{"id":"https://openalex.org/W1973201636","doi":"https://doi.org/10.1212/01.wnl.0000118285.18383.90","title":"Extended mutation analysis and association studies of Nurr1 ( NR4A2 ) in Parkinson disease","display_name":"Extended mutation analysis and association studies of Nurr1 ( NR4A2 ) in Parkinson disease","publication_year":2004,"publication_date":"2004-04-13","ids":{"openalex":"https://openalex.org/W1973201636","doi":"https://doi.org/10.1212/01.wnl.0000118285.18383.90","mag":"1973201636","pmid":"https://pubmed.ncbi.nlm.nih.gov/15079038"},"language":"en","primary_location":{"id":"doi:10.1212/01.wnl.0000118285.18383.90","doi":"https://doi.org/10.1212/01.wnl.0000118285.18383.90","is_oa":false,"landing_page_url":"https://doi.org/10.1212/01.wnl.0000118285.18383.90","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://orbilu.uni.lu/handle/10993/17141","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081750306","display_name":"Robert Hering","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]},{"id":"https://openalex.org/I4210141865","display_name":"Hertie Institute for Clinical Brain Research","ror":"https://ror.org/04zzwzx41","country_code":"DE","type":"other","lineage":["https://openalex.org/I4210094118","https://openalex.org/I4210141865","https://openalex.org/I8087733"]},{"id":"https://openalex.org/I4665924","display_name":"University of Rostock","ror":"https://ror.org/03zdwsf69","country_code":"DE","type":"education","lineage":["https://openalex.org/I4665924"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R. Hering","raw_affiliation_strings":["From the Department of Medical Genetics (Drs. Hering, Berg, Bauer, and Riess, S. Petrovic and E.-M. Mietz) and Neurodegeneration Laboratory (Dr. Kru\u0308ger), Center of Neurology, Hertie Institute of Clinical Brain Research, University of Tu\u0308bingen, Department of Medical Genetics (Dr. Holzmann), University of Rostock, Department of Neurology (Drs. Woitalla and Mu\u0308ller), Ruhr-University Bochum, Bochum, and Institute of Epidemiology and Social Medicine (Dr. Berger), University of Muenster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Genetics (Drs. Hering, Berg, Bauer, and Riess, S. Petrovic and E.-M. Mietz) and Neurodegeneration Laboratory (Dr. Kru\u0308ger), Center of Neurology, Hertie Institute of Clinical Brain Research, University of Tu\u0308bingen, Department of Medical Genetics (Dr. Holzmann), University of Rostock, Department of Neurology (Drs. Woitalla and Mu\u0308ller), Ruhr-University Bochum, Bochum, and Institute of Epidemiology and Social Medicine (Dr. Berger), University of Muenster, Germany","institution_ids":["https://openalex.org/I22465464","https://openalex.org/I4210141865","https://openalex.org/I4665924","https://openalex.org/I8087733","https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030596356","display_name":"Slobodanka Petrovic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]},{"id":"https://openalex.org/I4210141865","display_name":"Hertie Institute for Clinical Brain Research","ror":"https://ror.org/04zzwzx41","country_code":"DE","type":"other","lineage":["https://openalex.org/I4210094118","https://openalex.org/I4210141865","https://openalex.org/I8087733"]},{"id":"https://openalex.org/I4665924","display_name":"University of Rostock","ror":"https://ror.org/03zdwsf69","country_code":"DE","type":"education","lineage":["https://openalex.org/I4665924"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S. Petrovic","raw_affiliation_strings":["From the Department of Medical Genetics (Drs. Hering, Berg, Bauer, and Riess, S. Petrovic and E.-M. Mietz) and Neurodegeneration Laboratory (Dr. Kru\u0308ger), Center of Neurology, Hertie Institute of Clinical Brain Research, University of Tu\u0308bingen, Department of Medical Genetics (Dr. Holzmann), University of Rostock, Department of Neurology (Drs. Woitalla and Mu\u0308ller), Ruhr-University Bochum, Bochum, and Institute of Epidemiology and Social Medicine (Dr. Berger), University of Muenster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Genetics (Drs. Hering, Berg, Bauer, and Riess, S. Petrovic and E.-M. Mietz) and Neurodegeneration Laboratory (Dr. Kru\u0308ger), Center of Neurology, Hertie Institute of Clinical Brain Research, University of Tu\u0308bingen, Department of Medical Genetics (Dr. Holzmann), University of Rostock, Department of Neurology (Drs. Woitalla and Mu\u0308ller), Ruhr-University Bochum, Bochum, and Institute of Epidemiology and Social Medicine (Dr. Berger), University of Muenster, Germany","institution_ids":["https://openalex.org/I22465464","https://openalex.org/I4210141865","https://openalex.org/I4665924","https://openalex.org/I8087733","https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065449466","display_name":"Eva-Maria Mietz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]},{"id":"https://openalex.org/I4210141865","display_name":"Hertie Institute for Clinical Brain Research","ror":"https://ror.org/04zzwzx41","country_code":"DE","type":"other","lineage":["https://openalex.org/I4210094118","https://openalex.org/I4210141865","https://openalex.org/I8087733"]},{"id":"https://openalex.org/I4665924","display_name":"University of Rostock","ror":"https://ror.org/03zdwsf69","country_code":"DE","type":"education","lineage":["https://openalex.org/I4665924"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"E. -M. Mietz","raw_affiliation_strings":["From the Department of Medical Genetics (Drs. Hering, Berg, Bauer, and Riess, S. Petrovic and E.-M. Mietz) and Neurodegeneration Laboratory (Dr. Kru\u0308ger), Center of Neurology, Hertie Institute of Clinical Brain Research, University of Tu\u0308bingen, Department of Medical Genetics (Dr. Holzmann), University of Rostock, Department of Neurology (Drs. Woitalla and Mu\u0308ller), Ruhr-University Bochum, Bochum, and Institute of Epidemiology and Social Medicine (Dr. Berger), University of Muenster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Genetics (Drs. Hering, Berg, Bauer, and Riess, S. Petrovic and E.-M. Mietz) and Neurodegeneration Laboratory (Dr. Kru\u0308ger), Center of Neurology, Hertie Institute of Clinical Brain Research, University of Tu\u0308bingen, Department of Medical Genetics (Dr. Holzmann), University of Rostock, Department of Neurology (Drs. Woitalla and Mu\u0308ller), Ruhr-University Bochum, Bochum, and Institute of Epidemiology and Social Medicine (Dr. Berger), University of Muenster, Germany","institution_ids":["https://openalex.org/I22465464","https://openalex.org/I4210141865","https://openalex.org/I4665924","https://openalex.org/I8087733","https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048514196","display_name":"Carsten Holzmann","orcid":"https://orcid.org/0000-0001-7977-9093","observed_orcids":["https://orcid.org/0000-0001-7977-9093"]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]},{"id":"https://openalex.org/I4210141865","display_name":"Hertie Institute for Clinical Brain Research","ror":"https://ror.org/04zzwzx41","country_code":"DE","type":"other","lineage":["https://openalex.org/I4210094118","https://openalex.org/I4210141865","https://openalex.org/I8087733"]},{"id":"https://openalex.org/I4665924","display_name":"University of Rostock","ror":"https://ror.org/03zdwsf69","country_code":"DE","type":"education","lineage":["https://openalex.org/I4665924"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C. Holzmann","raw_affiliation_strings":["From the Department of Medical Genetics (Drs. Hering, Berg, Bauer, and Riess, S. Petrovic and E.-M. Mietz) and Neurodegeneration Laboratory (Dr. Kru\u0308ger), Center of Neurology, Hertie Institute of Clinical Brain Research, University of Tu\u0308bingen, Department of Medical Genetics (Dr. Holzmann), University of Rostock, Department of Neurology (Drs. Woitalla and Mu\u0308ller), Ruhr-University Bochum, Bochum, and Institute of Epidemiology and Social Medicine (Dr. Berger), University of Muenster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Genetics (Drs. Hering, Berg, Bauer, and Riess, S. Petrovic and E.-M. Mietz) and Neurodegeneration Laboratory (Dr. Kru\u0308ger), Center of Neurology, Hertie Institute of Clinical Brain Research, University of Tu\u0308bingen, Department of Medical Genetics (Dr. Holzmann), University of Rostock, Department of Neurology (Drs. Woitalla and Mu\u0308ller), Ruhr-University Bochum, Bochum, and Institute of Epidemiology and Social Medicine (Dr. Berger), University of Muenster, Germany","institution_ids":["https://openalex.org/I22465464","https://openalex.org/I4210141865","https://openalex.org/I4665924","https://openalex.org/I8087733","https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001790127","display_name":"Daniela Berg","orcid":"https://orcid.org/0000-0001-5796-5442","observed_orcids":["https://orcid.org/0000-0001-5796-5442"]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]},{"id":"https://openalex.org/I4210141865","display_name":"Hertie Institute for Clinical Brain Research","ror":"https://ror.org/04zzwzx41","country_code":"DE","type":"other","lineage":["https://openalex.org/I4210094118","https://openalex.org/I4210141865","https://openalex.org/I8087733"]},{"id":"https://openalex.org/I4665924","display_name":"University of Rostock","ror":"https://ror.org/03zdwsf69","country_code":"DE","type":"education","lineage":["https://openalex.org/I4665924"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"D. Berg","raw_affiliation_strings":["From the Department of Medical Genetics (Drs. Hering, Berg, Bauer, and Riess, S. Petrovic and E.-M. Mietz) and Neurodegeneration Laboratory (Dr. Kru\u0308ger), Center of Neurology, Hertie Institute of Clinical Brain Research, University of Tu\u0308bingen, Department of Medical Genetics (Dr. Holzmann), University of Rostock, Department of Neurology (Drs. Woitalla and Mu\u0308ller), Ruhr-University Bochum, Bochum, and Institute of Epidemiology and Social Medicine (Dr. Berger), University of Muenster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Genetics (Drs. Hering, Berg, Bauer, and Riess, S. Petrovic and E.-M. Mietz) and Neurodegeneration Laboratory (Dr. Kru\u0308ger), Center of Neurology, Hertie Institute of Clinical Brain Research, University of Tu\u0308bingen, Department of Medical Genetics (Dr. Holzmann), University of Rostock, Department of Neurology (Drs. Woitalla and Mu\u0308ller), Ruhr-University Bochum, Bochum, and Institute of Epidemiology and Social Medicine (Dr. Berger), University of Muenster, Germany","institution_ids":["https://openalex.org/I22465464","https://openalex.org/I4210141865","https://openalex.org/I4665924","https://openalex.org/I8087733","https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086201841","display_name":"Peter Bauer","orcid":"https://orcid.org/0000-0001-9414-4555","observed_orcids":["https://orcid.org/0000-0001-9414-4555"]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]},{"id":"https://openalex.org/I4210141865","display_name":"Hertie Institute for Clinical Brain Research","ror":"https://ror.org/04zzwzx41","country_code":"DE","type":"other","lineage":["https://openalex.org/I4210094118","https://openalex.org/I4210141865","https://openalex.org/I8087733"]},{"id":"https://openalex.org/I4665924","display_name":"University of Rostock","ror":"https://ror.org/03zdwsf69","country_code":"DE","type":"education","lineage":["https://openalex.org/I4665924"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"P. Bauer","raw_affiliation_strings":["From the Department of Medical Genetics (Drs. Hering, Berg, Bauer, and Riess, S. Petrovic and E.-M. Mietz) and Neurodegeneration Laboratory (Dr. Kru\u0308ger), Center of Neurology, Hertie Institute of Clinical Brain Research, University of Tu\u0308bingen, Department of Medical Genetics (Dr. Holzmann), University of Rostock, Department of Neurology (Drs. Woitalla and Mu\u0308ller), Ruhr-University Bochum, Bochum, and Institute of Epidemiology and Social Medicine (Dr. Berger), University of Muenster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Genetics (Drs. Hering, Berg, Bauer, and Riess, S. Petrovic and E.-M. Mietz) and Neurodegeneration Laboratory (Dr. Kru\u0308ger), Center of Neurology, Hertie Institute of Clinical Brain Research, University of Tu\u0308bingen, Department of Medical Genetics (Dr. Holzmann), University of Rostock, Department of Neurology (Drs. Woitalla and Mu\u0308ller), Ruhr-University Bochum, Bochum, and Institute of Epidemiology and Social Medicine (Dr. Berger), University of Muenster, Germany","institution_ids":["https://openalex.org/I22465464","https://openalex.org/I4210141865","https://openalex.org/I4665924","https://openalex.org/I8087733","https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065348931","display_name":"Dirk Woitalla","orcid":"https://orcid.org/0000-0002-5031-1478","observed_orcids":["https://orcid.org/0000-0002-5031-1478"]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]},{"id":"https://openalex.org/I4210141865","display_name":"Hertie Institute for Clinical Brain Research","ror":"https://ror.org/04zzwzx41","country_code":"DE","type":"other","lineage":["https://openalex.org/I4210094118","https://openalex.org/I4210141865","https://openalex.org/I8087733"]},{"id":"https://openalex.org/I4665924","display_name":"University of Rostock","ror":"https://ror.org/03zdwsf69","country_code":"DE","type":"education","lineage":["https://openalex.org/I4665924"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"D. Woitalla","raw_affiliation_strings":["From the Department of Medical Genetics (Drs. Hering, Berg, Bauer, and Riess, S. Petrovic and E.-M. Mietz) and Neurodegeneration Laboratory (Dr. Kru\u0308ger), Center of Neurology, Hertie Institute of Clinical Brain Research, University of Tu\u0308bingen, Department of Medical Genetics (Dr. Holzmann), University of Rostock, Department of Neurology (Drs. Woitalla and Mu\u0308ller), Ruhr-University Bochum, Bochum, and Institute of Epidemiology and Social Medicine (Dr. Berger), University of Muenster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Genetics (Drs. Hering, Berg, Bauer, and Riess, S. Petrovic and E.-M. Mietz) and Neurodegeneration Laboratory (Dr. Kru\u0308ger), Center of Neurology, Hertie Institute of Clinical Brain Research, University of Tu\u0308bingen, Department of Medical Genetics (Dr. Holzmann), University of Rostock, Department of Neurology (Drs. Woitalla and Mu\u0308ller), Ruhr-University Bochum, Bochum, and Institute of Epidemiology and Social Medicine (Dr. Berger), University of Muenster, Germany","institution_ids":["https://openalex.org/I22465464","https://openalex.org/I4210141865","https://openalex.org/I4665924","https://openalex.org/I8087733","https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":null,"display_name":"T. Mu\u0308ller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]},{"id":"https://openalex.org/I4210141865","display_name":"Hertie Institute for Clinical Brain Research","ror":"https://ror.org/04zzwzx41","country_code":"DE","type":"other","lineage":["https://openalex.org/I4210094118","https://openalex.org/I4210141865","https://openalex.org/I8087733"]},{"id":"https://openalex.org/I4665924","display_name":"University of Rostock","ror":"https://ror.org/03zdwsf69","country_code":"DE","type":"education","lineage":["https://openalex.org/I4665924"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T. Mu\u0308ller","raw_affiliation_strings":["From the Department of Medical Genetics (Drs. Hering, Berg, Bauer, and Riess, S. Petrovic and E.-M. Mietz) and Neurodegeneration Laboratory (Dr. Kru\u0308ger), Center of Neurology, Hertie Institute of Clinical Brain Research, University of Tu\u0308bingen, Department of Medical Genetics (Dr. Holzmann), University of Rostock, Department of Neurology (Drs. Woitalla and Mu\u0308ller), Ruhr-University Bochum, Bochum, and Institute of Epidemiology and Social Medicine (Dr. Berger), University of Muenster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Genetics (Drs. Hering, Berg, Bauer, and Riess, S. Petrovic and E.-M. Mietz) and Neurodegeneration Laboratory (Dr. Kru\u0308ger), Center of Neurology, Hertie Institute of Clinical Brain Research, University of Tu\u0308bingen, Department of Medical Genetics (Dr. Holzmann), University of Rostock, Department of Neurology (Drs. Woitalla and Mu\u0308ller), Ruhr-University Bochum, Bochum, and Institute of Epidemiology and Social Medicine (Dr. Berger), University of Muenster, Germany","institution_ids":["https://openalex.org/I22465464","https://openalex.org/I4210141865","https://openalex.org/I4665924","https://openalex.org/I8087733","https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067198140","display_name":"Klaus Berger","orcid":"https://orcid.org/0000-0001-8966-3684","observed_orcids":["https://orcid.org/0000-0001-8966-3684"]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]},{"id":"https://openalex.org/I4210141865","display_name":"Hertie Institute for Clinical Brain Research","ror":"https://ror.org/04zzwzx41","country_code":"DE","type":"other","lineage":["https://openalex.org/I4210094118","https://openalex.org/I4210141865","https://openalex.org/I8087733"]},{"id":"https://openalex.org/I4665924","display_name":"University of Rostock","ror":"https://ror.org/03zdwsf69","country_code":"DE","type":"education","lineage":["https://openalex.org/I4665924"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K. Berger","raw_affiliation_strings":["From the Department of Medical Genetics (Drs. Hering, Berg, Bauer, and Riess, S. Petrovic and E.-M. Mietz) and Neurodegeneration Laboratory (Dr. Kru\u0308ger), Center of Neurology, Hertie Institute of Clinical Brain Research, University of Tu\u0308bingen, Department of Medical Genetics (Dr. Holzmann), University of Rostock, Department of Neurology (Drs. Woitalla and Mu\u0308ller), Ruhr-University Bochum, Bochum, and Institute of Epidemiology and Social Medicine (Dr. Berger), University of Muenster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Genetics (Drs. Hering, Berg, Bauer, and Riess, S. Petrovic and E.-M. Mietz) and Neurodegeneration Laboratory (Dr. Kru\u0308ger), Center of Neurology, Hertie Institute of Clinical Brain Research, University of Tu\u0308bingen, Department of Medical Genetics (Dr. Holzmann), University of Rostock, Department of Neurology (Drs. Woitalla and Mu\u0308ller), Ruhr-University Bochum, Bochum, and Institute of Epidemiology and Social Medicine (Dr. Berger), University of Muenster, Germany","institution_ids":["https://openalex.org/I22465464","https://openalex.org/I4210141865","https://openalex.org/I4665924","https://openalex.org/I8087733","https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113669519","display_name":"Rejko Kr\u00fcger","orcid":"https://orcid.org/0000-0003-4258-6241","observed_orcids":["https://orcid.org/0000-0003-4258-6241"]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]},{"id":"https://openalex.org/I4210141865","display_name":"Hertie Institute for Clinical Brain Research","ror":"https://ror.org/04zzwzx41","country_code":"DE","type":"other","lineage":["https://openalex.org/I4210094118","https://openalex.org/I4210141865","https://openalex.org/I8087733"]},{"id":"https://openalex.org/I4665924","display_name":"University of Rostock","ror":"https://ror.org/03zdwsf69","country_code":"DE","type":"education","lineage":["https://openalex.org/I4665924"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R. Kru\u0308ger","raw_affiliation_strings":["From the Department of Medical Genetics (Drs. Hering, Berg, Bauer, and Riess, S. Petrovic and E.-M. Mietz) and Neurodegeneration Laboratory (Dr. Kru\u0308ger), Center of Neurology, Hertie Institute of Clinical Brain Research, University of Tu\u0308bingen, Department of Medical Genetics (Dr. Holzmann), University of Rostock, Department of Neurology (Drs. Woitalla and Mu\u0308ller), Ruhr-University Bochum, Bochum, and Institute of Epidemiology and Social Medicine (Dr. Berger), University of Muenster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Genetics (Drs. Hering, Berg, Bauer, and Riess, S. Petrovic and E.-M. Mietz) and Neurodegeneration Laboratory (Dr. Kru\u0308ger), Center of Neurology, Hertie Institute of Clinical Brain Research, University of Tu\u0308bingen, Department of Medical Genetics (Dr. Holzmann), University of Rostock, Department of Neurology (Drs. Woitalla and Mu\u0308ller), Ruhr-University Bochum, Bochum, and Institute of Epidemiology and Social Medicine (Dr. Berger), University of Muenster, Germany","institution_ids":["https://openalex.org/I22465464","https://openalex.org/I4210141865","https://openalex.org/I4665924","https://openalex.org/I8087733","https://openalex.org/I904495901"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063444804","display_name":"Olaf Rie\u00df","orcid":"https://orcid.org/0000-0002-7011-1369","observed_orcids":["https://orcid.org/0000-0002-7011-1369"]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]},{"id":"https://openalex.org/I4210141865","display_name":"Hertie Institute for Clinical Brain Research","ror":"https://ror.org/04zzwzx41","country_code":"DE","type":"other","lineage":["https://openalex.org/I4210094118","https://openalex.org/I4210141865","https://openalex.org/I8087733"]},{"id":"https://openalex.org/I4665924","display_name":"University of Rostock","ror":"https://ror.org/03zdwsf69","country_code":"DE","type":"education","lineage":["https://openalex.org/I4665924"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]},{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"O. Riess","raw_affiliation_strings":["From the Department of Medical Genetics (Drs. Hering, Berg, Bauer, and Riess, S. Petrovic and E.-M. Mietz) and Neurodegeneration Laboratory (Dr. Kru\u0308ger), Center of Neurology, Hertie Institute of Clinical Brain Research, University of Tu\u0308bingen, Department of Medical Genetics (Dr. Holzmann), University of Rostock, Department of Neurology (Drs. Woitalla and Mu\u0308ller), Ruhr-University Bochum, Bochum, and Institute of Epidemiology and Social Medicine (Dr. Berger), University of Muenster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Medical Genetics (Drs. Hering, Berg, Bauer, and Riess, S. Petrovic and E.-M. Mietz) and Neurodegeneration Laboratory (Dr. Kru\u0308ger), Center of Neurology, Hertie Institute of Clinical Brain Research, University of Tu\u0308bingen, Department of Medical Genetics (Dr. Holzmann), University of Rostock, Department of Neurology (Drs. Woitalla and Mu\u0308ller), Ruhr-University Bochum, Bochum, and Institute of Epidemiology and Social Medicine (Dr. Berger), University of Muenster, Germany","institution_ids":["https://openalex.org/I22465464","https://openalex.org/I4210141865","https://openalex.org/I4665924","https://openalex.org/I8087733","https://openalex.org/I904495901"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.5338,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.89008701,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"62","issue":"7","first_page":"1231","last_page":"1232"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.023099999874830246,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nurr1","display_name":"Nurr1","score":0.996999979019165},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/mutation-analysis","display_name":"mutation analysis","score":0.7570000290870667},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.9110000133514404}],"concepts":[{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.6365132927894592},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5989705324172974},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.5788239240646362},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5329583287239075},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4355786442756653},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.38637107610702515},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3727424442768097},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.336447536945343},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22417202591896057},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.1848410665988922},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.08920606970787048},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007438","descriptor_name":"Introns","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011618","descriptor_name":"Psychotic Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057126","descriptor_name":"Nuclear Receptor Subfamily 4, Group A, Member 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1212/01.wnl.0000118285.18383.90","doi":"https://doi.org/10.1212/01.wnl.0000118285.18383.90","is_oa":false,"landing_page_url":"https://doi.org/10.1212/01.wnl.0000118285.18383.90","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},{"id":"pmid:15079038","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15079038","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Journal Article"},{"id":"pmh:oai:orbilu.uni.lu:10993/17141","doi":null,"is_oa":true,"landing_page_url":"https://orbilu.uni.lu/handle/10993/17141","pdf_url":null,"source":{"id":"https://openalex.org/S4306401815","display_name":"Open Repository and Bibliography (University of Luxembourg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I186903577","host_organization_name":"University of Luxembourg","host_organization_lineage":["https://openalex.org/I186903577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neurology, 62 (7), 1231-2 (2004)","raw_type":"http://purl.org/coar/resource_type/c_6501"}],"best_oa_location":{"id":"pmh:oai:orbilu.uni.lu:10993/17141","doi":null,"is_oa":true,"landing_page_url":"https://orbilu.uni.lu/handle/10993/17141","pdf_url":null,"source":{"id":"https://openalex.org/S4306401815","display_name":"Open Repository and Bibliography (University of Luxembourg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I186903577","host_organization_name":"University of Luxembourg","host_organization_lineage":["https://openalex.org/I186903577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neurology, 62 (7), 1231-2 (2004)","raw_type":"http://purl.org/coar/resource_type/c_6501"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1966103866","https://openalex.org/W1976118041","https://openalex.org/W1981862471","https://openalex.org/W2066151738","https://openalex.org/W2066433054","https://openalex.org/W2114766028","https://openalex.org/W2117470697"],"related_works":["https://openalex.org/W2085131259","https://openalex.org/W2587869871","https://openalex.org/W2272984308","https://openalex.org/W2025383404","https://openalex.org/W2013468767","https://openalex.org/W2269293890","https://openalex.org/W2066433054","https://openalex.org/W1989428075","https://openalex.org/W2024872035","https://openalex.org/W2065916789"],"abstract_inverted_index":{"Mutations":[0],"in":[1,15,23,39,55,66,76,86,104,117,122],"four":[2],"genes":[3],"(\u03b1":[4],"-synuclein,":[5],"UCH-L1,":[6],"parkin":[7],",":[8],"and":[9,115,170],"DJ-1":[10],")":[11,34],"have":[12,36],"been":[13,37],"identified":[14],"familial":[16,42],"Parkinson":[17],"disease":[18,142],"(PD).":[19],"Recently,":[20],"two":[21,67,110,165],"mutations":[22],"the":[24,27,59,80,101,131,164],"5\u2032-region":[25],"of":[26,41,45,49,58,79,84,92,120,126,130,163],"orphan":[28],"nuclear":[29],"receptor":[30],"Nurr1":[31,60,72,85,121],"(":[32],"NR4A2":[33],"gene":[35,61],"found":[38],"10%":[40],"PD":[43,65,127,135],"cases,":[44],"which":[46],"one-third":[47],"were":[48,137],"German":[50],"ancestry.1":[51],"Furthermore,":[52],"a":[53,90,123,157],"polymorphism":[54,103],"intron":[56,105],"6":[57,106],"was":[62],"associated":[63],"with":[64,152],"independent":[68],"studies.2,3\u21d3\n\nThe":[69],"transcription":[70],"factor":[71],"is":[73],"highly":[74],"expressed":[75],"dopaminergic":[77,93],"cells":[78],"substantia":[81],"nigra.":[82],"Deficiency":[83],"mice":[87],"leads":[88],"to":[89],"lack":[91],"neurons.4":[94],"Based":[95],"on":[96],"these":[97],"data,":[98],"we":[99],"explored":[100],"7048G7049":[102,132],"as":[107,109],"well":[108],"novel":[111,166],"sequence":[112,167],"variations,":[113,168],"\u2212291Tdel":[114,169],"\u2212245T\u2192G,":[116,171],"exon":[118],"1":[119],"large":[124],"cohort":[125],"patients.\n\nFor":[128],"analysis":[129,162],"polymorphism,":[133],"424":[134],"patients":[136,154],"investigated":[138],"(mean":[139],"age":[140],"at":[141],"onset":[143],"55.4":[144],"\u00b1":[145],"12.1":[146],"years;":[147],"54.6%":[148],"male,":[149],"45.4%":[150],"female;":[151],"55":[153],"[13.0%]":[155],"having":[156],"positive":[158],"family":[159],"history).":[160],"For":[161],"\u2026":[172]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}