{"id":"https://openalex.org/W1973100767","doi":"https://doi.org/10.1002/bdrb.10055","title":"Chemically induced supernumerary lumbar ribs in CD\u20101 mice: Size distribution and dose response","display_name":"Chemically induced supernumerary lumbar ribs in CD\u20101 mice: Size distribution and dose response","publication_year":2004,"publication_date":"2004-02-01","ids":{"openalex":"https://openalex.org/W1973100767","doi":"https://doi.org/10.1002/bdrb.10055","mag":"1973100767","pmid":"https://pubmed.ncbi.nlm.nih.gov/14991907"},"language":"en","primary_location":{"id":"doi:10.1002/bdrb.10055","doi":"https://doi.org/10.1002/bdrb.10055","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bdrb.10055","pdf_url":null,"source":{"id":"https://openalex.org/S4394736883","display_name":"Birth Defects Research Part B Developmental and Reproductive Toxicology","issn_l":"1542-9733","issn":["1542-9733","1542-9741"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","norway-1","poland-40"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Birth Defects Research Part B: Developmental and Reproductive Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083702469","display_name":"John M. Rogers","orcid":"https://orcid.org/0000-0002-5881-1768","observed_orcids":["https://orcid.org/0000-0002-5881-1768"]},"institutions":[{"id":"https://openalex.org/I1302368450","display_name":"Environmental Protection Agency","ror":"https://ror.org/03tns0030","country_code":"US","type":"government","lineage":["https://openalex.org/I1302368450"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John M. Rogers","raw_affiliation_strings":["Developmental Biology Branch, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA. rogers.john@epa.gov","Developmental Biology Branch and Biostatistics Branch, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Biology Branch, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA. rogers.john@epa.gov","institution_ids":["https://openalex.org/I1302368450"]},{"raw_affiliation_string":"Developmental Biology Branch and Biostatistics Branch, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina","institution_ids":["https://openalex.org/I1302368450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000434134","display_name":"R. Woodrow Setzer","orcid":"https://orcid.org/0000-0002-6709-9186","observed_orcids":["https://orcid.org/0000-0002-6709-9186"]},"institutions":[{"id":"https://openalex.org/I1302368450","display_name":"Environmental Protection Agency","ror":"https://ror.org/03tns0030","country_code":"US","type":"government","lineage":["https://openalex.org/I1302368450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Woodrow Setzer","raw_affiliation_strings":["Biostatistics Branch, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics Branch, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina","institution_ids":["https://openalex.org/I1302368450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015088296","display_name":"Stacy Branch","orcid":"https://orcid.org/0000-0002-1048-6097","observed_orcids":["https://orcid.org/0000-0002-1048-6097"]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stacy Branch","raw_affiliation_strings":["Department of Toxicology, North Carolina State University Raleigh, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Toxicology, North Carolina State University Raleigh, North Carolina","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025952841","display_name":"Neil Chernoff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302368450","display_name":"Environmental Protection Agency","ror":"https://ror.org/03tns0030","country_code":"US","type":"government","lineage":["https://openalex.org/I1302368450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neil Chernoff","raw_affiliation_strings":["Developmental Biology Branch and Biostatistics Branch, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Biology Branch and Biostatistics Branch, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina","institution_ids":["https://openalex.org/I1302368450"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5083702469"],"corresponding_institution_ids":["https://openalex.org/I1302368450"],"apc_list":null,"apc_paid":null,"fwci":1.5476,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.81658537,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"71","issue":"1","first_page":"17","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.9272000193595886,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.9272000193595886,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.021199999377131462,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.014399999752640724,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/supernumerary-ribs","display_name":"supernumerary ribs","score":0.984000027179718},{"id":"https://openalex.org/keywords/developmental-toxicity","display_name":"developmental toxicity","score":0.628000020980835},{"id":"https://openalex.org/keywords/benomyl","display_name":"benomyl","score":0.7860000133514404},{"id":"https://openalex.org/keywords/dinoseb","display_name":"dinoseb","score":0.9980000257492065},{"id":"https://openalex.org/keywords/2-methoxyethanol","display_name":"2-methoxyethanol","score":0.9940000176429749},{"id":"https://openalex.org/keywords/valproic-acid","display_name":"valproic acid","score":1.0},{"id":"https://openalex.org/keywords/cd-1-mice","display_name":"ICR mice","score":0.7490000128746033},{"id":"https://openalex.org/keywords/prenatal-exposure","display_name":"prenatal exposure","score":0.414000004529953},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.7059999704360962},{"id":"https://openalex.org/keywords/congenital-malformations","display_name":"congenital malformations","score":0.6449999809265137},{"id":"https://openalex.org/keywords/risk-assessment","display_name":"risk assessment","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C2780610479","wikidata":"https://www.wikidata.org/wiki/Q7644068","display_name":"Supernumerary","level":2,"score":0.7892817258834839},{"id":"https://openalex.org/C179335377","wikidata":"https://www.wikidata.org/wiki/Q5266825","display_name":"Developmental toxicity","level":4,"score":0.6678886413574219},{"id":"https://openalex.org/C160306043","wikidata":"https://www.wikidata.org/wiki/Q2576226","display_name":"Rib cage","level":2,"score":0.5505594611167908},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5253157615661621},{"id":"https://openalex.org/C110121322","wikidata":"https://www.wikidata.org/wiki/Q865811","display_name":"Distribution (mathematics)","level":2,"score":0.4764828383922577},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.46991339325904846},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38483020663261414},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.38129720091819763},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3308635950088501},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2777210474014282},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2696687877178192},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1769551932811737},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1555871069431305},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.11249026656150818},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000014","descriptor_name":"Abnormalities, Drug-Induced","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000014","descriptor_name":"Abnormalities, Drug-Induced","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001542","descriptor_name":"Benomyl","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005026","descriptor_name":"Ethylene Glycols","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D005314","descriptor_name":"Embryonic and Fetal Development","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008161","descriptor_name":"Lumbosacral Region","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":false},{"descriptor_ui":"D012272","descriptor_name":"Ribs","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":true},{"descriptor_ui":"D013723","descriptor_name":"Teratogens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D014635","descriptor_name":"Valproic Acid","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D019297","descriptor_name":"2,4-Dinitrophenol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D019297","descriptor_name":"2,4-Dinitrophenol","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/bdrb.10055","doi":"https://doi.org/10.1002/bdrb.10055","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bdrb.10055","pdf_url":null,"source":{"id":"https://openalex.org/S4394736883","display_name":"Birth Defects Research Part B Developmental and Reproductive Toxicology","issn_l":"1542-9733","issn":["1542-9733","1542-9741"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","norway-1","poland-40"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Birth Defects Research Part B: Developmental and Reproductive Toxicology","raw_type":"journal-article"},{"id":"pmid:14991907","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14991907","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Birth defects research. Part B, Developmental and reproductive toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7997000217437744,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1513618424","https://openalex.org/W1969761972","https://openalex.org/W1972162864","https://openalex.org/W1976274041","https://openalex.org/W1977228369","https://openalex.org/W1990688856","https://openalex.org/W1996919521","https://openalex.org/W2009591915","https://openalex.org/W2047041872","https://openalex.org/W2049997726","https://openalex.org/W2058983330","https://openalex.org/W2088210995","https://openalex.org/W2095921953","https://openalex.org/W2107755320","https://openalex.org/W2121502130","https://openalex.org/W2123151350","https://openalex.org/W2144209290","https://openalex.org/W2151187751","https://openalex.org/W4233014035","https://openalex.org/W4242212377","https://openalex.org/W4300127172"],"related_works":["https://openalex.org/W4238037320","https://openalex.org/W1976274041","https://openalex.org/W2144209290","https://openalex.org/W1996561275","https://openalex.org/W7097932833","https://openalex.org/W245570637","https://openalex.org/W2092720285","https://openalex.org/W1996919521","https://openalex.org/W2121502130","https://openalex.org/W2123151350"],"abstract_inverted_index":{"Supernumerary":[0],"ribs":[1,141],"(SNR)":[2],"of":[3,17,72,114,133,139,151,154,157,165],"differing":[4],"sizes":[5],"are":[6],"commonly":[7],"observed":[8],"in":[9,20,22,32,34,76,80,99,159,190],"rodent":[10],"developmental":[11,181,191],"toxicity":[12,192],"studies,":[13],"and":[14,78,96,102,127,162,175,183,187],"the":[15,81,137,152,163,171],"significance":[16],"treatment-related":[18],"increases":[19,31],"SNR":[21,33,73,85,158,177],"standard":[23],"studies":[24,193],"has":[25],"been":[26],"contentious.":[27],"We":[28],"induced":[29,129],"dose-related":[30,131],"fetal":[35],"CD-1":[36],"mice":[37],"by":[38],"treating":[39],"on":[40,106],"gestation":[41],"days":[42],"7-8":[43],"with":[44,91],"benomyl":[45],"(BEN;":[46],"0,":[47,53,59,67],"75,":[48,60],"150":[49,61],"mg/kg/d),":[50,62],"dinoseb":[51],"(DIN;":[52],"30,":[54],"50":[55],"mg/kg/d);":[56],"2-methoxyethanol":[57],"(2-ME;":[58],"or":[63],"valproic":[64],"acid":[65],"(VPA;":[66],"125,":[68],"250":[69],"mg/kg/d).":[70],"Incidences":[71],"were":[74],"9.3-27.6%":[75],"controls":[77],"19.3-84.4%":[79],"high":[82],"dosage":[83],"groups.":[84,104],"length":[86,107,113],"showed":[87],"a":[88,130,160],"bimodal":[89],"distribution":[90],"peaks":[92],"at":[93,143],"0.3-0.4":[94],"mm":[95,98,116],"0.9-1.1":[97],"both":[100],"treated":[101],"control":[103,144],"Based":[105],"distributions,":[108],"we":[109],"used":[110],"an":[111],"actual":[112],"0.6":[115],"to":[117],"separate":[118,180],"short":[119],"(rudimentary)":[120],"from":[121],"long":[122],"(extra)":[123],"SNR.":[124],"DIN,":[125],"2-ME,":[126],"VPA":[128],"increase":[132],"extra":[134,174],"ribs,":[135],"while":[136],"incidence":[138],"rudimentary":[140,176],"remained":[142],"levels.":[145],"There":[146],"was":[147],"no":[148],"apparent":[149],"correlation":[150],"presence":[153],"either":[155],"type":[156],"fetus":[161],"occurrence":[164],"other":[166],"anomalies.":[167],"These":[168],"data":[169],"support":[170],"idea":[172],"that":[173],"may":[178],"reflect":[179],"phenomena,":[182],"should":[184],"be":[185],"considered":[186],"reported":[188],"separately":[189],"for":[194],"risk":[195],"assessment.":[196]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}