{"id":"https://openalex.org/W1973006294","doi":"https://doi.org/10.2147/nedt.2006.2.2.191","title":"Aripiprazole in the acute treatment of male patients with schizophrenia: effectiveness, acceptability, and risks in the inner-city hospital setting","display_name":"Aripiprazole in the acute treatment of male patients with schizophrenia: effectiveness, acceptability, and risks in the inner-city hospital setting","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W1973006294","doi":"https://doi.org/10.2147/nedt.2006.2.2.191","mag":"1973006294","pmid":"https://pubmed.ncbi.nlm.nih.gov/19412463","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2671787"},"language":"en","primary_location":{"id":"doi:10.2147/nedt.2006.2.2.191","doi":"https://doi.org/10.2147/nedt.2006.2.2.191","is_oa":false,"landing_page_url":"https://doi.org/10.2147/nedt.2006.2.2.191","pdf_url":null,"source":{"id":"https://openalex.org/S124245730","display_name":"Neuropsychiatric Disease and Treatment","issn_l":"1176-6328","issn":["1176-6328","1178-2021"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychiatric Disease and Treatment","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2671787","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025355697","display_name":"Luiz Dratcu","orcid":"https://orcid.org/0000-0002-5888-4991","observed_orcids":["https://orcid.org/0000-0002-5888-4991"]},"institutions":[{"id":"https://openalex.org/I1298207432","display_name":"Guy's Hospital","ror":"https://ror.org/04r33pf22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1298207432","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I200323923","display_name":"South London and Maudsley NHS Foundation Trust","ror":"https://ror.org/015803449","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200323923"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Luiz Dratcu","raw_affiliation_strings":["York Clinic, Guy's Hospital, South London and Maudsley NHS Trust, London, UK. Luiz.Dratcu@slam.nhs.uk","York Clinic, Guy's Hospital, South London and Maudsley NHS Trust, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"York Clinic, Guy's Hospital, South London and Maudsley NHS Trust, London, UK. Luiz.Dratcu@slam.nhs.uk","institution_ids":["https://openalex.org/I1298207432","https://openalex.org/I200323923"]},{"raw_affiliation_string":"York Clinic, Guy's Hospital, South London and Maudsley NHS Trust, London, UK","institution_ids":["https://openalex.org/I1298207432","https://openalex.org/I200323923"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020686262","display_name":"\u041f. \u041e\u043b\u043e\u0432\u0443","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1298207432","display_name":"Guy's Hospital","ror":"https://ror.org/04r33pf22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1298207432","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I200323923","display_name":"South London and Maudsley NHS Foundation Trust","ror":"https://ror.org/015803449","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200323923"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Patricia Olowu","raw_affiliation_strings":["York Clinic, Guy\u2019s Hospital, South London and Maudsley NHS Trust, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"York Clinic, Guy\u2019s Hospital, South London and Maudsley NHS Trust, London, UK","institution_ids":["https://openalex.org/I1298207432","https://openalex.org/I200323923"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053561665","display_name":"Muzafar Hawramy","orcid":"https://orcid.org/0000-0003-4679-2085","observed_orcids":["https://orcid.org/0000-0003-4679-2085"]},"institutions":[{"id":"https://openalex.org/I1298207432","display_name":"Guy's Hospital","ror":"https://ror.org/04r33pf22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1298207432","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I200323923","display_name":"South London and Maudsley NHS Foundation Trust","ror":"https://ror.org/015803449","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200323923"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Muzafar Hawramy","raw_affiliation_strings":["York Clinic, Guy\u2019s Hospital, South London and Maudsley NHS Trust, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"York Clinic, Guy\u2019s Hospital, South London and Maudsley NHS Trust, London, UK","institution_ids":["https://openalex.org/I1298207432","https://openalex.org/I200323923"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033314336","display_name":"Charitomeni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1298207432","display_name":"Guy's Hospital","ror":"https://ror.org/04r33pf22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1298207432","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I200323923","display_name":"South London and Maudsley NHS Foundation Trust","ror":"https://ror.org/015803449","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200323923"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Charitomeni","raw_affiliation_strings":["York Clinic, Guy's Hospital, South London and Maudsley NHS Trust, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"York Clinic, Guy's Hospital, South London and Maudsley NHS Trust, London, UK","institution_ids":["https://openalex.org/I1298207432","https://openalex.org/I200323923"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049015993","display_name":"Konstantinidou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1298207432","display_name":"Guy's Hospital","ror":"https://ror.org/04r33pf22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1298207432","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I200323923","display_name":"South London and Maudsley NHS Foundation Trust","ror":"https://ror.org/015803449","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200323923"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Konstantinidou","raw_affiliation_strings":["York Clinic, Guy's Hospital, South London and Maudsley NHS Trust, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"York Clinic, Guy's Hospital, South London and Maudsley NHS Trust, London, UK","institution_ids":["https://openalex.org/I1298207432","https://openalex.org/I200323923"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5025355697"],"corresponding_institution_ids":["https://openalex.org/I1298207432","https://openalex.org/I200323923"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":null,"fwci":0.212,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.60834621,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"2","issue":"2","first_page":"191","last_page":"197"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13944","display_name":"Psychiatric care and mental health services","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aripiprazole","display_name":"aripiprazole","score":1.0},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.9890000224113464},{"id":"https://openalex.org/keywords/acute-psychosis","display_name":"acute psychosis","score":0.6610000133514404},{"id":"https://openalex.org/keywords/atypical-antipsychotics","display_name":"atypical antipsychotics","score":0.9369999766349792},{"id":"https://openalex.org/keywords/dopamine-d2-receptor-partial-agonist","display_name":"dopamine D2 receptor partial agonist","score":0.8640000224113464},{"id":"https://openalex.org/keywords/monotherapy","display_name":"monotherapy","score":0.6349999904632568},{"id":"https://openalex.org/keywords/treatment-effectiveness","display_name":"treatment effectiveness","score":0.7170000076293945},{"id":"https://openalex.org/keywords/tolerability","display_name":"tolerability","score":0.847000002861023},{"id":"https://openalex.org/keywords/extrapyramidal-symptoms","display_name":"extrapyramidal symptoms","score":0.8560000061988831},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.9440000057220459},{"id":"https://openalex.org/keywords/tardive-dyskinesia","display_name":"tardive dyskinesia","score":0.9909999966621399},{"id":"https://openalex.org/keywords/male-patients","display_name":"male patients","score":0.7900000214576721}],"concepts":[{"id":"https://openalex.org/C2780211496","wikidata":"https://www.wikidata.org/wiki/Q411188","display_name":"Aripiprazole","level":3,"score":0.9846841096878052},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8725560307502747},{"id":"https://openalex.org/C2779158372","wikidata":"https://www.wikidata.org/wiki/Q1546328","display_name":"Tardive dyskinesia","level":3,"score":0.7665804624557495},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.6351789236068726},{"id":"https://openalex.org/C2780616385","wikidata":"https://www.wikidata.org/wiki/Q1385411","display_name":"Extrapyramidal symptoms","level":4,"score":0.5991013050079346},{"id":"https://openalex.org/C2780494398","wikidata":"https://www.wikidata.org/wiki/Q208144","display_name":"Antipsychotic","level":3,"score":0.5831219553947449},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5619985461235046},{"id":"https://openalex.org/C58732023","wikidata":"https://www.wikidata.org/wiki/Q770260","display_name":"Partial agonist","level":4,"score":0.529387891292572},{"id":"https://openalex.org/C2780405171","wikidata":"https://www.wikidata.org/wiki/Q629444","display_name":"Dyskinesia","level":4,"score":0.5032045245170593},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.4373273253440857},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3798981308937073},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.2665274441242218},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.12265631556510925},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06081107258796692},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.2147/nedt.2006.2.2.191","doi":"https://doi.org/10.2147/nedt.2006.2.2.191","is_oa":false,"landing_page_url":"https://doi.org/10.2147/nedt.2006.2.2.191","pdf_url":null,"source":{"id":"https://openalex.org/S124245730","display_name":"Neuropsychiatric Disease and Treatment","issn_l":"1176-6328","issn":["1176-6328","1178-2021"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychiatric Disease and Treatment","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2671787","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2671787","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychiatr Dis Treat","raw_type":"Text"},{"id":"pmid:19412463","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19412463","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychiatric disease and treatment","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2671787","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2671787","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychiatr Dis Treat","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1633465406","https://openalex.org/W1971179661","https://openalex.org/W1982212635","https://openalex.org/W2010741426","https://openalex.org/W2016709233","https://openalex.org/W2021454992","https://openalex.org/W2023196627","https://openalex.org/W2032469488","https://openalex.org/W2033155032","https://openalex.org/W2046695234","https://openalex.org/W2051171671","https://openalex.org/W2084462202","https://openalex.org/W2093449642","https://openalex.org/W2094347184","https://openalex.org/W2097167627","https://openalex.org/W2114801996","https://openalex.org/W2162707091","https://openalex.org/W2320362137","https://openalex.org/W2397672824","https://openalex.org/W2577243052","https://openalex.org/W3191110341"],"related_works":["https://openalex.org/W978192936","https://openalex.org/W40764528","https://openalex.org/W2042931617","https://openalex.org/W2042056993","https://openalex.org/W1526739248","https://openalex.org/W2162527458","https://openalex.org/W2142436561","https://openalex.org/W1967550266","https://openalex.org/W1895024953","https://openalex.org/W4362521864"],"abstract_inverted_index":{"Aripiprazole,":[0],"a":[1,8,58],"novel":[2],"atypical":[3],"antipsychotic":[4],"that":[5,147,158,167],"acts":[6],"as":[7],"partial":[9],"agonist":[10],"at":[11],"the":[12,23,29,37,52,153,176,193],"dopamine":[13,163],"D(2)":[14],"receptors,":[15],"has":[16],"been":[17],"reported":[18],"to":[19,41,73,85,103,179,191],"be":[20,106,150,170],"effective":[21],"in":[22,36,57,138,152,175],"treatment":[24,154],"of":[25,33,54,60,155,196],"chronic":[26],"schizophrenia.":[27],"However,":[28],"risks":[30],"and":[31,92,118,120,127,172,199],"benefits":[32],"using":[34],"aripiprazole":[35,55,86,110,168],"acute":[38,76],"hospital":[39,177],"setting":[40,178],"treat":[42,180],"severe":[43,142],"psychotic":[44,62,95,182],"disorders":[45,157],"are":[46,159,189],"unclear.":[47],"This":[48],"naturalistic":[49],"study":[50],"assessed":[51],"effectiveness":[53],"monotherapy":[56],"group":[59],"actively":[61],"male":[63],"patients":[64,80,183],"(n":[65,81,124,129],"=":[66,82,125,130],"10)":[67],"with":[68,141,162,184,203],"schizophrenia":[69],"who":[70,101],"were":[71,115],"admitted":[72],"an":[74],"inner-city":[75],"psychiatric":[77],"unit.":[78],"Most":[79],"7)":[83],"responded":[84,102],"treatment,":[87],"which":[88],"was":[89],"well":[90],"tolerated":[91],"significantly":[93],"ameliorated":[94],"symptoms":[96,123],"after":[97],"2-3":[98],"weeks.":[99],"Patients":[100],"it":[104,148],"could":[105],"safely":[107,171],"discharged":[108],"on":[109],"monotherapy.":[111],"Side":[112],"effects":[113],"observed":[114],"mostly":[116],"mild":[117],"transient,":[119],"included":[121],"extrapyramidal":[122],"1)":[126],"neutropenia":[128],"1).":[131],"Aripiprazole":[132],"also":[133,160],"remarkably":[134],"attenuated":[135],"dyskinetic":[136],"movements":[137],"1":[139],"patient":[140],"tardive":[143],"dyskinesia,":[144],"thereby":[145],"suggesting":[146],"may":[149],"useful":[151],"other":[156],"associated":[161,202],"dysfunction.":[164],"Results":[165],"showed":[166],"can":[169],"effectively":[173],"employed":[174],"severely":[181],"schizophrenia,":[185],"but":[186],"further":[187],"studies":[188],"required":[190],"establish":[192],"full":[194],"range":[195],"adverse":[197],"reactions":[198],"therapeutic":[200],"indications":[201],"its":[204],"use.":[205]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}