{"id":"https://openalex.org/W1973014418","doi":"https://doi.org/10.1016/0090-6980(81)90230-6","title":"Fish oil feeding lowers thromboxane- and prostacyclin production by rat platelets and aorta and does not result in the formation of prostaglandin I3","display_name":"Fish oil feeding lowers thromboxane- and prostacyclin production by rat platelets and aorta and does not result in the formation of prostaglandin I3","publication_year":1981,"publication_date":"1981-05-01","ids":{"openalex":"https://openalex.org/W1973014418","doi":"https://doi.org/10.1016/0090-6980(81)90230-6","mag":"1973014418","pmid":"https://pubmed.ncbi.nlm.nih.gov/6803303"},"language":"en","primary_location":{"id":"doi:10.1016/0090-6980(81)90230-6","doi":"https://doi.org/10.1016/0090-6980(81)90230-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0090-6980(81)90230-6","pdf_url":null,"source":{"id":"https://openalex.org/S161580142","display_name":"Prostaglandins","issn_l":"0090-6980","issn":["0090-6980","1878-416X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Prostaglandins","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009535255","display_name":"Gerard Hornstra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405281337","display_name":"Unilever Research and Development Vlaardingen","ror":"https://ror.org/047hzsk31","country_code":"NL","type":"facility","lineage":["https://openalex.org/I1342131907","https://openalex.org/I4210113155","https://openalex.org/I4405281337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"G. Hornstra","raw_affiliation_strings":["Unilever Research Vlaardingen, P.O. Box 114, 3130 AC Vlaardingen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unilever Research Vlaardingen, P.O. Box 114, 3130 AC Vlaardingen, The Netherlands","institution_ids":["https://openalex.org/I4405281337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088689502","display_name":"Elly Christ-Hazelhof","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405281337","display_name":"Unilever Research and Development Vlaardingen","ror":"https://ror.org/047hzsk31","country_code":"NL","type":"facility","lineage":["https://openalex.org/I1342131907","https://openalex.org/I4210113155","https://openalex.org/I4405281337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"E. Christ-Hazelhof","raw_affiliation_strings":["Unilever Research Vlaardingen, P.O. Box 114, 3130 AC Vlaardingen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unilever Research Vlaardingen, P.O. Box 114, 3130 AC Vlaardingen, The Netherlands","institution_ids":["https://openalex.org/I4405281337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055086183","display_name":"Edward Haddeman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405281337","display_name":"Unilever Research and Development Vlaardingen","ror":"https://ror.org/047hzsk31","country_code":"NL","type":"facility","lineage":["https://openalex.org/I1342131907","https://openalex.org/I4210113155","https://openalex.org/I4405281337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"E. Haddeman","raw_affiliation_strings":["Unilever Research Vlaardingen, P.O. Box 114, 3130 AC Vlaardingen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unilever Research Vlaardingen, P.O. Box 114, 3130 AC Vlaardingen, The Netherlands","institution_ids":["https://openalex.org/I4405281337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111558351","display_name":"F. ten Hoor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405281337","display_name":"Unilever Research and Development Vlaardingen","ror":"https://ror.org/047hzsk31","country_code":"NL","type":"facility","lineage":["https://openalex.org/I1342131907","https://openalex.org/I4210113155","https://openalex.org/I4405281337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"F. ten Hoor","raw_affiliation_strings":["Unilever Research Vlaardingen, P.O. Box 114, 3130 AC Vlaardingen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unilever Research Vlaardingen, P.O. Box 114, 3130 AC Vlaardingen, The Netherlands","institution_ids":["https://openalex.org/I4405281337"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111701805","display_name":"Diederik H. Nugteren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405281337","display_name":"Unilever Research and Development Vlaardingen","ror":"https://ror.org/047hzsk31","country_code":"NL","type":"facility","lineage":["https://openalex.org/I1342131907","https://openalex.org/I4210113155","https://openalex.org/I4405281337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"D.H. Nugteren","raw_affiliation_strings":["Unilever Research Vlaardingen, P.O. Box 114, 3130 AC Vlaardingen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unilever Research Vlaardingen, P.O. Box 114, 3130 AC Vlaardingen, The Netherlands","institution_ids":["https://openalex.org/I4405281337"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4405281337"],"apc_list":null,"apc_paid":null,"fwci":14.4093,"has_fulltext":false,"cited_by_count":198,"citation_normalized_percentile":{"value":0.99630672,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"21","issue":"5","first_page":"727","last_page":"738"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.798799991607666,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.798799991607666,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.09889999777078629,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.053199999034404755,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fish-oil","display_name":"fish oil","score":0.8230000138282776},{"id":"https://openalex.org/keywords/cod-liver-oil","display_name":"cod liver oil","score":0.9639999866485596},{"id":"https://openalex.org/keywords/thromboxane-a2","display_name":"thromboxane A2","score":0.8799999952316284},{"id":"https://openalex.org/keywords/prostacyclin","display_name":"prostacyclin","score":0.9909999966621399},{"id":"https://openalex.org/keywords/platelets","display_name":"platelets","score":0.8960000276565552},{"id":"https://openalex.org/keywords/aorta","display_name":"aorta","score":0.9369999766349792},{"id":"https://openalex.org/keywords/thromboregulation","display_name":"thromboregulation","score":0.8920000195503235},{"id":"https://openalex.org/keywords/arterial-thrombosis","display_name":"arterial thrombosis","score":0.9330000281333923},{"id":"https://openalex.org/keywords/bleeding-time","display_name":"bleeding time","score":0.9679999947547913},{"id":"https://openalex.org/keywords/dietary-fatty-acids","display_name":"dietary fatty acids","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C2781128415","wikidata":"https://www.wikidata.org/wiki/Q412050","display_name":"Prostacyclin","level":2,"score":0.8981629610061646},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.7930439710617065},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6486354470252991},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.6427392959594727},{"id":"https://openalex.org/C2776785769","wikidata":"https://www.wikidata.org/wiki/Q412212","display_name":"Thromboxane","level":3,"score":0.6290766000747681},{"id":"https://openalex.org/C2779980429","wikidata":"https://www.wikidata.org/wiki/Q101004","display_name":"Aorta","level":2,"score":0.6113576889038086},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5892331004142761},{"id":"https://openalex.org/C2993802102","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet aggregation","level":3,"score":0.5758938789367676},{"id":"https://openalex.org/C2781024287","wikidata":"https://www.wikidata.org/wiki/Q774909","display_name":"Thromboxane A2","level":3,"score":0.5582773685455322},{"id":"https://openalex.org/C2779946292","wikidata":"https://www.wikidata.org/wiki/Q1786125","display_name":"Fish oil","level":3,"score":0.5033804774284363},{"id":"https://openalex.org/C2781080829","wikidata":"https://www.wikidata.org/wiki/Q3009646","display_name":"Thromboxane B2","level":3,"score":0.46803855895996094},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46776503324508667},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.4616905450820923},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3240235447883606},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21146005392074585},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.16189119219779968}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003060","descriptor_name":"Cod Liver Oil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005395","descriptor_name":"Fish Oils","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006368","descriptor_name":"Helianthus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008084","descriptor_name":"Lipoxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009821","descriptor_name":"Oils","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011451","descriptor_name":"Prostaglandin-Endoperoxide Synthases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011453","descriptor_name":"Prostaglandins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D011464","descriptor_name":"Epoprostenol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D011464","descriptor_name":"Epoprostenol","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013928","descriptor_name":"Thromboxane A2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D013931","descriptor_name":"Thromboxanes","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0090-6980(81)90230-6","doi":"https://doi.org/10.1016/0090-6980(81)90230-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0090-6980(81)90230-6","pdf_url":null,"source":{"id":"https://openalex.org/S161580142","display_name":"Prostaglandins","issn_l":"0090-6980","issn":["0090-6980","1878-416X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Prostaglandins","raw_type":"journal-article"},{"id":"pmid:6803303","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6803303","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Prostaglandins","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1956932495","https://openalex.org/W1986111942","https://openalex.org/W1991619890","https://openalex.org/W1994207950","https://openalex.org/W1998907122","https://openalex.org/W1999087964","https://openalex.org/W2008006686","https://openalex.org/W2016489221","https://openalex.org/W2022342250","https://openalex.org/W2034371869","https://openalex.org/W2047206656","https://openalex.org/W2047419091","https://openalex.org/W2055319641","https://openalex.org/W2057544914","https://openalex.org/W2061004625","https://openalex.org/W2082951744","https://openalex.org/W2088333712","https://openalex.org/W2088643391","https://openalex.org/W2088748703","https://openalex.org/W2092852822","https://openalex.org/W2121496704","https://openalex.org/W2176700138","https://openalex.org/W2409674759","https://openalex.org/W2410296711","https://openalex.org/W2422847541","https://openalex.org/W2575530492"],"related_works":["https://openalex.org/W2467665039","https://openalex.org/W2063472665","https://openalex.org/W2035484797","https://openalex.org/W2885021279","https://openalex.org/W2044798583","https://openalex.org/W1973092633","https://openalex.org/W4205296843","https://openalex.org/W2884420036","https://openalex.org/W4231496727","https://openalex.org/W1969312162"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}