{"id":"https://openalex.org/W1973256430","doi":"https://doi.org/10.1002/mrm.1910320207","title":"Spreading waves of decreased diffusion coefficient lifter cortical stimulation in the rat brain","display_name":"Spreading waves of decreased diffusion coefficient lifter cortical stimulation in the rat brain","publication_year":1994,"publication_date":"1994-08-01","ids":{"openalex":"https://openalex.org/W1973256430","doi":"https://doi.org/10.1002/mrm.1910320207","mag":"1973256430","pmid":"https://pubmed.ncbi.nlm.nih.gov/7968441"},"language":"en","primary_location":{"id":"doi:10.1002/mrm.1910320207","doi":"https://doi.org/10.1002/mrm.1910320207","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mrm.1910320207","pdf_url":null,"source":{"id":"https://openalex.org/S111160002","display_name":"Magnetic Resonance in Medicine","issn_l":"0740-3194","issn":["0740-3194","1522-2594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnetic Resonance in Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006786561","display_name":"Lawrence L. Latour","orcid":"https://orcid.org/0000-0001-6160-5263","observed_orcids":["https://orcid.org/0000-0001-6160-5263"]},"institutions":[{"id":"https://openalex.org/I107077323","display_name":"Worcester Polytechnic Institute","ror":"https://ror.org/05ejpqr48","country_code":"US","type":"education","lineage":["https://openalex.org/I107077323"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawrence L. Latour","raw_affiliation_strings":["Department of Biomedical Engineering, Worcester Polytechnic Institute, MA 01609","Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Worcester Polytechnic Institute, MA 01609","institution_ids":["https://openalex.org/I107077323"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, Massachusetts","institution_ids":["https://openalex.org/I107077323"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028025164","display_name":"Yasuhiro Hasegawa","orcid":"https://orcid.org/0000-0003-3200-376X","observed_orcids":["https://orcid.org/0000-0003-3200-376X"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yasuhiro Hasegawa","raw_affiliation_strings":["Department of Neurology, Medical Center of Central Massachusetts, Worcester, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Medical Center of Central Massachusetts, Worcester, Massachusetts","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004018010","display_name":"James E. Formato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107077323","display_name":"Worcester Polytechnic Institute","ror":"https://ror.org/05ejpqr48","country_code":"US","type":"education","lineage":["https://openalex.org/I107077323"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James E. Formato","raw_affiliation_strings":["Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, Massachusetts","institution_ids":["https://openalex.org/I107077323"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036747513","display_name":"Marc Fisher","orcid":"https://orcid.org/0000-0002-6116-475X","observed_orcids":["https://orcid.org/0000-0002-6116-475X"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc Fisher","raw_affiliation_strings":["Department of Neurology, Medical Center of Central Massachusetts, Worcester, Massachusetts","Department of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Medical Center of Central Massachusetts, Worcester, Massachusetts","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Department of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072837575","display_name":"Christopher H. Sotak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107077323","display_name":"Worcester Polytechnic Institute","ror":"https://ror.org/05ejpqr48","country_code":"US","type":"education","lineage":["https://openalex.org/I107077323"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher H. Sotak","raw_affiliation_strings":["Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, Massachusetts","Department of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, Massachusetts","institution_ids":["https://openalex.org/I107077323"]},{"raw_affiliation_string":"Department of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts","institution_ids":["https://openalex.org/I166722992"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5072837575"],"corresponding_institution_ids":["https://openalex.org/I107077323","https://openalex.org/I166722992"],"apc_list":{"value":3680,"currency":"USD","value_usd":3680},"apc_paid":null,"fwci":12.4607,"has_fulltext":false,"cited_by_count":135,"citation_normalized_percentile":{"value":0.99243471,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"32","issue":"2","first_page":"189","last_page":"198"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.4668000042438507,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.4668000042438507,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.44850000739097595,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.04280000180006027,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cortical-spreading-depression","display_name":"cortical spreading depression","score":0.9399999976158142},{"id":"https://openalex.org/keywords/apparent-diffusion-coefficient","display_name":"apparent diffusion coefficient","score":0.9539999961853027},{"id":"https://openalex.org/keywords/non-invasive-detection","display_name":"non-invasive detection","score":0.5220000147819519},{"id":"https://openalex.org/keywords/rat-cerebral-cortex","display_name":"rat cortex","score":0.527999997138977},{"id":"https://openalex.org/keywords/neurological-disorders","display_name":"neurological disorders","score":0.4779999852180481}],"concepts":[{"id":"https://openalex.org/C122356138","wikidata":"https://www.wikidata.org/wiki/Q461576","display_name":"Cortical spreading depression","level":3,"score":0.7272365689277649},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.6838988065719604},{"id":"https://openalex.org/C2781041448","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cerebral cortex","level":2,"score":0.5819579362869263},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.5458210110664368},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5312965512275696},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5248656272888184},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5091549754142761},{"id":"https://openalex.org/C69357855","wikidata":"https://www.wikidata.org/wiki/Q163214","display_name":"Diffusion","level":2,"score":0.4913734495639801},{"id":"https://openalex.org/C70816921","wikidata":"https://www.wikidata.org/wiki/Q258852","display_name":"Effective diffusion coefficient","level":3,"score":0.45539987087249756},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.45373788475990295},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40298235416412354},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33285191655158997},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.24151334166526794},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.23664143681526184},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.23418954014778137},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.14332547783851624},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.12188398838043213},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C2778541695","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Migraine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011189","descriptor_name":"Potassium Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012965","descriptor_name":"Sodium Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013181","descriptor_name":"Cortical Spreading Depression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/mrm.1910320207","doi":"https://doi.org/10.1002/mrm.1910320207","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mrm.1910320207","pdf_url":null,"source":{"id":"https://openalex.org/S111160002","display_name":"Magnetic Resonance in Medicine","issn_l":"0740-3194","issn":["0740-3194","1522-2594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnetic Resonance in Medicine","raw_type":"journal-article"},{"id":"pmid:7968441","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7968441","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnetic resonance in medicine","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.umassmed.edu:neuro_pp-1135","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.umassmed.edu/neuro_pp/136","pdf_url":null,"source":{"id":"https://openalex.org/S7407064370","display_name":"eScholarship@UMassChan","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neurology Publications","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W138885055","https://openalex.org/W1838245412","https://openalex.org/W1967518926","https://openalex.org/W1968771657","https://openalex.org/W1977543906","https://openalex.org/W1978397314","https://openalex.org/W1987355656","https://openalex.org/W1988467711","https://openalex.org/W2003912106","https://openalex.org/W2004159749","https://openalex.org/W2011025976","https://openalex.org/W2021328964","https://openalex.org/W2022803091","https://openalex.org/W2030591899","https://openalex.org/W2037134906","https://openalex.org/W2037420975","https://openalex.org/W2038475538","https://openalex.org/W2039330211","https://openalex.org/W2041303077","https://openalex.org/W2043151182","https://openalex.org/W2046072169","https://openalex.org/W2051858265","https://openalex.org/W2065113098","https://openalex.org/W2068860991","https://openalex.org/W2069564285","https://openalex.org/W2074341090","https://openalex.org/W2084596340","https://openalex.org/W2084761689","https://openalex.org/W2084845465","https://openalex.org/W2086441427","https://openalex.org/W2087452412","https://openalex.org/W2100482324","https://openalex.org/W2103681669","https://openalex.org/W2106552966","https://openalex.org/W2114415505","https://openalex.org/W2133771732","https://openalex.org/W2140099191","https://openalex.org/W2142040044","https://openalex.org/W2167648645","https://openalex.org/W2217637761","https://openalex.org/W2398218207","https://openalex.org/W2413014582","https://openalex.org/W2413144892","https://openalex.org/W2413349161","https://openalex.org/W2465712080","https://openalex.org/W2471054245","https://openalex.org/W2597593464","https://openalex.org/W2768556492"],"related_works":["https://openalex.org/W2056127726","https://openalex.org/W2074827746","https://openalex.org/W2004159749","https://openalex.org/W2107583923","https://openalex.org/W1989195494","https://openalex.org/W2184194432","https://openalex.org/W7095690653","https://openalex.org/W7070564129","https://openalex.org/W2031213426","https://openalex.org/W2011010090"],"abstract_inverted_index":{"A":[0],"method":[1],"is":[2,114],"demonstrated":[3],"for":[4],"the":[5,28,42,66,70,91,95,111,120,142,158],"noninvasive":[6,143],"detection":[7],"and":[8,63,87,139,156],"study":[9,144,159],"of":[10,24,36,41,55,76,97,103,110,119,122,145,150,160],"spreading":[11],"cortical":[12],"depression.":[13],"Spreading":[14],"depression":[15],"(SD)":[16],"was":[17,79],"elicited":[18],"in":[19,38,85,90,147,162],"rats":[20],"by":[21,126],"topical":[22],"application":[23],"potassium":[25],"chloride":[26],"to":[27,65,81,88],"exposed":[29],"cortex.":[30],"The":[31,74,108,129],"apparent":[32],"diffusion":[33],"coefficient":[34],"(Dapp)":[35],"water":[37],"a":[39,46,100],"region":[40,75,113],"cortex,":[43,92],"measured":[44],"using":[45],"PFG-NMR":[47],"spin":[48],"echo":[49],"sequence":[50],"with":[51,99,116],"an":[52],"observation":[53],"time":[54],"40":[56],"ms,":[57],"declines":[58],"35%":[59],"within":[60,69],"30":[61,72],"s":[62],"recovers":[64],"normal":[67],"value":[68],"next":[71],"s.":[73],"decreased":[77],"Dapp":[78],"shown":[80],"be":[82,132],"2":[83],"mm":[84],"size":[86],"move":[89],"away":[93],"from":[94],"point":[96],"application,":[98],"uniform":[101],"velocity":[102],"3.3":[104],"+/-":[105],"0.5":[106],"mm/min.":[107],"behavior":[109,121],"affected":[112],"consistent":[115],"other":[117],"reports":[118],"SD":[123,146,161],"as":[124],"monitored":[125],"electrophysiological":[127],"means.":[128],"technique":[130],"can":[131],"implemented":[133],"on":[134],"currently":[135],"available":[136],"MRI":[137],"equipment":[138],"makes":[140],"possible":[141],"animal":[148],"models":[149],"neurological":[151],"disorders,":[152],"their":[153],"therapeutic":[154],"intervention,":[155],"possibly":[157],"humans.":[163]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}