{"id":"https://openalex.org/W1973050469","doi":"https://doi.org/10.1136/jmg.21.2.96","title":"Breast cancer, genetics, and age at first pregnancy.","display_name":"Breast cancer, genetics, and age at first pregnancy.","publication_year":1984,"publication_date":"1984-04-01","ids":{"openalex":"https://openalex.org/W1973050469","doi":"https://doi.org/10.1136/jmg.21.2.96","mag":"1973050469","pmid":"https://pubmed.ncbi.nlm.nih.gov/6716424","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1049233"},"language":"en","primary_location":{"id":"doi:10.1136/jmg.21.2.96","doi":"https://doi.org/10.1136/jmg.21.2.96","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jmg.21.2.96","pdf_url":"https://jmg.bmj.com/content/jmedgenet/21/2/96.full.pdf","source":{"id":"https://openalex.org/S112540174","display_name":"Journal of Medical Genetics","issn_l":"0022-2593","issn":["0022-2593","1468-6244"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jmg.bmj.com/content/jmedgenet/21/2/96.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111409806","display_name":"Henry T. Lynch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114493937","display_name":"Creighton University","ror":"https://ror.org/05wf30g94","country_code":"US","type":"education","lineage":["https://openalex.org/I114493937"]},{"id":"https://openalex.org/I1307497284","display_name":"Boys Town","ror":"https://ror.org/03ebg0v16","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307497284"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H T Lynch","raw_affiliation_strings":["the Department of Preventive Medicine/Public Health , and tthe Department of Surgery , Creighton University School of Medicine ; and +the Department of Otolaryngology , Boys Town Institute for Hearing and Speech Disorders in Children , Omaha , Nebraska , USA","Creighton University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Preventive Medicine/Public Health , and tthe Department of Surgery , Creighton University School of Medicine ; and +the Department of Otolaryngology , Boys Town Institute for Hearing and Speech Disorders in Children , Omaha , Nebraska , USA","institution_ids":["https://openalex.org/I114493937","https://openalex.org/I1307497284"]},{"raw_affiliation_string":"Creighton University;","institution_ids":["https://openalex.org/I114493937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053182965","display_name":"William A. Albano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114493937","display_name":"Creighton University","ror":"https://ror.org/05wf30g94","country_code":"US","type":"education","lineage":["https://openalex.org/I114493937"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W A Albano","raw_affiliation_strings":["Creighton University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Creighton University;","institution_ids":["https://openalex.org/I114493937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080253689","display_name":"Michael A. Layton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114493937","display_name":"Creighton University","ror":"https://ror.org/05wf30g94","country_code":"US","type":"education","lineage":["https://openalex.org/I114493937"]},{"id":"https://openalex.org/I1307497284","display_name":"Boys Town","ror":"https://ror.org/03ebg0v16","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307497284"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M A Layton","raw_affiliation_strings":["the Department of Preventive Medicine/Public Health , and tthe Department of Surgery , Creighton University School of Medicine ; and +the Department of Otolaryngology , Boys Town Institute for Hearing and Speech Disorders in Children , Omaha , Nebraska , USA","Creighton University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Preventive Medicine/Public Health , and tthe Department of Surgery , Creighton University School of Medicine ; and +the Department of Otolaryngology , Boys Town Institute for Hearing and Speech Disorders in Children , Omaha , Nebraska , USA","institution_ids":["https://openalex.org/I114493937","https://openalex.org/I1307497284"]},{"raw_affiliation_string":"Creighton University;","institution_ids":["https://openalex.org/I114493937"]}]},{"author_position":"middle","author":{"id":null,"display_name":"W J Kimberling","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W J Kimberling","raw_affiliation_strings":["Center for Sensory Neuroscience"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Sensory Neuroscience","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111803652","display_name":"J. F. Lynch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114493937","display_name":"Creighton University","ror":"https://ror.org/05wf30g94","country_code":"US","type":"education","lineage":["https://openalex.org/I114493937"]},{"id":"https://openalex.org/I1307497284","display_name":"Boys Town","ror":"https://ror.org/03ebg0v16","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307497284"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J F Lynch","raw_affiliation_strings":["the Department of Preventive Medicine/Public Health, and tthe Department of Surgery, Creighton University School of Medicine; and +the Department of Otolaryngology, Boys Town Institute for Hearing and Speech Disorders in Children, Omaha, Nebraska, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Preventive Medicine/Public Health, and tthe Department of Surgery, Creighton University School of Medicine; and +the Department of Otolaryngology, Boys Town Institute for Hearing and Speech Disorders in Children, Omaha, Nebraska, USA","institution_ids":["https://openalex.org/I114493937","https://openalex.org/I1307497284"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5574,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.59833795,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"21","issue":"2","first_page":"96","last_page":"98"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hereditary-breast-cancer","display_name":"hereditary breast cancer","score":0.949999988079071},{"id":"https://openalex.org/keywords/age-at-first-pregnancy","display_name":"age at first pregnancy","score":0.9729999899864197},{"id":"https://openalex.org/keywords/nulliparity","display_name":"nulliparity","score":0.6539999842643738},{"id":"https://openalex.org/keywords/breast-cancer-risk-factors","display_name":"breast cancer risk factors","score":0.7490000128746033},{"id":"https://openalex.org/keywords/natural-history-of-breast-cancer","display_name":"natural history of breast cancer","score":0.796999990940094},{"id":"https://openalex.org/keywords/genetic-risk","display_name":"genetic risk","score":0.3659999966621399},{"id":"https://openalex.org/keywords/age-at-diagnosis","display_name":"age at diagnosis","score":0.4390000104904175}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.843843936920166},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.7215996980667114},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6467238664627075},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6143592000007629},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5607112050056458},{"id":"https://openalex.org/C2781179581","wikidata":"https://www.wikidata.org/wiki/Q2857712","display_name":"Family history","level":2,"score":0.44415271282196045},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.43923473358154297},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.43874433636665344},{"id":"https://openalex.org/C2777767895","wikidata":"https://www.wikidata.org/wiki/Q4691924","display_name":"Age of onset","level":3,"score":0.4380112886428833},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3816482424736023},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3527415990829468},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26748719811439514},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14988866448402405},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12397387623786926},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010298","descriptor_name":"Parity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1136/jmg.21.2.96","doi":"https://doi.org/10.1136/jmg.21.2.96","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jmg.21.2.96","pdf_url":"https://jmg.bmj.com/content/jmedgenet/21/2/96.full.pdf","source":{"id":"https://openalex.org/S112540174","display_name":"Journal of Medical Genetics","issn_l":"0022-2593","issn":["0022-2593","1468-6244"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Genetics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1049233","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1049233","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1049233/pdf/jmedgene00100-0016.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Med Genet","raw_type":"Text"},{"id":"pmid:6716424","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6716424","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medical genetics","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.904.6248","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.904.6248","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jmg.bmj.com/content/21/2/96.full.pdf","raw_type":"text"},{"id":"mag:2187513899","doi":null,"is_oa":false,"landing_page_url":"https://jmg.bmj.com/content/21/2/96.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1136/jmg.21.2.96","doi":"https://doi.org/10.1136/jmg.21.2.96","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jmg.21.2.96","pdf_url":"https://jmg.bmj.com/content/jmedgenet/21/2/96.full.pdf","source":{"id":"https://openalex.org/S112540174","display_name":"Journal of Medical Genetics","issn_l":"0022-2593","issn":["0022-2593","1468-6244"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1973050469.pdf","grobid_xml":"https://content.openalex.org/works/W1973050469.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W630752951","https://openalex.org/W1583725305","https://openalex.org/W1909250455","https://openalex.org/W1977629755","https://openalex.org/W1977788069","https://openalex.org/W1979481599","https://openalex.org/W1988000039","https://openalex.org/W1995763951","https://openalex.org/W2004267594","https://openalex.org/W2022642204","https://openalex.org/W2027425896","https://openalex.org/W2038713075","https://openalex.org/W2054644728","https://openalex.org/W2098810807","https://openalex.org/W2117505164","https://openalex.org/W2122624442","https://openalex.org/W2144811183","https://openalex.org/W2168022861","https://openalex.org/W2263096912","https://openalex.org/W2284799479","https://openalex.org/W2414419036","https://openalex.org/W2466435070"],"related_works":["https://openalex.org/W2149597080","https://openalex.org/W7096764332","https://openalex.org/W2051592955","https://openalex.org/W2004267594","https://openalex.org/W6946331957","https://openalex.org/W2766652121","https://openalex.org/W1948725475","https://openalex.org/W4299653487","https://openalex.org/W2007782822","https://openalex.org/W4414700837"],"abstract_inverted_index":{"Hereditary":[0],"breast":[1,42,65,87,102,127,150,173,209],"cancer":[2,43,88,103,128,167,174,210],"shows":[3],"a":[4],"distinctive":[5],"natural":[6,206],"history":[7,207],"characterised":[8],"by":[9],"an":[10,73,83,163],"earlier":[11,84,164],"age":[12,53,75,85,93,98,154,165,171],"of":[13,54,76,86,101,112,149,172,208],"onset,":[14],"excess":[15],"bilaterality,":[16],"vertical":[17],"transmission,":[18],"heterogeneous":[19],"tumour":[20],"associations,":[21],"and":[22,46,97,169],"improved":[23],"survival":[24],"when":[25],"compared":[26,121],"to":[27,39,123],"its":[28],"sporadic":[29],"counterpart.":[30],"To":[31],"date,":[32],"very":[33],"little":[34],"attention":[35],"has":[36,58],"been":[37,59],"given":[38],"interrelationships":[40],"between":[41],"risk":[44],"factors":[45],"genetics.":[47],"In":[48,67,135],"the":[49,92,117,131,136,147,205,212,219],"general":[50],"population,":[51,200],"early":[52,74,140,153],"first":[55,77,95,141,156],"term":[56,142,157,191],"pregnancy":[57,78,96,143,158,201],"generally":[60],"accepted":[61],"as":[62],"protective":[63],"against":[64],"cancer.":[66],"addition,":[68],"recent":[69],"findings":[70],"suggest":[71],"that":[72,184,196,215],"may":[79],"be":[80],"associated":[81,161],"with":[82,162],"diagnosis.":[89],"We":[90,119,193],"studied":[91],"at":[94,99,107,155,166,188,221],"onset":[100,175],"among":[104],"162":[105],"females":[106,178,186],"50%":[108],"genetic":[109],"risk,":[110],"72":[111],"whom":[113],"had":[114],"already":[115],"developed":[116],"disease.":[118],"then":[120],"them":[122],"154":[124],"consecutively":[125],"ascertained":[126],"patients":[129],"from":[130],"Creighton":[132],"Cancer":[133],"Center.":[134],"hereditary":[137,199],"subset":[138],"(1)":[139],"did":[144],"not":[145,160,180,203],"alter":[146],"frequency":[148],"cancer;":[151],"(2)":[152],"was":[159,179],"diagnosis;":[168],"(3)":[170],"in":[176,185,197,211,218],"nulliparous":[177],"significantly":[181],"lower":[182],"than":[183],"having":[187],"least":[189],"one":[190],"pregnancy.":[192],"speculate,":[194],"therefore,":[195],"our":[198],"does":[202,217],"influence":[204],"same":[213],"way":[214],"it":[216],"population":[220],"large.":[222]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
