{"id":"https://openalex.org/W1973228751","doi":"https://doi.org/10.1177/1545109707301248","title":"Safety of HIV-1 Perinatal Transmission Prophylaxis With Zidovudine and Nevirapine in Rural South India","display_name":"Safety of HIV-1 Perinatal Transmission Prophylaxis With Zidovudine and Nevirapine in Rural South India","publication_year":2007,"publication_date":"2007-05-30","ids":{"openalex":"https://openalex.org/W1973228751","doi":"https://doi.org/10.1177/1545109707301248","mag":"1973228751","pmid":"https://pubmed.ncbi.nlm.nih.gov/17538004"},"language":"en","primary_location":{"id":"doi:10.1177/1545109707301248","doi":"https://doi.org/10.1177/1545109707301248","is_oa":false,"landing_page_url":"https://doi.org/10.1177/1545109707301248","pdf_url":null,"source":{"id":"https://openalex.org/S59806885","display_name":"Journal of the International Association of Physicians in AIDS Care","issn_l":"1081-454X","issn":["1081-454X","1545-1097","1557-0886"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the International Association of Physicians in AIDS Care","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054013231","display_name":"Jennifer S. Read","orcid":"https://orcid.org/0000-0001-6079-0559","observed_orcids":["https://orcid.org/0000-0001-6079-0559"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer S. Read","raw_affiliation_strings":["Pediatric, Adolescent, and Maternal AIDS Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric, Adolescent, and Maternal AIDS Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland,","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108493002","display_name":"N Samuel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800701874","display_name":"Tamil Nadu Dr. M.G.R. Medical University","ror":"https://ror.org/00b3mhg89","country_code":"IN","type":"education","lineage":["https://openalex.org/I2800701874"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"N.M. Samuel","raw_affiliation_strings":["Tamil Nadu Dr. M.G.R. Medical University, Chennai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tamil Nadu Dr. M.G.R. Medical University, Chennai, India","institution_ids":["https://openalex.org/I2800701874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012625311","display_name":"S. Parameshwari","orcid":"https://orcid.org/0000-0002-8053-9780","observed_orcids":["https://orcid.org/0000-0002-8053-9780"]},"institutions":[{"id":"https://openalex.org/I2800701874","display_name":"Tamil Nadu Dr. M.G.R. Medical University","ror":"https://ror.org/00b3mhg89","country_code":"IN","type":"education","lineage":["https://openalex.org/I2800701874"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"S. Parameshwari","raw_affiliation_strings":["Tamil Nadu Dr. M.G.R. Medical University, Chennai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tamil Nadu Dr. M.G.R. Medical University, Chennai, India","institution_ids":["https://openalex.org/I2800701874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079389666","display_name":"Shoba Dharmarajan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800701874","display_name":"Tamil Nadu Dr. M.G.R. Medical University","ror":"https://ror.org/00b3mhg89","country_code":"IN","type":"education","lineage":["https://openalex.org/I2800701874"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shoba Dharmarajan","raw_affiliation_strings":["Tamil Nadu Dr. M.G.R. Medical University, Chennai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tamil Nadu Dr. M.G.R. Medical University, Chennai, India","institution_ids":["https://openalex.org/I2800701874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002391748","display_name":"Hannah M. Van Hook","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1333523220","display_name":"Westat (United States)","ror":"https://ror.org/00wt7xg39","country_code":"US","type":"company","lineage":["https://openalex.org/I1333523220"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hannah M. Van Hook","raw_affiliation_strings":["Westat, Rockville, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Westat, Rockville, Maryland","institution_ids":["https://openalex.org/I1333523220"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103476722","display_name":"Saramma Mini Jacob","orcid":"https://orcid.org/0000-0002-4107-1812","observed_orcids":["https://orcid.org/0000-0002-4107-1812"]},"institutions":[{"id":"https://openalex.org/I2800701874","display_name":"Tamil Nadu Dr. M.G.R. Medical University","ror":"https://ror.org/00b3mhg89","country_code":"IN","type":"education","lineage":["https://openalex.org/I2800701874"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"S. Mini Jacob","raw_affiliation_strings":["Tamil Nadu Dr. M.G.R. Medical University, Chennai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tamil Nadu Dr. M.G.R. Medical University, Chennai, India","institution_ids":["https://openalex.org/I2800701874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061063398","display_name":"Viju Junankar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1333523220","display_name":"Westat (United States)","ror":"https://ror.org/00wt7xg39","country_code":"US","type":"company","lineage":["https://openalex.org/I1333523220"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Viju Junankar","raw_affiliation_strings":["Westat, Rockville, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Westat, Rockville, Maryland","institution_ids":["https://openalex.org/I1333523220"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028032774","display_name":"James Bethel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1333523220","display_name":"Westat (United States)","ror":"https://ror.org/00wt7xg39","country_code":"US","type":"company","lineage":["https://openalex.org/I1333523220"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Bethel","raw_affiliation_strings":["Westat, Rockville, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Westat, Rockville, Maryland","institution_ids":["https://openalex.org/I1333523220"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101438802","display_name":"Jiahong Xu","orcid":"https://orcid.org/0009-0001-2905-8623","observed_orcids":["https://orcid.org/0009-0001-2905-8623"]},"institutions":[{"id":"https://openalex.org/I1333523220","display_name":"Westat (United States)","ror":"https://ror.org/00wt7xg39","country_code":"US","type":"company","lineage":["https://openalex.org/I1333523220"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiahong Xu","raw_affiliation_strings":["Westat, Rockville, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Westat, Rockville, Maryland","institution_ids":["https://openalex.org/I1333523220"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003192771","display_name":"Sonia Stoszek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1333523220","display_name":"Westat (United States)","ror":"https://ror.org/00wt7xg39","country_code":"US","type":"company","lineage":["https://openalex.org/I1333523220"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sonia K. Stoszek","raw_affiliation_strings":["Westat, Rockville, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Westat, Rockville, Maryland","institution_ids":["https://openalex.org/I1333523220"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.21,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.60345299,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"6","issue":"2","first_page":"125","last_page":"136"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.017500000074505806,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.7630000114440918},{"id":"https://openalex.org/keywords/perinatal-transmission","display_name":"perinatal transmission","score":0.890999972820282},{"id":"https://openalex.org/keywords/zidovudine","display_name":"zidovudine","score":0.9309999942779541},{"id":"https://openalex.org/keywords/nevirapine","display_name":"nevirapine","score":1.0},{"id":"https://openalex.org/keywords/antiretroviral-prophylaxis","display_name":"antiretroviral prophylaxis","score":0.9739999771118164},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.8130000233650208},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.6470000147819519},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.9330000281333923},{"id":"https://openalex.org/keywords/maternal-hiv-infection","display_name":"maternal HIV","score":0.6349999904632568},{"id":"https://openalex.org/keywords/infant-prophylaxis","display_name":"infant prophylaxis","score":0.6679999828338623},{"id":"https://openalex.org/keywords/rural-south-india","display_name":"rural South India","score":0.6890000104904175}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9350510835647583},{"id":"https://openalex.org/C2779130552","wikidata":"https://www.wikidata.org/wiki/Q263713","display_name":"Nevirapine","level":5,"score":0.9159927368164062},{"id":"https://openalex.org/C2780216070","wikidata":"https://www.wikidata.org/wiki/Q198504","display_name":"Zidovudine","level":4,"score":0.8626643419265747},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.6628533601760864},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.5333983898162842},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.44819700717926025},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4469963312149048},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.44434648752212524},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.4390104413032532},{"id":"https://openalex.org/C2778283251","wikidata":"https://www.wikidata.org/wiki/Q1361206","display_name":"Post-exposure prophylaxis","level":3,"score":0.41063880920410156},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.36636877059936523},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27546077966690063},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.183020681142807},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.1691860854625702},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14035692811012268},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.13792920112609863},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.11647564172744751},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015215","descriptor_name":"Zidovudine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018445","descriptor_name":"Infectious Disease Transmission, Vertical","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019829","descriptor_name":"Nevirapine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1177/1545109707301248","doi":"https://doi.org/10.1177/1545109707301248","is_oa":false,"landing_page_url":"https://doi.org/10.1177/1545109707301248","pdf_url":null,"source":{"id":"https://openalex.org/S59806885","display_name":"Journal of the International Association of Physicians in AIDS Care","issn_l":"1081-454X","issn":["1081-454X","1545-1097","1557-0886"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the International Association of Physicians in AIDS Care","raw_type":"journal-article"},{"id":"pmid:17538004","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17538004","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6402193777","display_name":null,"funder_award_id":"N01-3-3345","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1543697753","https://openalex.org/W1974877011","https://openalex.org/W1990105675","https://openalex.org/W2005206478","https://openalex.org/W2024884240","https://openalex.org/W2034665973","https://openalex.org/W2083691996","https://openalex.org/W2086040638","https://openalex.org/W2089742146","https://openalex.org/W2102919880","https://openalex.org/W2104853744","https://openalex.org/W2114790957","https://openalex.org/W2116258000","https://openalex.org/W2125436283","https://openalex.org/W2131832679","https://openalex.org/W2133939403","https://openalex.org/W2147072996","https://openalex.org/W2150248811","https://openalex.org/W2155050390","https://openalex.org/W2170947401","https://openalex.org/W2316970929"],"related_works":["https://openalex.org/W2282421395","https://openalex.org/W2088077019","https://openalex.org/W2147072996","https://openalex.org/W2795288029","https://openalex.org/W2104853744","https://openalex.org/W2311998961","https://openalex.org/W2045370722","https://openalex.org/W281595089","https://openalex.org/W2118914188","https://openalex.org/W1558389229"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"authors":[2],"assessed":[3],"acceptance":[4],"and":[5,8,59,79,108,156],"safety":[6],"of,":[7],"adherence":[9,94],"to,":[10],"perinatal":[11],"HIV-1":[12],"transmission":[13],"prophylaxis":[14,87,100,105],"at":[15,33],"2":[16],"public":[17],"hospitals":[18],"in":[19],"rural":[20],"Tamil":[21],"Nadu,":[22],"India.":[23],"METHODS:":[24],"Eligible":[25],"HIV-1-infected":[26],"women":[27,65,78,131],"were":[28],"offered":[29],"zidovudine":[30],"(ZDV)":[31],"beginning":[32],"28-weeks":[34],"gestation":[35],"until":[36],"delivery.":[37],"Their":[38],"infants":[39,85],"received":[40,86],"ZDV":[41,96,107,137,141,162],"for":[42,57,70,145],"6":[43],"weeks.":[44],"A":[45],"subsequent":[46],"revision":[47],"to":[48,95,136],"the":[49,71,121,150],"protocol":[50],"added":[51],"1":[52,128],"dose":[53],"of":[54,63,75,129,152],"nevirapine":[55],"(NVP)":[56],"mother":[58],"infant.":[60,147],"RESULTS:":[61],"Sixty":[62],"67":[64],"(90%)":[66],"met":[67],"inclusion":[68],"criteria":[69],"cohort":[72],"study.":[73,89],"Thirty-four":[74],"36":[76],"eligible":[77,82],"all":[80],"19":[81],"live":[83],"born":[84],"on":[88],"Infant,":[90],"but":[91],"not":[92,143],"maternal,":[93],"varied":[97],"by":[98],"antiretroviral":[99],"group":[101],"(those":[102],"receiving":[103],"combined":[104],"with":[106,132],"NVP":[109,166],"had":[110],"lower":[111],"median":[112],"adherence)":[113],"(P":[114],"=":[115],".02).":[116],"Neutropenia":[117],"(usually":[118],"transient)":[119],"was":[120,142],"most":[122],"common":[123],"severe":[124],"adverse":[125],"event.":[126],"Only":[127],"5":[130],"neutropenia":[133],"possibly":[134],"related":[135],"permanently":[138],"discontinued":[139,144],"ZDV.":[140],"any":[146],"CONCLUSION:":[148],"With":[149],"exception":[151],"neutropenia,":[153],"usually":[154],"transient":[155],"always":[157],"without":[158,165],"clinical":[159],"consequences,":[160],"long-term":[161],"(with":[163],"or":[164],"prophylaxis)":[167],"is":[168],"well":[169],"tolerated.":[170]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}