{"id":"https://openalex.org/W1972834302","doi":"https://doi.org/10.1542/peds.108.6.1374","title":"Sn-Mesoporphyrin Interdiction of Severe Hyperbilirubinemia in Jehovah\u2019s Witness Newborns as an Alternative to Exchange Transfusion","display_name":"Sn-Mesoporphyrin Interdiction of Severe Hyperbilirubinemia in Jehovah\u2019s Witness Newborns as an Alternative to Exchange Transfusion","publication_year":2001,"publication_date":"2001-12-01","ids":{"openalex":"https://openalex.org/W1972834302","doi":"https://doi.org/10.1542/peds.108.6.1374","mag":"1972834302","pmid":"https://pubmed.ncbi.nlm.nih.gov/11731664"},"language":"en","primary_location":{"id":"doi:10.1542/peds.108.6.1374","doi":"https://doi.org/10.1542/peds.108.6.1374","is_oa":false,"landing_page_url":"https://doi.org/10.1542/peds.108.6.1374","pdf_url":null,"source":{"id":"https://openalex.org/S77494981","display_name":"PEDIATRICS","issn_l":"0031-4005","issn":["0031-4005","1098-4275"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315734","host_organization_name":"American Academy of Pediatrics","host_organization_lineage":["https://openalex.org/P4310315734"],"host_organization_lineage_names":["American Academy of Pediatrics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111525820","display_name":"Attallah Kappas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Attallah Kappas","raw_affiliation_strings":["Rockefeller University &#x2028; New York, NY 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rockefeller University &#x2028; New York, NY 10021","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110119090","display_name":"George S. Drummond","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George S. Drummond","raw_affiliation_strings":["Rockefeller University &#x2028; New York, NY 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rockefeller University &#x2028; New York, NY 10021","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031079646","display_name":"David P. Munson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189957204","display_name":"University of South Dakota","ror":"https://ror.org/0043h8f16","country_code":"US","type":"education","lineage":["https://openalex.org/I189957204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David P. Munson","raw_affiliation_strings":["Department of Pediatrics &#x2028; University of South Dakota School of Medicine &#x2028; Sioux Falls, SD 57117"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics &#x2028; University of South Dakota School of Medicine &#x2028; Sioux Falls, SD 57117","institution_ids":["https://openalex.org/I189957204"]}]},{"author_position":"last","author":{"id":null,"display_name":"James R. Marshall","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James R. Marshall","raw_affiliation_strings":["Abilene Regional Medical Center &#x2028; Abilene, TX 79606"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abilene Regional Medical Center &#x2028; Abilene, TX 79606","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.7959,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.94482837,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"108","issue":"6","first_page":"1374","last_page":"1377"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperbilirubinemia","display_name":"hyperbilirubinemia","score":0.9309999942779541},{"id":"https://openalex.org/keywords/exchange-transfusion","display_name":"exchange transfusion","score":0.7839999794960022},{"id":"https://openalex.org/keywords/jehovah-s-witnesses","display_name":"Jehovah's Witnesses","score":0.8949999809265137},{"id":"https://openalex.org/keywords/hemolytic-disease-of-the-newborn","display_name":"hemolytic disease of the newborn","score":0.9300000071525574},{"id":"https://openalex.org/keywords/heme-oxygenase-inhibition","display_name":"heme oxygenase inhibition","score":0.9520000219345093},{"id":"https://openalex.org/keywords/neonatal-jaundice","display_name":"neonatal jaundice","score":0.7409999966621399},{"id":"https://openalex.org/keywords/parental-refusal-of-treatment","display_name":"parental refusal of treatment","score":0.5860000252723694},{"id":"https://openalex.org/keywords/litigation","display_name":"litigation","score":0.3140000104904175},{"id":"https://openalex.org/keywords/preterm-infants","display_name":"preterm infants","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9018694162368774},{"id":"https://openalex.org/C2779042277","wikidata":"https://www.wikidata.org/wiki/Q886468","display_name":"Exchange transfusion","level":2,"score":0.8609657287597656},{"id":"https://openalex.org/C2777513400","wikidata":"https://www.wikidata.org/wiki/Q104219","display_name":"Bilirubin","level":2,"score":0.5555499196052551},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4879881739616394},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.46054428815841675},{"id":"https://openalex.org/C2778456037","wikidata":"https://www.wikidata.org/wiki/Q133244","display_name":"Jaundice","level":2,"score":0.4366447925567627},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2802053689956665},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.11544778943061829},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001663","descriptor_name":"Bilirubin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D001803","descriptor_name":"Blood Transfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002835","descriptor_name":"Christianity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004899","descriptor_name":"Erythroblastosis, Fetal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006419","descriptor_name":"Heme Oxygenase (Decyclizing)","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006932","descriptor_name":"Hyperbilirubinemia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007234","descriptor_name":"Infant, Premature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008665","descriptor_name":"Metalloporphyrins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012068","descriptor_name":"Religion and Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1542/peds.108.6.1374","doi":"https://doi.org/10.1542/peds.108.6.1374","is_oa":false,"landing_page_url":"https://doi.org/10.1542/peds.108.6.1374","pdf_url":null,"source":{"id":"https://openalex.org/S77494981","display_name":"PEDIATRICS","issn_l":"0031-4005","issn":["0031-4005","1098-4275"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315734","host_organization_name":"American Academy of Pediatrics","host_organization_lineage":["https://openalex.org/P4310315734"],"host_organization_lineage_names":["American Academy of Pediatrics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"journal-article"},{"id":"pmid:11731664","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11731664","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[{"id":"https://openalex.org/G410420417","display_name":null,"funder_award_id":"N01-HD5-3234","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1591048367","https://openalex.org/W1838242598","https://openalex.org/W1976999894","https://openalex.org/W2013139556","https://openalex.org/W2128849018","https://openalex.org/W2136776491","https://openalex.org/W3021514809"],"related_works":["https://openalex.org/W2007002583","https://openalex.org/W2013139556","https://openalex.org/W2087608035","https://openalex.org/W1838242598","https://openalex.org/W4416665021","https://openalex.org/W1515488587","https://openalex.org/W1591048367","https://openalex.org/W2028749476","https://openalex.org/W2289634069","https://openalex.org/W2088047016"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1,378,483,525,599,619,686],"religious":[2,719],"convictions":[3],"of":[4,17,53,80,100,155,163,176,189,210,275,290,297,300,308,313,341,381,395,402,437,478,501,509,542,555,560,601,621,629,657,665,676,682,696,701,727,734,746,752,770],"parents":[5,114],"who":[6,103,527],"are":[7],"Jehovah's":[8,112,332,529],"Witness":[9,113,333,530],"adherents":[10],"lead":[11],"them":[12],"to":[13,33,46,50,62,71,85,165,219,310,317,338,346,369,385,440,446,464,493,539,549,557,569,623,710,743,761,764],"reject":[14],"the":[15,54,77,87,101,116,130,158,187,194,203,233,280,288,298,306,325,331,342,359,365,370,386,393,400,403,447,459,487,510,514,533,543,565,570,594,627,655,674,694,713,732,744,750,768],"use":[16,52,76,340,355,401,541,554,607,620,745],"exchange":[18,66,105,133,236,321,724,747],"transfusions":[19,106],"as":[20,125],"therapy":[21],"for":[22,40,107,196,235,292,350,519,553,718],"severe":[23,57,108,516,630,728,753],"hyperbilirubinemia":[24,58,109,190,396,631,677,702,729],"in":[25,27,91,94,121,126,161,169,173,185,192,199,287,373,407,451,486,576,580,610,632,650,672,678,690,698,703,705,749],"newborns":[26,633],"whom":[28,706],"intensive":[29,270],"phototherapy":[30,63,198,271,309,469,707],"has":[31,646,668,757],"failed":[32,709],"control":[34,559,712],"this":[35,347,550,691],"problem.":[36],"Consequently,":[37],"physicians":[38],"caring":[39],"such":[41,92],"infants":[42,96,222,704],"may":[43],"be":[44,465,739],"obliged":[45],"initiate":[47],"legal":[48,336,537],"action":[49,337,538],"compel":[51,339,540],"procedure":[55],"when":[56,132,229,593],"not":[59,722,758],"sufficiently":[60,711,760],"responsive":[61],"warrants":[64],"an":[65,320,740],"transfusion.":[67,237],"Our":[68],"goal":[69],"was":[70,119,216,242,266,323,352,356,367,383,430,462,473,480,523,547,567,596],"determine":[72],"if":[73],"we":[74],"could":[75],"potent":[78,153],"inhibitor":[79,154,366,404,664],"bilirubin":[81,141,258,503,666,735,771],"production,":[82],"Sn-Mesoporphyrin":[83],"(SnMP),":[84],"resolve":[86],"troubling":[88],"medical-legal":[89],"issues":[90],"situations":[93],"2":[95,204,489,687],"with":[97,223,272,284,427,637,736],"hemolytic":[98],"disease":[99],"newborn":[102,754],"required":[104,443],"but":[110],"whose":[111,256,716],"rejected":[115,329],"procedure.":[117,534],"SnMP":[118,150,181,211,351,382,556,566,606,622,697,737],"administered":[120,217,384,579],"a":[122,152,207,227,243,315,344,471,475,520,545,581],"single":[123,174,208,379,582],"dose,":[124],"previous":[127],"studies,":[128],"at":[129,145,226,261,388,588],"time":[131,228],"transfusion":[134,322,522,748],"would":[135,721],"have":[136,659],"been":[137,647,660],"initiated":[138],"and":[139,191,277,303,305,361,364,398,435,513,578,604,715],"plasma":[140,257],"levels":[142],"were":[143,528],"monitored":[144],"close":[146],"intervals":[147],"thereafter.":[148],"METHODS:":[149],"is":[151,182,405,608],"heme":[156,164],"oxygenase,":[157],"rate-limiting":[159],"enzyme":[160],"catabolism":[162],"bilirubin.":[166],"We":[167],"found":[168],"earlier":[170],"studies":[171],"that":[172,756],"doses":[175],"6":[177],"micromol/kg":[178,213,585],"birth":[179,214,252,265,423,458,586,592],"weight,":[180],"extremely":[183],"effective":[184,741],"moderating":[186,673],"course":[188,394,600,675],"eliminating":[193],"need":[195,234],"supplemental":[197],"jaundiced":[200,221],"newborns.":[201],"In":[202,295,507],"cases":[205,688],"described,":[206],"dose":[209,380,583],"(6":[212,584],"weight)":[215,587],"intramuscularly":[218],"severely":[220],"immune":[224,301,428],"hemolysis":[225,429],"clinical":[230,499,511,653],"circumstances":[231,512],"dictated":[232],"CASE":[238,413],"1:":[239],"This":[240,415,663],"patient":[241],"preterm":[244],"male":[245],"infant":[246,387,418],"(gestational":[247,419],"age:":[248,420],"35":[249],"5/7":[250],"weeks;":[251,422],"weight:":[253,424],"2790":[254],"g)":[255,426],"concentration":[259],"(PBC)":[260],"1":[262,278],"hour":[263],"after":[264,391,399,457,591,605],"5.0":[267],"mg/dL.":[268,467,598],"Despite":[269],"3":[273],"banks":[274],"lights":[276,479],"biliblanket,":[279],"PBC":[281,461,484,595],"increased":[282],"steadily":[283],"no":[285],"diminution":[286],"rate":[289],"increase":[291],"75":[293,389],"hours.":[294],"view":[296,508],"problems":[299,438],"hemolysis,":[302],"prematurity,":[304],"inability":[307],"stop":[311],"progression":[312,700],"hyperbilirubinemia,":[314,517],"decision":[316,326],"carry":[318],"out":[319],"made;":[324,353],"was,":[327],"however,":[328],"by":[330,358,432,730],"parents.":[334],"Pending":[335],"procedure,":[343],"request":[345,546],"(Rockefeller)":[348,551],"laboratory":[349,552],"its":[354],"approved":[357],"Food":[360],"Drug":[362],"Administration;":[363],"delivered":[368,431,568],"physician-in-charge":[371],"(D.P.M.)":[372],"Sioux":[374],"Falls,":[375],"South":[376],"Dakota.":[377],"hours":[390,456,590],"birth;":[392],"before":[397,603],"shown":[406,609],"Fig":[408,611],"1.":[409],"[figure:":[410,613],"see":[411,614],"text].":[412,615],"2:":[414],"female":[416],"term":[417,636],"38-39":[421],"4140":[425],"cesarean":[433],"section":[434],"because":[436],"related":[439],"meconium":[441],"aspiration":[442],"helicopter":[444],"transfer":[445],"Special":[448],"Care":[449],"Nursery":[450],"Abilene,":[452],"Texas,":[453],"where":[454],"10":[455],"first":[460],"determined":[463],"18.0":[466],"Double-bank":[468],"plus":[470],"biliblanket":[472],"initiated;":[474],"third":[476],"bank":[477],"later":[481],"ordered.":[482],"fluctuated":[485],"ensuing":[488],"days":[490],"between":[491],"13.8":[492],"25.8":[494],"mg/dL":[495],"during":[496],"which":[497,658],"suggestive":[498],"signs":[500],"possible":[502],"encephalopathy":[504],"became":[505],"manifest.":[506],"continued":[515],"permission":[518],"double-exchange":[521],"requested.":[524],"parents,":[526,717],"adherents,":[531],"refused":[532],"While":[535],"preparing":[536],"exchange,":[544],"made":[548],"attempt":[558],"hyperbilirubinemia.":[561],"With":[562],"FDA":[563],"approval,":[564],"attending":[571],"neonatologist":[572],"(J.":[573],"R.":[574],"M.)":[575],"Abilene":[577],"56":[589],"19.5":[597],"bilirubinemia":[602],"2.":[612],"RESULTS":[616],"AND":[617],"CONCLUSIONS:":[618],"moderate":[624],"or":[625],"prevent":[626],"development":[628,769],"(preterm,":[634],"near-term,":[635],"high":[638],"PBCs":[639],"[15-18":[640],"mg/dL],":[641],"ABO-incompatibility;":[642],"glucose-6-phosphate":[643],"dehydrogenase":[644],"deficiency)":[645],"extensively":[648],"studied":[649],"carefully":[651],"conducted":[652],"trials":[654],"results":[656],"reported":[661],"earlier.":[662],"production":[667,733],"demonstrated":[669],"marked":[670],"efficacy":[671,695],"all":[679],"diagnostic":[680],"groups":[681],"unconjugated":[683],"neonatal":[684],"jaundice.":[685],"described":[689],"report":[692],"confirmed":[693],"terminating":[699],"had":[708],"problem":[714],"reasons,":[720],"permit":[723],"transfusions.":[725],"Interdiction":[726],"inhibiting":[731],"can":[738],"alternative":[742],"management":[751],"jaundice":[755],"responded":[759],"light":[762],"treatment":[763],"ease":[765],"concern":[766],"about":[767],"encephalopathy.":[772]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
