{"id":"https://openalex.org/W1973163757","doi":"https://doi.org/10.1016/0002-8703(84)90755-5","title":"Myocardial metabolic and hemodynamic effects of intravenous MDL-17,043, a new cardiotonic drug, in patients with chronic severe heart failure","display_name":"Myocardial metabolic and hemodynamic effects of intravenous MDL-17,043, a new cardiotonic drug, in patients with chronic severe heart failure","publication_year":1984,"publication_date":"1984-11-01","ids":{"openalex":"https://openalex.org/W1973163757","doi":"https://doi.org/10.1016/0002-8703(84)90755-5","mag":"1973163757","pmid":"https://pubmed.ncbi.nlm.nih.gov/6238513"},"language":"en","primary_location":{"id":"doi:10.1016/0002-8703(84)90755-5","doi":"https://doi.org/10.1016/0002-8703(84)90755-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0002-8703(84)90755-5","pdf_url":null,"source":{"id":"https://openalex.org/S46995015","display_name":"American Heart Journal","issn_l":"0002-8703","issn":["0002-8703","1097-6744"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Heart Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112155205","display_name":"Devendra K. Amin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Devendra K Amin","raw_affiliation_strings":["Department of Medicine, Cedars-Sinai Medical Center Los Angeles, Calif., USA","Division of Cardiology, Cedars-Sinai Medical Center Los Angeles, Calif., USA","UCLA School of Medicine Los Angeles, Calif., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Cedars-Sinai Medical Center Los Angeles, Calif., USA","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Division of Cardiology, Cedars-Sinai Medical Center Los Angeles, Calif., USA","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"UCLA School of Medicine Los Angeles, Calif., USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003094687","display_name":"Prediman K. Shah","orcid":"https://orcid.org/0000-0002-6351-8291","observed_orcids":["https://orcid.org/0000-0002-6351-8291"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Prediman K Shah","raw_affiliation_strings":["Department of Medicine, Cedars-Sinai Medical Center Los Angeles, Calif., USA","Division of Cardiology, Cedars-Sinai Medical Center Los Angeles, Calif., USA","UCLA School of Medicine Los Angeles, Calif., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Cedars-Sinai Medical Center Los Angeles, Calif., USA","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Division of Cardiology, Cedars-Sinai Medical Center Los Angeles, Calif., USA","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"UCLA School of Medicine Los Angeles, Calif., USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041257857","display_name":"Sharon Hulse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharon Hulse","raw_affiliation_strings":["Department of Medicine, Cedars-Sinai Medical Center Los Angeles, Calif., USA","Division of Cardiology, Cedars-Sinai Medical Center Los Angeles, Calif., USA","UCLA School of Medicine Los Angeles, Calif., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Cedars-Sinai Medical Center Los Angeles, Calif., USA","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Division of Cardiology, Cedars-Sinai Medical Center Los Angeles, Calif., USA","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"UCLA School of Medicine Los Angeles, Calif., USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029448792","display_name":"Frank G. Shellock","orcid":"https://orcid.org/0000-0002-6823-6031","observed_orcids":["https://orcid.org/0000-0002-6823-6031"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank G Shellock","raw_affiliation_strings":["Department of Medicine, Cedars-Sinai Medical Center Los Angeles, Calif., USA","Division of Cardiology, Cedars-Sinai Medical Center Los Angeles, Calif., USA","UCLA School of Medicine Los Angeles, Calif., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Cedars-Sinai Medical Center Los Angeles, Calif., USA","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Division of Cardiology, Cedars-Sinai Medical Center Los Angeles, Calif., USA","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"UCLA School of Medicine Los Angeles, Calif., USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110286485","display_name":"H.J.C. Swan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H.J.C Swan","raw_affiliation_strings":["Department of Medicine, Cedars-Sinai Medical Center Los Angeles, Calif., USA","Division of Cardiology, Cedars-Sinai Medical Center Los Angeles, Calif., USA","UCLA School of Medicine Los Angeles, Calif., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Cedars-Sinai Medical Center Los Angeles, Calif., USA","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Division of Cardiology, Cedars-Sinai Medical Center Los Angeles, Calif., USA","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"UCLA School of Medicine Los Angeles, Calif., USA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5003094687"],"corresponding_institution_ids":["https://openalex.org/I1282927834","https://openalex.org/I161318765"],"apc_list":{"value":4070,"currency":"USD","value_usd":4070},"apc_paid":null,"fwci":8.8339,"has_fulltext":false,"cited_by_count":75,"citation_normalized_percentile":{"value":0.98095424,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"108","issue":"5","first_page":"1285","last_page":"1292"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.8812999725341797,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.8812999725341797,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.07930000126361847,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inotropic-agents","display_name":"inotropic agents","score":0.46799999475479126},{"id":"https://openalex.org/keywords/vasodilators","display_name":"vasodilators","score":0.9039999842643738},{"id":"https://openalex.org/keywords/chronic-heart-failure","display_name":"chronic heart failure","score":0.8379999995231628},{"id":"https://openalex.org/keywords/myocardial-metabolism","display_name":"myocardial metabolism","score":0.8330000042915344},{"id":"https://openalex.org/keywords/myocardial-oxygen-consumption","display_name":"myocardial oxygen consumption","score":0.9350000023841858},{"id":"https://openalex.org/keywords/myocardial-efficiency","display_name":"myocardial efficiency","score":0.6890000104904175},{"id":"https://openalex.org/keywords/stroke-work-index","display_name":"stroke work index","score":0.8820000290870667},{"id":"https://openalex.org/keywords/left-ventricular-filling-pressure","display_name":"left ventricular filling pressure","score":0.8799999952316284},{"id":"https://openalex.org/keywords/systemic-vascular-resistance","display_name":"systemic vascular resistance","score":0.9879999756813049},{"id":"https://openalex.org/keywords/coronary-sinus-flow","display_name":"coronary sinus blood flow","score":0.8799999952316284},{"id":"https://openalex.org/keywords/myocardial-lactate-extraction","display_name":"myocardial lactate extraction","score":0.8799999952316284},{"id":"https://openalex.org/keywords/hemodynamic-effects","display_name":"hemodynamic effects","score":0.5600000023841858},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.3840000033378601}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8990399837493896},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.7428117990493774},{"id":"https://openalex.org/C31861589","wikidata":"https://www.wikidata.org/wiki/Q618068","display_name":"Cardiac index","level":4,"score":0.6991822123527527},{"id":"https://openalex.org/C139940330","wikidata":"https://www.wikidata.org/wiki/Q596579","display_name":"Cardiac output","level":3,"score":0.6679697036743164},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.6503466963768005},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6392350196838379},{"id":"https://openalex.org/C155710745","wikidata":"https://www.wikidata.org/wiki/Q575278","display_name":"Inotrope","level":2,"score":0.6120307445526123},{"id":"https://openalex.org/C80461066","wikidata":"https://www.wikidata.org/wiki/Q1698533","display_name":"Stroke volume","level":4,"score":0.6119541525840759},{"id":"https://openalex.org/C58245268","wikidata":"https://www.wikidata.org/wiki/Q456026","display_name":"Vascular resistance","level":3,"score":0.6076308488845825},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5934488773345947},{"id":"https://openalex.org/C2780685332","wikidata":"https://www.wikidata.org/wiki/Q4797550","display_name":"Arteriovenous oxygen difference","level":5,"score":0.5436701774597168},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.5036785006523132},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.4869340658187866},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4557878077030182},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3888779580593109}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001783","descriptor_name":"Blood Flow Velocity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002316","descriptor_name":"Cardiotonic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007263","descriptor_name":"Infusions, Parenteral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007773","descriptor_name":"Lactates","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017335","descriptor_name":"Enoximone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0002-8703(84)90755-5","doi":"https://doi.org/10.1016/0002-8703(84)90755-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0002-8703(84)90755-5","pdf_url":null,"source":{"id":"https://openalex.org/S46995015","display_name":"American Heart Journal","issn_l":"0002-8703","issn":["0002-8703","1097-6744"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Heart Journal","raw_type":"journal-article"},{"id":"pmid:6238513","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6238513","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American heart journal","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.979200005531311,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W26675341","https://openalex.org/W1577502712","https://openalex.org/W1968370421","https://openalex.org/W1978252024","https://openalex.org/W2017380495","https://openalex.org/W2024386613","https://openalex.org/W2034197345","https://openalex.org/W2038378301","https://openalex.org/W2039449043","https://openalex.org/W2055103382","https://openalex.org/W2058597127","https://openalex.org/W2068182585","https://openalex.org/W2076723747","https://openalex.org/W2095976535","https://openalex.org/W2140299723","https://openalex.org/W2312437912","https://openalex.org/W2322612078","https://openalex.org/W2336602334","https://openalex.org/W2408239957","https://openalex.org/W2462601490"],"related_works":["https://openalex.org/W2062252786","https://openalex.org/W2155689368","https://openalex.org/W1970205478","https://openalex.org/W2073740300","https://openalex.org/W2077417808","https://openalex.org/W2016105854","https://openalex.org/W2039449043","https://openalex.org/W1989524686","https://openalex.org/W2035377210","https://openalex.org/W2075876428"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}