{"id":"https://openalex.org/W1973195150","doi":"https://doi.org/10.1073/pnas.0810759106","title":"EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation","display_name":"EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation","publication_year":2009,"publication_date":"2009-03-16","ids":{"openalex":"https://openalex.org/W1973195150","doi":"https://doi.org/10.1073/pnas.0810759106","mag":"1973195150","pmid":"https://pubmed.ncbi.nlm.nih.gov/19289832","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2656557"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0810759106","doi":"https://doi.org/10.1073/pnas.0810759106","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0810759106","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2656557/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040347320","display_name":"G\u00fcnther H.S. Richter","orcid":"https://orcid.org/0000-0003-4782-5539","observed_orcids":["https://orcid.org/0000-0003-4782-5539"]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G\u00fcnther H. S. Richter","raw_affiliation_strings":["Laboratory for Functional Genomics and Transplantation Biology, Department of Pediatrics, Technische Universit\u00e4t M\u00fcnchen and Pediatric Oncology Center, 81664 Munich, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Functional Genomics and Transplantation Biology, Department of Pediatrics, Technische Universit\u00e4t M\u00fcnchen and Pediatric Oncology Center, 81664 Munich, Germany;","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078658517","display_name":"Stephanie Plehm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stephanie Plehm","raw_affiliation_strings":["Laboratory for Functional Genomics and Transplantation Biology, Department of Pediatrics, Technische Universit\u00e4t M\u00fcnchen and Pediatric Oncology Center, 81664 Munich, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Functional Genomics and Transplantation Biology, Department of Pediatrics, Technische Universit\u00e4t M\u00fcnchen and Pediatric Oncology Center, 81664 Munich, Germany;","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070087226","display_name":"Annette Fasan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Annette Fasan","raw_affiliation_strings":["Laboratory for Functional Genomics and Transplantation Biology, Department of Pediatrics, Technische Universit\u00e4t M\u00fcnchen and Pediatric Oncology Center, 81664 Munich, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Functional Genomics and Transplantation Biology, Department of Pediatrics, Technische Universit\u00e4t M\u00fcnchen and Pediatric Oncology Center, 81664 Munich, Germany;","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069951301","display_name":"Sabine R\u00f6ssler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sabine R\u00f6ssler","raw_affiliation_strings":["Laboratory for Functional Genomics and Transplantation Biology, Department of Pediatrics, Technische Universit\u00e4t M\u00fcnchen and Pediatric Oncology Center, 81664 Munich, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Functional Genomics and Transplantation Biology, Department of Pediatrics, Technische Universit\u00e4t M\u00fcnchen and Pediatric Oncology Center, 81664 Munich, Germany;","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025154148","display_name":"Rebekka Unland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]},{"id":"https://openalex.org/I4210103666","display_name":"University Hospital M\u00fcnster","ror":"https://ror.org/01856cw59","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210103666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rebekka Unland","raw_affiliation_strings":["Department of Medicine, Hematology, and Oncology, and Interdisciplinary Center for Clinical Research (IZKF), and","Department of Pediatric Hematology and Oncology, University Children's Hospital, University of M\u00fcnster, 48149 M\u00fcnster, Gemany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Hematology, and Oncology, and Interdisciplinary Center for Clinical Research (IZKF), and","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatric Hematology and Oncology, University Children's Hospital, University of M\u00fcnster, 48149 M\u00fcnster, Gemany;","institution_ids":["https://openalex.org/I22465464","https://openalex.org/I4210103666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044486192","display_name":"Idriss M. Bennani-Ba\u00efti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388891777","display_name":"St. Anna Children's Cancer Research Institute","ror":"https://ror.org/05bd7c383","country_code":"AT","type":"nonprofit","lineage":["https://openalex.org/I4388891777"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Idriss M. Bennani-Baiti","raw_affiliation_strings":["Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, 1090 Vienna, Austria;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, 1090 Vienna, Austria;","institution_ids":["https://openalex.org/I4388891777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060931240","display_name":"Marc Hotfilder","orcid":"https://orcid.org/0000-0001-9964-1761","observed_orcids":["https://orcid.org/0000-0001-9964-1761"]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]},{"id":"https://openalex.org/I4210103666","display_name":"University Hospital M\u00fcnster","ror":"https://ror.org/01856cw59","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210103666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marc Hotfilder","raw_affiliation_strings":["Department of Pediatric Hematology and Oncology, University Children's Hospital, University of M\u00fcnster, 48149 M\u00fcnster, Gemany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Hematology and Oncology, University Children's Hospital, University of M\u00fcnster, 48149 M\u00fcnster, Gemany;","institution_ids":["https://openalex.org/I22465464","https://openalex.org/I4210103666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060525062","display_name":"Diana L\u00f6wel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Diana L\u00f6wel","raw_affiliation_strings":["Laboratory for Functional Genomics and Transplantation Biology, Department of Pediatrics, Technische Universit\u00e4t M\u00fcnchen and Pediatric Oncology Center, 81664 Munich, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Functional Genomics and Transplantation Biology, Department of Pediatrics, Technische Universit\u00e4t M\u00fcnchen and Pediatric Oncology Center, 81664 Munich, Germany;","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027430345","display_name":"Irene von Luettichau","orcid":"https://orcid.org/0000-0003-0754-1478","observed_orcids":["https://orcid.org/0000-0003-0754-1478"]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Irene von Luettichau","raw_affiliation_strings":["Laboratory for Functional Genomics and Transplantation Biology, Department of Pediatrics, Technische Universit\u00e4t M\u00fcnchen and Pediatric Oncology Center, 81664 Munich, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Functional Genomics and Transplantation Biology, Department of Pediatrics, Technische Universit\u00e4t M\u00fcnchen and Pediatric Oncology Center, 81664 Munich, Germany;","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051589571","display_name":"Ilona Mo\u00dfbrugger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ilona Mossbrugger","raw_affiliation_strings":["Institute of Pathology, Helmholtz Center Munich, German Research Center for Environmental Health, D-85764 Neuherberg, Germany; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, Helmholtz Center Munich, German Research Center for Environmental Health, D-85764 Neuherberg, Germany; and","institution_ids":["https://openalex.org/I3018134672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029333060","display_name":"Leticia Quintanilla\u2010Mart\u00ednez","orcid":"https://orcid.org/0000-0001-7156-5365","observed_orcids":["https://orcid.org/0000-0001-7156-5365"]},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Leticia Quintanilla-Martinez","raw_affiliation_strings":["Institute of Pathology, Helmholtz Center Munich, German Research Center for Environmental Health, D-85764 Neuherberg, Germany; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, Helmholtz Center Munich, German Research Center for Environmental Health, D-85764 Neuherberg, Germany; and","institution_ids":["https://openalex.org/I3018134672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028542112","display_name":"Heinrich Kovar","orcid":"https://orcid.org/0000-0001-6873-9109","observed_orcids":["https://orcid.org/0000-0001-6873-9109"]},"institutions":[{"id":"https://openalex.org/I4388891777","display_name":"St. Anna Children's Cancer Research Institute","ror":"https://ror.org/05bd7c383","country_code":"AT","type":"nonprofit","lineage":["https://openalex.org/I4388891777"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Heinrich Kovar","raw_affiliation_strings":["Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, 1090 Vienna, Austria;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, 1090 Vienna, Austria;","institution_ids":["https://openalex.org/I4388891777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055109962","display_name":"Martin Sebastian Staege","orcid":"https://orcid.org/0000-0003-3765-7068","observed_orcids":["https://orcid.org/0000-0003-3765-7068"]},"institutions":[{"id":"https://openalex.org/I68956291","display_name":"Martin Luther University Halle-Wittenberg","ror":"https://ror.org/05gqaka33","country_code":"DE","type":"education","lineage":["https://openalex.org/I68956291"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin S. Staege","raw_affiliation_strings":["Department of Pediatrics, Martin-Luther-University Halle-Wittenberg, 06097 Halle, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Martin-Luther-University Halle-Wittenberg, 06097 Halle, Germany","institution_ids":["https://openalex.org/I68956291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028388949","display_name":"Carsten M\u00fcller\u2010Tidow","orcid":"https://orcid.org/0000-0002-7166-5232","observed_orcids":["https://orcid.org/0000-0002-7166-5232"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carsten M\u00fcller-Tidow","raw_affiliation_strings":["Department of Medicine, Hematology, and Oncology, and Interdisciplinary Center for Clinical Research (IZKF), and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Hematology, and Oncology, and Interdisciplinary Center for Clinical Research (IZKF), and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021490889","display_name":"Stefan E.G. Burdach","orcid":"https://orcid.org/0000-0001-6400-4471","observed_orcids":["https://orcid.org/0000-0001-6400-4471"]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Burdach","raw_affiliation_strings":["Laboratory for Functional Genomics and Transplantation Biology, Department of Pediatrics, Technische Universit\u00e4t M\u00fcnchen and Pediatric Oncology Center, 81664 Munich, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Functional Genomics and Transplantation Biology, Department of Pediatrics, Technische Universit\u00e4t M\u00fcnchen and Pediatric Oncology Center, 81664 Munich, Germany;","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":12.6919,"has_fulltext":false,"cited_by_count":313,"citation_normalized_percentile":{"value":0.99126122,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"106","issue":"13","first_page":"5324","last_page":"5329"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.8773999810218811,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.8773999810218811,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.022700000554323196,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.018400000408291817,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ezh2","display_name":"EZH2","score":0.9380000233650208},{"id":"https://openalex.org/keywords/ewing-sarcoma","display_name":"Ewing sarcoma","score":0.9829999804496765},{"id":"https://openalex.org/keywords/ews-fli1-fusion","display_name":"EWS-FLI1 fusion","score":0.8960000276565552},{"id":"https://openalex.org/keywords/histone-methyltransferase","display_name":"histone methyltransferase","score":0.972000002861023},{"id":"https://openalex.org/keywords/histone-deacetylase","display_name":"histone deacetylase","score":0.9210000038146973},{"id":"https://openalex.org/keywords/cancer-stemness","display_name":"cancer stemness","score":0.8600000143051147},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.49399998784065247},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/endothelial-cell-differentiation","display_name":"endothelial differentiation","score":0.9100000262260437},{"id":"https://openalex.org/keywords/neuroectodermal-differentiation","display_name":"neuroectodermal differentiation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/neural-crest","display_name":"neural crest","score":0.8130000233650208},{"id":"https://openalex.org/keywords/nerve-growth-factor-receptor","display_name":"nerve growth factor receptor","score":0.6669999957084656},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.8009999990463257},{"id":"https://openalex.org/keywords/oncogenic-transformation","display_name":"oncogenic transformation","score":0.8169999718666077},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.6779999732971191}],"concepts":[{"id":"https://openalex.org/C50171091","wikidata":"https://www.wikidata.org/wiki/Q17917770","display_name":"EZH2","level":4,"score":0.6675294041633606},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6533294916152954},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.639897346496582},{"id":"https://openalex.org/C150425827","wikidata":"https://www.wikidata.org/wiki/Q2560317","display_name":"Histone methyltransferase","level":4,"score":0.43736207485198975},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.43301960825920105},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.38060763478279114},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.26570314168930054},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.23846325278282166},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13634154200553894},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09441807866096497}],"mesh":[{"descriptor_ui":"D000071221","descriptor_name":"Enhancer of Zeste Homolog 2 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006655","descriptor_name":"Histone Deacetylases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012512","descriptor_name":"Sarcoma, Ewing","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D012512","descriptor_name":"Sarcoma, Ewing","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015514","descriptor_name":"Oncogene Proteins, Fusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034802","descriptor_name":"RNA-Binding Protein EWS","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051789","descriptor_name":"Proto-Oncogene Protein c-fli-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054258","descriptor_name":"Neural Plate","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063151","descriptor_name":"Polycomb Repressive Complex 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1073/pnas.0810759106","doi":"https://doi.org/10.1073/pnas.0810759106","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0810759106","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:19289832","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19289832","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2656557","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2656557/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmh:oai:mediatum.ub.tum.de:node/976135","doi":null,"is_oa":false,"landing_page_url":"https://mediatum.ub.tum.de/976135","pdf_url":null,"source":{"id":"https://openalex.org/S4377196330","display_name":"mediaTUM  (Technical University of Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:opus-zb.helmholtz-muenchen.de:881","doi":null,"is_oa":false,"landing_page_url":"https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=881","pdf_url":null,"source":{"id":"https://openalex.org/S4377196115","display_name":"Site cant be reached","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc. Natl. Acad. Sci. U.S.A. 106, 5324-5329 (2009)","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2656557","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2656557/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1510180204","https://openalex.org/W1595661151","https://openalex.org/W1969670934","https://openalex.org/W1977621555","https://openalex.org/W1977836335","https://openalex.org/W1977937947","https://openalex.org/W1987402927","https://openalex.org/W1988184119","https://openalex.org/W1996487270","https://openalex.org/W2011684607","https://openalex.org/W2025309264","https://openalex.org/W2027739413","https://openalex.org/W2033392236","https://openalex.org/W2035239768","https://openalex.org/W2042087070","https://openalex.org/W2046516893","https://openalex.org/W2049607045","https://openalex.org/W2053421436","https://openalex.org/W2056524601","https://openalex.org/W2075179204","https://openalex.org/W2082138815","https://openalex.org/W2083009197","https://openalex.org/W2084860391","https://openalex.org/W2092261551","https://openalex.org/W2100365251","https://openalex.org/W2102249538","https://openalex.org/W2110050415","https://openalex.org/W2138712261","https://openalex.org/W2150926065","https://openalex.org/W2150946713","https://openalex.org/W2151526351","https://openalex.org/W2157795344","https://openalex.org/W2163374376","https://openalex.org/W2164220875","https://openalex.org/W2170210082","https://openalex.org/W2170984819","https://openalex.org/W2171439874","https://openalex.org/W4294107304","https://openalex.org/W6651612191","https://openalex.org/W7074230359","https://openalex.org/W7217022270"],"related_works":["https://openalex.org/W2531402976","https://openalex.org/W1973770222","https://openalex.org/W2748667632","https://openalex.org/W2329890411","https://openalex.org/W2756912699","https://openalex.org/W2313065565","https://openalex.org/W7014959370","https://openalex.org/W2563105197","https://openalex.org/W1187071477","https://openalex.org/W2403918887"],"abstract_inverted_index":{"Ewing":[0],"tumors":[1],"(ET)":[2],"are":[3,13],"highly":[4],"malignant,":[5],"localized":[6],"in":[7,50,58,72,78,90,98,107,135,145,163,183],"bone":[8],"or":[9],"soft":[10],"tissue,":[11],"and":[12,30,60,74,80,103,133,165,171,190],"molecularly":[14],"defined":[15],"by":[16,87,95,143,186],"ews/ets":[17],"translocations.":[18],"DNA":[19],"microarray":[20,125],"analysis":[21,126],"revealed":[22,138],"a":[23,180],"relationship":[24],"of":[25,37,41,54,85,127,194],"ET":[26,79,91,184],"to":[27,47,68,116],"both":[28],"endothelium":[29],"fetal":[31],"neural":[32],"crest.":[33],"We":[34],"identified":[35],"expression":[36,77],"histone":[38,120],"methyltransferase":[39],"enhancer":[40],"Zeste,":[42],"Drosophila,":[43],"Homolog":[44],"2":[45],"(EZH2)":[46],"be":[48,117],"increased":[49],"ET.":[51,146],"Suppressive":[52],"activity":[53],"EZH2":[55,70,76,86,128,144,147,177],"maintains":[56],"stemness":[57,149],"normal":[59],"malignant":[61],"cells.":[62,83],"Here,":[63],"we":[64],"found":[65],"EWS/FLI1":[66],"bound":[67],"the":[69,188],"promoter":[71],"vivo,":[73],"induced":[75],"mesenchymal":[81],"stem":[82,191],"Down-regulation":[84],"RNA":[88],"interference":[89],"suppressed":[92,106],"oncogenic":[93],"transformation":[94],"inhibiting":[96],"clonogenicity":[97],"vitro.":[99],"Similarly,":[100],"tumor":[101],"development":[102],"metastasis":[104],"was":[105,114],"immunodeficient":[108],"Rag2(-/-)gamma(C)(-/-)":[109],"mice.":[110],"EZH2-mediated":[111],"gene":[112],"silencing":[113],"shown":[115],"dependent":[118],"on":[119],"deacetylase":[121],"(HDAC)":[122],"activity.":[123],"Subsequent":[124],"knock":[129],"down,":[130],"HDAC-inhibitor":[131],"treatment":[132],"confirmation":[134],"independent":[136],"assays":[137],"an":[139],"undifferentiated":[140],"phenotype":[141,193],"maintained":[142],"regulated":[148],"genes":[150,161],"such":[151],"as":[152,158,160],"nerve":[153],"growth":[154],"factor":[155],"receptor":[156],"(NGFR),":[157],"well":[159],"involved":[162],"neuroectodermal":[164],"endothelial":[166],"differentiation":[167],"(EMP1,":[168],"EPHB2,":[169],"GFAP,":[170],"GAP43).":[172],"These":[173],"data":[174],"suggest":[175],"that":[176],"might":[178],"have":[179],"central":[181],"role":[182],"pathology":[185],"shaping":[187],"oncogenicity":[189],"cell":[192],"this":[195],"tumor.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":23},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":29},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":29},{"year":2013,"cited_by_count":20},{"year":2012,"cited_by_count":19}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
