{"id":"https://openalex.org/W1973158655","doi":"https://doi.org/10.1109/lissa.2009.4906706","title":"Endomicroscopy and biocompatible fluorescent nanocomplexes for clinical translation of high-resolution optical molecular imaging","display_name":"Endomicroscopy and biocompatible fluorescent nanocomplexes for clinical translation of high-resolution optical molecular imaging","publication_year":2009,"publication_date":"2009-04-01","ids":{"openalex":"https://openalex.org/W1973158655","doi":"https://doi.org/10.1109/lissa.2009.4906706","mag":"1973158655"},"language":"en","primary_location":{"id":"doi:10.1109/lissa.2009.4906706","doi":"https://doi.org/10.1109/lissa.2009.4906706","is_oa":false,"landing_page_url":"https://doi.org/10.1109/lissa.2009.4906706","pdf_url":null,"source":{"id":"https://openalex.org/S4306422796","display_name":"IEEE/NIH Life Science Systems and Applications Workshop","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 IEEE/NIH Life Science Systems and Applications Workshop","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109031304","display_name":"Jiefeng Xi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiefeng Xi","raw_affiliation_strings":["Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA","Department of Biomedical Engineering; Johns Hopkins University; Baltimore MD 21205 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Biomedical Engineering; Johns Hopkins University; Baltimore MD 21205 USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058148831","display_name":"Yicong Wu","orcid":"https://orcid.org/0000-0002-8819-7527","observed_orcids":["https://orcid.org/0000-0002-8819-7527"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yicong Wu","raw_affiliation_strings":["Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA","Department of Biomedical Engineering; Johns Hopkins University; Baltimore MD 21205 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Biomedical Engineering; Johns Hopkins University; Baltimore MD 21205 USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tae Hee Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tae Hee Kim","raw_affiliation_strings":["Department of Bioengineering, University of Washington, Seattle, WA, USA","Department of Bioengineering. University of Washington, Seattle 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Bioengineering. University of Washington, Seattle 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yongping Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yongping Chen","raw_affiliation_strings":["Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA","Department of Biomedical Engineering; Johns Hopkins University; Baltimore MD 21205 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Biomedical Engineering; Johns Hopkins University; Baltimore MD 21205 USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Desheng Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Desheng Zheng","raw_affiliation_strings":["Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA","Department of Biomedical Engineering; Johns Hopkins University; Baltimore MD 21205 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Biomedical Engineering; Johns Hopkins University; Baltimore MD 21205 USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083814030","display_name":"Li Huo","orcid":"https://orcid.org/0000-0003-3175-3702","observed_orcids":["https://orcid.org/0000-0003-3175-3702"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Huo","raw_affiliation_strings":["Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA","Department of Biomedical Engineering; Johns Hopkins University; Baltimore MD 21205 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Biomedical Engineering; Johns Hopkins University; Baltimore MD 21205 USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048031366","display_name":"Michael J. Cobb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Cobb","raw_affiliation_strings":["Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA","Department of Biomedical Engineering; Johns Hopkins University; Baltimore MD 21205 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Biomedical Engineering; Johns Hopkins University; Baltimore MD 21205 USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075083361","display_name":"Suzie Hwang Pun","orcid":"https://orcid.org/0000-0003-1443-4996","observed_orcids":["https://orcid.org/0000-0003-1443-4996"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suzie Pun","raw_affiliation_strings":["Department of Bioengineering, University of Washington, Seattle, WA, USA","Department of Bioengineering. University of Washington, Seattle 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Bioengineering. University of Washington, Seattle 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066929075","display_name":"Joo Ha Hwang","orcid":"https://orcid.org/0000-0002-7534-230X","observed_orcids":["https://orcid.org/0000-0002-7534-230X"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joo Ha Hwang","raw_affiliation_strings":["Department of Medicine, University of Washington, Seattle, WA, USA","Department of Medicine, University of Washington, Seattle 98195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle 98195, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014330564","display_name":"Xingde D. Li","orcid":"https://orcid.org/0000-0002-4725-3297","observed_orcids":["https://orcid.org/0000-0002-4725-3297"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xingde Li","raw_affiliation_strings":["Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA","Department of Biomedical Engineering; Johns Hopkins University; Baltimore MD 21205 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Biomedical Engineering; Johns Hopkins University; Baltimore MD 21205 USA","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09204123,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"83","issue":null,"first_page":"48","last_page":"51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11569","display_name":"Optical Coherence Tomography Applications","score":0.5253999829292297,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11569","display_name":"Optical Coherence Tomography Applications","score":0.5253999829292297,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.39750000834465027,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.01940000057220459,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/balloon-catheter","display_name":"balloon catheter","score":0.6269999742507935},{"id":"https://openalex.org/keywords/molecular-targeting","display_name":"molecular targeting","score":0.6240000128746033},{"id":"https://openalex.org/keywords/optical-molecular-imaging","display_name":"optical molecular imaging","score":0.9010000228881836},{"id":"https://openalex.org/keywords/clinical-translation","display_name":"clinical translation","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C17480853","wikidata":"https://www.wikidata.org/wiki/Q5376368","display_name":"Endomicroscopy","level":3,"score":0.8666524887084961},{"id":"https://openalex.org/C136339569","wikidata":"https://www.wikidata.org/wiki/Q1142297","display_name":"Molecular imaging","level":3,"score":0.5923700332641602},{"id":"https://openalex.org/C1318750","wikidata":"https://www.wikidata.org/wiki/Q865663","display_name":"Biocompatible material","level":2,"score":0.5710198879241943},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.551633894443512},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5030927062034607},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.4732395112514496},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.47127076983451843},{"id":"https://openalex.org/C92630104","wikidata":"https://www.wikidata.org/wiki/Q4115103","display_name":"Optical imaging","level":2,"score":0.4421662390232086},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.334919273853302},{"id":"https://openalex.org/C136009344","wikidata":"https://www.wikidata.org/wiki/Q336201","display_name":"Confocal","level":2,"score":0.26843512058258057},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.21049517393112183},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.18139630556106567},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16917747259140015},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09745928645133972},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/lissa.2009.4906706","doi":"https://doi.org/10.1109/lissa.2009.4906706","is_oa":false,"landing_page_url":"https://doi.org/10.1109/lissa.2009.4906706","pdf_url":null,"source":{"id":"https://openalex.org/S4306422796","display_name":"IEEE/NIH Life Science Systems and Applications Workshop","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 IEEE/NIH Life Science Systems and Applications Workshop","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1978456810","https://openalex.org/W2007822613","https://openalex.org/W2008400015","https://openalex.org/W2034219056","https://openalex.org/W2040143851","https://openalex.org/W2076584129","https://openalex.org/W2078082301","https://openalex.org/W2122380766","https://openalex.org/W2151643657"],"related_works":["https://openalex.org/W4242605419","https://openalex.org/W2009689861","https://openalex.org/W2018076386","https://openalex.org/W4250480609","https://openalex.org/W4238936962","https://openalex.org/W4416722524","https://openalex.org/W2060836714","https://openalex.org/W2147968210","https://openalex.org/W2032306104","https://openalex.org/W2125148946"],"abstract_inverted_index":{"This":[0],"paper":[1],"reports":[2],"on":[3],"our":[4,118],"recent":[5],"development":[6],"of":[7,9,18,34,38,57,146],"two-types":[8],"all-fiber-optic":[10],"scanning":[11],"endomicroscopy":[12,52,169],"technologies":[13,170],"for":[14,132,156,171],"high-resolution":[15,173],"optical":[16,174],"imaging":[17,33,141,176],"internal":[19,39],"organs.":[20],"The":[21,46],"first":[22],"one":[23],"is":[24,48],"an":[25],"OCT":[26],"balloon":[27],"catheter":[28],"technology":[29,53],"that":[30,54],"permits":[31],"systematic":[32],"fine":[35],"architectural":[36],"morphologies":[37],"luminal":[40],"organs":[41],"over":[42],"a":[43,49,62,69,80],"large":[44],"area.":[45],"second":[47],"two-photon":[50],"fluorescence":[51],"enables":[55],"assessment":[56],"tissue":[58,88],"biochemical/metabolic":[59],"information":[60,86],"with":[61,79,168],"superb":[63],"spatial":[64],"resolution.":[65],"Both":[66],"endomicroscopes":[67],"have":[68],"small":[70],"diameter":[71],"(1.2-2.4":[72],"mm)":[73],"and":[74,90,92,108,140,153,179],"can":[75,129,163],"be":[76,130,164],"readily":[77],"integrated":[78],"standard":[81],"clinical":[82,157],"gastroscope,":[83],"providing":[84],"complementary":[85],"about":[87],"structure":[89],"function":[91],"helping":[93],"improve":[94,137],"diagnostic":[95],"yield.":[96],"We":[97],"will":[98,115],"discuss":[99],"the":[100,160],"basic":[101],"design":[102],"principles,":[103],"major":[104],"engineering":[105],"challenges,":[106],"solutions,":[107],"some":[109],"preliminary":[110],"results.":[111],"In":[112],"addition,":[113],"we":[114],"also":[116],"present":[117],"approach":[119],"in":[120,166,177,180],"developing":[121],"near":[122],"infrared":[123],"(NIR)":[124],"fluorescent":[125],"nanocomplexes":[126,162],"(ICG-micelles),":[127],"which":[128],"functionalized":[131],"active":[133],"molecular":[134,138,175],"targeting":[135],"to":[136],"specificity":[139],"contrast.":[142],"These":[143],"nanocomplexes,":[144],"made":[145],"FDA":[147],"approved":[148],"building":[149],"blocks,":[150],"are":[151],"biocompatible":[152],"very":[154],"promising":[155],"translation.":[158],"Ultimately":[159],"NIR":[161],"used":[165],"conjunction":[167],"performing":[172],"vivo":[178],"real":[181],"time.":[182]},"counts_by_year":[],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2016-06-24T00:00:00"}