{"id":"https://openalex.org/W1972966488","doi":"https://doi.org/10.1097/00006123-198706000-00006","title":"Effect of Hypoxia on Traumatic Brain Injury in Rats: Part 2","display_name":"Effect of Hypoxia on Traumatic Brain Injury in Rats: Part 2","publication_year":1987,"publication_date":"1987-06-01","ids":{"openalex":"https://openalex.org/W1972966488","doi":"https://doi.org/10.1097/00006123-198706000-00006","mag":"1972966488","pmid":"https://pubmed.ncbi.nlm.nih.gov/3614564"},"language":"en","primary_location":{"id":"doi:10.1097/00006123-198706000-00006","doi":"https://doi.org/10.1097/00006123-198706000-00006","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00006123-198706000-00006","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"N Ishige","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N Ishige","raw_affiliation_strings":["Departments of Neurological Surgery and Pharmaceutical Chemistry, Schools of Medicine and Pharmacy, University of California, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurological Surgery and Pharmaceutical Chemistry, Schools of Medicine and Pharmacy, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109923917","display_name":"Lawrence H. Pitts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L H Pitts","raw_affiliation_strings":["Departments of Neurological Surgery and Pharmaceutical Chemistry, Schools of Medicine and Pharmacy, University of California, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurological Surgery and Pharmaceutical Chemistry, Schools of Medicine and Pharmacy, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006077714","display_name":"Lionello Pogliani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L Pogliani","raw_affiliation_strings":["Departments of Neurological Surgery and Pharmaceutical Chemistry, Schools of Medicine and Pharmacy, University of California, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurological Surgery and Pharmaceutical Chemistry, Schools of Medicine and Pharmacy, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007660557","display_name":"Takahiro Hashimoto","orcid":"https://orcid.org/0000-0001-8479-0609","observed_orcids":["https://orcid.org/0000-0001-8479-0609"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T Hashimoto","raw_affiliation_strings":["Departments of Neurological Surgery and Pharmaceutical Chemistry, Schools of Medicine and Pharmacy, University of California, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurological Surgery and Pharmaceutical Chemistry, Schools of Medicine and Pharmacy, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066169300","display_name":"Merry C. Nishimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M C Nishimura","raw_affiliation_strings":["Departments of Neurological Surgery and Pharmaceutical Chemistry, Schools of Medicine and Pharmacy, University of California, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurological Surgery and Pharmaceutical Chemistry, Schools of Medicine and Pharmacy, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080094098","display_name":"Henry M. Bartkowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H M Bartkowski","raw_affiliation_strings":["Departments of Neurological Surgery and Pharmaceutical Chemistry, Schools of Medicine and Pharmacy, University of California, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurological Surgery and Pharmaceutical Chemistry, Schools of Medicine and Pharmacy, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109876171","display_name":"Thomas Leroy James","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T L James","raw_affiliation_strings":["Departments of Neurological Surgery and Pharmaceutical Chemistry, Schools of Medicine and Pharmacy, University of California, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurological Surgery and Pharmaceutical Chemistry, Schools of Medicine and Pharmacy, University of California, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":null,"apc_paid":null,"fwci":3.1592,"has_fulltext":false,"cited_by_count":78,"citation_normalized_percentile":{"value":0.90811639,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"20","issue":"6","first_page":"854","last_page":"854???8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.9639999866485596},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9909999966621399},{"id":"https://openalex.org/keywords/phosphate-metabolism","display_name":"phosphate metabolism","score":0.902999997138977},{"id":"https://openalex.org/keywords/phosphocreatine","display_name":"phosphocreatine","score":0.8799999952316284},{"id":"https://openalex.org/keywords/inorganic-phosphate","display_name":"inorganic phosphate","score":0.9789999723434448},{"id":"https://openalex.org/keywords/high-energy-phosphates","display_name":"high-energy phosphates","score":0.6470000147819519},{"id":"https://openalex.org/keywords/fluid-percussion-injury","display_name":"fluid percussion injury","score":0.8410000205039978},{"id":"https://openalex.org/keywords/intracellular-ph","display_name":"intracellular pH","score":0.8289999961853027},{"id":"https://openalex.org/keywords/brain-energy-metabolism","display_name":"brain energy metabolism","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C2778626300","wikidata":"https://www.wikidata.org/wiki/Q1984607","display_name":"Phosphocreatine","level":3,"score":0.9156846404075623},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.7985109090805054},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6952428817749023},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.5864856243133545},{"id":"https://openalex.org/C53009064","wikidata":"https://www.wikidata.org/wiki/Q167","display_name":"Pi","level":2,"score":0.5662251114845276},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5133273005485535},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5108913779258728},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.49419930577278137},{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.4281787574291229},{"id":"https://openalex.org/C2779564974","wikidata":"https://www.wikidata.org/wiki/Q80863","display_name":"Adenosine triphosphate","level":2,"score":0.41730350255966187},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.3039069175720215},{"id":"https://openalex.org/C2986317502","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Energy metabolism","level":2,"score":0.26515233516693115},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.18500927090644836},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1759006679058075},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16615906357765198},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002534","descriptor_name":"Hypoxia, Brain","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D002534","descriptor_name":"Hypoxia, Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010710","descriptor_name":"Phosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010725","descriptor_name":"Phosphocreatine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/00006123-198706000-00006","doi":"https://doi.org/10.1097/00006123-198706000-00006","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00006123-198706000-00006","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"},{"id":"doi:10.1227/00006123-198706000-00006","doi":"https://doi.org/10.1227/00006123-198706000-00006","is_oa":false,"landing_page_url":"https://doi.org/10.1227/00006123-198706000-00006","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"},{"id":"pmid:3614564","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3614564","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4252104899","https://openalex.org/W2171902246","https://openalex.org/W1963907349","https://openalex.org/W2071956393","https://openalex.org/W2069797329","https://openalex.org/W2138331490","https://openalex.org/W7144559639","https://openalex.org/W2088616939","https://openalex.org/W2086353424","https://openalex.org/W2384179328"],"abstract_inverted_index":{"The":[0],"effect":[1],"of":[2,5,13,36,56,81,101,119,127,130,148,160,163,177,209],"different":[3],"degrees":[4],"hypoxia":[6,43,161,207],"on":[7],"phosphate":[8,83],"metabolism":[9],"in":[10,19,29,67,73,170,182,193,222],"the":[11,79,99,137,149,194,228],"brains":[12],"impact-injured":[14,77,171],"rats":[15,41,112],"was":[16],"studied":[17],"using":[18],"vivo":[20],"phosphorus-31":[21],"magnetic":[22],"resonance":[23],"(P-31":[24],"MR)":[25],"spectroscopy.":[26],"Sequential":[27],"changes":[28,66,221],"P-31":[30],"MR":[31],"spectra":[32,69],"within":[33],"60":[34],"minutes":[35],"insult":[37],"were":[38,122,174],"compared":[39],"among":[40],"with":[42,113],"alone,":[44,47],"impact":[45,117,150,217],"injury":[46,118,218],"or":[48],"a":[49,71,114,128,143,190],"combined":[50],"impact-hypoxic":[51],"insult.":[52],"Hypoxia":[53],"alone":[54,151],"(PaO2":[55,162,208],"40":[57,131,164],"mm":[58,132,165,211],"Hg":[59,133,166,212],"for":[60,88,134,167,184,213],"30":[61,168,214],"minutes)":[62,169,215],"caused":[63,189,219],"no":[64],"remarkable":[65],"phosphorus":[68],"except":[70],"decrease":[72,192],"intracellular":[74],"pH.":[75],"In":[76],"rats,":[78,172],"concentration":[80],"inorganic":[82],"(Pi)":[84],"increased,":[85],"but":[86],"signals":[87,183],"phosphocreatine":[89],"(PCr)":[90],"and":[91,98,179,186,227],"beta-adenosine":[92],"triphosphate":[93],"(beta-ATP)":[94],"did":[95],"not":[96],"change,":[97],"ratio":[100,139,196,230],"PCr/Pi":[102,138,195,229],"changed":[103],"only":[104],"slightly":[105],"to":[106,124,197,232],"7%":[107],"below":[108,146,199,234],"control":[109,200,235],"value.":[110],"When":[111],"fluid":[115],"percussion":[116],"5":[120],"atm":[121],"subjected":[123],"hypoxic":[125],"conditions":[126],"PaO2":[129],"15":[135],"minutes,":[136],"decreased":[140,231],"by":[141],"14%,":[142],"value":[144],"significantly":[145],"that":[147],"group":[152],"(P":[153,202],"less":[154,203],"than":[155,204],"0.05).":[156],"After":[157],"longer":[158],"periods":[159],"there":[173],"marked":[175,191],"increases":[176],"Pi":[178],"significant":[180],"decreases":[181],"PCr":[185],"beta-ATP,":[187],"which":[188],"39%":[198],"values":[201],"0.001).":[205],"Milder":[206],"50":[210],"plus":[216],"smaller":[220],"high":[223],"energy":[224],"metabolite":[225],"concentrations,":[226],"15%":[233],"values.(ABSTRACT":[236],"TRUNCATED":[237],"AT":[238],"250":[239],"WORDS)":[240]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
