{"id":"https://openalex.org/W1972921069","doi":"https://doi.org/10.1111/j.1749-6632.1991.tb17010.x","title":"Role of Antileukoprotease in the Human Lung","display_name":"Role of Antileukoprotease in the Human Lung","publication_year":1991,"publication_date":"1991-05-01","ids":{"openalex":"https://openalex.org/W1972921069","doi":"https://doi.org/10.1111/j.1749-6632.1991.tb17010.x","mag":"1972921069","pmid":"https://pubmed.ncbi.nlm.nih.gov/2064252"},"language":"en","primary_location":{"id":"doi:10.1111/j.1749-6632.1991.tb17010.x","doi":"https://doi.org/10.1111/j.1749-6632.1991.tb17010.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1749-6632.1991.tb17010.x","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111889772","display_name":"J. A. Kramps","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"J. A. KRAMPS","raw_affiliation_strings":["Department of Pulmonology, University Hospital, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonology, University Hospital, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044638211","display_name":"Arjan Rudolphus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"A. RUDOLPHUS","raw_affiliation_strings":["Department of Pulmonology University Hospital Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonology University Hospital Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041348182","display_name":"Jan N Stolk","orcid":"https://orcid.org/0000-0002-7887-386X","observed_orcids":["https://orcid.org/0000-0002-7887-386X"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J. STOLK","raw_affiliation_strings":["Department of Pulmonology University Hospital Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonology University Hospital Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052552737","display_name":"Luc Willems","orcid":"https://orcid.org/0000-0002-0563-2213","observed_orcids":["https://orcid.org/0000-0002-0563-2213"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"L. N. A. WILLEMS","raw_affiliation_strings":["Department of Pulmonology University Hospital Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonology University Hospital Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109947507","display_name":"Joop H. Dijkman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J. H. DIJKMAN","raw_affiliation_strings":["Department of Pulmonology University Hospital Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonology University Hospital Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111889772"],"corresponding_institution_ids":["https://openalex.org/I2800006345"],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":null,"fwci":0.2748,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.31446541,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"624","issue":"1","first_page":"97","last_page":"108"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.8115000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.8115000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.07490000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.026900000870227814,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-1-antitrypsin","display_name":"alpha-1-antitrypsin","score":0.9390000104904175},{"id":"https://openalex.org/keywords/lung","display_name":"lung","score":0.5289999842643738},{"id":"https://openalex.org/keywords/protease-inhibitors","display_name":"protease inhibitors","score":0.6980000138282776},{"id":"https://openalex.org/keywords/neutrophil-elastase","display_name":"neutrophil elastase","score":0.7680000066757202},{"id":"https://openalex.org/keywords/lung-injury","display_name":"lung injury","score":0.38499999046325684}],"concepts":[{"id":"https://openalex.org/C179585855","wikidata":"https://www.wikidata.org/wiki/Q203337","display_name":"Pulmonology","level":2,"score":0.9705889225006104},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7303580045700073},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6067100763320923},{"id":"https://openalex.org/C2910186565","wikidata":"https://www.wikidata.org/wiki/Q203337","display_name":"Pulmonary medicine","level":2,"score":0.5005156993865967},{"id":"https://openalex.org/C3017595490","wikidata":"https://www.wikidata.org/wiki/Q17006263","display_name":"University hospital","level":2,"score":0.49566972255706787},{"id":"https://openalex.org/C2780708616","wikidata":"https://www.wikidata.org/wiki/Q193866","display_name":"Annals","level":2,"score":0.47926995158195496},{"id":"https://openalex.org/C2780724011","wikidata":"https://www.wikidata.org/wiki/Q1295316","display_name":"Emergency department","level":2,"score":0.4376406669616699},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.37122857570648193},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.13847798109054565},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.06932097673416138},{"id":"https://openalex.org/C74916050","wikidata":"https://www.wikidata.org/wiki/Q841090","display_name":"Classics","level":1,"score":0.0670139491558075},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.061279356479644775}],"mesh":[{"descriptor_ui":"D000515","descriptor_name":"alpha 1-Antitrypsin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004549","descriptor_name":"Elastin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011656","descriptor_name":"Pulmonary Emphysema","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D015842","descriptor_name":"Serine Proteinase Inhibitors","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015842","descriptor_name":"Serine Proteinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015842","descriptor_name":"Serine Proteinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D053491","descriptor_name":"Proteinase Inhibitory Proteins, Secretory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1749-6632.1991.tb17010.x","doi":"https://doi.org/10.1111/j.1749-6632.1991.tb17010.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1749-6632.1991.tb17010.x","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:2064252","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2064252","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7768999934196472,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W183064","https://openalex.org/W22038449","https://openalex.org/W40818130","https://openalex.org/W87834436","https://openalex.org/W1494805566","https://openalex.org/W1764196602","https://openalex.org/W1965227648","https://openalex.org/W1978571525","https://openalex.org/W1979084634","https://openalex.org/W1980897534","https://openalex.org/W1987824779","https://openalex.org/W1992697535","https://openalex.org/W2019005100","https://openalex.org/W2022707326","https://openalex.org/W2024882709","https://openalex.org/W2030087885","https://openalex.org/W2033248984","https://openalex.org/W2053240521","https://openalex.org/W2059390092","https://openalex.org/W2059819867","https://openalex.org/W2072796605","https://openalex.org/W2073432936","https://openalex.org/W2074522344","https://openalex.org/W2074780039","https://openalex.org/W2083132689","https://openalex.org/W2093697092","https://openalex.org/W2099347625","https://openalex.org/W2108806703","https://openalex.org/W2137633894","https://openalex.org/W2140422547","https://openalex.org/W2154286661","https://openalex.org/W2156728327","https://openalex.org/W2226178899","https://openalex.org/W2249931443","https://openalex.org/W2286532130","https://openalex.org/W2320669445","https://openalex.org/W2323886210","https://openalex.org/W2397407438","https://openalex.org/W2400700292","https://openalex.org/W2401298078","https://openalex.org/W2404188520","https://openalex.org/W2408178740","https://openalex.org/W2414571050","https://openalex.org/W2416322887","https://openalex.org/W2418151500","https://openalex.org/W2419653422","https://openalex.org/W2419697384","https://openalex.org/W2426557420","https://openalex.org/W2432066894","https://openalex.org/W4214589643"],"related_works":["https://openalex.org/W4256099111","https://openalex.org/W1987008012","https://openalex.org/W2195753869","https://openalex.org/W2003513781","https://openalex.org/W2414084536","https://openalex.org/W2057002385","https://openalex.org/W4250115493","https://openalex.org/W1981775290","https://openalex.org/W1991422332","https://openalex.org/W1970050781"],"abstract_inverted_index":null,"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
