{"id":"https://openalex.org/W1973045287","doi":"https://doi.org/10.1038/srep07979","title":"The Evidence of Glioblastoma Heterogeneity","display_name":"The Evidence of Glioblastoma Heterogeneity","publication_year":2015,"publication_date":"2015-01-27","ids":{"openalex":"https://openalex.org/W1973045287","doi":"https://doi.org/10.1038/srep07979","mag":"1973045287","pmid":"https://pubmed.ncbi.nlm.nih.gov/25623281","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4306917"},"language":"en","primary_location":{"id":"doi:10.1038/srep07979","doi":"https://doi.org/10.1038/srep07979","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep07979","pdf_url":"https://www.nature.com/articles/srep07979.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/srep07979.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055202531","display_name":"Akio Soeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Akio Soeda","raw_affiliation_strings":["Department of Neurosurgery, Gifu University School of Medicine, Gifu City, Gifu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Gifu University School of Medicine, Gifu City, Gifu, Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015424874","display_name":"Akira Hara","orcid":"https://orcid.org/0000-0002-5554-8060","observed_orcids":["https://orcid.org/0000-0002-5554-8060"]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Hara","raw_affiliation_strings":["Department of Tumor Pathology, Gifu University School of Medicine, Gifu City, Gifu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Tumor Pathology, Gifu University School of Medicine, Gifu City, Gifu, Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003472940","display_name":"Takahiro Kunisada","orcid":"https://orcid.org/0000-0003-1651-2716","observed_orcids":["https://orcid.org/0000-0003-1651-2716"]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahiro Kunisada","raw_affiliation_strings":["Department of Tissue and Organ Regeneration, Gifu University School of Medicine, Gifu City, Gifu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Tissue and Organ Regeneration, Gifu University School of Medicine, Gifu City, Gifu, Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101887473","display_name":"Shinichi Yoshimura","orcid":"https://orcid.org/0000-0001-5633-9132","observed_orcids":["https://orcid.org/0000-0001-5633-9132"]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shin-ichi Yoshimura","raw_affiliation_strings":["Department of Neurosurgery, Gifu University School of Medicine, Gifu City, Gifu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Gifu University School of Medicine, Gifu City, Gifu, Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064878753","display_name":"Toru Iwama","orcid":"https://orcid.org/0000-0002-9426-284X","observed_orcids":["https://orcid.org/0000-0002-9426-284X"]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toru Iwama","raw_affiliation_strings":["Department of Neurosurgery, Gifu University School of Medicine, Gifu City, Gifu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Gifu University School of Medicine, Gifu City, Gifu, Japan","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061314376","display_name":"Deric M. Park","orcid":"https://orcid.org/0000-0002-8683-7340","observed_orcids":["https://orcid.org/0000-0002-8683-7340"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Deric M. Park","raw_affiliation_strings":["Department of Neurological Surgery, University of Virginia, Charlottesville, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, University of Virginia, Charlottesville, VA, USA","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5055202531","https://openalex.org/A5061314376"],"corresponding_institution_ids":["https://openalex.org/I42405503","https://openalex.org/I51556381"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":11.3834,"has_fulltext":true,"cited_by_count":214,"citation_normalized_percentile":{"value":0.99250549,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"5","issue":"1","first_page":"7979","last_page":"7979"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.7196999788284302,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.7196999788284302,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.2694999873638153,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.972000002861023},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.9919999837875366},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.9129999876022339},{"id":"https://openalex.org/keywords/proliferative-potential","display_name":"proliferative capacity","score":0.8389999866485596},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.6520000100135803}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7844642400741577},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.7258727550506592},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.6060101389884949},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5775409936904907},{"id":"https://openalex.org/C113968399","wikidata":"https://www.wikidata.org/wiki/Q7559241","display_name":"Somatic evolution in cancer","level":3,"score":0.5654116868972778},{"id":"https://openalex.org/C2778630268","wikidata":"https://www.wikidata.org/wiki/Q17113277","display_name":"Cell sorting","level":3,"score":0.545968770980835},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.47331273555755615},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4539080858230591},{"id":"https://openalex.org/C64618202","wikidata":"https://www.wikidata.org/wiki/Q3733697","display_name":"Genetic heterogeneity","level":4,"score":0.42672234773635864},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.36139029264450073},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27728086709976196},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2594265639781952}],"mesh":[{"descriptor_ui":"D000077156","descriptor_name":"Gefitinib","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000090602","descriptor_name":"Collagen Type I, alpha 1 Chain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016688","descriptor_name":"Mice, Inbred NOD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018969","descriptor_name":"Insulin-Like Growth Factor Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024042","descriptor_name":"Collagen Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/srep07979","doi":"https://doi.org/10.1038/srep07979","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep07979","pdf_url":"https://www.nature.com/articles/srep07979.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmid:25623281","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25623281","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4306917","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4306917/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/srep07979","doi":"https://doi.org/10.1038/srep07979","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep07979","pdf_url":"https://www.nature.com/articles/srep07979.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1397604035","display_name":"The hierarchy and heterogeneity of malignant brain tumor","funder_award_id":"24659647","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3513739415","display_name":"The possible role of IDH1 mutation, IGFBP7 and COLA1 for gliomagenesis.","funder_award_id":"26670639","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1973045287.pdf","grobid_xml":"https://content.openalex.org/works/W1973045287.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1536266814","https://openalex.org/W1792532087","https://openalex.org/W1972093598","https://openalex.org/W1983593213","https://openalex.org/W2000167417","https://openalex.org/W2001544973","https://openalex.org/W2011173910","https://openalex.org/W2025183726","https://openalex.org/W2037536005","https://openalex.org/W2046716216","https://openalex.org/W2048281866","https://openalex.org/W2060551076","https://openalex.org/W2070705072","https://openalex.org/W2079937854","https://openalex.org/W2096287682","https://openalex.org/W2098538891","https://openalex.org/W2107591555","https://openalex.org/W2108101104","https://openalex.org/W2146601467","https://openalex.org/W2163292580","https://openalex.org/W2167648407"],"related_works":["https://openalex.org/W2037605886","https://openalex.org/W2082411701","https://openalex.org/W2194120132","https://openalex.org/W2332452431","https://openalex.org/W4385367716","https://openalex.org/W2898833970","https://openalex.org/W2030452983","https://openalex.org/W6887896986","https://openalex.org/W7062937977","https://openalex.org/W2810994851"],"abstract_inverted_index":{"Cancers":[0],"are":[1,59],"composed":[2,106],"of":[3,6,61,91,107,110,115,121,134,141],"heterogeneous":[4,159,183],"combinations":[5],"cells":[7,25,42],"that":[8,35,43,55,102,154,161,173],"exhibit":[9,162],"distinct":[10,108],"phenotypic":[11],"characteristics":[12],"and":[13,39,82,88,98,139,143,165,167,190],"proliferative":[14,46,89,168],"potentials.":[15],"Because":[16],"most":[17],"cancers":[18],"have":[19],"a":[20,74,129,155,178],"clonal":[21],"origin,":[22],"cancer":[23,41],"stem":[24],"(CSCs)":[26],"must":[27],"generate":[28],"phenotypically":[29,182],"diverse":[30],"progenies":[31,185],"including":[32],"mature":[33],"CSCs":[34,58],"can":[36,180],"self-renew":[37],"indefinitely":[38],"differentiated":[40],"possess":[44],"limited":[45],"potential.":[47],"However,":[48],"no":[49],"convincing":[50],"evidence":[51,153],"exists":[52],"to":[53,118],"suggest":[54,172],"only":[56],"single":[57,174],"representative":[60],"patients'":[62],"tumors.":[63],"To":[64],"investigate":[65],"the":[66,86,92,113,116,135,137],"CSCs'":[67],"diversity,":[68],"we":[69,150],"established":[70],"4":[71],"subclones":[72,78,93,117,160,176],"from":[73,177],"glioblastoma":[75],"patient.":[76],"These":[77],"were":[79,126,146],"subsequently":[80],"propagated":[81],"analyzed.":[83],"The":[84],"morphology,":[85],"self-renewal":[87,166],"capacities":[90],"differed.":[94],"Fluorescence-activated":[95],"cell":[96],"sorting":[97],"cDNA-microarray":[99],"analyses":[100],"revealed":[101],"each":[103],"subclone":[104],"was":[105],"populations":[109],"cells.":[111],"Moreover,":[112],"sensitivities":[114],"an":[119],"inhibitor":[120],"epidermal":[122],"growth":[123],"factor":[124],"receptor":[125],"dissimilar.":[127],"In":[128],"mouse":[130],"model":[131],"featuring":[132],"xenografts":[133],"subclones,":[136],"progression":[138],"invasion":[140],"tumors":[142],"animal":[144],"survival":[145],"also":[147],"different.":[148],"Here,":[149],"present":[151],"clear":[152],"brain":[156],"tumor":[157],"contains":[158],"dissimilar":[163],"morphologies":[164],"capacities.":[169],"Our":[170],"results":[171],"cell-derived":[175],"patient":[179],"produce":[181],"self-renewing":[184],"in":[186,188,191],"both":[187],"vitro":[189],"vivo":[192],"settings.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":23},{"year":2020,"cited_by_count":27},{"year":2019,"cited_by_count":25},{"year":2018,"cited_by_count":30},{"year":2017,"cited_by_count":27},{"year":2016,"cited_by_count":18},{"year":2015,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
