{"id":"https://openalex.org/W1973117779","doi":"https://doi.org/10.1080/09553009514550501","title":"Effects of Topoisomerase I-targeted Drugs on Radiation Response of L5178Y Sublines Differentially Radiation and Drug Sensitive","display_name":"Effects of Topoisomerase I-targeted Drugs on Radiation Response of L5178Y Sublines Differentially Radiation and Drug Sensitive","publication_year":1995,"publication_date":"1995-01-01","ids":{"openalex":"https://openalex.org/W1973117779","doi":"https://doi.org/10.1080/09553009514550501","mag":"1973117779","pmid":"https://pubmed.ncbi.nlm.nih.gov/7738407"},"language":"en","primary_location":{"id":"doi:10.1080/09553009514550501","doi":"https://doi.org/10.1080/09553009514550501","is_oa":false,"landing_page_url":"https://doi.org/10.1080/09553009514550501","pdf_url":null,"source":{"id":"https://openalex.org/S44383424","display_name":"International Journal of Radiation Biology","issn_l":"0955-3002","issn":["0955-3002","1362-3095"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111674215","display_name":"I. Szumiel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097320","display_name":"Instytut Chemii i Techniki J\u0105drowej","ror":"https://ror.org/00w3hap50","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210097320"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"I. Szumiel","raw_affiliation_strings":["Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195, Warsaw, Poland","Institute of Nuclear Chemistry and Technology, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195, Warsaw, Poland","institution_ids":["https://openalex.org/I4210097320"]},{"raw_affiliation_string":"Institute of Nuclear Chemistry and Technology, Warsaw, Poland","institution_ids":["https://openalex.org/I4210097320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063175693","display_name":"Iwona Buraczewska","orcid":"https://orcid.org/0000-0002-2360-0186","observed_orcids":["https://orcid.org/0000-0002-2360-0186"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I. Buraczewska","raw_affiliation_strings":["Department of Radiotherapy, Center of Oncology, 31-134, Cracow, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiotherapy, Center of Oncology, 31-134, Cracow, Poland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065626665","display_name":"Iwona Gr\u0105dzka","orcid":"https://orcid.org/0000-0002-2860-9518","observed_orcids":["https://orcid.org/0000-0002-2860-9518"]},"institutions":[{"id":"https://openalex.org/I4210097320","display_name":"Instytut Chemii i Techniki J\u0105drowej","ror":"https://ror.org/00w3hap50","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210097320"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"I. Gradzka","raw_affiliation_strings":["Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195, Warsaw, Poland","institution_ids":["https://openalex.org/I4210097320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083992826","display_name":"Anna Gasi\u0144ska","orcid":"https://orcid.org/0000-0002-8421-4764","observed_orcids":["https://orcid.org/0000-0002-8421-4764"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Gasinska","raw_affiliation_strings":["Department of Radiotherapy, Center of Oncology, 31-134, Cracow, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiotherapy, Center of Oncology, 31-134, Cracow, Poland","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3112,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.46082696,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"67","issue":"4","first_page":"441","last_page":"448"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.0406000018119812,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.024700000882148743,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/topoisomerase-i-inhibitor","display_name":"topoisomerase I inhibitor","score":0.953000009059906},{"id":"https://openalex.org/keywords/camptothecin","display_name":"camptothecin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.6859999895095825},{"id":"https://openalex.org/keywords/radioresistance-biology","display_name":"radioresistance (biology)","score":0.8769999742507935},{"id":"https://openalex.org/keywords/dna-protein-cross-links","display_name":"DNA-protein crosslinks","score":0.8529999852180481},{"id":"https://openalex.org/keywords/cell-cycle-distribution","display_name":"cell cycle distribution","score":0.8130000233650208},{"id":"https://openalex.org/keywords/beta-lapachone","display_name":"\u03b2-lapachone","score":0.8600000143051147},{"id":"https://openalex.org/keywords/x-ray-irradiation","display_name":"X-ray irradiation","score":0.8299999833106995},{"id":"https://openalex.org/keywords/drug-radiation-interaction","display_name":"drug-radiation interaction","score":0.49399998784065247}],"concepts":[{"id":"https://openalex.org/C2779682216","wikidata":"https://www.wikidata.org/wiki/Q419964","display_name":"Camptothecin","level":2,"score":0.8754438161849976},{"id":"https://openalex.org/C147897179","wikidata":"https://www.wikidata.org/wiki/Q407828","display_name":"Topoisomerase","level":3,"score":0.8381856679916382},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5991198420524597},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.5464810132980347},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.46099594235420227},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44281861186027527},{"id":"https://openalex.org/C2778616834","wikidata":"https://www.wikidata.org/wiki/Q281044","display_name":"Topoisomerase inhibitor","level":4,"score":0.4422321021556854},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.440216600894928},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4344238042831421},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3819201588630676},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3568313717842102},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2522798776626587},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20074215531349182},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09834599494934082},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007940","descriptor_name":"Leukemia L5178","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007940","descriptor_name":"Leukemia L5178","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007940","descriptor_name":"Leukemia L5178","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D009285","descriptor_name":"Naphthoquinones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011836","descriptor_name":"Radiation Tolerance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011838","descriptor_name":"Radiation-Sensitizing Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059004","descriptor_name":"Topoisomerase I Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1080/09553009514550501","doi":"https://doi.org/10.1080/09553009514550501","is_oa":false,"landing_page_url":"https://doi.org/10.1080/09553009514550501","pdf_url":null,"source":{"id":"https://openalex.org/S44383424","display_name":"International Journal of Radiation Biology","issn_l":"0955-3002","issn":["0955-3002","1362-3095"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Biology","raw_type":"journal-article"},{"id":"pmid:7738407","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7738407","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of radiation biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1530401629","https://openalex.org/W1967555518","https://openalex.org/W1968975825","https://openalex.org/W1969551117","https://openalex.org/W1969718056","https://openalex.org/W1975025621","https://openalex.org/W1979532948","https://openalex.org/W1983532914","https://openalex.org/W1985729303","https://openalex.org/W1989367240","https://openalex.org/W1991068605","https://openalex.org/W1991666948","https://openalex.org/W1993397062","https://openalex.org/W2010658187","https://openalex.org/W2024028524","https://openalex.org/W2024815175","https://openalex.org/W2036511917","https://openalex.org/W2043703023","https://openalex.org/W2054111016","https://openalex.org/W2061955668","https://openalex.org/W2062114187","https://openalex.org/W2094885416","https://openalex.org/W2095534724","https://openalex.org/W2103012321","https://openalex.org/W2103444229","https://openalex.org/W2127533333","https://openalex.org/W2136887070","https://openalex.org/W2159921901","https://openalex.org/W2162232120","https://openalex.org/W2162277598","https://openalex.org/W2218826013","https://openalex.org/W4240610241","https://openalex.org/W4255244349"],"related_works":["https://openalex.org/W1968975825","https://openalex.org/W2025556845","https://openalex.org/W1975327657","https://openalex.org/W2087202363","https://openalex.org/W2084475570","https://openalex.org/W1997757896","https://openalex.org/W1993397062","https://openalex.org/W1985729303","https://openalex.org/W1967555518","https://openalex.org/W1991068605"],"abstract_inverted_index":{"The":[0,81,145],"murine":[1],"L5178Y":[2],"(LY)":[3],"lymphoma":[4],"sublines,":[5],"LY-R":[6,35,115],"(radiation":[7,11],"resistant)":[8],"and":[9,78,89,133,159],"LY-S":[10,21,47,55,108],"sensitive)":[12],"display":[13],"a":[14],"difference":[15],"in":[16,54,85,93],"susceptibility":[17],"to":[18,26,152,162],"camptothecin":[19],"(CPT):":[20],"cells":[22,56,94,109,116],"are":[23,147],"less":[24],"sensitive":[25,151],"killing":[27],"by":[28,142,164],"this":[29],"inhibitor":[30],"of":[31,61,76,83,129,136,140],"topoisomerase":[32,156],"I":[33,157],"than":[34,72],"cells.":[36,48],"Post-treatment":[37],"(CPT":[38],"present":[39],"until":[40],"3":[41],"h":[42],"after":[43,65],"irradiation)":[44],"sensitizes":[45],"only":[46,53],"In":[49],"agreement":[50],"with":[51,67,167],"this,":[52],"is":[57,99],"the":[58,86,127,134,137,168],"relative":[59],"number":[60],"DNA-protein":[62],"cross-links":[63],"formed":[64],"treatment":[66,98,166],"CPT":[68,143],"+":[69],"X":[70],"higher":[71],"expected":[73],"for":[74,104,107,112,114,119],"additivity":[75],"X-ray":[77],"CPT-induced":[79],"damage.":[80],"pattern":[82],"changes":[84],"labelling":[87],"indices":[88],"cell":[90,130],"cycle":[91,131],"distribution":[92],"that":[95,102,111,118],"underwent":[96],"combined":[97],"essentially":[100],"like":[101,110,117],"seen":[103],"single-agent":[105],"treatment:":[106],"radiation,":[113],"CPT.":[120],"We":[121],"found":[122],"no":[123],"direct":[124],"relation":[125],"between":[126],"patterns":[128],"distributions":[132],"enhancement":[135],"lethal":[138],"effect":[139],"X-irradiation":[141],"post-treatment.":[144],"sublines":[146],"not":[148,160],"markedly":[149],"differentially":[150],"beta-lapachone,":[153],"which":[154],"modifies":[155],"activity,":[158],"sensitized":[161],"X-rays":[163],"post-irradiation":[165],"drug.":[169]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}