{"id":"https://openalex.org/W1973249045","doi":"https://doi.org/10.1111/j.1530-0277.1997.tb04470.x","title":"Effects of Ethanol on Rat Sertoli Cell Function: Studies In Vitro and In Vivo","display_name":"Effects of Ethanol on Rat Sertoli Cell Function: Studies In Vitro and In Vivo","publication_year":1997,"publication_date":"1997-11-01","ids":{"openalex":"https://openalex.org/W1973249045","doi":"https://doi.org/10.1111/j.1530-0277.1997.tb04470.x","mag":"1973249045","pmid":"https://pubmed.ncbi.nlm.nih.gov/9394112"},"language":"en","primary_location":{"id":"doi:10.1111/j.1530-0277.1997.tb04470.x","doi":"https://doi.org/10.1111/j.1530-0277.1997.tb04470.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1530-0277.1997.tb04470.x","pdf_url":null,"source":{"id":"https://openalex.org/S115510430","display_name":"Alcoholism Clinical and Experimental Research","issn_l":"0145-6008","issn":["0145-6008","1530-0277","2993-7175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcoholism: Clinical and Experimental Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103496967","display_name":"Qianlong Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qianlong Zhu","raw_affiliation_strings":["Department of Alcoholism and Liver Disease (Q.Z., D.H.V.T.) and Department of Women's Health Research (J.S.G.), Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Alcoholism and Liver Disease (Q.Z., D.H.V.T.) and Department of Women's Health Research (J.S.G.), Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma","institution_ids":["https://openalex.org/I30558944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101621295","display_name":"David H. Van Thiel","orcid":"https://orcid.org/0000-0001-5410-2131","observed_orcids":["https://orcid.org/0000-0001-5410-2131"]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David H. Van Thiel","raw_affiliation_strings":["Department of Alcoholism and Liver Disease (Q.Z., D.H.V.T.) and Department of Women's Health Research (J.S.G.), Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Alcoholism and Liver Disease (Q.Z., D.H.V.T.) and Department of Women's Health Research (J.S.G.), Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma","institution_ids":["https://openalex.org/I30558944"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043329757","display_name":"Judith S. Gavaler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judith S. Gavaler","raw_affiliation_strings":["Department of Alcoholism and Liver Disease (Q.Z., D.H.V.T.) and Department of Women's Health Research (J.S.G.), Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Alcoholism and Liver Disease (Q.Z., D.H.V.T.) and Department of Women's Health Research (J.S.G.), Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma","institution_ids":["https://openalex.org/I30558944"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I30558944"],"apc_list":{"value":4110,"currency":"USD","value_usd":4110},"apc_paid":null,"fwci":0.657,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.63633409,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"21","issue":"8","first_page":"1409","last_page":"1409"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ethanol","display_name":"ethanol","score":0.9729999899864197},{"id":"https://openalex.org/keywords/sertoli-cells","display_name":"Sertoli cells","score":0.9729999899864197},{"id":"https://openalex.org/keywords/testicular-injury","display_name":"testicular damage","score":0.6200000047683716},{"id":"https://openalex.org/keywords/transferrin","display_name":"transferrin","score":0.8270000219345093},{"id":"https://openalex.org/keywords/ornithine-decarboxylase","display_name":"ornithine decarboxylase","score":1.0},{"id":"https://openalex.org/keywords/spermatogenesis","display_name":"spermatogenesis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/testicular-atrophy","display_name":"testicular atrophy","score":0.8830000162124634},{"id":"https://openalex.org/keywords/gonadal-failure","display_name":"gonadal failure","score":0.8019999861717224},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6420000195503235}],"concepts":[{"id":"https://openalex.org/C2781068068","wikidata":"https://www.wikidata.org/wiki/Q195614","display_name":"Sertoli cell","level":3,"score":0.9437211155891418},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6405844688415527},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6191497445106506},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6188371181488037},{"id":"https://openalex.org/C22814914","wikidata":"https://www.wikidata.org/wiki/Q410473","display_name":"Transferrin","level":2,"score":0.5873297452926636},{"id":"https://openalex.org/C123765429","wikidata":"https://www.wikidata.org/wiki/Q36961","display_name":"Spermatogenesis","level":2,"score":0.5371561646461487},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.532941460609436},{"id":"https://openalex.org/C2779066085","wikidata":"https://www.wikidata.org/wiki/Q9384","display_name":"Testicle","level":2,"score":0.5118419528007507},{"id":"https://openalex.org/C121289238","wikidata":"https://www.wikidata.org/wiki/Q931579","display_name":"Ornithine decarboxylase","level":3,"score":0.45214352011680603},{"id":"https://openalex.org/C2778054371","wikidata":"https://www.wikidata.org/wiki/Q503431","display_name":"Seminiferous tubule","level":4,"score":0.4440149664878845},{"id":"https://openalex.org/C2777736315","wikidata":"https://www.wikidata.org/wiki/Q636846","display_name":"Leydig cell","level":4,"score":0.43804416060447693},{"id":"https://openalex.org/C2777892665","wikidata":"https://www.wikidata.org/wiki/Q1622678","display_name":"Testicular atrophy","level":2,"score":0.4300056993961334},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.42748916149139404},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.42580926418304443},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.33521291613578796},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.17994701862335205},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.17481723427772522},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13717854022979736},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12117114663124084},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.05596959590911865},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000437","descriptor_name":"Alcoholism","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009955","descriptor_name":"Ornithine Decarboxylase","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009955","descriptor_name":"Ornithine Decarboxylase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012708","descriptor_name":"Sertoli Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012708","descriptor_name":"Sertoli Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013091","descriptor_name":"Spermatogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014168","descriptor_name":"Transferrin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014168","descriptor_name":"Transferrin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1530-0277.1997.tb04470.x","doi":"https://doi.org/10.1111/j.1530-0277.1997.tb04470.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1530-0277.1997.tb04470.x","pdf_url":null,"source":{"id":"https://openalex.org/S115510430","display_name":"Alcoholism Clinical and Experimental Research","issn_l":"0145-6008","issn":["0145-6008","1530-0277","2993-7175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcoholism: Clinical and Experimental Research","raw_type":"journal-article"},{"id":"doi:10.1097/00000374-199711000-00010","doi":"https://doi.org/10.1097/00000374-199711000-00010","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000374-199711000-00010","pdf_url":null,"source":{"id":"https://openalex.org/S115510430","display_name":"Alcoholism Clinical and Experimental Research","issn_l":"0145-6008","issn":["0145-6008","1530-0277","2993-7175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcoholism: Clinical & Experimental Research","raw_type":"journal-article"},{"id":"pmid:9394112","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9394112","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcoholism, clinical and experimental research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W26127271","https://openalex.org/W81943987","https://openalex.org/W88714887","https://openalex.org/W319104132","https://openalex.org/W628273134","https://openalex.org/W806097815","https://openalex.org/W961709218","https://openalex.org/W1582694379","https://openalex.org/W1594848967","https://openalex.org/W1654261715","https://openalex.org/W1718872407","https://openalex.org/W1977178910","https://openalex.org/W1978195300","https://openalex.org/W1978498632","https://openalex.org/W1980307860","https://openalex.org/W1985051242","https://openalex.org/W1988871431","https://openalex.org/W1989568748","https://openalex.org/W1994377022","https://openalex.org/W2013461586","https://openalex.org/W2019835627","https://openalex.org/W2020848003","https://openalex.org/W2021208748","https://openalex.org/W2021704113","https://openalex.org/W2024893274","https://openalex.org/W2030427298","https://openalex.org/W2030909322","https://openalex.org/W2034915393","https://openalex.org/W2040468089","https://openalex.org/W2040515008","https://openalex.org/W2053856783","https://openalex.org/W2058962308","https://openalex.org/W2059856417","https://openalex.org/W2065542167","https://openalex.org/W2072295775","https://openalex.org/W2083122143","https://openalex.org/W2091172645","https://openalex.org/W2094381759","https://openalex.org/W2099224788","https://openalex.org/W2125178121","https://openalex.org/W2127112840","https://openalex.org/W2128635872","https://openalex.org/W2130094975","https://openalex.org/W2134812217","https://openalex.org/W2145665513","https://openalex.org/W2157110915","https://openalex.org/W2166437338","https://openalex.org/W2222725215","https://openalex.org/W2334886837","https://openalex.org/W2411552644","https://openalex.org/W4238270754"],"related_works":["https://openalex.org/W2019291683","https://openalex.org/W1994431795","https://openalex.org/W2353981443","https://openalex.org/W2189314679","https://openalex.org/W1985344294","https://openalex.org/W2094309007","https://openalex.org/W2049070827","https://openalex.org/W239503681","https://openalex.org/W2351508642","https://openalex.org/W4376058349"],"abstract_inverted_index":{"Chronic":[0],"alcohol":[1,29],"administration":[2],"to":[3,18,176,187],"male":[4],"animals":[5],"is":[6,162],"associated":[7,163],"with":[8,164],"testicular":[9,22,39,81],"atrophy":[10],"and":[11,40,50,60,65,80,86,101,125,136,171],"gonadal":[12,208],"failure.":[13],"The":[14],"Sertoli":[15,42,57,111,121,131,160,199],"cell":[16,23,43,58,122,132,200],"seems":[17],"be":[19,177,202],"the":[20,33,45,75,148,167,180,188,196,198],"first":[21],"injured":[24],"as":[25],"a":[26],"result":[27],"of":[28,36,47,63,77,97,150,158,169,182,190],"exposure.":[30],"To":[31],"investigate":[32],"adverse":[34],"effects":[35],"ethanol":[37,53,72,118,156],"on":[38,55],"particularly":[41],"function,":[44],"consequences":[46],"in":[48,51,104,115,140,147,166,179],"vivo":[49,105],"vitro":[52],"exposure":[54,73,89,119,129,157],"rat":[56,159],"mRNA":[59,126,135,170],"protein":[61,85,100,124,137,172],"levels":[62,76,96,168],"transferrin":[64,84,123],"ornithine":[66,98,133],"decarboxylase":[67,99,134],"were":[68,107,113],"investigated.":[69],"In":[70],"vivo,":[71],"enhanced":[74,91],"both":[78],"hepatic":[79],"(Sertoli":[82],"cell)":[83],"mRNA.":[87,102],"Ethanol":[88,128],"also":[90],"testicular,":[92],"but":[93,143],"not":[94,144],"hepatic,":[95],"These":[103,152,184],"findings":[106,185],"confirmed":[108],"when":[109,138,145],"isolated":[110],"cells":[112,161],"studied":[114],"vitro.":[116],"Specifically,":[117],"increased":[120,130],"levels.":[127],"cultured":[139,146],"serum-free":[141],"media,":[142],"presence":[149],"serum.":[151],"studies":[153],"demonstrate":[154],"that":[155,173,192],"alterations":[165],"are":[174],"known":[175],"important":[178,204],"process":[181],"spermatogenesis.":[183],"add":[186],"body":[189],"evidence":[191],"suggests":[193],"that,":[194],"within":[195],"testes,":[197],"may":[201],"an":[203],"target":[205],"for":[206],"ethanol-induced":[207],"injury.":[209]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}