{"id":"https://openalex.org/W1972938656","doi":null,"title":"Thyromimetic and Proteomic Analysis of Secondary Wastewater Effluent","display_name":"Thyromimetic and Proteomic Analysis of Secondary Wastewater Effluent","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W1972938656","mag":"1972938656"},"language":"en","primary_location":{"id":"mag:1972938656","doi":null,"is_oa":false,"landing_page_url":"http://arizona.openrepository.com/arizona/bitstream/10150/193857/1/azu_etd_2442_sip1_m.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054013970","display_name":"Peter Littlehat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Peter Littlehat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5054013970"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.9312000274658203,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10419","display_name":"Pharmaceutical and Antibiotic Environmental Impacts","score":0.021700000390410423,"subfield":{"id":"https://openalex.org/subfields/2310","display_name":"Pollution"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11781","display_name":"Wastewater Treatment and Reuse","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/2311","display_name":"Waste Management and Disposal"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endocrine-disruptors","display_name":"endocrine disruptors","score":0.7889999747276306},{"id":"https://openalex.org/keywords/secondary-effluent","display_name":"secondary effluent","score":0.8080000281333923},{"id":"https://openalex.org/keywords/thyroid-hormone-receptor-beta","display_name":"thyroid hormone receptor beta","score":0.5649999976158142},{"id":"https://openalex.org/keywords/protein-expression-profiling","display_name":"protein expression profiling","score":0.5860000252723694},{"id":"https://openalex.org/keywords/2d-dige","display_name":"2D-DIGE","score":0.7789999842643738},{"id":"https://openalex.org/keywords/t47d-cells","display_name":"T47D cells","score":0.8769999742507935},{"id":"https://openalex.org/keywords/recycled-water","display_name":"reclaimed water","score":0.5090000033378601},{"id":"https://openalex.org/keywords/wastewater-reclamation","display_name":"wastewater reclamation","score":0.5529999732971191},{"id":"https://openalex.org/keywords/protein-identification","display_name":"protein identification","score":0.3319999873638153}],"concepts":[{"id":"https://openalex.org/C147455438","wikidata":"https://www.wikidata.org/wiki/Q1057706","display_name":"Effluent","level":2,"score":0.7314352989196777},{"id":"https://openalex.org/C94061648","wikidata":"https://www.wikidata.org/wiki/Q336191","display_name":"Wastewater","level":2,"score":0.6821439862251282},{"id":"https://openalex.org/C109115496","wikidata":"https://www.wikidata.org/wiki/Q2539644","display_name":"Thyroid hormone receptor","level":3,"score":0.6107754707336426},{"id":"https://openalex.org/C104488531","wikidata":"https://www.wikidata.org/wiki/Q864212","display_name":"Bioassay","level":2,"score":0.6075822114944458},{"id":"https://openalex.org/C39432304","wikidata":"https://www.wikidata.org/wiki/Q188847","display_name":"Environmental science","level":0,"score":0.5984283685684204},{"id":"https://openalex.org/C76177295","wikidata":"https://www.wikidata.org/wiki/Q161598","display_name":"Groundwater","level":2,"score":0.5344215035438538},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.49160581827163696},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.39221999049186707},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3736606240272522},{"id":"https://openalex.org/C87717796","wikidata":"https://www.wikidata.org/wiki/Q146326","display_name":"Environmental engineering","level":1,"score":0.364582896232605},{"id":"https://openalex.org/C524765639","wikidata":"https://www.wikidata.org/wiki/Q1501619","display_name":"Water resource management","level":1,"score":0.34395885467529297},{"id":"https://openalex.org/C107872376","wikidata":"https://www.wikidata.org/wiki/Q321355","display_name":"Environmental chemistry","level":1,"score":0.33679360151290894},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3293997347354889},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.25129765272140503},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.11154130101203918},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.08087158203125},{"id":"https://openalex.org/C187320778","wikidata":"https://www.wikidata.org/wiki/Q1349130","display_name":"Geotechnical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:1972938656","doi":null,"is_oa":false,"landing_page_url":"http://arizona.openrepository.com/arizona/bitstream/10150/193857/1/azu_etd_2442_sip1_m.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6","score":0.965499997138977},{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033},{"display_name":"Responsible consumption and production","id":"https://metadata.un.org/sdg/12","score":0.5925999879837036}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":121,"referenced_works":["https://openalex.org/W7532581","https://openalex.org/W300744513","https://openalex.org/W592578666","https://openalex.org/W633806619","https://openalex.org/W636932751","https://openalex.org/W788001335","https://openalex.org/W1486845435","https://openalex.org/W1497938403","https://openalex.org/W1511049454","https://openalex.org/W1549850749","https://openalex.org/W1552837821","https://openalex.org/W1565489784","https://openalex.org/W1586608728","https://openalex.org/W1911685251","https://openalex.org/W1963841973","https://openalex.org/W1964929724","https://openalex.org/W1965661828","https://openalex.org/W1966668423","https://openalex.org/W1966821981","https://openalex.org/W1969487024","https://openalex.org/W1970618773","https://openalex.org/W1970697012","https://openalex.org/W1971425761","https://openalex.org/W1975863449","https://openalex.org/W1978672243","https://openalex.org/W1978800202","https://openalex.org/W1979371039","https://openalex.org/W1980977242","https://openalex.org/W1982071978","https://openalex.org/W1984346186","https://openalex.org/W1984845582","https://openalex.org/W1985822851","https://openalex.org/W1987184305","https://openalex.org/W1987227107","https://openalex.org/W1987652819","https://openalex.org/W1988030686","https://openalex.org/W1988179233","https://openalex.org/W1995135039","https://openalex.org/W2000303521","https://openalex.org/W2002909502","https://openalex.org/W2005149088","https://openalex.org/W2006787141","https://openalex.org/W2006890927","https://openalex.org/W2011717087","https://openalex.org/W2014035689","https://openalex.org/W2015028096","https://openalex.org/W2015944836","https://openalex.org/W2016970173","https://openalex.org/W2020885903","https://openalex.org/W2024003691","https://openalex.org/W2028017879","https://openalex.org/W2030320957","https://openalex.org/W2033187549","https://openalex.org/W2033638549","https://openalex.org/W2034079702","https://openalex.org/W2034859055","https://openalex.org/W2035004174","https://openalex.org/W2037728383","https://openalex.org/W2037766564","https://openalex.org/W2039013813","https://openalex.org/W2039168363","https://openalex.org/W2042124938","https://openalex.org/W2042298854","https://openalex.org/W2042614655","https://openalex.org/W2042892924","https://openalex.org/W2042896209","https://openalex.org/W2045123003","https://openalex.org/W2053413857","https://openalex.org/W2054804796","https://openalex.org/W2055365420","https://openalex.org/W2058147250","https://openalex.org/W2060664702","https://openalex.org/W2066837860","https://openalex.org/W2067314116","https://openalex.org/W2068443944","https://openalex.org/W2069160027","https://openalex.org/W2070185436","https://openalex.org/W2076312446","https://openalex.org/W2078142935","https://openalex.org/W2078199102","https://openalex.org/W2078720603","https://openalex.org/W2078861858","https://openalex.org/W2080441798","https://openalex.org/W2081805307","https://openalex.org/W2085406269","https://openalex.org/W2090601295","https://openalex.org/W2095167055","https://openalex.org/W2095718513","https://openalex.org/W2095879551","https://openalex.org/W2100492886","https://openalex.org/W2103941692","https://openalex.org/W2106883177","https://openalex.org/W2107608797","https://openalex.org/W2108241608","https://openalex.org/W2109579863","https://openalex.org/W2111909451","https://openalex.org/W2116397033","https://openalex.org/W2122309560","https://openalex.org/W2124241458","https://openalex.org/W2124374523","https://openalex.org/W2127394974","https://openalex.org/W2128676243","https://openalex.org/W2129965256","https://openalex.org/W2136262030","https://openalex.org/W2139685584","https://openalex.org/W2141261534","https://openalex.org/W2147594982","https://openalex.org/W2149127070","https://openalex.org/W2154606831","https://openalex.org/W2156112336","https://openalex.org/W2158567075","https://openalex.org/W2158927639","https://openalex.org/W2159778518","https://openalex.org/W2160166542","https://openalex.org/W2160240007","https://openalex.org/W2166439602","https://openalex.org/W2169697629","https://openalex.org/W2170863772","https://openalex.org/W2178676006","https://openalex.org/W2186477014","https://openalex.org/W2340100936"],"related_works":["https://openalex.org/W2327384285","https://openalex.org/W2001958954","https://openalex.org/W2006673008","https://openalex.org/W2746709701","https://openalex.org/W2024346922","https://openalex.org/W2972420884","https://openalex.org/W1979730231","https://openalex.org/W2765710644","https://openalex.org/W2003070275","https://openalex.org/W2885046920"],"abstract_inverted_index":{"Wastewater":[0],"reclamation":[1],"and":[2,48,86,100,162,177],"reuse":[3],"is":[4,71,107,323],"imperative":[5],"in":[6,126,153,170,196,241,253,266,274,336,346],"water-starved":[7],"areas":[8],"such":[9],"as":[10,251],"the":[11,16,26,31,38,49,58,80,87,109,135,163,171,192,207,267,278,292,321,330,340],"southwestern":[12],"United":[13],"States.":[14],"In":[15],"Tucson":[17],"Active":[18],"Management":[19],"Area,":[20],"a":[21,146,200,227,244],"geographic":[22],"region":[23],"defined":[24],"for":[25,34,73,83,184,206,258,301],"purpose":[27],"of":[28,44,89,104,123,134,262,281,296,306,333,342],"groundwater":[29,67],"management,":[30],"total":[32],"demand":[33,60],"water":[35,40,47,70,85,93],"already":[36],"exceeds":[37],"available":[39],"supply,":[41],"which":[42,140],"consists":[43],"renewable":[45],"ground":[46],"regional":[50,59],"entitlement":[51],"to":[52,66,115,155,191,198,216,256,290,325],"Central":[53],"Arizona":[54],"Project":[55],"water.":[56],"Thus,":[57],"cannot":[61],"be":[62],"satisfied":[63],"without":[64],"resorting":[65],"mining":[68],"unless":[69],"reclaimed":[72,84],"local":[74],"beneficial":[75],"use.":[76],"Less":[77],"certain":[78],"are":[79,121],"acceptable":[81],"uses":[82],"nature":[88],"use-dependent":[90],"treatments":[91],"or":[92,304],"quality":[94],"requirements":[95],"that":[96,311],"will":[97],"protect":[98],"human":[99,164,172,178,268],"ecological":[101],"health.":[102],"Disruption":[103],"thyroid-mediated":[105],"actions":[106],"among":[108],"possible":[110],"risks":[111],"from":[112,222,226],"chronic":[113],"exposure":[114],"environmental":[116,157,217],"contaminants.":[117],"Endocrine":[118],"disrupting":[119],"compounds":[120],"generally":[122],"greater":[124],"concern":[125],"this":[127,242,275],"context":[128],"than":[129],"other":[130],"trace":[131],"contaminants":[132],"because":[133],"very":[136],"low":[137],"concentrations":[138],"at":[139],"hormones":[141,335],"induce":[142],"physiological":[143],"responses.":[144],"Accordingly,":[145],"sensitive":[147],"nuclear-based":[148],"bioassay":[149,209,255,276],"system":[150],"was":[151,182,213,249,299],"developed":[152],"order":[154,197],"evaluate":[156],"samples.":[158],"A":[159],"luciferase-reporter":[160],"construct":[161,169],"thyroid":[165,193,202,237],"receptor":[166],"\u03b2":[167],"(TR-\u03b2)":[168],"hepatoma":[173],"cell":[174,271,347],"line":[175],"(HepG2)":[176],"medulloblastoma":[179],"cells":[180,188,345],"(TE671)":[181],"evaluated":[183],"sensitivity.":[185],"The":[186,211,233,294],"transfected":[187],"were":[189,312,314],"exposed":[190],"hormone,":[194],"T3,":[195],"establish":[199],"lower":[201],"hormone":[203],"detection":[204],"limit":[205],"new":[208],"procedure.":[210],"assay":[212],"then":[214],"applied":[215],"samples":[218,235],"containing":[219],"organics":[220],"concentrated":[221],"final":[223],"effluent":[224,234],"derived":[225],"conventional":[228],"secondary":[229],"wastewater":[230,259,338],"treatment":[231],"plant.":[232],"activated":[236],"receptor-mediated":[238],"transcription.":[239],"Also":[240],"study,":[243],"two-dimensional":[245],"gel":[246],"electrophoresis":[247,289],"(2D-DIGE)":[248],"used":[250,324],"an":[252],"vitro":[254],"look":[257],"related":[260],"alteration":[261],"cellular":[263],"protein":[264,307],"expression":[265],"breast":[269],"cancer":[270],"T47D.":[272],"Steps":[273],"include":[277],"one-dimensional":[279],"separation":[280],"proteins":[282,310],"by":[283,287],"isoelectric":[284],"focusing":[285],"followed":[286],"orthogonal":[288],"isolate":[291],"proteins.":[293],"consistency":[295],"test":[297],"response":[298],"examined":[300],"wastewater-dependent":[302],"up-":[303],"down-regulation":[305],"expression.":[308],"Some":[309],"upregulated":[313],"preliminarily":[315],"identified":[316],"via":[317],"mass":[318],"spectrometry.":[319],"Here,":[320],"procedure":[322],"provide":[326],"direct":[327],"information":[328],"regarding":[329],"probable":[331],"effects":[332],"residual":[334],"treated":[337],"on":[339],"activities":[341],"human,":[343],"estrogen-responsive":[344],"culture.":[348]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}