{"id":"https://openalex.org/W1973201289","doi":"https://doi.org/10.1055/s-2007-991874","title":"Branched chain amino acids decrease top-down event-related potentials in healthy subjects","display_name":"Branched chain amino acids decrease top-down event-related potentials in healthy subjects","publication_year":2007,"publication_date":"2007-09-01","ids":{"openalex":"https://openalex.org/W1973201289","doi":"https://doi.org/10.1055/s-2007-991874","mag":"1973201289"},"language":"en","primary_location":{"id":"doi:10.1055/s-2007-991874","doi":"https://doi.org/10.1055/s-2007-991874","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2007-991874","pdf_url":null,"source":{"id":"https://openalex.org/S4122505","display_name":"Pharmacopsychiatry","issn_l":"0176-3679","issn":["0176-3679","1439-0795"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacopsychiatry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055945283","display_name":"Andres H. Neuhaus","orcid":"https://orcid.org/0000-0003-2644-610X","observed_orcids":["https://orcid.org/0000-0003-2644-610X"]},"institutions":[{"id":"https://openalex.org/I4392738228","display_name":"Stiftung Charit\u00e9","ror":"https://ror.org/016rf0n60","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4392738228","https://openalex.org/I7877124"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"AH Neuhaus","raw_affiliation_strings":["Department of Psychiatry and Psychotherapy, Charit\u00e9 University Medicine, Campus Benjamin Franklin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Psychotherapy, Charit\u00e9 University Medicine, Campus Benjamin Franklin, Berlin, Germany","institution_ids":["https://openalex.org/I4392738228","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076825438","display_name":"TE Goldberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302444339","display_name":"Northwell Health","ror":"https://ror.org/02bxt4m23","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339"]},{"id":"https://openalex.org/I4210166545","display_name":"Zucker Hillside Hospital","ror":"https://ror.org/05vh9vp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339","https://openalex.org/I4210166545"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"TE Goldberg","raw_affiliation_strings":["Department of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, New York City, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, New York City, NY, USA","institution_ids":["https://openalex.org/I1302444339","https://openalex.org/I4210166545"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029348870","display_name":"Youssef Hassoun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302444339","display_name":"Northwell Health","ror":"https://ror.org/02bxt4m23","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339"]},{"id":"https://openalex.org/I4210166545","display_name":"Zucker Hillside Hospital","ror":"https://ror.org/05vh9vp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339","https://openalex.org/I4210166545"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y Hassoun","raw_affiliation_strings":["Department of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, New York City, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, New York City, NY, USA","institution_ids":["https://openalex.org/I1302444339","https://openalex.org/I4210166545"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083446439","display_name":"J.A. Bates","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302444339","display_name":"Northwell Health","ror":"https://ror.org/02bxt4m23","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339"]},{"id":"https://openalex.org/I4210166545","display_name":"Zucker Hillside Hospital","ror":"https://ror.org/05vh9vp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339","https://openalex.org/I4210166545"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JA Bates","raw_affiliation_strings":["Department of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, New York City, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, New York City, NY, USA","institution_ids":["https://openalex.org/I1302444339","https://openalex.org/I4210166545"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047938517","display_name":"Katharine W. Nassauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302444339","display_name":"Northwell Health","ror":"https://ror.org/02bxt4m23","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339"]},{"id":"https://openalex.org/I4210166545","display_name":"Zucker Hillside Hospital","ror":"https://ror.org/05vh9vp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339","https://openalex.org/I4210166545"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"KW Nassauer","raw_affiliation_strings":["Department of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, New York City, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, New York City, NY, USA","institution_ids":["https://openalex.org/I1302444339","https://openalex.org/I4210166545"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113537140","display_name":"Serge M. Sevy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302444339","display_name":"Northwell Health","ror":"https://ror.org/02bxt4m23","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339"]},{"id":"https://openalex.org/I4210166545","display_name":"Zucker Hillside Hospital","ror":"https://ror.org/05vh9vp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339","https://openalex.org/I4210166545"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Sevy","raw_affiliation_strings":["Department of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, New York City, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, New York City, NY, USA","institution_ids":["https://openalex.org/I1302444339","https://openalex.org/I4210166545"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013163176","display_name":"Carolin Opgen\u2010Rhein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4392738228","display_name":"Stiftung Charit\u00e9","ror":"https://ror.org/016rf0n60","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4392738228","https://openalex.org/I7877124"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C Opgen-Rhein","raw_affiliation_strings":["Department of Psychiatry and Psychotherapy, Charit\u00e9 University Medicine, Campus Benjamin Franklin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Psychotherapy, Charit\u00e9 University Medicine, Campus Benjamin Franklin, Berlin, Germany","institution_ids":["https://openalex.org/I4392738228","https://openalex.org/I7877124"]}]},{"author_position":"last","author":{"id":null,"display_name":"AK Malhotra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302444339","display_name":"Northwell Health","ror":"https://ror.org/02bxt4m23","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339"]},{"id":"https://openalex.org/I4210166545","display_name":"Zucker Hillside Hospital","ror":"https://ror.org/05vh9vp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302444339","https://openalex.org/I4210166545"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"AK Malhotra","raw_affiliation_strings":["Department of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, New York City, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, New York City, NY, USA","institution_ids":["https://openalex.org/I1302444339","https://openalex.org/I4210166545"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08078493,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":"05","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.8101000189781189,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.8101000189781189,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.13109999895095825,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.04170000180602074,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/branched-chain-amino-acids","display_name":"branched-chain amino acids","score":0.9940000176429749},{"id":"https://openalex.org/keywords/dopamine-depletion","display_name":"dopamine depletion","score":0.8790000081062317},{"id":"https://openalex.org/keywords/top-down-processing","display_name":"top-down processing","score":0.8149999976158142},{"id":"https://openalex.org/keywords/event-related-potentials","display_name":"event-related potentials","score":0.9079999923706055},{"id":"https://openalex.org/keywords/n2-component","display_name":"N2 component","score":0.8080000281333923},{"id":"https://openalex.org/keywords/p300","display_name":"P300","score":0.7760000228881836},{"id":"https://openalex.org/keywords/mismatch-negativity","display_name":"mismatch negativity","score":0.7269999980926514},{"id":"https://openalex.org/keywords/prolactin","display_name":"prolactin","score":0.9079999923706055},{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"prefrontal cortex","score":0.902999997138977},{"id":"https://openalex.org/keywords/cognitive-processes","display_name":"cognitive processes","score":0.46000000834465027}],"concepts":[{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.7788814306259155},{"id":"https://openalex.org/C91831460","wikidata":"https://www.wikidata.org/wiki/Q7117899","display_name":"P3b","level":4,"score":0.7438215017318726},{"id":"https://openalex.org/C21715850","wikidata":"https://www.wikidata.org/wiki/Q2720968","display_name":"Mismatch negativity","level":3,"score":0.6156675219535828},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5472646355628967},{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.5354509353637695},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5305312871932983},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.5075289011001587},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5053966045379639},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.38893213868141174},{"id":"https://openalex.org/C67359045","wikidata":"https://www.wikidata.org/wiki/Q14026181","display_name":"Event-related potential","level":3,"score":0.34443312883377075},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2782684564590454}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-2007-991874","doi":"https://doi.org/10.1055/s-2007-991874","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2007-991874","pdf_url":null,"source":{"id":"https://openalex.org/S4122505","display_name":"Pharmacopsychiatry","issn_l":"0176-3679","issn":["0176-3679","1439-0795"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacopsychiatry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6299999952316284,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2145002104","https://openalex.org/W2109896425","https://openalex.org/W2140077272","https://openalex.org/W2083463233","https://openalex.org/W1979044287","https://openalex.org/W126063226","https://openalex.org/W2012677890","https://openalex.org/W1972674645","https://openalex.org/W2793905841","https://openalex.org/W4414041352"],"abstract_inverted_index":{"Introduction:":[0],"Cerebral":[1],"dopamine":[2,20,26,34,134],"is":[3],"thought":[4],"to":[5,118],"be":[6,119,145],"crucially":[7],"involved":[8,120],"in":[9,60,70,121],"cognitive":[10],"processing.":[11],"Branched":[12],"chain":[13],"amino":[14],"acids":[15],"(BCAAs)":[16],"acutely":[17,146],"lower":[18],"cerebral":[19],"precursor":[21],"availability":[22],"and":[23,47,53,83],"induce":[24],"short-term":[25],"depletion.":[27,135],"We":[28],"examined":[29],"the":[30],"effects":[31],"of":[32,94,130],"acute":[33],"depletion":[35],"on":[36],"cortical":[37,141],"processing":[38,124,143],"via":[39],"event-related":[40],"potentials":[41],"(ERPs).":[42],"Methods:":[43],"Serum":[44],"prolactin":[45,81],"levels":[46,82],"attentive":[48,96,104],"ERP":[49,85],"components":[50],"N2":[51,87],"(MMN/N2b)":[52],"P3b":[54,106],"were":[55],"investigated":[56],"using":[57],"high-density":[58],"electroencephalography":[59],"22":[61],"healthy":[62,137],"male":[63,138],"subjects":[64],"after":[65],"receiving":[66],"BCAAs":[67,78],"or":[68],"placebo":[69],"a":[71],"randomized,":[72],"double-blind,":[73],"placebo-controlled":[74],"crossover":[75],"design.":[76],"Results:":[77],"increased":[79],"serum":[80],"reduced":[84],"component":[86],"(MMN/N2b).":[88],"Subcomponent":[89],"analysis":[90],"revealed":[91],"an":[92],"attenuation":[93],"early":[95,122,140],"N2b":[97,132],"over":[98],"fronto-central":[99],"scalp":[100],"sites,":[101],"while":[102],"late":[103],"prefrontal":[105,131],"showed":[107],"trend-level":[108],"reductions.":[109],"MMN":[110],"was":[111],"not":[112],"affected.":[113],"Conclusions:":[114],"Dopaminergic":[115],"neurotransmission":[116],"seems":[117],"top-down":[123,142],"as":[125],"indexed":[126],"by":[127,148],"selective":[128],"reduction":[129],"during":[133],"In":[136],"subjects,":[139],"can":[144],"dysregulated":[147],"BCAAs.":[149]},"counts_by_year":[],"updated_date":"2026-10-22T18:32:59.640997","created_date":"2016-06-24T00:00:00"}
