{"id":"https://openalex.org/W1973237320","doi":"https://doi.org/10.1074/jbc.m709103200","title":"Identification and Biological Characterization of Mouse \u03b2-Defensin 14, the Orthologue of Human \u03b2-Defensin 3","display_name":"Identification and Biological Characterization of Mouse \u03b2-Defensin 14, the Orthologue of Human \u03b2-Defensin 3","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W1973237320","doi":"https://doi.org/10.1074/jbc.m709103200","mag":"1973237320","pmid":"https://pubmed.ncbi.nlm.nih.gov/18167348"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m709103200","doi":"https://doi.org/10.1074/jbc.m709103200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m709103200","pdf_url":"http://www.jbc.org/article/S002192582057261X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S002192582057261X/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076282563","display_name":"Johann R\u00f6hrl","orcid":"https://orcid.org/0009-0003-2238-5351","observed_orcids":["https://orcid.org/0009-0003-2238-5351"]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Johann R\u00f6hrl","raw_affiliation_strings":["Institute of Immunology University of Regensburg, D-93042 Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Immunology University of Regensburg, D-93042 Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042752501","display_name":"De Yang","orcid":"https://orcid.org/0000-0001-6705-8504","observed_orcids":["https://orcid.org/0000-0001-6705-8504"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"De Yang","raw_affiliation_strings":["Laboratory of Molecular Immunregulation, Division of Basic Science, NCI, National Institutes of Health, Frederick, Maryland 21702-1201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Immunregulation, Division of Basic Science, NCI, National Institutes of Health, Frederick, Maryland 21702-1201","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042240287","display_name":"Joost J. Oppenheim","orcid":"https://orcid.org/0000-0003-0271-7921","observed_orcids":["https://orcid.org/0000-0003-0271-7921"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joost J. Oppenheim","raw_affiliation_strings":["Laboratory of Molecular Immunregulation, Division of Basic Science, NCI, National Institutes of Health, Frederick, Maryland 21702-1201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Immunregulation, Division of Basic Science, NCI, National Institutes of Health, Frederick, Maryland 21702-1201","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059017498","display_name":"Thomas Hehlgans","orcid":"https://orcid.org/0000-0003-4459-6371","observed_orcids":["https://orcid.org/0000-0003-4459-6371"]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Thomas Hehlgans","raw_affiliation_strings":["Institute of Immunology University of Regensburg, D-93042 Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Immunology University of Regensburg, D-93042 Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5059017498"],"corresponding_institution_ids":["https://openalex.org/I60668342"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":8.5965,"has_fulltext":true,"cited_by_count":84,"citation_normalized_percentile":{"value":0.97916367,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"283","issue":"9","first_page":"5414","last_page":"5419"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-beta-defensin-3","display_name":"human beta-defensin 3","score":0.9559999704360962},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.9100000262260437},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.8730000257492065},{"id":"https://openalex.org/keywords/ccr6","display_name":"CCR6","score":0.8510000109672546},{"id":"https://openalex.org/keywords/nod2-card15","display_name":"NOD2/CARD15","score":0.8799999952316284},{"id":"https://openalex.org/keywords/toll-like-receptor-signaling","display_name":"Toll-like receptor signaling","score":0.8389999866485596},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.8799999952316284},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.7699999809265137},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.968999981880188},{"id":"https://openalex.org/keywords/chemotaxis","display_name":"chemotaxis","score":0.7919999957084656},{"id":"https://openalex.org/keywords/tissue-expression","display_name":"tissue expression","score":0.3790000081062317},{"id":"https://openalex.org/keywords/orthologs","display_name":"orthologs","score":0.4740000069141388}],"concepts":[{"id":"https://openalex.org/C2776498113","wikidata":"https://www.wikidata.org/wiki/Q412820","display_name":"Defensin","level":3,"score":0.9302350878715515},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.7084298729896545},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5895421504974365},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4566594064235687},{"id":"https://openalex.org/C129437159","wikidata":"https://www.wikidata.org/wiki/Q4897294","display_name":"Beta defensin","level":4,"score":0.4117332398891449},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30569207668304443},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2846795320510864},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007369","descriptor_name":"Interferon Inducers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011070","descriptor_name":"Poly I-C","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023083","descriptor_name":"beta-Defensins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D023083","descriptor_name":"beta-Defensins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D023083","descriptor_name":"beta-Defensins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D023083","descriptor_name":"beta-Defensins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053473","descriptor_name":"Nod2 Signaling Adaptor Protein","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D053473","descriptor_name":"Nod2 Signaling Adaptor Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054399","descriptor_name":"Receptors, CCR6","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D054399","descriptor_name":"Receptors, CCR6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054399","descriptor_name":"Receptors, CCR6","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1074/jbc.m709103200","doi":"https://doi.org/10.1074/jbc.m709103200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m709103200","pdf_url":"http://www.jbc.org/article/S002192582057261X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:18167348","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18167348","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:epub.uni-regensburg.de:68380","doi":null,"is_oa":false,"landing_page_url":"https://epub.uni-regensburg.de/68380/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m709103200","doi":"https://doi.org/10.1074/jbc.m709103200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m709103200","pdf_url":"http://www.jbc.org/article/S002192582057261X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1973237320.pdf","grobid_xml":"https://content.openalex.org/works/W1973237320.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1607924481","https://openalex.org/W1839029331","https://openalex.org/W1915452953","https://openalex.org/W1966126294","https://openalex.org/W1971455822","https://openalex.org/W1972758309","https://openalex.org/W1985029163","https://openalex.org/W1992579069","https://openalex.org/W1995053645","https://openalex.org/W1997683664","https://openalex.org/W2000327035","https://openalex.org/W2031576296","https://openalex.org/W2042675697","https://openalex.org/W2048389635","https://openalex.org/W2049682225","https://openalex.org/W2066456239","https://openalex.org/W2081221541","https://openalex.org/W2084175456","https://openalex.org/W2090042814","https://openalex.org/W2103685679","https://openalex.org/W2104159258","https://openalex.org/W2124508823","https://openalex.org/W2126834402","https://openalex.org/W2138207315","https://openalex.org/W2156911913","https://openalex.org/W2165998893","https://openalex.org/W2169759699"],"related_works":["https://openalex.org/W39486571","https://openalex.org/W2128115224","https://openalex.org/W2094208784","https://openalex.org/W2035621513","https://openalex.org/W1989398510","https://openalex.org/W2011807378","https://openalex.org/W1992924089","https://openalex.org/W2131479848","https://openalex.org/W2615676002","https://openalex.org/W2029207047"],"abstract_inverted_index":{"beta-Defensins":[0],"are":[1,6],"small":[2],"antimicrobial":[3,19,200],"polypeptides":[4],"that":[5,36,197],"mainly":[7],"expressed":[8,109],"by":[9,57,148,158,175,186],"epithelial":[10],"cells":[11,225],"and":[12,52,119,124,155,157,165,216,236,252],"play":[13],"an":[14,73,258],"important":[15],"role":[16],"in":[17,110,134],"the":[18,26,40,45,60,103,122,178,218,227],"innate":[20,50],"immune":[21,55],"response.":[22],"In":[23,232],"addition":[24],"to":[25,47,92,172,256],"direct":[27],"microbicidal":[28],"effects":[29],"of":[30,39,75,114,121,143,169,177,260],"these":[31],"polypeptides,":[32],"it":[33],"became":[34],"evident":[35],"certain":[37],"members":[38],"beta-defensin":[41,68,77,104],"super":[42,105],"family":[43],"have":[44,65],"capacity":[46],"promote":[48],"local":[49],"inflammatory":[51],"systemic":[53],"adaptive":[54],"responses":[56],"interacting":[58],"with":[59],"CC-chemokine":[61,229],"receptor":[62,150,182,230],"CCR6.":[63,231],"We":[64,190],"identified":[66,220],"mouse":[67,228,243],"14":[69],"(mBD14,":[70],"Defb14)":[71],"as":[72,153,184],"orthologue":[74,259],"human":[76,94],"3":[78],"(hBD3":[79],"or":[80],"DEFB103).":[81],"Based":[82],"on":[83,250],"primary":[84],"structural":[85,251],"analysis,":[86],"mBD14":[87,107,132,144,170,221,237],"demonstrates":[88],"greater":[89],"(68%)":[90],"homology":[91],"its":[93],"orthologue,":[95],"containing":[96],"three":[97],"conserved":[98],"cystein":[99],"linkages,":[100],"characteristic":[101],"for":[102,224,240],"family.":[106],"is":[108],"a":[111,192],"wide":[112],"variety":[113],"tissues":[115,120],"including":[116],"spleen,":[117],"colon,":[118],"upper":[123],"lower":[125],"respiratory":[126],"tract.":[127],"Interestingly,":[128],"we":[129],"also":[130,217],"detected":[131],"expression":[133,142,168],"immature":[135],"CD11c+":[136],"bone":[137],"marrow-derived":[138],"dendritic":[139],"cells.":[140,246],"The":[141],"can":[145],"be":[146,173,257],"induced":[147],"Toll-like":[149],"agonists":[151],"such":[152],"lipopolysaccharide":[154],"poly(I:C)":[156],"pro-inflammatory":[159],"stimuli":[160],"e.g.":[161],"tumor":[162],"necrosis":[163],"factor":[164],"interferon-gamma.":[166],"Furthermore,":[167],"seems":[171],"regulated":[174],"activation":[176],"intracellular":[179],"pattern":[180],"recognition":[181],"NOD2/CARD15":[183],"revealed":[185],"reporter":[187],"gene":[188],"analysis.":[189],"prepared":[191],"recombinant":[193],"mBD14-Ig":[194],"fusion":[195],"protein":[196],"retained":[198],"potent":[199],"activity":[201],"against":[202,209],"several":[203],"Escherichia":[204],"coli":[205],"strains":[206],"but":[207],"not":[208],"various":[210],"Gram-positive":[211],"Staphylococcus":[212],"aureus":[213],"strains.":[214],"hBD3":[215,235],"newly":[219],"were":[222,238],"chemotactic":[223,239],"expressing":[226],"addition,":[233],"both":[234],"freshly":[241],"isolated":[242],"resident":[244],"peritoneal":[245],"Thus,":[247],"mBD14,":[248],"based":[249],"functional":[253],"similarities,":[254],"appears":[255],"hBD3.":[261]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}