{"id":"https://openalex.org/W1973075403","doi":"https://doi.org/10.1073/pnas.0400778101","title":"Identification of a major locus for age-related cortical cataract on chromosome 6p12-q12 in the Beaver Dam Eye Study","display_name":"Identification of a major locus for age-related cortical cataract on chromosome 6p12-q12 in the Beaver Dam Eye Study","publication_year":2004,"publication_date":"2004-09-27","ids":{"openalex":"https://openalex.org/W1973075403","doi":"https://doi.org/10.1073/pnas.0400778101","mag":"1973075403","pmid":"https://pubmed.ncbi.nlm.nih.gov/15452352","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/521942"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0400778101","doi":"https://doi.org/10.1073/pnas.0400778101","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0400778101","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/521942","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034748018","display_name":"Sudha K. Iyengar","orcid":"https://orcid.org/0000-0001-7488-250X","observed_orcids":["https://orcid.org/0000-0001-7488-250X"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sudha K. Iyengar","raw_affiliation_strings":["Departments of Epidemiology and Biostatistics and Ophthalmology, Case Western Reserve University, Cleveland, OH 44106; and Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI 53792"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Epidemiology and Biostatistics and Ophthalmology, Case Western Reserve University, Cleveland, OH 44106; and Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI 53792","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061631272","display_name":"Ronald Klein","orcid":"https://orcid.org/0000-0002-4428-6237","observed_orcids":["https://orcid.org/0000-0002-4428-6237"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara E. K. Klein","raw_affiliation_strings":["Departments of Epidemiology and Biostatistics and Ophthalmology, Case Western Reserve University, Cleveland, OH 44106; and Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI 53792"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Epidemiology and Biostatistics and Ophthalmology, Case Western Reserve University, Cleveland, OH 44106; and Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI 53792","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061631272","display_name":"Ronald Klein","orcid":"https://orcid.org/0000-0002-4428-6237","observed_orcids":["https://orcid.org/0000-0002-4428-6237"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald Klein","raw_affiliation_strings":["Departments of Epidemiology and Biostatistics and Ophthalmology, Case Western Reserve University, Cleveland, OH 44106; and Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI 53792"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Epidemiology and Biostatistics and Ophthalmology, Case Western Reserve University, Cleveland, OH 44106; and Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI 53792","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035614830","display_name":"Gyungah Jun","orcid":"https://orcid.org/0000-0002-3230-8697","observed_orcids":["https://orcid.org/0000-0002-3230-8697"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gyungah Jun","raw_affiliation_strings":["Departments of Epidemiology and Biostatistics and Ophthalmology, Case Western Reserve University, Cleveland, OH 44106; and Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI 53792"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Epidemiology and Biostatistics and Ophthalmology, Case Western Reserve University, Cleveland, OH 44106; and Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI 53792","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045045659","display_name":"James H. Schick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James H. Schick","raw_affiliation_strings":["Departments of Epidemiology and Biostatistics and Ophthalmology, Case Western Reserve University, Cleveland, OH 44106; and Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI 53792"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Epidemiology and Biostatistics and Ophthalmology, Case Western Reserve University, Cleveland, OH 44106; and Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI 53792","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Christopher Millard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Millard","raw_affiliation_strings":["Departments of Epidemiology and Biostatistics and Ophthalmology, Case Western Reserve University, Cleveland, OH 44106; and Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI 53792"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Epidemiology and Biostatistics and Ophthalmology, Case Western Reserve University, Cleveland, OH 44106; and Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI 53792","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014750091","display_name":"Rachel Liptak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel Liptak","raw_affiliation_strings":["Departments of Epidemiology and Biostatistics and Ophthalmology, Case Western Reserve University, Cleveland, OH 44106; and Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI 53792"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Epidemiology and Biostatistics and Ophthalmology, Case Western Reserve University, Cleveland, OH 44106; and Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI 53792","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087987189","display_name":"Karlie Russo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karlie Russo","raw_affiliation_strings":["Departments of Epidemiology and Biostatistics and Ophthalmology, Case Western Reserve University, Cleveland, OH 44106; and Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI 53792"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Epidemiology and Biostatistics and Ophthalmology, Case Western Reserve University, Cleveland, OH 44106; and Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI 53792","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024539691","display_name":"Kristine E. Lee","orcid":"https://orcid.org/0000-0002-9102-4627","observed_orcids":["https://orcid.org/0000-0002-9102-4627"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristine E. Lee","raw_affiliation_strings":["Departments of Epidemiology and Biostatistics and Ophthalmology, Case Western Reserve University, Cleveland, OH 44106; and Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI 53792"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Epidemiology and Biostatistics and Ophthalmology, Case Western Reserve University, Cleveland, OH 44106; and Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI 53792","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008471831","display_name":"Robert C. Elston","orcid":"https://orcid.org/0000-0002-4743-8531","observed_orcids":["https://orcid.org/0000-0002-4743-8531"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert C. Elston","raw_affiliation_strings":["Departments of Epidemiology and Biostatistics and Ophthalmology, Case Western Reserve University, Cleveland, OH 44106; and Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI 53792"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Epidemiology and Biostatistics and Ophthalmology, Case Western Reserve University, Cleveland, OH 44106; and Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI 53792","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.6248,"has_fulltext":false,"cited_by_count":74,"citation_normalized_percentile":{"value":0.89768925,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"101","issue":"40","first_page":"14485","last_page":"14490"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.7782999873161316,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.7782999873161316,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.06599999964237213,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.04729999974370003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/susceptibility-loci","display_name":"genetic susceptibility loci","score":0.6520000100135803},{"id":"https://openalex.org/keywords/genome-wide-linkage-analysis","display_name":"genome-wide linkage analysis","score":0.7070000171661377},{"id":"https://openalex.org/keywords/fine-mapping","display_name":"fine mapping","score":0.7710000276565552},{"id":"https://openalex.org/keywords/beaver-dam-eye-study","display_name":"Beaver Dam Eye Study","score":0.902999997138977},{"id":"https://openalex.org/keywords/sib-pair-analysis","display_name":"sib-pair analysis","score":0.6589999794960022},{"id":"https://openalex.org/keywords/visual-impairment","display_name":"visual impairment","score":0.38100001215934753}],"concepts":[{"id":"https://openalex.org/C2780225610","wikidata":"https://www.wikidata.org/wiki/Q127724","display_name":"Cataracts","level":2,"score":0.8456491231918335},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6853780746459961},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.6753457188606262},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5630520582199097},{"id":"https://openalex.org/C142870003","wikidata":"https://www.wikidata.org/wiki/Q843863","display_name":"Genetic linkage","level":3,"score":0.5443735122680664},{"id":"https://openalex.org/C130693829","wikidata":"https://www.wikidata.org/wiki/Q510786","display_name":"Chromosome 19","level":4,"score":0.43709269165992737},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.37108632922172546},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.25063973665237427}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002386","descriptor_name":"Cataract","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002896","descriptor_name":"Chromosomes, Human, Pair 6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014922","descriptor_name":"Wisconsin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.0400778101","doi":"https://doi.org/10.1073/pnas.0400778101","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0400778101","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1993452","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/521942","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:521942","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/521942","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:15452352","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15452352","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1993452","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/521942","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1097323614","display_name":null,"funder_award_id":"GM-28356","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2882500740","display_name":"Human Genetic Analysis Resource","funder_award_id":"P41RR003655","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3133591713","display_name":"Genetic Analysis of Multifactorial Traits","funder_award_id":"R37GM028356","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3747377097","display_name":"Epidemiology of Age-related Macular Degeneration and Other Retinal Diseases","funder_award_id":"U10EY006594","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G4573245855","display_name":"Biometric Genetic Analysis of CardiopulmonaryDisease","funder_award_id":"T32HL007567","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G467719950","display_name":"GENETIC ANALYSIS OF MULTIFACTORIAL TRAITS","funder_award_id":"R01GM028356","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G641053335","display_name":"LINKAGE STUDIES OF AGE RELATED OCULAR DISORDERS","funder_award_id":"R01EY010605","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W4362793","https://openalex.org/W121540244","https://openalex.org/W122360965","https://openalex.org/W129305155","https://openalex.org/W133964162","https://openalex.org/W1590772693","https://openalex.org/W1605505097","https://openalex.org/W1744641194","https://openalex.org/W1766032241","https://openalex.org/W1964511379","https://openalex.org/W1970189083","https://openalex.org/W1973676412","https://openalex.org/W1976741643","https://openalex.org/W1977104259","https://openalex.org/W1979558522","https://openalex.org/W1979852819","https://openalex.org/W1986193081","https://openalex.org/W1992563221","https://openalex.org/W1993529515","https://openalex.org/W1995506875","https://openalex.org/W2004617457","https://openalex.org/W2005511088","https://openalex.org/W2010013694","https://openalex.org/W2013867274","https://openalex.org/W2013935385","https://openalex.org/W2016439933","https://openalex.org/W2020967643","https://openalex.org/W2031675408","https://openalex.org/W2050087227","https://openalex.org/W2051414935","https://openalex.org/W2068553992","https://openalex.org/W2090951971","https://openalex.org/W2099377210","https://openalex.org/W2105200825","https://openalex.org/W2105409288","https://openalex.org/W2106879392","https://openalex.org/W2107254532","https://openalex.org/W2112786757","https://openalex.org/W2114490649","https://openalex.org/W2118094114","https://openalex.org/W2127532617","https://openalex.org/W2135983365","https://openalex.org/W2149715144","https://openalex.org/W2154702101","https://openalex.org/W2157487201","https://openalex.org/W2162103288","https://openalex.org/W2166969259","https://openalex.org/W2170278458","https://openalex.org/W2305149488","https://openalex.org/W2333035725","https://openalex.org/W2336047139","https://openalex.org/W2540687437","https://openalex.org/W4232531025","https://openalex.org/W4234404675","https://openalex.org/W4253047841","https://openalex.org/W4300997042","https://openalex.org/W6601559548"],"related_works":["https://openalex.org/W2333840039","https://openalex.org/W2991987599","https://openalex.org/W3017786100","https://openalex.org/W133964162","https://openalex.org/W1410608457","https://openalex.org/W1491334837","https://openalex.org/W990158525","https://openalex.org/W7213972230","https://openalex.org/W2783677241","https://openalex.org/W2101461562"],"abstract_inverted_index":{"Age-related":[0],"cataracts":[1,194],"are":[2,120],"one":[3],"of":[4,8,50,79,122,131,176,199],"the":[5,14,24,60,106,132,152,165,207],"leading":[6],"causes":[7],"visual":[9],"impairment":[10],"and":[11,65,96,117,151,169],"blindness":[12],"among":[13],"elderly":[15],"worldwide.":[16],"Among":[17],"age-related":[18,192,217],"cataracts,":[19,45],"cortical":[20,44,80,193],"opacities":[21],"rank":[22],"as":[23],"second":[25],"most":[26],"common":[27],"type;":[28],"however,":[29],"little":[30],"is":[31],"known":[32],"about":[33],"their":[34],"molecular":[35],"pathogenesis":[36],"or":[37,126,129,136,216],"genetics.":[38],"To":[39],"identify":[40],"susceptibility":[41],"loci":[42],"for":[43,72,85,148,191],"we":[46],"genotyped":[47],"a":[48,67,76],"subset":[49],"families":[51],"(102":[52],"families;":[53],"n":[54],"=":[55,127,137],"224":[56],"sib":[57],"pairs)":[58],"from":[59],"Beaver":[61],"Dam":[62],"Eye":[63],"Study":[64],"performed":[66],"model-free":[68],"genome-wide":[69],"linkage":[70,86,123,177],"analysis":[71],"markers":[73,163],"linked":[74],"to":[75,157,197],"quantitative":[77],"measure":[78],"opacity.":[81],"We":[82],"obtained":[83],"evidence":[84,175],"at":[87,97,182],"marker":[88,98],"D1S1622":[89],"on":[90,100,112,143,179],"chromosome":[91,180],"1p35":[92],"(P":[93,102,124,184],"<":[94,103,125,185],"0.0002)":[95],"D6S1053":[99,183],"6q12":[101],"0.00008)":[104],"in":[105,164,206,214],"initial":[107],"scan.":[108],"Five":[109],"additional":[110],"regions":[111,204],"1q31,":[113],"2p24,":[114],"2q11,":[115],"4q28,":[116],"15q13":[118],"that":[119],"suggestive":[121],"0.01":[128],"logarithm":[130],"likelihood":[133],"ratio":[134],">":[135],"1.18)":[138],"were":[139],"observed.":[140],"The":[141,187],"region":[142],"chromosomes":[144],"6p12-q12":[145,181],"was":[146,155],"selected":[147],"fine":[149,172],"mapping,":[150,173],"intermarker":[153],"distance":[154],"reduced":[156],"3":[158],"cM":[159],"by":[160],"adding":[161],"11":[162],"interval":[166],"between":[167],"D6S1017":[168],"D6S1021.":[170],"After":[171],"significant":[174],"remained":[178],"0.00005).":[186],"current":[188,208],"genome":[189],"scan":[190,209],"may":[195],"lead":[196],"identification":[198],"novel":[200],"genes,":[201],"because":[202],"few":[203],"identified":[205],"have":[210],"previously":[211],"been":[212],"implicated":[213],"congenital":[215],"cataracts.":[218]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}