{"id":"https://openalex.org/W1972890601","doi":"https://doi.org/10.1073/pnas.0909345106","title":"Functional genomic screens identify CINP as a genome maintenance protein","display_name":"Functional genomic screens identify CINP as a genome maintenance protein","publication_year":2009,"publication_date":"2009-11-04","ids":{"openalex":"https://openalex.org/W1972890601","doi":"https://doi.org/10.1073/pnas.0909345106","mag":"1972890601","pmid":"https://pubmed.ncbi.nlm.nih.gov/19889979","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2780779"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0909345106","doi":"https://doi.org/10.1073/pnas.0909345106","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0909345106","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2780779","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047981987","display_name":"Courtney A. Lovejoy","orcid":"https://orcid.org/0000-0001-9178-5226","observed_orcids":["https://orcid.org/0000-0001-9178-5226"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Courtney A. Lovejoy","raw_affiliation_strings":["Department of Biochemistry,","Dept of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry,","institution_ids":[]},{"raw_affiliation_string":"Dept of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049781553","display_name":"Xin Xu","orcid":"https://orcid.org/0000-0003-4608-4556","observed_orcids":["https://orcid.org/0000-0003-4608-4556"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xin Xu","raw_affiliation_strings":["Department of Biochemistry,","aDepartment of Biochemistry,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry,","institution_ids":[]},{"raw_affiliation_string":"aDepartment of Biochemistry,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035479095","display_name":"Carol E. Bansbach","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carol E. Bansbach","raw_affiliation_strings":["Department of Biochemistry,","aDepartment of Biochemistry,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry,","institution_ids":[]},{"raw_affiliation_string":"aDepartment of Biochemistry,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070707099","display_name":"Gloria G. Glick","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gloria G. Glick","raw_affiliation_strings":["Department of Biochemistry,","aDepartment of Biochemistry,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry,","institution_ids":[]},{"raw_affiliation_string":"aDepartment of Biochemistry,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088086755","display_name":"Runxiang Zhao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Runxiang Zhao","raw_affiliation_strings":["Department of Biochemistry,","aDepartment of Biochemistry,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry,","institution_ids":[]},{"raw_affiliation_string":"aDepartment of Biochemistry,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100357202","display_name":"Fei Ye","orcid":"https://orcid.org/0000-0001-6472-5076","observed_orcids":["https://orcid.org/0000-0001-6472-5076"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fei Ye","raw_affiliation_strings":["Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232","bDepartment of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"bDepartment of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021758753","display_name":"Bianca M. Sirbu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bianca M. Sirbu","raw_affiliation_strings":["Department of Biochemistry,","aDepartment of Biochemistry,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry,","institution_ids":[]},{"raw_affiliation_string":"aDepartment of Biochemistry,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021754437","display_name":"Laura C. Titus","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura C. Titus","raw_affiliation_strings":["Department of Biochemistry,","aDepartment of Biochemistry,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry,","institution_ids":[]},{"raw_affiliation_string":"aDepartment of Biochemistry,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062656698","display_name":"Yu Shyr","orcid":"https://orcid.org/0000-0003-2086-9670","observed_orcids":["https://orcid.org/0000-0003-2086-9670"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu Shyr","raw_affiliation_strings":["Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232","bDepartment of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"bDepartment of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100675679","display_name":"David Cortez","orcid":"https://orcid.org/0000-0003-0154-140X","observed_orcids":["https://orcid.org/0000-0003-0154-140X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Cortez","raw_affiliation_strings":["Department of Biochemistry,","aDepartment of Biochemistry,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry,","institution_ids":[]},{"raw_affiliation_string":"aDepartment of Biochemistry,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.1248,"has_fulltext":false,"cited_by_count":64,"citation_normalized_percentile":{"value":0.92340117,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"106","issue":"46","first_page":"19304","last_page":"19309"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.8259999752044678},{"id":"https://openalex.org/keywords/genome-maintenance","display_name":"genome maintenance","score":0.8830000162124634},{"id":"https://openalex.org/keywords/atr-signaling","display_name":"ATR signaling","score":0.6389999985694885},{"id":"https://openalex.org/keywords/replication-stress","display_name":"replication stress","score":0.5879999995231628},{"id":"https://openalex.org/keywords/g2-checkpoint","display_name":"G2 checkpoint","score":0.9509999752044678},{"id":"https://openalex.org/keywords/cell-cycle-checkpoints","display_name":"cell cycle checkpoints","score":0.7450000047683716},{"id":"https://openalex.org/keywords/micronuclei","display_name":"micronuclei","score":0.7820000052452087},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.6150000095367432},{"id":"https://openalex.org/keywords/rnai-screen","display_name":"RNAi screen","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7230555415153503},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.6893419623374939},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.6875312328338623},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.6225305795669556},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5895763039588928},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.5702983736991882},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5560947060585022},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5397108793258667},{"id":"https://openalex.org/C54086632","wikidata":"https://www.wikidata.org/wiki/Q5512671","display_name":"G2-M DNA damage checkpoint","level":5,"score":0.5385391116142273},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5221760272979736},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5183878540992737},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.5009341239929199},{"id":"https://openalex.org/C50001416","wikidata":"https://www.wikidata.org/wiki/Q17861750","display_name":"CHEK1","level":5,"score":0.4768446683883667},{"id":"https://openalex.org/C207177822","wikidata":"https://www.wikidata.org/wiki/Q5050812","display_name":"Genetic screen","level":4,"score":0.47441408038139343},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4274473786354065},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3315737843513489},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.11965954303741455},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.077155202627182}],"mesh":[{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020798","descriptor_name":"Two-Hybrid System Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064007","descriptor_name":"Ataxia Telangiectasia Mutated Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.0909345106","doi":"https://doi.org/10.1073/pnas.0909345106","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0909345106","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2780779","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2780779","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:19889979","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19889979","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2780779","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2780779","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1286696915","display_name":"Function of the ATR-ATRIP complex","funder_award_id":"R01CA102729","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5061398596","display_name":"Center in Molecular Toxicology","funder_award_id":"P30ES000267","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G5374450897","display_name":"Functional Analysis of Replication Stress Response Proteins","funder_award_id":"R01CA136933","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5778519213","display_name":"Regulation of Genome Stability by ATM","funder_award_id":"R21CA132010","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7248731751","display_name":"SPORE in Breast Cancer","funder_award_id":"P50CA098131","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W346292765","https://openalex.org/W1821860584","https://openalex.org/W1967630574","https://openalex.org/W1967743500","https://openalex.org/W1968552183","https://openalex.org/W1981504084","https://openalex.org/W1986693601","https://openalex.org/W1987718758","https://openalex.org/W1990569322","https://openalex.org/W2007349181","https://openalex.org/W2015631955","https://openalex.org/W2031203839","https://openalex.org/W2035300822","https://openalex.org/W2036292773","https://openalex.org/W2041156660","https://openalex.org/W2043895957","https://openalex.org/W2059971436","https://openalex.org/W2063158825","https://openalex.org/W2063461424","https://openalex.org/W2065588235","https://openalex.org/W2068077324","https://openalex.org/W2069949084","https://openalex.org/W2082559623","https://openalex.org/W2086333179","https://openalex.org/W2099024365","https://openalex.org/W2109910662","https://openalex.org/W2110817748","https://openalex.org/W2111772438","https://openalex.org/W2114126312","https://openalex.org/W2116964110","https://openalex.org/W2120627772","https://openalex.org/W2121371748","https://openalex.org/W2125299927","https://openalex.org/W2127251317","https://openalex.org/W2127720624","https://openalex.org/W2129016093","https://openalex.org/W2133940489","https://openalex.org/W2147974847","https://openalex.org/W2167196101","https://openalex.org/W2170500510","https://openalex.org/W2170519022","https://openalex.org/W2186961771","https://openalex.org/W4211195653","https://openalex.org/W4238448376","https://openalex.org/W4240237951","https://openalex.org/W7064184311"],"related_works":["https://openalex.org/W3169677303","https://openalex.org/W21737543","https://openalex.org/W7097741222","https://openalex.org/W2597324346","https://openalex.org/W4238510386","https://openalex.org/W6928689756","https://openalex.org/W2492701447","https://openalex.org/W2020928883","https://openalex.org/W2146016701","https://openalex.org/W1967630574"],"abstract_inverted_index":{"The":[0,28,78,114],"DNA":[1,24,39],"damage":[2],"response":[3],"(DDR)":[4],"has":[5],"a":[6,16,108,150],"critical":[7],"role":[8],"in":[9,63,87,126],"maintaining":[10],"genome":[11],"integrity":[12],"and":[13,26,51,59,159,167],"serves":[14],"as":[15,149],"barrier":[17],"to":[18,66,73,140,164],"tumorigenesis":[19],"by":[20,34,48],"promoting":[21],"cell-cycle":[22,151],"arrest,":[23],"repair,":[25],"apoptosis.":[27],"DDR":[29,94,124],"is":[30],"activated":[31,49],"not":[32],"only":[33],"genotoxic":[35,132],"agents":[36],"that":[37,120],"induce":[38,123],"damage,":[40],"but":[41],"also":[42,101],"during":[43],"aberrant":[44],"cell-division":[45],"cycles":[46],"caused":[47,102],"oncogenes":[50],"inactivated":[52],"tumor":[53],"suppressors.":[54],"Here":[55],"we":[56],"use":[57],"RNAi":[58,79,143],"cDNA":[60,115],"overexpression":[61],"screens":[62,144],"human":[64],"cells":[65],"identify":[67],"genes":[68,83,100,119,138],"that,":[69,84],"when":[70,85,121],"deregulated,":[71],"lead":[72],"activation":[74,125],"of":[75,98,106,110,129,137],"the":[76,127],"DDR.":[77],"screen":[80,116],"identified":[81,117,145],"73":[82],"silenced":[86],"at":[88],"least":[89],"two":[90],"cell":[91],"types,":[92],"cause":[93],"activation.":[95],"Silencing":[96],"several":[97],"these":[99],"an":[103,135],"increased":[104],"frequency":[105],"micronuclei,":[107],"marker":[109],"genetically":[111],"unstable":[112],"cells.":[113],"97":[118],"overexpressed":[122],"absence":[128],"any":[130],"exogenous":[131],"agent,":[133],"with":[134,156],"overrepresentation":[136],"linked":[139],"cancer.":[141],"Secondary":[142],"CDK2-interacting":[146],"protein":[147,158],"(CINP)":[148],"checkpoint":[152,169],"protein.":[153],"CINP":[154],"interacts":[155],"ATR-interacting":[157],"regulates":[160],"ATR-dependent":[161],"signaling,":[162],"resistance":[163],"replication":[165],"stress,":[166],"G2":[168],"integrity.":[170]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}