00276.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1539-6924.1994.tb00276.x","pdf_url":null,"source":{"id":"https://openalex.org/S161248890","display_name":"Risk Analysis","issn_l":"0272-4332","issn":["0272-4332","1539-6924"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Risk Analysis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069129452","display_name":"Paul J. Catalano","orcid":"https://orcid.org/0000-0002-1105-8852","observed_orcids":["https://orcid.org/0000-0002-1105-8852"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Catalano","raw_affiliation_strings":["Department of Biostatistics, Dana Farber Cancer Institute, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Dana Farber Cancer Institute, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082642762","display_name":"LOUISE M. RYAN","orcid":"https://orcid.org/0000-0001-5957-2490","observed_orcids":["https://orcid.org/0000-0001-5957-2490"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Louise Ryan","raw_affiliation_strings":["Department of Biostatistics, Dana Farber Cancer Institute, and Harvard School of Public Health, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Dana Farber Cancer Institute, and Harvard School of Public Health, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028193922","display_name":"Daniel O. Scharfstein","orcid":"https://orcid.org/0000-0001-7482-9653","observed_orcids":["https://orcid.org/0000-0001-7482-9653"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Scharfstein","raw_affiliation_strings":["Department of Biostatistics, Dana Farber Cancer Institute, and Harvard School of Public Health, Boston, Massachusetts 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Dana Farber Cancer Institute, and Harvard School of Public Health, Boston, Massachusetts 02115","institution_ids":["https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":null,"fwci":0.8804,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.73213455,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"14","issue":"4","first_page":"629","last_page":"637"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14374","display_name":"Statistical Methods in Epidemiology","score":0.2915000021457672,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T14374","display_name":"Statistical Methods in Epidemiology","score":0.2915000021457672,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.18629999458789825,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10243","display_name":"Statistical Methods and Bayesian Inference","score":0.13349999487400055,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fetal-death","display_name":"fetal death","score":0.796999990940094},{"id":"https://openalex.org/keywords/fetal-malformations","display_name":"fetal malformations","score":0.8370000123977661},{"id":"https://openalex.org/keywords/developmental-toxicity","display_name":"developmental toxicity","score":0.9810000061988831},{"id":"https://openalex.org/keywords/dose-response-modeling","display_name":"dose-response modeling","score":0.949999988079071},{"id":"https://openalex.org/keywords/risk-assessment","display_name":"risk assessment","score":0.6940000057220459},{"id":"https://openalex.org/keywords/binary-data","display_name":"binary data","score":0.6169999837875366},{"id":"https://openalex.org/keywords/multinomial-distribution","display_name":"multinomial distribution","score":0.8140000104904175},{"id":"https://openalex.org/keywords/continuation-ratio-model","display_name":"continuation ratio model","score":0.8429999947547913},{"id":"https://openalex.org/keywords/generalized-estimating-equations","display_name":"generalized estimating equations","score":0.972000002861023},{"id":"https://openalex.org/keywords/benchmark-dose","display_name":"benchmark dose","score":0.9539999961853027},{"id":"https://openalex.org/keywords/lower-confidence-limits","display_name":"lower confidence bound","score":0.9150000214576721},{"id":"https://openalex.org/keywords/excess-risk","display_name":"excess risk","score":0.722000002861023},{"id":"https://openalex.org/keywords/di-2-ethylhexyl-phthalate","display_name":"DEHP","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C179335377","wikidata":"https://www.wikidata.org/wiki/Q5266825","display_name":"Developmental toxicity","level":4,"score":0.7186551094055176},{"id":"https://openalex.org/C192065140","wikidata":"https://www.wikidata.org/wiki/Q1147928","display_name":"Multinomial distribution","level":2,"score":0.4920634627342224},{"id":"https://openalex.org/C48372109","wikidata":"https://www.wikidata.org/wiki/Q3913","display_name":"Binary number","level":2,"score":0.45875051617622375},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.4440893828868866},{"id":"https://openalex.org/C88626702","wikidata":"https://www.wikidata.org/wiki/Q1128903","display_name":"Continuation","level":2,"score":0.4380117654800415},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.4369296133518219},{"id":"https://openalex.org/C185798385","wikidata":"https://www.wikidata.org/wiki/Q1161707","display_name":"Benchmark (surveying)","level":2,"score":0.4353697597980499},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4227652847766876},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.32161688804626465},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3207228183746338},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3178105056285858},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.3015948235988617},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.299530029296875},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28325098752975464},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17448639869689941},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.17402416467666626},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0936477780342102},{"id":"https://openalex.org/C13280743","wikidata":"https://www.wikidata.org/wiki/Q131089","display_name":"Geodesy","level":1,"score":0.0},{"id":"https://openalex.org/C94375191","wikidata":"https://www.wikidata.org/wiki/Q11205","display_name":"Arithmetic","level":1,"score":0.0},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000014","descriptor_name":"Abnormalities, Drug-Induced","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005313","descriptor_name":"Fetal Death","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014116","descriptor_name":"Toxicology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015386","descriptor_name":"Hazardous Substances","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015386","descriptor_name":"Hazardous Substances","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015386","descriptor_name":"Hazardous Substances","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1539-6924.1994.tb00276.x","doi":"https://doi.org/10.1111/j.1539-6924.1994.tb00276.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1539-6924.1994.tb00276.x","pdf_url":null,"source":{"id":"https://openalex.org/S161248890","display_name":"Risk Analysis","issn_l":"0272-4332","issn":["0272-4332","1539-6924"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Risk Analysis","raw_type":"journal-article"},{"id":"pmid:7972963","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7972963","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Risk analysis : an official publication of the Society for Risk Analysis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1528905581","https://openalex.org/W1975107997","https://openalex.org/W1976059704","https://openalex.org/W1978136073","https://openalex.org/W1989474424","https://openalex.org/W1989776682","https://openalex.org/W1990065954","https://openalex.org/W2009170796","https://openalex.org/W2031688249","https://openalex.org/W2064040848","https://openalex.org/W2067252236","https://openalex.org/W2068127700","https://openalex.org/W2070688896","https://openalex.org/W2092558216","https://openalex.org/W2110362996","https://openalex.org/W2132873473","https://openalex.org/W2136804084","https://openalex.org/W2149860264","https://openalex.org/W2150931474","https://openalex.org/W2317756138","https://openalex.org/W2322775683","https://openalex.org/W2527404613","https://openalex.org/W4254456397","https://openalex.org/W4301673846","https://openalex.org/W4301861531","https://openalex.org/W4322382706"],"related_works":["https://openalex.org/W2150931474","https://openalex.org/W2017490372","https://openalex.org/W2096313580","https://openalex.org/W2507588713","https://openalex.org/W1990065954","https://openalex.org/W2046422884","https://openalex.org/W2005365030","https://openalex.org/W2009170796","https://openalex.org/W7135313681","https://openalex.org/W1604651397"],"abstract_inverted_index":{"We":[0,89],"review":[1],"approaches":[2],"to":[3,37,48,62,66,103],"dose-response":[4],"modeling":[5,22],"and":[6,25,27,87,99,134],"risk":[7],"assessment":[8],"for":[9,41,50],"binary":[10,96,105],"data":[11,124],"from":[12,125],"developmental":[13,127],"toxicity":[14,128],"studies.":[15],"In":[16],"particular,":[17],"we":[18],"focus":[19],"on":[20,94],"jointly":[21],"fetal":[23],"death":[24],"malformation":[26],"use":[28],"a":[29,39,67,78,104],"continuation":[30],"ratio":[31],"formulation":[32],"of":[33,52,70,75,107],"the":[34,111,138],"multinomial":[35],"distribution":[36],"provide":[38],"model":[40,58],"risk.":[42,72],"Generalized":[43],"estimating":[44],"equations":[45],"are":[46,85,121],"used":[47,61],"account":[49],"clustering":[51],"animals":[53],"within":[54],"litters.":[55],"The":[56,119],"fitted":[57],"is":[59],"then":[60],"calculate":[63],"doses":[64],"corresponding":[65],"specified":[68],"level":[69],"excess":[71],"Two":[73],"methods":[74],"arriving":[76],"at":[77],"lower":[79],"confidence":[80],"limit":[81],"or":[82,109,117],"Benchmark":[83],"dose":[84],"illustrated":[86,122],"compared.":[88],"also":[90],"discuss":[91],"models":[92,120],"based":[93],"single":[95],"end":[97],"points":[98],"compare":[100],"our":[101],"approach":[102],"analysis":[106],"whether":[108],"not":[110],"animal":[112],"was":[113],"'affected'":[114],"(either":[115],"dead":[116],"malformed).":[118],"using":[123],"four":[126],"studies":[129],"in":[130],"EG,":[131],"DEHP,":[132],"TGDM,":[133],"DYME":[135],"conducted":[136],"through":[137],"National":[139],"Toxicology":[140],"Program.":[141]},"counts_by_year":[{"year":2019,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
