{"id":"https://openalex.org/W1973395178","doi":"https://doi.org/10.1055/s-0029-1217617","title":"Synthesis of (+)-Peloruside A","display_name":"Synthesis of (+)-Peloruside A","publication_year":2009,"publication_date":"2009-08-21","ids":{"openalex":"https://openalex.org/W1973395178","doi":"https://doi.org/10.1055/s-0029-1217617","mag":"1973395178"},"language":"en","primary_location":{"id":"doi:10.1055/s-0029-1217617","doi":"https://doi.org/10.1055/s-0029-1217617","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0029-1217617","pdf_url":null,"source":{"id":"https://openalex.org/S135102583","display_name":"Synfacts","issn_l":"1861-194X","issn":["1861-194X","1861-1958"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310321135","host_organization_name":"Georg Thieme Verlag","host_organization_lineage":["https://openalex.org/P4310321135","https://openalex.org/P4310320000"],"host_organization_lineage_names":["Georg Thieme Verlag","Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Synfacts","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035782410","display_name":"David Albert Evans","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. A. Evans","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045508062","display_name":"Dennie S. Welch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. S. Welch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071015095","display_name":"Alexander W. H. Speed","orcid":"https://orcid.org/0000-0002-8997-3807","observed_orcids":["https://orcid.org/0000-0002-8997-3807"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. W. H. Speed","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043461259","display_name":"George A. Moniz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. A. Moniz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064563123","display_name":"Andreas F. Reichelt","orcid":"https://orcid.org/0000-0003-3402-7394","observed_orcids":["https://orcid.org/0000-0003-3402-7394"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Reichelt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108028531","display_name":"Stephen Ho","orcid":"https://orcid.org/0000-0003-1837-6201","observed_orcids":["https://orcid.org/0000-0003-1837-6201"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Ho","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"2009","issue":"09","first_page":"0945","last_page":"0945"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13859","display_name":"Organic Chemistry Synthesis Methods","score":0.4438000023365021,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13859","display_name":"Organic Chemistry Synthesis Methods","score":0.4438000023365021,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11340","display_name":"Marine Sponges and Natural Products","score":0.1914999932050705,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13971","display_name":"Isoquinoline Alkaloid Synthesis","score":0.17249999940395355,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peloruside-a","display_name":"peloruside A","score":0.9269999861717224},{"id":"https://openalex.org/keywords/total-synthesis","display_name":"total synthesis","score":0.800000011920929},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7179999947547913},{"id":"https://openalex.org/keywords/p388-leukemia-cells","display_name":"P388 leukemia cells","score":0.9279999732971191},{"id":"https://openalex.org/keywords/marine-natural-products","display_name":"marine natural products","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8339799642562866},{"id":"https://openalex.org/C61156836","wikidata":"https://www.wikidata.org/wiki/Q494392","display_name":"Aldol reaction","level":3,"score":0.8250426054000854},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.7275945544242859},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.7256026864051819},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.6791489720344543},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.6525811553001404},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6329291462898254},{"id":"https://openalex.org/C157369684","wikidata":"https://www.wikidata.org/wiki/Q34740","display_name":"Genus","level":2,"score":0.5581416487693787},{"id":"https://openalex.org/C2778849931","wikidata":"https://www.wikidata.org/wiki/Q18960","display_name":"Sponge","level":2,"score":0.5059112906455994},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4460427165031433},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3100748658180237},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1659165918827057},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.12635710835456848},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.08906477689743042},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.08214050531387329},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.07792836427688599},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07627531886100769},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05786013603210449}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0029-1217617","doi":"https://doi.org/10.1055/s-0029-1217617","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0029-1217617","pdf_url":null,"source":{"id":"https://openalex.org/S135102583","display_name":"Synfacts","issn_l":"1861-194X","issn":["1861-194X","1861-1958"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310321135","host_organization_name":"Georg Thieme Verlag","host_organization_lineage":["https://openalex.org/P4310321135","https://openalex.org/P4310320000"],"host_organization_lineage_names":["Georg Thieme Verlag","Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Synfacts","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4043000042438507}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1701636197","https://openalex.org/W2901252304","https://openalex.org/W4233360712","https://openalex.org/W2077240916","https://openalex.org/W7062145506","https://openalex.org/W4229059710","https://openalex.org/W191536157","https://openalex.org/W1985621995","https://openalex.org/W4206317261","https://openalex.org/W640218960"],"abstract_inverted_index":{"Significance":[0],"(+)-Peloruside":[1],"A":[2],"is":[3,25,32],"a":[4,7],"metabolite":[5],"of":[6,42],"sponge":[8],"from":[9],"the":[10,33],"genus":[11],"Mycale":[12],".":[13],"It":[14],"displays":[15],"nanomolar":[16],"cytotoxicity":[17],"towards":[18],"P388":[19],"murine":[20],"leukemia":[21],"cells.":[22],"Its":[23],"potency":[24],"similar":[26],"to":[27,36],"paclitaxel.":[28],"The":[29],"synthesis":[30],"depicted":[31],"4":[34],"th":[35],"date":[37],"and":[38],"makes":[39],"efficient":[40],"use":[41],"two":[43],"1,5-":[44],"anti":[45],"-directed":[46],"aldol":[47],"reactions.":[48]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
