{"id":"https://openalex.org/W1973134689","doi":"https://doi.org/10.1016/j.tetlet.2009.03.083","title":"Synthesis of a COMC\u2013estradiol conjugate for targeted, tissue-selective cancer chemotherapy","display_name":"Synthesis of a COMC\u2013estradiol conjugate for targeted, tissue-selective cancer chemotherapy","publication_year":2009,"publication_date":"2009-03-17","ids":{"openalex":"https://openalex.org/W1973134689","doi":"https://doi.org/10.1016/j.tetlet.2009.03.083","mag":"1973134689"},"language":"en","primary_location":{"id":"doi:10.1016/j.tetlet.2009.03.083","doi":"https://doi.org/10.1016/j.tetlet.2009.03.083","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tetlet.2009.03.083","pdf_url":null,"source":{"id":"https://openalex.org/S133942674","display_name":"Tetrahedron Letters","issn_l":"0040-4039","issn":["0040-4039","1873-3581"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tetrahedron Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072328364","display_name":"Jennifer M. Oaksmith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Marie Oaksmith","raw_affiliation_strings":["Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, NY 14853-1301, United States","Department of Chemistry & Chemical Biology, Baker Laboratory, Cornell University, Ithaca, NY 14853-1301, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, NY 14853-1301, United States","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Department of Chemistry & Chemical Biology, Baker Laboratory, Cornell University, Ithaca, NY 14853-1301, United States","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035275755","display_name":"Bruce Ganem","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bruce Ganem","raw_affiliation_strings":["Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, NY 14853-1301, United States","Department of Chemistry & Chemical Biology, Baker Laboratory, Cornell University, Ithaca, NY 14853-1301, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, NY 14853-1301, United States","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Department of Chemistry & Chemical Biology, Baker Laboratory, Cornell University, Ithaca, NY 14853-1301, United States","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5035275755"],"corresponding_institution_ids":["https://openalex.org/I205783295"],"apc_list":{"value":3610,"currency":"USD","value_usd":3610},"apc_paid":null,"fwci":0.3225,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.55072789,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"50","issue":"26","first_page":"3497","last_page":"3498"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.7734000086784363,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.7734000086784363,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0674000009894371,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.03400000184774399,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclohexenones","display_name":"cyclohexenones","score":0.6869999766349792},{"id":"https://openalex.org/keywords/targeted-cancer-chemotherapy","display_name":"targeted cancer chemotherapy","score":0.5899999737739563},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.6269999742507935},{"id":"https://openalex.org/keywords/conjugate-synthesis","display_name":"conjugate synthesis","score":0.574999988079071},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9300280809402466},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.9136337637901306},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.611793577671051},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5905792713165283},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.400835245847702},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36970990896224976},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31698113679885864},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3130267262458801},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.tetlet.2009.03.083","doi":"https://doi.org/10.1016/j.tetlet.2009.03.083","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tetlet.2009.03.083","pdf_url":null,"source":{"id":"https://openalex.org/S133942674","display_name":"Tetrahedron Letters","issn_l":"0040-4039","issn":["0040-4039","1873-3581"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tetrahedron Letters","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1970119101","https://openalex.org/W1981753790","https://openalex.org/W1991908876","https://openalex.org/W1997301648","https://openalex.org/W1997371990","https://openalex.org/W2007331274","https://openalex.org/W2009024430","https://openalex.org/W2015118959","https://openalex.org/W2024010130","https://openalex.org/W2026247557","https://openalex.org/W2026322544","https://openalex.org/W2038339127","https://openalex.org/W2081313071","https://openalex.org/W2090873010","https://openalex.org/W2092325848","https://openalex.org/W2095093204","https://openalex.org/W2125984898","https://openalex.org/W2132061426","https://openalex.org/W2132185105","https://openalex.org/W4253809729"],"related_works":["https://openalex.org/W2072975653","https://openalex.org/W1981753790","https://openalex.org/W1991908876","https://openalex.org/W2317590132","https://openalex.org/W2273090795","https://openalex.org/W2058145547","https://openalex.org/W1973529052","https://openalex.org/W2373849236","https://openalex.org/W2306701052","https://openalex.org/W783453611"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}