{"id":"https://openalex.org/W1973010036","doi":"https://doi.org/10.1055/s-0033-1361111","title":"Erythropoietin-induced Treatment Costs in Patients Suffering from Renal Anemia \u2013 A Comparison between Biosimilar and Originator Drugs","display_name":"Erythropoietin-induced Treatment Costs in Patients Suffering from Renal Anemia \u2013 A Comparison between Biosimilar and Originator Drugs","publication_year":2014,"publication_date":"2014-02-03","ids":{"openalex":"https://openalex.org/W1973010036","doi":"https://doi.org/10.1055/s-0033-1361111","mag":"1973010036","pmid":"https://pubmed.ncbi.nlm.nih.gov/24493578"},"language":"en","primary_location":{"id":"doi:10.1055/s-0033-1361111","doi":"https://doi.org/10.1055/s-0033-1361111","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0033-1361111","pdf_url":null,"source":{"id":"https://openalex.org/S33786796","display_name":"Das Gesundheitswesen","issn_l":"0941-3790","issn":["0941-3790","1439-4421"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Das Gesundheitswesen","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1973010036"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054383605","display_name":"Franziska H\u00f6rbrand","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. H\u00f6rbrand","raw_affiliation_strings":["Kassen\u00e4rztliche Vereinigung Bayerns, Referat Vertragspolitik und Arzneimittel, M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kassen\u00e4rztliche Vereinigung Bayerns, Referat Vertragspolitik und Arzneimittel, M\u00fcnchen, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023066627","display_name":"Dominik Rottenkolber","orcid":"https://orcid.org/0009-0000-4028-5774","observed_orcids":["https://orcid.org/0009-0000-4028-5774"]},"institutions":[{"id":"https://openalex.org/I4405281680","display_name":"M\u00fcnchner Zentrum f\u00fcr Gesundheitswissenschaften","ror":"https://ror.org/04qd38p60","country_code":"DE","type":"education","lineage":["https://openalex.org/I4405281680","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"D. Rottenkolber","raw_affiliation_strings":["Institut f\u00fcr Gesundheits\u00f6konomie und Management im Gesundheitswesen, Ludwig-Maximilians-Universit\u00e4t und M\u00fcnchner Zentrum f\u00fcr Gesundheitswissenschaften, M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Gesundheits\u00f6konomie und Management im Gesundheitswesen, Ludwig-Maximilians-Universit\u00e4t und M\u00fcnchner Zentrum f\u00fcr Gesundheitswissenschaften, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I4405281680","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009783073","display_name":"Johann Fischaleck","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Fischaleck","raw_affiliation_strings":["Kassen\u00e4rztliche Vereinigung Bayerns, Referat Vertragspolitik und Arzneimittel, M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kassen\u00e4rztliche Vereinigung Bayerns, Referat Vertragspolitik und Arzneimittel, M\u00fcnchen, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086462994","display_name":"Joerg Hasford","orcid":"https://orcid.org/0000-0002-9685-4769","observed_orcids":["https://orcid.org/0000-0002-9685-4769"]},"institutions":[{"id":"https://openalex.org/I4405260893","display_name":"Institut f\u00fcr Medizinische Informationsverarbeitung, Biometrie und Epidemiologie","ror":"https://ror.org/04eb1yz45","country_code":"DE","type":"education","lineage":["https://openalex.org/I4405260893","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. Hasford","raw_affiliation_strings":["Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Institut f\u00fcr Medizinische Informationsverarbeitung, Biometrie und \u00adEpidemiologie, M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Institut f\u00fcr Medizinische Informationsverarbeitung, Biometrie und \u00adEpidemiologie, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I4405260893","https://openalex.org/I8204097"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.195,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.75794675,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"76","issue":"11","first_page":"e79","last_page":"e84"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.7656000256538391,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.7656000256538391,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":0.21619999408721924,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11792","display_name":"Pharmaceutical Economics and Policy","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erythropoietin","display_name":"erythropoietin","score":0.9769999980926514},{"id":"https://openalex.org/keywords/anemia-of-chronic-kidney-disease","display_name":"anemia of chronic kidney disease","score":0.859000027179718},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.7310000061988831},{"id":"https://openalex.org/keywords/biosimilars","display_name":"biosimilars","score":0.6959999799728394},{"id":"https://openalex.org/keywords/brand-name-drugs","display_name":"brand-name drugs","score":0.8149999976158142},{"id":"https://openalex.org/keywords/erythropoiesis-stimulating-agents","display_name":"erythropoiesis-stimulating agents","score":0.9589999914169312},{"id":"https://openalex.org/keywords/treatment-costs","display_name":"treatment costs","score":0.7710000276565552},{"id":"https://openalex.org/keywords/hemodialysis","display_name":"hemodialysis","score":0.8019999861717224},{"id":"https://openalex.org/keywords/defined-daily-doses","display_name":"defined daily doses","score":0.7749999761581421},{"id":"https://openalex.org/keywords/cost-reduction","display_name":"cost reduction","score":0.593999981880188},{"id":"https://openalex.org/keywords/biosimilar-substitution","display_name":"biosimilar substitution","score":0.8130000233650208}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8964799642562866},{"id":"https://openalex.org/C59491497","wikidata":"https://www.wikidata.org/wiki/Q864715","display_name":"Biosimilar","level":2,"score":0.8806676268577576},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.6953115463256836},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.670242428779602},{"id":"https://openalex.org/C2779978075","wikidata":"https://www.wikidata.org/wiki/Q202301","display_name":"Dialysis","level":2,"score":0.5497926473617554},{"id":"https://openalex.org/C2426938","wikidata":"https://www.wikidata.org/wiki/Q3355478","display_name":"Medical prescription","level":2,"score":0.5262869000434875},{"id":"https://openalex.org/C2778063415","wikidata":"https://www.wikidata.org/wiki/Q391744","display_name":"Hemodialysis","level":2,"score":0.5007717609405518},{"id":"https://openalex.org/C104863432","wikidata":"https://www.wikidata.org/wiki/Q614304","display_name":"Pharmacy","level":2,"score":0.49303576350212097},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46171972155570984},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.45986342430114746},{"id":"https://openalex.org/C2909884793","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disorder","level":3,"score":0.45812758803367615},{"id":"https://openalex.org/C2778534260","wikidata":"https://www.wikidata.org/wiki/Q218706","display_name":"Erythropoietin","level":2,"score":0.44705265760421753},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.423947274684906},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.17930996417999268},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.15858736634254456},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.10998785495758057}],"mesh":[{"descriptor_ui":"D000740","descriptor_name":"Anemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000740","descriptor_name":"Anemia","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D000740","descriptor_name":"Anemia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D003362","descriptor_name":"Cost-Benefit Analysis","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D005102","descriptor_name":"Health Expenditures","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D005858","descriptor_name":"Germany","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006397","descriptor_name":"Hematinics","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D006397","descriptor_name":"Hematinics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011307","descriptor_name":"Drug Prescriptions","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D011307","descriptor_name":"Drug Prescriptions","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D017048","descriptor_name":"Health Care Costs","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D059451","descriptor_name":"Biosimilar Pharmaceuticals","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D059451","descriptor_name":"Biosimilar Pharmaceuticals","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1055/s-0033-1361111","doi":"https://doi.org/10.1055/s-0033-1361111","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0033-1361111","pdf_url":null,"source":{"id":"https://openalex.org/S33786796","display_name":"Das Gesundheitswesen","issn_l":"0941-3790","issn":["0941-3790","1439-4421"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Das Gesundheitswesen","raw_type":"journal-article"},{"id":"pmid:24493578","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24493578","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany))","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3205904621","https://openalex.org/W3092805879","https://openalex.org/W1616092448","https://openalex.org/W2034110300","https://openalex.org/W4397041400","https://openalex.org/W4235135984","https://openalex.org/W2889838580","https://openalex.org/W2906580487","https://openalex.org/W3215978276","https://openalex.org/W1903089191"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Renal":[1],"anemia":[2,46,184],"is":[3],"a":[4,21,163,192],"serious":[5],"concern":[6],"for":[7,120,129],"morbidity":[8],"and":[9,68,75,105,122,152],"lower":[10],"quality-of-life":[11],"of":[12,32,61,79,87,90,160,166],"patients":[13,42,82,97,136,185],"suffering":[14,43,186],"from":[15,44,187],"chronic":[16,106,111,188],"kidney":[17,112,189],"disease":[18,113,190],"resulting":[19],"in":[20,41,84,182],"high":[22],"economic":[23,194],"burden":[24],"when":[25],"administering":[26],"erythropoiesis-stimulating":[27],"agents":[28],"(ESAs).":[29],"The":[30],"aim":[31],"this":[33],"study":[34,132],"was":[35,59],"to":[36,110,125],"estimate":[37],"erythropoietin-induced":[38],"treatment":[39,74,101],"costs":[40,145],"renal":[45,183],"undergoing":[47],"dialysis":[48,81],"treated":[49],"with":[50],"originator":[51],"or":[52],"biosimilar":[53,157,180],"drugs.":[54],"METHODS:":[55],"A":[56,156,177],"retrospective":[57],"analysis":[58],"undertaken":[60],"ESA-related":[62],"pharmacotherapy":[63],"between":[64],"January":[65],"1,":[66],"2008":[67],"December":[69],"31,":[70],"2010":[71],"based":[72],"on":[73],"pharmacy":[76],"claims":[77],"data":[78],"16,895":[80],"contained":[83],"the":[85,88,130],"database":[86],"Association":[89],"Statutory":[91],"Health":[92],"Insurance":[93],"Physicians,":[94],"Bavaria.":[95],"All":[96],"received":[98],"an":[99],"ESA":[100],"(ATC":[102],"code":[103],"B03XA)":[104],"maintenance":[107],"hemodialysis":[108,135],"due":[109],"stage":[114],"5.":[115],"RESULTS:":[116],"Total":[117],"drug":[118],"expenditures":[119],"ESA-originators":[121],"biosimilars":[123],"amounted":[124],"\u20ac":[126,149,153,167,171],"78.447":[127],"million":[128,169,173],"3-year":[131],"period.":[133],"In":[134],"cumulative":[137],"defined":[138],"daily":[139],"doses":[140],"(DDDs)":[141],"were":[142,148],"7,727,782.14.":[143],"Mean":[144],"per":[146],"DDD":[147],"10.79":[150],"(originators)":[151],"8.56":[154],"(biosimilars).":[155],"substitution":[158],"quota":[159],"50%":[161],"provides":[162,191],"savings":[164,195],"potential":[165],"6.14":[168],"[range":[170],"3.07-9.22":[172],"(25-75%":[174],"quota)].":[175],"CONCLUSION:":[176],"more":[178],"common":[179],"prescription":[181],"noteworthy":[193],"potential.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}