{"id":"https://openalex.org/W1972808110","doi":"https://doi.org/10.1016/s0022-5347(01)65258-3","title":"Acidosis Impairs Rabbit Trabecular Smooth Muscle Contractility","display_name":"Acidosis Impairs Rabbit Trabecular Smooth Muscle Contractility","publication_year":1997,"publication_date":"1997-02-01","ids":{"openalex":"https://openalex.org/W1972808110","doi":"https://doi.org/10.1016/s0022-5347(01)65258-3","mag":"1972808110","pmid":"https://pubmed.ncbi.nlm.nih.gov/8996406"},"language":"en","primary_location":{"id":"doi:10.1016/s0022-5347(01)65258-3","doi":"https://doi.org/10.1016/s0022-5347(01)65258-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-5347(01)65258-3","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1097/00005392-199702000-00096","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111411619","display_name":"I\u00f1igo S\u00e1enz de Tejada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Inigo Saenz De Tejada","raw_affiliation_strings":["Departments of Urology and Physiology, Boston University School of Medicine, Massachusetts, and the Department of Urology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Urology and Physiology, Boston University School of Medicine, Massachusetts, and the Department of Urology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084333425","display_name":"Noel N. Kim","orcid":"https://orcid.org/0000-0003-1843-5363","observed_orcids":["https://orcid.org/0000-0003-1843-5363"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Noel N. Kim","raw_affiliation_strings":["Departments of Urology and Physiology, Boston University School of Medicine, Massachusetts, and the Department of Urology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Urology and Physiology, Boston University School of Medicine, Massachusetts, and the Department of Urology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jennifer T. Daley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer T. Daley","raw_affiliation_strings":["Departments of Urology and Physiology, Boston University School of Medicine, Massachusetts, and the Department of Urology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Urology and Physiology, Boston University School of Medicine, Massachusetts, and the Department of Urology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007051726","display_name":"Ramin Royai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ramin Royai","raw_affiliation_strings":["Departments of Urology and Physiology, Boston University School of Medicine, Massachusetts, and the Department of Urology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Urology and Physiology, Boston University School of Medicine, Massachusetts, and the Department of Urology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062348711","display_name":"JOSEPH A. HYPOLITE","orcid":"https://orcid.org/0000-0002-4909-7988","observed_orcids":["https://orcid.org/0000-0002-4909-7988"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Hypolite","raw_affiliation_strings":["Departments of Urology and Physiology, Boston University School of Medicine, Massachusetts, and the Department of Urology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Urology and Physiology, Boston University School of Medicine, Massachusetts, and the Department of Urology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075702619","display_name":"Gregory A. Broderick","orcid":"https://orcid.org/0000-0003-2949-5425","observed_orcids":["https://orcid.org/0000-0003-2949-5425"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory A. Broderick","raw_affiliation_strings":["Departments of Urology and Physiology, Boston University School of Medicine, Massachusetts, and the Department of Urology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Urology and Physiology, Boston University School of Medicine, Massachusetts, and the Department of Urology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061189714","display_name":"Fernando Garcia-Diaz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fernando Garcia-Diaz","raw_affiliation_strings":["Departments of Urology and Physiology, Boston University School of Medicine, Massachusetts, and the Department of Urology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Urology and Physiology, Boston University School of Medicine, Massachusetts, and the Department of Urology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042687042","display_name":"Robert M. Levin","orcid":"https://orcid.org/0000-0003-1578-6870","observed_orcids":["https://orcid.org/0000-0003-1578-6870"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Levin","raw_affiliation_strings":["Departments of Urology and Physiology, Boston University School of Medicine, Massachusetts, and the Department of Urology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Urology and Physiology, Boston University School of Medicine, Massachusetts, and the Department of Urology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":0.0,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.13504578,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"157","issue":"2","first_page":"722","last_page":"726"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.42649999260902405,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.42649999260902405,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10459","display_name":"Sexual function and dysfunction studies","score":0.1136000007390976,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.045099999755620956,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acidosis","display_name":"acidosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/corpus-cavernosum","display_name":"corpus cavernosum","score":0.9440000057220459},{"id":"https://openalex.org/keywords/smooth-muscle-contractility","display_name":"smooth muscle contractility","score":0.9810000061988831},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.8500000238418579},{"id":"https://openalex.org/keywords/potassium-induced-contraction","display_name":"potassium-induced contraction","score":0.7429999709129333},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.843999981880188},{"id":"https://openalex.org/keywords/ischemic-priapism","display_name":"ischemic priapism","score":0.9139999747276306},{"id":"https://openalex.org/keywords/priapism","display_name":"priapism","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.7807400226593018},{"id":"https://openalex.org/C2778553927","wikidata":"https://www.wikidata.org/wiki/Q185089","display_name":"Acidosis","level":2,"score":0.767903745174408},{"id":"https://openalex.org/C103486182","wikidata":"https://www.wikidata.org/wiki/Q1216236","display_name":"Isometric exercise","level":2,"score":0.726539134979248},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6304001212120056},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5711453557014465},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5462847948074341},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.5387426614761353},{"id":"https://openalex.org/C2776050358","wikidata":"https://www.wikidata.org/wiki/Q127006","display_name":"Muscle contraction","level":2,"score":0.5364644527435303},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.5255364775657654},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4463620185852051},{"id":"https://openalex.org/C134897140","wikidata":"https://www.wikidata.org/wiki/Q6058355","display_name":"Intracellular pH","level":3,"score":0.42971867322921753},{"id":"https://openalex.org/C3018112276","wikidata":"https://www.wikidata.org/wiki/Q1147377","display_name":"Muscle tension","level":2,"score":0.42828643321990967},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.41521143913269043},{"id":"https://openalex.org/C2777952589","wikidata":"https://www.wikidata.org/wiki/Q421910","display_name":"Phenylephrine","level":3,"score":0.4113122224807739},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.28891557455062866},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13216757774353027},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000138","descriptor_name":"Acidosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007424","descriptor_name":"Intracellular Fluid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010413","descriptor_name":"Penis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010413","descriptor_name":"Penis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D010413","descriptor_name":"Penis","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0022-5347(01)65258-3","doi":"https://doi.org/10.1016/s0022-5347(01)65258-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-5347(01)65258-3","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},{"id":"doi:10.1097/00005392-199702000-00096","doi":"https://doi.org/10.1097/00005392-199702000-00096","is_oa":true,"landing_page_url":"https://doi.org/10.1097/00005392-199702000-00096","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Urology","raw_type":"journal-article"},{"id":"pmid:8996406","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8996406","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of urology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1097/00005392-199702000-00096","doi":"https://doi.org/10.1097/00005392-199702000-00096","is_oa":true,"landing_page_url":"https://doi.org/10.1097/00005392-199702000-00096","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Urology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W164606542","https://openalex.org/W1977699477","https://openalex.org/W1989501272","https://openalex.org/W2017571833","https://openalex.org/W2022051017","https://openalex.org/W2032781213","https://openalex.org/W2046524679","https://openalex.org/W2057034766","https://openalex.org/W2074605520","https://openalex.org/W2093995446","https://openalex.org/W2098598909","https://openalex.org/W2103244347","https://openalex.org/W2107308340","https://openalex.org/W2118698512","https://openalex.org/W2141207242","https://openalex.org/W2167475003","https://openalex.org/W2324962193","https://openalex.org/W2399845617","https://openalex.org/W2402558353","https://openalex.org/W2410001321","https://openalex.org/W2410802890","https://openalex.org/W2421666099","https://openalex.org/W6658626752"],"related_works":["https://openalex.org/W1990877862","https://openalex.org/W1980945503","https://openalex.org/W2066526532","https://openalex.org/W2185253684","https://openalex.org/W2060841035","https://openalex.org/W40866122","https://openalex.org/W2093995446","https://openalex.org/W2056914374","https://openalex.org/W2292295772","https://openalex.org/W1992084945"],"abstract_inverted_index":{"PURPOSE:":[0],"The":[1],"aim":[2],"of":[3,11,16,57,67,206,217,225,234,246],"our":[4],"study":[5],"was":[6,74,139],"to":[7,30,72,106,133,145,170,203],"define":[8],"the":[9,14,46,143,204,209,231,244,247],"effects":[10],"acidosis":[12,220],"on":[13],"contractility":[15,233],"trabecular":[17,194,235],"smooth":[18,60,195,236],"muscle.":[19],"METHODS:":[20],"Rabbit":[21],"corpus":[22,58],"cavernosal":[23],"strips":[24],"were":[25,42,89,102,115,183],"mounted":[26],"in":[27,111,161,179,243],"organ":[28],"chambers":[29],"measure":[31],"isometric":[32,52],"tension.":[33],"Additionally,":[34],"intracellular":[35,47,163],"free":[36,164],"Ca2+":[37,165,180],"concentration":[38],"([Ca2+]i)":[39],"and":[40,51,97,108,154,166,181,188,211],"tension":[41,53,167,182],"measured":[43],"simultaneously":[44],"utilising":[45],"fluorescent":[48],"dye,":[49],"FURA-2,":[50],"recordings.":[54],"RESULTS:":[55],"Contraction":[56],"cavernosum":[59],"muscle":[61,196,237],"following":[62],"transmural":[63],"electrical":[64,109],"stimulation":[65],"(TES)":[66],"constrictor":[68],"nerves":[69],"or":[70],"exposure":[71,169],"norepinephrine":[73],"depressed":[75],"under":[76,125,185],"acidic":[77,135,189],"(pH":[78,82],"6.9)":[79],"vs.":[80],"control":[81,126],"7.4)":[83],"conditions.":[84,190],"Twenty":[85],"mM":[86,99,123,147,172,176],"K(+)-induced":[87,177],"contractions":[88,101],"also":[90],"inhibited":[91,151],"by":[92,117,141],"acidosis,":[93],"however":[94],"40,":[95],"80,":[96],"120":[98],"K+":[100,124],"unaffected.":[103],"Relaxation":[104],"responses":[105],"acetylcholine":[107],"stimulation,":[110],"phenylephrine":[112],"contracted":[113,120],"tissues,":[114],"unaffected":[116],"acidosis.":[118],"Tissues":[119],"with":[121,208],"20":[122,171],"conditions,":[127],"relaxed":[128],"approximately":[129],"50%":[130],"when":[131],"exposed":[132],"an":[134,222],"environment.":[136],"This":[137,198],"relaxation":[138],"blocked":[140],"exposing":[142],"tissue":[144],"80":[146,175],"K+.":[148],"Acidic":[149],"conditions":[150],"basal":[152],"tone":[153],"[Ca2+]i":[155],"as":[156,158],"well":[157],"normal":[159],"increases":[160,178],"both":[162,186],"upon":[168],"K+,":[173],"while":[174],"comparable":[184],"neutral":[187],"CONCLUSION:":[191],"Acidosis":[192],"impairs":[193],"contractility.":[197],"alteration":[199],"is":[200,221],"probably":[201],"secondary":[202],"interference":[205],"[H+]":[207],"intra":[210],"extracellular":[212],"mechanisms":[213],"that":[214,230],"regulate":[215],"homeostasis":[216],"[Ca2+]i.":[218],"Since":[219],"early":[223],"complication":[224],"ischemic":[226,248],"priapism,":[227],"we":[228],"propose":[229],"reduced":[232],"may":[238],"be":[239],"a":[240],"significant":[241],"factor":[242],"perpetuation":[245],"state.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}