{"id":"https://openalex.org/W1973191527","doi":"https://doi.org/10.1093/emboj/21.9.2139","title":"N\u2010methyl\u2010D\u2010aspartate receptor signaling results in Aurora kinase\u2010catalyzed CPEB phosphorylation and \u03b1CaMKII mRNA polyadenylation at synapses","display_name":"N\u2010methyl\u2010D\u2010aspartate receptor signaling results in Aurora kinase\u2010catalyzed CPEB phosphorylation and \u03b1CaMKII mRNA polyadenylation at synapses","publication_year":2002,"publication_date":"2002-05-01","ids":{"openalex":"https://openalex.org/W1973191527","doi":"https://doi.org/10.1093/emboj/21.9.2139","mag":"1973191527","pmid":"https://pubmed.ncbi.nlm.nih.gov/11980711","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/125376"},"language":"en","primary_location":{"id":"doi:10.1093/emboj/21.9.2139","doi":"https://doi.org/10.1093/emboj/21.9.2139","is_oa":true,"landing_page_url":"https://doi.org/10.1093/emboj/21.9.2139","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1093/emboj/21.9.2139","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1973191527"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1093/emboj/21.9.2139","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027427537","display_name":"Yi\u2010Shuian Huang","orcid":"https://orcid.org/0000-0001-9000-7748","observed_orcids":["https://orcid.org/0000-0001-9000-7748"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi\u2010Shuian Huang","raw_affiliation_strings":["Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mi\u2010Young Jung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mi\u2010Young Jung","raw_affiliation_strings":["Program in Molecular Medicine, University of Massachusetts Medical SchoolWorcesterMA01605USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Molecular Medicine, University of Massachusetts Medical SchoolWorcesterMA01605USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043994291","display_name":"Madathia Sarkissian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Madathia Sarkissian","raw_affiliation_strings":["Program in Molecular Medicine, University of Massachusetts Medical SchoolWorcesterMA01605USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Molecular Medicine, University of Massachusetts Medical SchoolWorcesterMA01605USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"last","author":{"id":null,"display_name":"Joel D. Richter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joel D. Richter","raw_affiliation_strings":["Program in Molecular Medicine, University of Massachusetts Medical SchoolWorcesterMA01605USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Molecular Medicine, University of Massachusetts Medical SchoolWorcesterMA01605USA","institution_ids":["https://openalex.org/I166722992"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I166722992"],"apc_list":{"value":7990,"currency":"USD","value_usd":7990},"apc_paid":null,"fwci":5.6779,"has_fulltext":true,"cited_by_count":270,"citation_normalized_percentile":{"value":0.97486171,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"21","issue":"9","first_page":"2139","last_page":"2148"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.6439999938011169,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.6439999938011169,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.32199999690055847,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.016499999910593033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nmda-receptor-signaling","display_name":"NMDA receptor signaling","score":0.9649999737739563},{"id":"https://openalex.org/keywords/aurora-kinases","display_name":"Aurora kinases","score":0.968999981880188},{"id":"https://openalex.org/keywords/cytoplasmic-polyadenylation","display_name":"cytoplasmic polyadenylation","score":0.9150000214576721},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.8859999775886536},{"id":"https://openalex.org/keywords/hippocampal-neurons","display_name":"hippocampal neurons","score":0.8500000238418579},{"id":"https://openalex.org/keywords/poly-a-polymerase","display_name":"poly(A) polymerase","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cleavage-and-polyadenylation-specificity-factor","display_name":"cleavage and polyadenylation specificity factor","score":0.972000002861023},{"id":"https://openalex.org/keywords/rna-binding-proteins","display_name":"RNA-binding proteins","score":0.7440000176429749}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8400753736495972},{"id":"https://openalex.org/C142575336","wikidata":"https://www.wikidata.org/wiki/Q412148","display_name":"Polyadenylation","level":4,"score":0.8079204559326172},{"id":"https://openalex.org/C62531158","wikidata":"https://www.wikidata.org/wiki/Q21100335","display_name":"Cleavage and polyadenylation specificity factor","level":5,"score":0.6079097986221313},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5522470474243164},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.5299281477928162},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.4636821150779724},{"id":"https://openalex.org/C67492840","wikidata":"https://www.wikidata.org/wiki/Q22326127","display_name":"Cleavage stimulation factor","level":5,"score":0.4627200961112976},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.44602102041244507},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.3566284775733948},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32339704036712646},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2363891899585724},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2105606496334076},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014981","descriptor_name":"Xenopus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D026723","descriptor_name":"Polyadenylation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D029867","descriptor_name":"Xenopus Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D039221","descriptor_name":"mRNA Cleavage and Polyadenylation Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054732","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinase Type 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064127","descriptor_name":"Aurora Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/emboj/21.9.2139","doi":"https://doi.org/10.1093/emboj/21.9.2139","is_oa":true,"landing_page_url":"https://doi.org/10.1093/emboj/21.9.2139","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1093/emboj/21.9.2139","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},{"id":"pmid:11980711","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11980711","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:125376","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC125376/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO J","raw_type":"Text"},{"id":"pmh:oai:escholarship.umassmed.edu:gsbs_sp-1553","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.umassmed.edu/gsbs_sp/554","pdf_url":null,"source":{"id":"https://openalex.org/S4306400883","display_name":"The Journal of the American Medical Association (JAMA) Network (American Medical Association)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173654999","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/I173654999"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Morningside Graduate School of Biomedical Sciences Student Publications","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1093/emboj/21.9.2139","doi":"https://doi.org/10.1093/emboj/21.9.2139","is_oa":true,"landing_page_url":"https://doi.org/10.1093/emboj/21.9.2139","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1093/emboj/21.9.2139","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6972568906","display_name":"CONTROL OF PROTEIN SYNTHESIS-DEPENDENT SYNAPTIC PLASTIC","funder_award_id":"P01NS039321","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1973191527.pdf","grobid_xml":"https://content.openalex.org/works/W1973191527.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W80205452","https://openalex.org/W634789460","https://openalex.org/W645770732","https://openalex.org/W1528493806","https://openalex.org/W1591026223","https://openalex.org/W1781445228","https://openalex.org/W1886278373","https://openalex.org/W1971633875","https://openalex.org/W1974753375","https://openalex.org/W1979496428","https://openalex.org/W1980084095","https://openalex.org/W1985046929","https://openalex.org/W1986699200","https://openalex.org/W1987030209","https://openalex.org/W1987105275","https://openalex.org/W1988432188","https://openalex.org/W1990118065","https://openalex.org/W2001442825","https://openalex.org/W2009514858","https://openalex.org/W2011599467","https://openalex.org/W2026998769","https://openalex.org/W2044273755","https://openalex.org/W2056994440","https://openalex.org/W2067722908","https://openalex.org/W2069246118","https://openalex.org/W2069930342","https://openalex.org/W2076658638","https://openalex.org/W2080252952","https://openalex.org/W2083820747","https://openalex.org/W2096473946","https://openalex.org/W2101336937","https://openalex.org/W2109851824","https://openalex.org/W2118654091","https://openalex.org/W2136667549","https://openalex.org/W2137429755","https://openalex.org/W2137433892","https://openalex.org/W2142862020","https://openalex.org/W2142979031","https://openalex.org/W2146686648","https://openalex.org/W2148256023","https://openalex.org/W2149155691","https://openalex.org/W2150443013","https://openalex.org/W2155166279","https://openalex.org/W2157497892","https://openalex.org/W2169423035","https://openalex.org/W4251911047"],"related_works":["https://openalex.org/W2603677239","https://openalex.org/W2118654091","https://openalex.org/W2044273755","https://openalex.org/W2071950386","https://openalex.org/W2158323020","https://openalex.org/W3015995681","https://openalex.org/W2141545756","https://openalex.org/W1966714844","https://openalex.org/W2042355101","https://openalex.org/W1991869273"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":23}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}