{"id":"https://openalex.org/W1973178457","doi":"https://doi.org/10.1002/path.1128","title":"Molecular cytogenetic differences between histological subtypes of malignant mesotheliomas: DNA cytometry and comparative genomic hybridization of 90 cases","display_name":"Molecular cytogenetic differences between histological subtypes of malignant mesotheliomas: DNA cytometry and comparative genomic hybridization of 90 cases","publication_year":2002,"publication_date":"2002-06-10","ids":{"openalex":"https://openalex.org/W1973178457","doi":"https://doi.org/10.1002/path.1128","mag":"1973178457","pmid":"https://pubmed.ncbi.nlm.nih.gov/12115883"},"language":"en","primary_location":{"id":"doi:10.1002/path.1128","doi":"https://doi.org/10.1002/path.1128","is_oa":false,"landing_page_url":"https://doi.org/10.1002/path.1128","pdf_url":null,"source":{"id":"https://openalex.org/S4394736614","display_name":"The Journal of Pathology","issn_l":"0022-3417","issn":["0022-3417","1096-9896"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082106843","display_name":"Michael Krismann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Krismann","raw_affiliation_strings":["Institute of Pathology and German Mesothelioma Registry, University Clinic, Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology and German Mesothelioma Registry, University Clinic, Bochum, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110082788","display_name":"Klaus\u2010Michael M\u00fcller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Klaus\u2010Michael M\u00fcller","raw_affiliation_strings":["Institute of Pathology and German Mesothelioma Registry, University Clinic, Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology and German Mesothelioma Registry, University Clinic, Bochum, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Malgorzata Jaworska","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Malgorzata Jaworska","raw_affiliation_strings":["Institute of Pathology and German Mesothelioma Registry, University Clinic, Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology and German Mesothelioma Registry, University Clinic, Bochum, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075945234","display_name":"Georg Johnen","orcid":"https://orcid.org/0000-0002-3773-5946","observed_orcids":["https://orcid.org/0000-0002-3773-5946"]},"institutions":[{"id":"https://openalex.org/I4210139845","display_name":"BG University Hospital Bergmannsheil Bochum","ror":"https://ror.org/04j9bvy88","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I4210139845"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Georg Johnen","raw_affiliation_strings":["Institute of Pathology and German Mesothelioma Registry, University Clinic, Bochum, Germany","Institute of Pathology, University Clinic Bergmannsheil Bochum, B\u00fcrkle\u2010de\u2010la\u2010Camp\u2010Platz 1, D\u201044789 Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology and German Mesothelioma Registry, University Clinic, Bochum, Germany","institution_ids":[]},{"raw_affiliation_string":"Institute of Pathology, University Clinic Bergmannsheil Bochum, B\u00fcrkle\u2010de\u2010la\u2010Camp\u2010Platz 1, D\u201044789 Bochum, Germany","institution_ids":["https://openalex.org/I4210139845"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5075945234"],"corresponding_institution_ids":["https://openalex.org/I4210139845"],"apc_list":{"value":5450,"currency":"USD","value_usd":5450},"apc_paid":null,"fwci":1.6827,"has_fulltext":false,"cited_by_count":66,"citation_normalized_percentile":{"value":0.84082959,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"197","issue":"3","first_page":"363","last_page":"371"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/malignant-mesothelioma","display_name":"malignant mesothelioma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/histological-subtypes","display_name":"histological subtypes","score":0.9940000176429749},{"id":"https://openalex.org/keywords/epithelioid-mesothelioma","display_name":"epithelioid mesothelioma","score":0.9750000238418579},{"id":"https://openalex.org/keywords/sarcomatoid-mesothelioma","display_name":"sarcomatoid mesothelioma","score":1.0},{"id":"https://openalex.org/keywords/biphasic-mesothelioma","display_name":"biphasic mesothelioma","score":0.9729999899864197},{"id":"https://openalex.org/keywords/aneuploidy","display_name":"aneuploidy","score":0.8799999952316284},{"id":"https://openalex.org/keywords/chromosomal-imbalances","display_name":"chromosomal imbalances","score":0.9629999995231628},{"id":"https://openalex.org/keywords/dna-cytometry","display_name":"DNA cytometry","score":0.6029999852180481},{"id":"https://openalex.org/keywords/comparative-genomic-hybridization","display_name":"comparative genomic hybridization","score":0.9610000252723694},{"id":"https://openalex.org/keywords/tumor-genomic-heterogeneity","display_name":"tumor genomic heterogeneity","score":0.5540000200271606},{"id":"https://openalex.org/keywords/amplicons","display_name":"amplicons","score":0.5960000157356262},{"id":"https://openalex.org/keywords/chromosome-9p21","display_name":"chromosome 9p21","score":0.7210000157356262},{"id":"https://openalex.org/keywords/chromosome-22q","display_name":"chromosome 22q","score":0.8849999904632568},{"id":"https://openalex.org/keywords/chromosome-17p","display_name":"chromosome 17p","score":0.7860000133514404}],"concepts":[{"id":"https://openalex.org/C124942203","wikidata":"https://www.wikidata.org/wiki/Q656638","display_name":"Comparative genomic hybridization","level":4,"score":0.8745769262313843},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8004252314567566},{"id":"https://openalex.org/C8185291","wikidata":"https://www.wikidata.org/wiki/Q2844457","display_name":"Amplicon","level":4,"score":0.6215850710868835},{"id":"https://openalex.org/C2779672484","wikidata":"https://www.wikidata.org/wiki/Q529622","display_name":"Aneuploidy","level":4,"score":0.5685938596725464},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5303493142127991},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.5138959884643555},{"id":"https://openalex.org/C53226629","wikidata":"https://www.wikidata.org/wiki/Q189967","display_name":"Karyotype","level":4,"score":0.5122489333152771},{"id":"https://openalex.org/C174475383","wikidata":"https://www.wikidata.org/wiki/Q246128","display_name":"Cytogenetics","level":4,"score":0.49950432777404785},{"id":"https://openalex.org/C17757408","wikidata":"https://www.wikidata.org/wiki/Q4135516","display_name":"genomic DNA","level":3,"score":0.45425111055374146},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.41894134879112244},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4169568419456482},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3062070608139038},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.21845632791519165},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19807052612304688},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07424655556678772}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008654","descriptor_name":"Mesothelioma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008654","descriptor_name":"Mesothelioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010534","descriptor_name":"Peritoneal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010534","descriptor_name":"Peritoneal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010997","descriptor_name":"Pleural Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010997","descriptor_name":"Pleural Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020732","descriptor_name":"Cytogenetic Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/path.1128","doi":"https://doi.org/10.1002/path.1128","is_oa":false,"landing_page_url":"https://doi.org/10.1002/path.1128","pdf_url":null,"source":{"id":"https://openalex.org/S4394736614","display_name":"The Journal of Pathology","issn_l":"0022-3417","issn":["0022-3417","1096-9896"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pathology","raw_type":"journal-article"},{"id":"pmid:12115883","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12115883","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of pathology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1513602342","https://openalex.org/W1547608553","https://openalex.org/W1553377466","https://openalex.org/W1609687385","https://openalex.org/W1909097318","https://openalex.org/W1916759441","https://openalex.org/W1964657899","https://openalex.org/W1968046362","https://openalex.org/W1972729636","https://openalex.org/W1991767969","https://openalex.org/W1996961433","https://openalex.org/W2013780823","https://openalex.org/W2026967566","https://openalex.org/W2038673291","https://openalex.org/W2043609794","https://openalex.org/W2058808716","https://openalex.org/W2059343899","https://openalex.org/W2074809432","https://openalex.org/W2075009035","https://openalex.org/W2077026583","https://openalex.org/W2100846507","https://openalex.org/W2113459016","https://openalex.org/W2125647452","https://openalex.org/W2133814361","https://openalex.org/W2153046265","https://openalex.org/W2414200173","https://openalex.org/W2435475339","https://openalex.org/W2462310577","https://openalex.org/W6992151464"],"related_works":["https://openalex.org/W2001074789","https://openalex.org/W2126166336","https://openalex.org/W1513602342","https://openalex.org/W2059343899","https://openalex.org/W2160072596","https://openalex.org/W4321366260","https://openalex.org/W2026967566","https://openalex.org/W2624989568","https://openalex.org/W2747110571","https://openalex.org/W1964657899"],"abstract_inverted_index":{"It":[0],"is":[1,195],"established":[2],"that":[3,207],"subtypes":[4],"of":[5,18,53,65,86,100,158,192,202,218,231,234],"human":[6],"malignant":[7],"mesotheliomas":[8],"(MM)":[9],"are":[10,112,141,166,171],"associated":[11],"with":[12,30,49,173,214],"different":[13],"survival":[14],"times.":[15],"Ninety":[16],"cases":[17],"MM":[19,90,165,194,208],"were":[20,81],"examined":[21],"using":[22],"DNA":[23,44],"cytometry":[24,45],"and":[25,39,58,135,149,163,224],"comparative":[26],"genomic":[27,101],"hybridization":[28],"(CGH),":[29],"emphasis":[31],"on":[32,74,143],"the":[33,50,56,59,62,115,156,159,174,229,235],"main":[34],"histological":[35],"subtypes;":[36],"epithelioid,":[37],"sarcomatoid":[38,60,164,193],"biphasic.":[40],"A":[41],"comparison":[42],"by":[43],"revealed":[46],"moderate":[47],"differences,":[48],"rare":[51],"subgroup":[52],"mesodermomas":[54],"having":[55],"highest":[57],"group":[61],"lowest":[63],"rate":[64],"aneuploidy.":[66],"Using":[67],"CGH,":[68],"6.2":[69],"chromosomal":[70,87,116,178,232],"imbalances":[71,233],"per":[72],"case":[73],"average":[75],"could":[76],"be":[77,104],"detected.":[78],"Losses":[79],"(4.1/case)":[80],"more":[82,197,226],"common":[83],"than":[84,198],"gains":[85,140],"material":[88],"(2.1/case).":[89],"show":[91,184],"no":[92],"single,":[93],"specific":[94],"defect,":[95],"but":[96],"a":[97,196,210,215],"typical":[98],"pattern":[99],"defects":[102,160],"can":[103],"attributed":[105],"to":[106],"this":[107],"tumour":[108,212],"entity.":[109],"Common":[110,139],"losses":[111],"clustered":[113],"at":[114],"regions":[117],"9p21":[118],"(34%),":[119],"22q":[120],"(32%),":[121],"4q31-32":[122],"(29%),":[123],"4p12-13":[124],"(25%),":[125],"14q12-24":[126],"(23%),":[127],"1p21":[128],"(21%),":[129],"13q13-14":[130],"(19%),":[131],"3p21,":[132],"6q22,":[133],"10p13-pter":[134],"17p12-pter":[136],"(16%":[137],"each).":[138,152],"located":[142],"8q22-23":[144],"(18%),":[145],"1q23/1q32":[146],"(16%),":[147],"7p14-15":[148],"15q22-25":[150],"(14%":[151],"While":[153],"differences":[154],"in":[155,222,228],"frequencies":[157],"between":[161],"epithelioid":[162],"not":[167],"as":[168,170,220],"pronounced":[169,189],"seen":[172],"pleomorphic":[175],"mesodermomas,":[176],"several":[177],"locations":[179],"(3p,":[180],"7q,":[181],"15q,":[182],"17p)":[183],"significant":[185],"variations.":[186],"The":[187],"most":[188],"distinguishing":[190],"feature":[191],"fourfold":[199],"higher":[200],"number":[201],"amplicons.":[203],"These":[204],"data":[205],"indicate":[206],"has":[209],"distinctive":[211],"biology":[213],"broad":[216],"spectrum":[217],"heterogeneity,":[219],"reflected":[221],"morphology":[223],"also,":[225],"subtly,":[227],"patterns":[230],"subtypes.":[236]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
