{"id":"https://openalex.org/W1973008447","doi":"https://doi.org/10.1089/thy.2012.0134","title":"RET Proto-Oncogene Genetic Screening of Families with Multiple Endocrine Neoplasia Type 2 Optimizes Diagnostic and Clinical Management in China","display_name":"RET Proto-Oncogene Genetic Screening of Families with Multiple Endocrine Neoplasia Type 2 Optimizes Diagnostic and Clinical Management in China","publication_year":2012,"publication_date":"2012-12-01","ids":{"openalex":"https://openalex.org/W1973008447","doi":"https://doi.org/10.1089/thy.2012.0134","mag":"1973008447","pmid":"https://pubmed.ncbi.nlm.nih.gov/23210566"},"language":"en","primary_location":{"id":"doi:10.1089/thy.2012.0134","doi":"https://doi.org/10.1089/thy.2012.0134","is_oa":false,"landing_page_url":"https://doi.org/10.1089/thy.2012.0134","pdf_url":null,"source":{"id":"https://openalex.org/S27569427","display_name":"Thyroid","issn_l":"1050-7256","issn":["1050-7256","1557-9077"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thyroid","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006006872","display_name":"Xiao-Ping Qi","orcid":"https://orcid.org/0000-0003-1543-0727","observed_orcids":["https://orcid.org/0000-0003-1543-0727"]},"institutions":[{"id":"https://openalex.org/I4210098570","display_name":"117th Hospital of People's Liberation Army","ror":"https://ror.org/015z4kn26","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098570"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiao-Ping Qi","raw_affiliation_strings":["Departments of Oncologic Surgery, Urologic Surgery, and Pathology, and Clinical Experimental Center, The 117th PLA Hospital, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Oncologic Surgery, Urologic Surgery, and Pathology, and Clinical Experimental Center, The 117th PLA Hospital, Hangzhou, China","institution_ids":["https://openalex.org/I4210098570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100408255","display_name":"Xiaoling Chen","orcid":"https://orcid.org/0000-0002-5240-1506","observed_orcids":["https://orcid.org/0000-0002-5240-1506","https://orcid.org/0009-0002-9279-8007"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Ling Chen","raw_affiliation_strings":["Department of Cell Biology and Medical Genetics, National Education Base for Basic Medical Sciences, Institute of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Medical Genetics, National Education Base for Basic Medical Sciences, Institute of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108314087","display_name":"Juming Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098570","display_name":"117th Hospital of People's Liberation Army","ror":"https://ror.org/015z4kn26","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ju-Ming Ma","raw_affiliation_strings":["Departments of Oncologic Surgery, Urologic Surgery, and Pathology, and Clinical Experimental Center, The 117th PLA Hospital, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Oncologic Surgery, Urologic Surgery, and Pathology, and Clinical Experimental Center, The 117th PLA Hospital, Hangzhou, China","institution_ids":["https://openalex.org/I4210098570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020496167","display_name":"Zhenfang Du","orcid":"https://orcid.org/0000-0001-6364-1321","observed_orcids":["https://orcid.org/0000-0001-6364-1321"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhen-Fang Du","raw_affiliation_strings":["Department of Cell Biology and Medical Genetics, National Education Base for Basic Medical Sciences, Institute of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Medical Genetics, National Education Base for Basic Medical Sciences, Institute of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jun Fei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098570","display_name":"117th Hospital of People's Liberation Army","ror":"https://ror.org/015z4kn26","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Fei","raw_affiliation_strings":["Departments of Oncologic Surgery, Urologic Surgery, and Pathology, and Clinical Experimental Center, The 117th PLA Hospital, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Oncologic Surgery, Urologic Surgery, and Pathology, and Clinical Experimental Center, The 117th PLA Hospital, Hangzhou, China","institution_ids":["https://openalex.org/I4210098570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028357961","display_name":"Chang-ping Yang","orcid":"https://orcid.org/0009-0003-9268-2212","observed_orcids":["https://orcid.org/0009-0003-9268-2212"]},"institutions":[{"id":"https://openalex.org/I4210098570","display_name":"117th Hospital of People's Liberation Army","ror":"https://ror.org/015z4kn26","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chang-Ping Yang","raw_affiliation_strings":["Departments of Oncologic Surgery, Urologic Surgery, and Pathology, and Clinical Experimental Center, The 117th PLA Hospital, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Oncologic Surgery, Urologic Surgery, and Pathology, and Clinical Experimental Center, The 117th PLA Hospital, Hangzhou, China","institution_ids":["https://openalex.org/I4210098570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024004854","display_name":"Jun Cheng","orcid":"https://orcid.org/0000-0001-7796-1342","observed_orcids":["https://orcid.org/0000-0001-7796-1342"]},"institutions":[{"id":"https://openalex.org/I4210098570","display_name":"117th Hospital of People's Liberation Army","ror":"https://ror.org/015z4kn26","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Cheng","raw_affiliation_strings":["Departments of Oncologic Surgery, Urologic Surgery, and Pathology, and Clinical Experimental Center, The 117th PLA Hospital, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Oncologic Surgery, Urologic Surgery, and Pathology, and Clinical Experimental Center, The 117th PLA Hospital, Hangzhou, China","institution_ids":["https://openalex.org/I4210098570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111813101","display_name":"Qi\u2010Zhe Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098570","display_name":"117th Hospital of People's Liberation Army","ror":"https://ror.org/015z4kn26","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi-Zhe Song","raw_affiliation_strings":["Departments of Oncologic Surgery, Urologic Surgery, and Pathology, and Clinical Experimental Center, The 117th PLA Hospital, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Oncologic Surgery, Urologic Surgery, and Pathology, and Clinical Experimental Center, The 117th PLA Hospital, Hangzhou, China","institution_ids":["https://openalex.org/I4210098570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021815949","display_name":"Jianshan Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098570","display_name":"117th Hospital of People's Liberation Army","ror":"https://ror.org/015z4kn26","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian-Shan Han","raw_affiliation_strings":["Departments of Oncologic Surgery, Urologic Surgery, and Pathology, and Clinical Experimental Center, The 117th PLA Hospital, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Oncologic Surgery, Urologic Surgery, and Pathology, and Clinical Experimental Center, The 117th PLA Hospital, Hangzhou, China","institution_ids":["https://openalex.org/I4210098570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050037683","display_name":"Hang-Yang Jin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098570","display_name":"117th Hospital of People's Liberation Army","ror":"https://ror.org/015z4kn26","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hang-Yang Jin","raw_affiliation_strings":["Departments of Oncologic Surgery, Urologic Surgery, and Pathology, and Clinical Experimental Center, The 117th PLA Hospital, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Oncologic Surgery, Urologic Surgery, and Pathology, and Clinical Experimental Center, The 117th PLA Hospital, Hangzhou, China","institution_ids":["https://openalex.org/I4210098570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103059568","display_name":"Zhenguang Chen","orcid":"https://orcid.org/0009-0005-9814-9720","observed_orcids":["https://orcid.org/0009-0005-9814-9720"]},"institutions":[{"id":"https://openalex.org/I4210098570","display_name":"117th Hospital of People's Liberation Army","ror":"https://ror.org/015z4kn26","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhen-Guang Chen","raw_affiliation_strings":["Departments of Oncologic Surgery, Urologic Surgery, and Pathology, and Clinical Experimental Center, The 117th PLA Hospital, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Oncologic Surgery, Urologic Surgery, and Pathology, and Clinical Experimental Center, The 117th PLA Hospital, Hangzhou, China","institution_ids":["https://openalex.org/I4210098570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101468859","display_name":"Jinquan Wang","orcid":"https://orcid.org/0000-0002-8193-8118","observed_orcids":["https://orcid.org/0000-0002-8193-8118","https://orcid.org/0000-0002-6079-299X"]},"institutions":[{"id":"https://openalex.org/I4210098570","display_name":"117th Hospital of People's Liberation Army","ror":"https://ror.org/015z4kn26","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jin-Quan Wang","raw_affiliation_strings":["Departments of Oncologic Surgery, Urologic Surgery, and Pathology, and Clinical Experimental Center, The 117th PLA Hospital, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Oncologic Surgery, Urologic Surgery, and Pathology, and Clinical Experimental Center, The 117th PLA Hospital, Hangzhou, China","institution_ids":["https://openalex.org/I4210098570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000442490","display_name":"You-ping Yang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"You-Ping Yang","raw_affiliation_strings":["Departments of Pathology and Oncologic Surgery, Tumor Hospital of Taizhou, Wenling, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology and Oncologic Surgery, Tumor Hospital of Taizhou, Wenling, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032203286","display_name":"Rongbiao Ying","orcid":"https://orcid.org/0000-0001-9147-9923","observed_orcids":["https://orcid.org/0000-0001-9147-9923"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rong-Biao Ying","raw_affiliation_strings":["Departments of Pathology and Oncologic Surgery, Tumor Hospital of Taizhou, Wenling, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology and Oncologic Surgery, Tumor Hospital of Taizhou, Wenling, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100629206","display_name":"Wenting Liu","orcid":"https://orcid.org/0000-0001-9524-4224","observed_orcids":["https://orcid.org/0000-0001-9524-4224","https://orcid.org/0009-0007-7592-4813","https://orcid.org/0000-0001-7388-1433"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen-Ting Liu","raw_affiliation_strings":["Department of Cell Biology and Medical Genetics, National Education Base for Basic Medical Sciences, Institute of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Medical Genetics, National Education Base for Basic Medical Sciences, Institute of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100727733","display_name":"Yan Mei Zhao","orcid":"https://orcid.org/0009-0005-4105-2696","observed_orcids":["https://orcid.org/0009-0005-4105-2696"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Zhao","raw_affiliation_strings":["Department of Cell Biology and Medical Genetics, National Education Base for Basic Medical Sciences, Institute of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Medical Genetics, National Education Base for Basic Medical Sciences, Institute of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031716423","display_name":"Chun-Yue Chen","orcid":"https://orcid.org/0000-0001-8504-7681","observed_orcids":["https://orcid.org/0000-0001-8504-7681"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chun-Yue Chen","raw_affiliation_strings":["Department of Cell Biology and Medical Genetics, National Education Base for Basic Medical Sciences, Institute of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Medical Genetics, National Education Base for Basic Medical Sciences, Institute of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050776514","display_name":"Huling Jiang","orcid":"https://orcid.org/0000-0002-4809-9244","observed_orcids":["https://orcid.org/0000-0002-4809-9244"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hu-Ling Jiang","raw_affiliation_strings":["Department of Cell Biology and Medical Genetics, National Education Base for Basic Medical Sciences, Institute of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Medical Genetics, National Education Base for Basic Medical Sciences, Institute of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112211179","display_name":"Haiping Ke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143588","display_name":"Ningbo College of Health Sciences","ror":"https://ror.org/041tqx430","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210143588"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hai-Ping Ke","raw_affiliation_strings":["Department of Biology, Ningbo College of Health Sciences, Ningbo, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Ningbo College of Health Sciences, Ningbo, China","institution_ids":["https://openalex.org/I4210143588"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004443237","display_name":"Xianning Zhang","orcid":"https://orcid.org/0000-0003-1081-3833","observed_orcids":["https://orcid.org/0000-0003-1081-3833"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xian-Ning Zhang","raw_affiliation_strings":["Department of Cell Biology and Medical Genetics, National Education Base for Basic Medical Sciences, Institute of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Medical Genetics, National Education Base for Basic Medical Sciences, Institute of Cell Biology, Zhejiang University School of Medicine, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5004443237","https://openalex.org/A5006006872"],"corresponding_institution_ids":["https://openalex.org/I4210098570","https://openalex.org/I76130692"],"apc_list":null,"apc_paid":null,"fwci":1.7957,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.85023155,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"22","issue":"12","first_page":"1257","last_page":"1265"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.8618000149726868,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.8618000149726868,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.04500000178813934,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-endocrine-neoplasia-type-2","display_name":"multiple endocrine neoplasia type 2","score":0.9610000252723694},{"id":"https://openalex.org/keywords/ret-proto-oncogene","display_name":"RET proto-oncogene","score":0.9919999837875366},{"id":"https://openalex.org/keywords/germline-ret-mutation","display_name":"RET germline mutation","score":0.8690000176429749},{"id":"https://openalex.org/keywords/men2a","display_name":"MEN2A","score":0.8199999928474426},{"id":"https://openalex.org/keywords/men2b","display_name":"MEN2B","score":0.828000009059906},{"id":"https://openalex.org/keywords/pheochromocytoma","display_name":"pheochromocytoma","score":0.9100000262260437},{"id":"https://openalex.org/keywords/thyroidectomy","display_name":"thyroidectomy","score":0.6480000019073486},{"id":"https://openalex.org/keywords/mutation-carriers","display_name":"mutation carriers","score":0.6019999980926514},{"id":"https://openalex.org/keywords/penetrance","display_name":"penetrance","score":0.6150000095367432},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.6940000057220459},{"id":"https://openalex.org/keywords/age-at-surgery","display_name":"age at surgery","score":0.41200000047683716},{"id":"https://openalex.org/keywords/tnm-staging","display_name":"TNM staging","score":0.6890000104904175},{"id":"https://openalex.org/keywords/chinese-family","display_name":"Chinese family","score":0.4560000002384186},{"id":"https://openalex.org/keywords/genetic-screening","display_name":"genetic screening","score":0.5410000085830688}],"concepts":[{"id":"https://openalex.org/C2776512331","wikidata":"https://www.wikidata.org/wiki/Q604075","display_name":"Multiple endocrine neoplasia type 2","level":5,"score":0.8907987475395203},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7741245031356812},{"id":"https://openalex.org/C200544954","wikidata":"https://www.wikidata.org/wiki/Q516389","display_name":"Penetrance","level":4,"score":0.7227684259414673},{"id":"https://openalex.org/C2779644188","wikidata":"https://www.wikidata.org/wiki/Q415976","display_name":"RET proto-oncogene","level":5,"score":0.6929805278778076},{"id":"https://openalex.org/C2777074255","wikidata":"https://www.wikidata.org/wiki/Q1351681","display_name":"Thyroidectomy","level":3,"score":0.6226069927215576},{"id":"https://openalex.org/C2779512018","wikidata":"https://www.wikidata.org/wiki/Q536269","display_name":"Pheochromocytoma","level":2,"score":0.5626855492591858},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.5341858863830566},{"id":"https://openalex.org/C2780103800","wikidata":"https://www.wikidata.org/wiki/Q1553018","display_name":"Multiple endocrine neoplasia","level":3,"score":0.5171553492546082},{"id":"https://openalex.org/C447327","wikidata":"https://www.wikidata.org/wiki/Q1639798","display_name":"Index case","level":3,"score":0.45584458112716675},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44851213693618774},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4123556613922119},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3852965235710144},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3635822534561157},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.21957454085350037},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19200053811073303},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10734042525291443},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10417461395263672},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000090063","descriptor_name":"Proto-Oncogene Mas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000310","descriptor_name":"Adrenal Gland Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010673","descriptor_name":"Pheochromocytoma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D011519","descriptor_name":"Proto-Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D013965","descriptor_name":"Thyroidectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018095","descriptor_name":"Germ-Line Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018813","descriptor_name":"Multiple Endocrine Neoplasia Type 2a","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D018813","descriptor_name":"Multiple Endocrine Neoplasia Type 2a","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018813","descriptor_name":"Multiple Endocrine Neoplasia Type 2a","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D051096","descriptor_name":"Proto-Oncogene Proteins c-ret","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1089/thy.2012.0134","doi":"https://doi.org/10.1089/thy.2012.0134","is_oa":false,"landing_page_url":"https://doi.org/10.1089/thy.2012.0134","pdf_url":null,"source":{"id":"https://openalex.org/S27569427","display_name":"Thyroid","issn_l":"1050-7256","issn":["1050-7256","1557-9077"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thyroid","raw_type":"journal-article"},{"id":"pmid:23210566","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23210566","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thyroid : official journal of the American Thyroid Association","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W44469847","https://openalex.org/W138495997","https://openalex.org/W184653811","https://openalex.org/W1429697846","https://openalex.org/W1483784033","https://openalex.org/W1528750937","https://openalex.org/W1544851750","https://openalex.org/W1976809202","https://openalex.org/W1988101947","https://openalex.org/W1988823135","https://openalex.org/W1989888312","https://openalex.org/W2000937414","https://openalex.org/W2011640651","https://openalex.org/W2014541442","https://openalex.org/W2025526034","https://openalex.org/W2035003798","https://openalex.org/W2042518558","https://openalex.org/W2044761914","https://openalex.org/W2046246867","https://openalex.org/W2047599009","https://openalex.org/W2054803217","https://openalex.org/W2071282056","https://openalex.org/W2084517128","https://openalex.org/W2096710550","https://openalex.org/W2097892428","https://openalex.org/W2108671184","https://openalex.org/W2108758630","https://openalex.org/W2111778007","https://openalex.org/W2114578972","https://openalex.org/W2119807305","https://openalex.org/W2121875161","https://openalex.org/W2126481448","https://openalex.org/W2139143694","https://openalex.org/W2141646146","https://openalex.org/W2146718153","https://openalex.org/W2150286428","https://openalex.org/W2153489113","https://openalex.org/W2154459385","https://openalex.org/W2160863198","https://openalex.org/W2163928686","https://openalex.org/W4237879541","https://openalex.org/W4239180165","https://openalex.org/W4241911214","https://openalex.org/W4248988283"],"related_works":["https://openalex.org/W3031568495","https://openalex.org/W2399455907","https://openalex.org/W2092749410","https://openalex.org/W2062862086","https://openalex.org/W3029559911","https://openalex.org/W3195463543","https://openalex.org/W1833008413","https://openalex.org/W2578649298","https://openalex.org/W38665904","https://openalex.org/W2293469251"],"abstract_inverted_index":{"BACKGROUND:":[0],"Genetic":[1,87],"screening":[2],"for":[3],"germline":[4],"mutations":[5,137],"in":[6,41,46,91,104,153,160,179,244,311,318,336],"the":[7,17,42,47,169,205,209,220,245,249,291,312],"RET":[8,99,136,305],"proto-oncogene":[9],"has":[10,322],"been":[11],"extensively":[12],"exploited":[13],"worldwide":[14],"to":[15,71,324],"optimize":[16],"diagnostic":[18],"and":[19,30,60,79,128,148,157,192,204,215,248,284,321,327],"clinical":[20,61,121,172],"management":[21,313],"of":[22,50,63,177,187,198,208,251,302,314,332],"multiple":[23],"endocrine":[24],"neoplasia":[25],"type":[26],"2":[27],"(MEN2)":[28],"patients":[29,51,106,180,189,252,333],"their":[31,199],"relatives.":[32],"However,":[33],"a":[34,57,195,242,308],"distinct":[35],"lag":[36],"period":[37],"exists":[38],"not":[39],"only":[40],"recognition":[43],"but":[44],"also":[45,241],"medical":[48],"treatment":[49,331],"with":[52,107,114,166,181,219,334],"MEN2.":[53],"Here":[54],"we":[55],"present":[56],"comprehensive":[58],"genetic":[59],"analysis":[62],"MEN2":[64,315,335],"among":[65],"Chinese":[66],"families":[67],"followed":[68],"from":[69,82],"1975":[70],"2011.":[72],"Our":[73,295],"series":[74],"comprises":[75],"36":[76],"index":[77,155,221],"cases":[78,156,222],"134":[80],"relatives":[81,163],"11":[83],"independent":[84],"families.":[85],"METHODS:":[86],"diagnosis":[88,326],"was":[89,102,183,194,240],"performed":[90,103],"all":[92,97,303],"participants":[93],"by":[94],"direct":[95],"sequencing":[96],"relevant":[98,304],"exons.":[100],"Thyroidectomy":[101],"50":[105,188],"varying":[108],"cervical":[109],"neck":[110],"dissection":[111],"procedures.":[112],"Patients":[113],"pheochromocytoma":[115],"(PHEO)":[116],"underwent":[117,190,254],"specific":[118],"surgery.":[119],"Demographic,":[120],"profiles,":[122],"mutation":[123,210],"types,":[124],"tumor":[125,206],"histopathologic":[126],"features,":[127],"follow-up":[129],"records":[130],"were":[131,151,213,288],"systematically":[132],"analyzed.":[133],"RESULTS:":[134],"The":[135,174],"p.C634Y":[138],"(n=34),":[139],"p.C634R":[140],"(n=6),":[141],"p.C618S":[142],"(n=13),":[143],"p.V292M/R67H/R982C":[144],"(n=7),":[145],"p.L790F":[146],"(n=2),":[147],"p.C634Y/V292M/R67H/R982C":[149],"(n=1)":[150,283],"confirmed":[152],"31":[154],"then":[158],"identified":[159],"32":[161],"at-risk":[162],"(mutation":[164],"carriers),":[165],"MEN2A":[167,182],"as":[168],"most":[170],"common":[171],"subtype.":[173],"overall":[175],"penetrance":[176],"PHEO":[178],"46.7%.":[184],"A":[185],"total":[186],"thyroidectomy,":[191],"there":[193],"significant":[196],"lowering":[197],"mean":[200],"age":[201],"at":[202,224],"thyroidectomy":[203],"diameter":[207],"carriers":[211],"that":[212,299],"detected":[214],"operated":[216],"on":[217],"compared":[218],"(age":[223],"first":[225],"surgery:":[226,265],"29.3":[227],"vs.":[228,235,261,267,276],"39.3":[229],"years,":[230],"p<0.05;":[231],"maximum":[232],"size:":[233],"1.1":[234],"3.3":[236],"cm,":[237],"p<0.001).":[238],"There":[239],"decrease":[243],"TNM":[246],"staging":[247],"proportion":[250],"who":[253],"inappropriate":[255,264],"initial":[256,330],"thyroid":[257,281],"surgery":[258],"(pN1:":[259],"31.6%":[260],"100%,":[262],"p<0.001;":[263],"0%":[266],"29%).":[268],"Meanwhile,":[269],"disease-free":[270],"survival":[271],"(DFS)":[272],"increased":[273],"(DFS:":[274],"100%":[275],"58.1%,":[277],"p<0.05).":[278],"Both":[279],"medullary":[280],"carcinoma-specific":[282],"PHEO-specific":[285],"(n=5)":[286],"deaths":[287],"reported":[289],"during":[290],"study":[292],"period.":[293],"CONCLUSIONS:":[294],"results":[296],"further":[297],"substantiate":[298],"gene":[300],"scanning":[301],"exons":[306],"is":[307],"powerful":[309],"tool":[310],"patients,":[316],"especially":[317],"asymptomatic":[319],"carriers,":[320],"led":[323],"earlier":[325],"more":[328],"complete":[329],"China.":[337]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
