{"id":"https://openalex.org/W1973404273","doi":"https://doi.org/10.1097/ta.0b013e318166b7d9","title":"Toll-like Receptor 2 and 4 Ligation Results in Complex Altered Cytokine Profiles Early and Late After Burn Injury","display_name":"Toll-like Receptor 2 and 4 Ligation Results in Complex Altered Cytokine Profiles Early and Late After Burn Injury","publication_year":2008,"publication_date":"2008-04-01","ids":{"openalex":"https://openalex.org/W1973404273","doi":"https://doi.org/10.1097/ta.0b013e318166b7d9","mag":"1973404273","pmid":"https://pubmed.ncbi.nlm.nih.gov/18404077"},"language":"en","primary_location":{"id":"doi:10.1097/ta.0b013e318166b7d9","doi":"https://doi.org/10.1097/ta.0b013e318166b7d9","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ta.0b013e318166b7d9","pdf_url":null,"source":{"id":"https://openalex.org/S2312674","display_name":"The Journal of Trauma: Injury, Infection, and Critical Care","issn_l":"0022-5282","issn":["0022-5282","1529-8809"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Trauma: Injury, Infection & Critical Care","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113584482","display_name":"Bruce A. Cairns","orcid":"https://orcid.org/0000-0003-2360-2840","observed_orcids":["https://orcid.org/0000-0003-2360-2840"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce A. Cairns","raw_affiliation_strings":["Department of Surgery and North Carolina Jaycee Burn Center, Chapel Hill, North Carolina, USA. bruce_cairns@med.unc.edu","Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery and North Carolina Jaycee Burn Center, Chapel Hill, North Carolina, USA. bruce_cairns@med.unc.edu","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Carolina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029252868","display_name":"Carie M. Barnes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carie M. Barnes","raw_affiliation_strings":["From the Department of Surgery and North Carolina Jaycee Burn Center (B.A.C., C.M.B., S.M., A.A.M., R.M.), Chapel Hill, North Carolina","and Department of Microbiology and Immunology (B.A.C., R.M.), University of North Carolina, Chapel Hill, North Carolina","Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Surgery and North Carolina Jaycee Burn Center (B.A.C., C.M.B., S.M., A.A.M., R.M.), Chapel Hill, North Carolina","institution_ids":[]},{"raw_affiliation_string":"and Department of Microbiology and Immunology (B.A.C., R.M.), University of North Carolina, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Carolina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089101581","display_name":"Stefan Mlot","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefan Mlot","raw_affiliation_strings":["From the Department of Surgery and North Carolina Jaycee Burn Center (B.A.C., C.M.B., S.M., A.A.M., R.M.), Chapel Hill, North Carolina","and Department of Microbiology and Immunology (B.A.C., R.M.), University of North Carolina, Chapel Hill, North Carolina","Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Surgery and North Carolina Jaycee Burn Center (B.A.C., C.M.B., S.M., A.A.M., R.M.), Chapel Hill, North Carolina","institution_ids":[]},{"raw_affiliation_string":"and Department of Microbiology and Immunology (B.A.C., R.M.), University of North Carolina, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Carolina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041245842","display_name":"Anthony A. Meyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony A. Meyer","raw_affiliation_strings":["From the Department of Surgery and North Carolina Jaycee Burn Center (B.A.C., C.M.B., S.M., A.A.M., R.M.), Chapel Hill, North Carolina","and Department of Microbiology and Immunology (B.A.C., R.M.), University of North Carolina, Chapel Hill, North Carolina","Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Surgery and North Carolina Jaycee Burn Center (B.A.C., C.M.B., S.M., A.A.M., R.M.), Chapel Hill, North Carolina","institution_ids":[]},{"raw_affiliation_string":"and Department of Microbiology and Immunology (B.A.C., R.M.), University of North Carolina, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Carolina","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007601702","display_name":"Robert Maile","orcid":"https://orcid.org/0000-0002-9126-4188","observed_orcids":["https://orcid.org/0000-0002-9126-4188"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Maile","raw_affiliation_strings":["From the Department of Surgery and North Carolina Jaycee Burn Center (B.A.C., C.M.B., S.M., A.A.M., R.M.), Chapel Hill, North Carolina","and Department of Microbiology and Immunology (B.A.C., R.M.), University of North Carolina, Chapel Hill, North Carolina","Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Surgery and North Carolina Jaycee Burn Center (B.A.C., C.M.B., S.M., A.A.M., R.M.), Chapel Hill, North Carolina","institution_ids":[]},{"raw_affiliation_string":"and Department of Microbiology and Immunology (B.A.C., R.M.), University of North Carolina, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Carolina","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":null,"apc_paid":null,"fwci":1.3119,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.78248027,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"64","issue":"4","first_page":"1069","last_page":"1078"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.8384000062942505,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.8384000062942505,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11422","display_name":"Burn Injury Management and Outcomes","score":0.15600000321865082,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tlr2","display_name":"TLR2","score":0.8960000276565552},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":1.0},{"id":"https://openalex.org/keywords/burns","display_name":"burns","score":0.9940000176429749},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8330000042915344},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.7580000162124634},{"id":"https://openalex.org/keywords/tlr2-ligands","display_name":"TLR2 ligands","score":0.6200000047683716},{"id":"https://openalex.org/keywords/tlr4-ligands","display_name":"TLR4 ligands","score":0.9929999709129333},{"id":"https://openalex.org/keywords/peptidoglycan","display_name":"peptidoglycan","score":0.9129999876022339},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":1.0},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8109999895095825},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9760000109672546},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9210000038146973},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.9390000104904175},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.7089999914169312},{"id":"https://openalex.org/keywords/macrophage-accumulation","display_name":"macrophage accumulation","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C179437574","wikidata":"https://www.wikidata.org/wiki/Q15089798","display_name":"Ligation","level":2,"score":0.5848196148872375},{"id":"https://openalex.org/C2993242423","wikidata":"https://www.wikidata.org/wiki/Q170518","display_name":"Burn injury","level":2,"score":0.5696887969970703},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.566670835018158},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.5059289336204529},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4491892457008362},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39889660477638245},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37131205201148987},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21310165524482727},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.1441301703453064},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.09797340631484985}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002056","descriptor_name":"Burns","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002056","descriptor_name":"Burns","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010457","descriptor_name":"Peptidoglycan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051195","descriptor_name":"Toll-Like Receptor 2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051195","descriptor_name":"Toll-Like Receptor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/ta.0b013e318166b7d9","doi":"https://doi.org/10.1097/ta.0b013e318166b7d9","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ta.0b013e318166b7d9","pdf_url":null,"source":{"id":"https://openalex.org/S2312674","display_name":"The Journal of Trauma: Injury, Infection, and Critical Care","issn_l":"0022-5282","issn":["0022-5282","1529-8809"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Trauma: Injury, Infection & Critical Care","raw_type":"journal-article"},{"id":"pmid:18404077","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18404077","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of trauma","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6070666683","display_name":"Cellular mechanism of immune dysfunction following burn injury","funder_award_id":"R01GM076250","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6707377683","display_name":"CD8+ T Cell Response to Burn Injury","funder_award_id":"K08GM067147","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1480085362","https://openalex.org/W1483848921","https://openalex.org/W1542238822","https://openalex.org/W1566386178","https://openalex.org/W1574613805","https://openalex.org/W1641771393","https://openalex.org/W1906591077","https://openalex.org/W1909391377","https://openalex.org/W1976302471","https://openalex.org/W1978921829","https://openalex.org/W1995228412","https://openalex.org/W2010453472","https://openalex.org/W2017320131","https://openalex.org/W2025028553","https://openalex.org/W2046783872","https://openalex.org/W2070149147","https://openalex.org/W2071913639","https://openalex.org/W2075055100","https://openalex.org/W2088563427","https://openalex.org/W2090640877","https://openalex.org/W2100140378","https://openalex.org/W2101898188","https://openalex.org/W2121552559","https://openalex.org/W2134285943","https://openalex.org/W2143497981","https://openalex.org/W2149711010","https://openalex.org/W2151235764","https://openalex.org/W2153323269","https://openalex.org/W2162370513","https://openalex.org/W2165413779","https://openalex.org/W2167085933","https://openalex.org/W2424515314","https://openalex.org/W6629131604"],"related_works":["https://openalex.org/W1995905514","https://openalex.org/W2064481028","https://openalex.org/W4249508703","https://openalex.org/W7098277140","https://openalex.org/W1872711974","https://openalex.org/W2036413346","https://openalex.org/W2611155373","https://openalex.org/W2071913639","https://openalex.org/W2354327126","https://openalex.org/W2485565291"],"abstract_inverted_index":{"BACKGROUND:":[0],"Toll-like":[1],"receptors":[2],"(TLR)":[3],"2":[4],"and":[5,94,114,116,127,152,160,168,234,255,285,305,316,321],"TLR4":[6,38,84,161,169,231,286,317],"expressed":[7],"on":[8,47],"innate":[9,48],"immune":[10,17,49,327],"cells":[11],"are":[12,273,291,306],"important":[13],"mediators":[14],"of":[15,141,158,171,175,269,299],"the":[16,139,267,312,326],"response":[18,328],"to":[19,57,275,329],"pathogens.":[20],"In":[21,214,244],"this":[22],"study,":[23],"we":[24],"hypothesized":[25],"that":[26,40],"burn":[27,61,112,148,165,181,197,225,259,289,330],"injury":[28,70,113,132,149,182,198,226,290],"results":[29,133],"in":[30,134,138,187,203,250,293,311,324],"altered":[31,44,292],"cytokine":[32,188,252],"secretion":[33,189,207,238,281],"profiles":[34,282],"after":[35,69,111,147,164,180,196,224,227,258,283,288],"TLR2":[36,80,115,151,159,167,229,284,315],"or":[37,62,66,73,83,230,302],"ligation":[39,170,287,318],"is":[41,263],"associated":[42,307],"with":[43,79,191,211,308],"TLR":[45,270],"expression":[46,118,162],"cells.":[50],"METHODS:":[51],"Female":[52],"C56BL/6":[53],"mice":[54],"were":[55,77,88,107],"subjected":[56],"20%":[58],"full":[59],"thickness":[60],"sham":[63,212,242],"injury.":[64,166,260,331],"Three":[65],"14":[67,109,194,256],"days":[68,110,179,195,254,257],"whole":[71,246],"splenocytes":[72],"purified":[74,145,176],"splenic":[75],"macrophages":[76,106,177,209],"cultured":[78],"ligand":[81,85],"peptidoglycan":[82],"lipopolysaccharide.":[86],"Supernatants":[87],"assayed":[89],"for":[90],"TNF-alpha,":[91],"MCP-1,":[92],"IL-6":[93],"IL-10.":[95],"Cell":[96],"death":[97],"was":[98,119,217,239],"assessed":[99],"using":[100],"flow":[101,128],"cytometry.":[102,129],"Innate":[103],"CD11b":[104],"F4/80":[105],"sorted":[108],"4":[117],"determined":[120],"by":[121,155,208,266],"quantitative":[122],"reverse-transcriptase":[123],"polymerase":[124],"chain":[125],"reaction":[126],"RESULTS:":[130],"Burn":[131],"a":[135,156,200,294],"steady":[136],"accumulation":[137,268],"periphery":[140],"CD11bF4/80":[142],"macrophages.":[143],"Macrophages":[144],"early":[146],"upregulated":[150],"4,":[153],"followed":[154],"decrease":[157],"late":[163,223],"an":[172,300],"equivalent":[173],"number":[174],"3":[178,253],"revealed":[183,199],"no":[184],"significant":[185,201],"differences":[186],"compared":[190,210],"sham.":[192],"Stimulation":[193],"reduction":[202],"tumor":[204],"necrosis":[205],"factor-alpha":[206],"mice.":[213],"contrast,":[215,245],"interleukin-10":[216],"significantly":[218],"increased":[219,251],"(mean,":[220],"approximately":[221],"1.8-fold)":[222],"either":[228],"stimulation.":[232],"Interleukin-6":[233],"monocyte":[235],"chemotactic":[236],"protein-1":[237],"unchanged":[240],"from":[241],"levels.":[243],"splenocyte":[247],"stimulation":[248],"resulted":[249],"This":[261],"effect":[262],"likely":[264],"caused":[265],"macrophages,":[271],"which":[272],"resistant":[274],"TLR-induced":[276],"cell":[277],"death.":[278],"CONCLUSIONS:":[279],"Cytokine":[280],"manner":[295],"not":[296],"clearly":[297],"reflective":[298],"anti-inflammatory":[301],"proinflammatory":[303],"state":[304],"unique":[309],"changes":[310],"macrophage":[313],"population.":[314],"have":[319],"complex":[320],"varied":[322],"roles":[323],"mediating":[325]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}