{"id":"https://openalex.org/W1972888924","doi":"https://doi.org/10.1159/000233712","title":"In vitro Synthesis of IgE by Human Peripheral Blood Leucocytes","display_name":"In vitro Synthesis of IgE by Human Peripheral Blood Leucocytes","publication_year":2009,"publication_date":"2009-08-04","ids":{"openalex":"https://openalex.org/W1972888924","doi":"https://doi.org/10.1159/000233712","mag":"1972888924","pmid":"https://pubmed.ncbi.nlm.nih.gov/2858452"},"language":"en","primary_location":{"id":"doi:10.1159/000233712","doi":"https://doi.org/10.1159/000233712","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000233712","pdf_url":null,"source":{"id":"https://openalex.org/S4210168027","display_name":"International Archives of Allergy and Applied Immunology","issn_l":"0020-5915","issn":["0020-5915","2571-6662"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Archives of Allergy and Applied Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111621826","display_name":"Keven J. Turner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K.J. Turner","raw_affiliation_strings":["Clinical Immunology Research Unit, Princess Margaret Hospital, Subiaco, Western Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Immunology Research Unit, Princess Margaret Hospital, Subiaco, Western Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017272011","display_name":"Patrick G. Holt","orcid":"https://orcid.org/0000-0003-1193-0935","observed_orcids":["https://orcid.org/0000-0003-1193-0935"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P.G. Holt","raw_affiliation_strings":["Clinical Immunology Research Unit, Princess Margaret Hospital, Subiaco, Western Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Immunology Research Unit, Princess Margaret Hospital, Subiaco, Western Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049800893","display_name":"John D. Hobday","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J.D. Hobday","raw_affiliation_strings":["Clinical Immunology Research Unit, Princess Margaret Hospital, Subiaco, Western Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Immunology Research Unit, Princess Margaret Hospital, Subiaco, Western Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078737775","display_name":"K.J. Cameron","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K.J. Cameron","raw_affiliation_strings":["Clinical Immunology Research Unit, Princess Margaret Hospital, Subiaco, Western Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Immunology Research Unit, Princess Margaret Hospital, Subiaco, Western Australia","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073140725","display_name":"B.J. Holt","orcid":"https://orcid.org/0009-0001-2560-085X","observed_orcids":["https://orcid.org/0009-0001-2560-085X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B.J. Holt","raw_affiliation_strings":["Clinical Immunology Research Unit, Princess Margaret Hospital, Subiaco, Western Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Immunology Research Unit, Princess Margaret Hospital, Subiaco, Western Australia","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.1485633,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"76","issue":"4","first_page":"308","last_page":"312"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.46140000224113464,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.46140000224113464,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.3677000105381012,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.11129999905824661,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ige-production","display_name":"IgE production","score":0.8880000114440918},{"id":"https://openalex.org/keywords/ige-secretion","display_name":"IgE secretion","score":0.9679999947547913},{"id":"https://openalex.org/keywords/allergic-asthma","display_name":"allergic asthma","score":0.5550000071525574},{"id":"https://openalex.org/keywords/t-cell-help","display_name":"T cell help","score":0.7239999771118164},{"id":"https://openalex.org/keywords/t-cell-suppression","display_name":"T cell suppression","score":0.9860000014305115},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.8330000042915344},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.8040000200271606},{"id":"https://openalex.org/keywords/peripheral-blood-leukocytes","display_name":"peripheral blood leukocytes","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7686129808425903},{"id":"https://openalex.org/C3017910909","wikidata":"https://www.wikidata.org/wiki/Q618363","display_name":"Peripheral blood","level":2,"score":0.6184141039848328},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6036229133605957},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.5936679244041443},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4746842086315155},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3176215887069702},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.22503721714019775},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006969","descriptor_name":"Hypersensitivity, Immediate","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007073","descriptor_name":"Immunoglobulin E","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1159/000233712","doi":"https://doi.org/10.1159/000233712","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000233712","pdf_url":null,"source":{"id":"https://openalex.org/S4210168027","display_name":"International Archives of Allergy and Applied Immunology","issn_l":"0020-5915","issn":["0020-5915","2571-6662"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Archives of Allergy and Applied Immunology","raw_type":"journal-article"},{"id":"pmid:2858452","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2858452","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International archives of allergy and applied immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1620024601","https://openalex.org/W1984516528","https://openalex.org/W2415880479","https://openalex.org/W2395855123","https://openalex.org/W2037890793","https://openalex.org/W2404085871","https://openalex.org/W105789523","https://openalex.org/W1966523030","https://openalex.org/W2021971629","https://openalex.org/W7099559471"],"abstract_inverted_index":{"The":[0,26,61],"assessment":[1],"of":[2,7,35,51,63,98,105],"IgE":[3,21,36,76],"production":[4],"in":[5,23,58,71,81,110],"cultures":[6],"T-":[8],"and":[9,31,38,49,78,80,85],"B-cells":[10],"from":[11,68],"peripheral":[12,64],"blood":[13,65],"is":[14],"proving":[15],"a":[16],"useful":[17],"tool":[18],"to":[19],"probe":[20],"immunoregulation":[22],"human":[24],"atopics.":[25,60],"present":[27],"study":[28,73],"contrasts":[29],"secretion":[30],"synthesis":[32,77],"as":[33,118,120],"indices":[34],"production,":[37],"demonstrates":[39],"that":[40,102],"these":[41],"measures":[42],"yield":[43],"comparable":[44],"data":[45],"upon":[46],"the":[47,69,93,103],"magnitude":[48],"direction":[50,104],"regulatory":[52],"T-cell":[53,83,106],"effects":[54,107],"(help":[55],"vs.":[56],"suppression)":[57],"severe":[59],"majority":[62],"B-cell":[66],"samples":[67],"atopics":[70,100,115],"this":[72],"exhibited":[74],"spontaneous":[75],"secretion,":[79],"vitro":[82],"help":[84],"suppression":[86],"were":[87],"observed":[88],"with":[89],"equal":[90],"frequency":[91],"within":[92],"sample":[94],"population.":[95],"Repeated":[96],"testing":[97],"individual":[99],"indicated":[101],"remained":[108],"stable":[109],"some":[111],"(but":[112],"not":[113],"all)":[114],"over":[116],"periods":[117],"long":[119],"3":[121],"years.":[122]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}