{"id":"https://openalex.org/W1972802490","doi":"https://doi.org/10.1111/j.1524-4725.2005.31002","title":"Candida Antigen in the Treatment of Basal Cell Carcinoma","display_name":"Candida Antigen in the Treatment of Basal Cell Carcinoma","publication_year":2006,"publication_date":"2006-03-21","ids":{"openalex":"https://openalex.org/W1972802490","doi":"https://doi.org/10.1111/j.1524-4725.2005.31002","mag":"1972802490","pmid":"https://pubmed.ncbi.nlm.nih.gov/15720089"},"language":"en","primary_location":{"id":"doi:10.1111/j.1524-4725.2005.31002","doi":"https://doi.org/10.1111/j.1524-4725.2005.31002","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1524-4725.2005.31002","pdf_url":null,"source":{"id":"https://openalex.org/S153994436","display_name":"Dermatologic Surgery","issn_l":"1076-0512","issn":["1076-0512","1524-4725"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dermatologic Surgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019440020","display_name":"Kent Aftergut","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kent Aftergut","raw_affiliation_strings":["Department of Dermatology, University of Texas Southwestern, Dallas, Texas, USA","Department of Dermatology, University of Texas Southwestern, Dallas, Texas","KENT AFTERGUT, MD, MARY CURRY, MD, AND JACK COHEN, DO, HAVE INDICATED THAT THE CANDIDA ANTIGEN USED IN THIS STUDY WAS PROVIDED TO UTSW DEPARTMENT OF DERMATOLOGY AT A DISCOUNT","Kent Aftergut, MD, 3450 W Wheatland Road, #225, Dallas, TX 75237"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of Texas Southwestern, Dallas, Texas, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Dermatology, University of Texas Southwestern, Dallas, Texas","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"KENT AFTERGUT, MD, MARY CURRY, MD, AND JACK COHEN, DO, HAVE INDICATED THAT THE CANDIDA ANTIGEN USED IN THIS STUDY WAS PROVIDED TO UTSW DEPARTMENT OF DERMATOLOGY AT A DISCOUNT","institution_ids":[]},{"raw_affiliation_string":"Kent Aftergut, MD, 3450 W Wheatland Road, #225, Dallas, TX 75237","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020194773","display_name":"Mary L. Curry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Curry","raw_affiliation_strings":["Department of Dermatology, University of Texas Southwestern, Dallas, Texas","KENT AFTERGUT, MD, MARY CURRY, MD, AND JACK COHEN, DO, HAVE INDICATED THAT THE CANDIDA ANTIGEN USED IN THIS STUDY WAS PROVIDED TO UTSW DEPARTMENT OF DERMATOLOGY AT A DISCOUNT","Kent Aftergut, MD, 3450 W Wheatland Road, #225, Dallas, TX 75237"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of Texas Southwestern, Dallas, Texas","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"KENT AFTERGUT, MD, MARY CURRY, MD, AND JACK COHEN, DO, HAVE INDICATED THAT THE CANDIDA ANTIGEN USED IN THIS STUDY WAS PROVIDED TO UTSW DEPARTMENT OF DERMATOLOGY AT A DISCOUNT","institution_ids":[]},{"raw_affiliation_string":"Kent Aftergut, MD, 3450 W Wheatland Road, #225, Dallas, TX 75237","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113736723","display_name":"Jack B. Cohen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jack Cohen","raw_affiliation_strings":["Department of Dermatology, University of Texas Southwestern, Dallas, Texas","KENT AFTERGUT, MD, MARY CURRY, MD, AND JACK COHEN, DO, HAVE INDICATED THAT THE CANDIDA ANTIGEN USED IN THIS STUDY WAS PROVIDED TO UTSW DEPARTMENT OF DERMATOLOGY AT A DISCOUNT","Kent Aftergut, MD, 3450 W Wheatland Road, #225, Dallas, TX 75237"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of Texas Southwestern, Dallas, Texas","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"KENT AFTERGUT, MD, MARY CURRY, MD, AND JACK COHEN, DO, HAVE INDICATED THAT THE CANDIDA ANTIGEN USED IN THIS STUDY WAS PROVIDED TO UTSW DEPARTMENT OF DERMATOLOGY AT A DISCOUNT","institution_ids":[]},{"raw_affiliation_string":"Kent Aftergut, MD, 3450 W Wheatland Road, #225, Dallas, TX 75237","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":null,"apc_paid":null,"fwci":0.7316,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.74357699,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"31","issue":"1","first_page":"16","last_page":"18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11868","display_name":"Cancer and Skin Lesions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/basal-cell-carcinoma","display_name":"basal cell carcinoma","score":0.9879999756813049},{"id":"https://openalex.org/keywords/nodular-basal-cell-carcinoma","display_name":"nodular basal cell carcinoma","score":0.8830000162124634},{"id":"https://openalex.org/keywords/candida-antigen","display_name":"Candida antigen","score":0.984000027179718},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.7369999885559082},{"id":"https://openalex.org/keywords/intralesional-injection","display_name":"intralesional injection","score":0.949999988079071},{"id":"https://openalex.org/keywords/tumor-clearance","display_name":"tumor clearance","score":0.8849999904632568},{"id":"https://openalex.org/keywords/skin-cancer-treatment","display_name":"skin cancer treatment","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C2778804307","wikidata":"https://www.wikidata.org/wiki/Q809758","display_name":"Basal cell carcinoma","level":3,"score":0.7964118719100952},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.723975419998169},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.657341480255127},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5502684712409973},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5045377016067505},{"id":"https://openalex.org/C2909938017","wikidata":"https://www.wikidata.org/wiki/Q2712836","display_name":"Candida infections","level":3,"score":0.4793420732021332},{"id":"https://openalex.org/C2777789703","wikidata":"https://www.wikidata.org/wiki/Q192102","display_name":"Skin cancer","level":3,"score":0.4548991918563843},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.4427661597728729},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.43443459272384644},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40504971146583557},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.39945128560066223},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.37867942452430725},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.34964117407798767},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34658297896385193},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.33396679162979126},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.25135165452957153},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2504785358905792},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000946","descriptor_name":"Antigens, Fungal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002175","descriptor_name":"Candida","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002280","descriptor_name":"Basal Cell Carcinoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015552","descriptor_name":"Injections, Intralesional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1524-4725.2005.31002","doi":"https://doi.org/10.1111/j.1524-4725.2005.31002","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1524-4725.2005.31002","pdf_url":null,"source":{"id":"https://openalex.org/S153994436","display_name":"Dermatologic Surgery","issn_l":"1076-0512","issn":["1076-0512","1524-4725"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dermatologic Surgery","raw_type":"journal-article"},{"id":"pmid:15720089","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15720089","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8600000143051147}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W33611989","https://openalex.org/W1540221256","https://openalex.org/W1942879517","https://openalex.org/W1948122542","https://openalex.org/W2020467293","https://openalex.org/W2028898761","https://openalex.org/W2062782045","https://openalex.org/W2080528529","https://openalex.org/W2158149578","https://openalex.org/W2337846238","https://openalex.org/W2340619777","https://openalex.org/W2419523197"],"related_works":["https://openalex.org/W7220433232","https://openalex.org/W4312194853","https://openalex.org/W4220815082","https://openalex.org/W2182887102","https://openalex.org/W2174436471","https://openalex.org/W1999941818","https://openalex.org/W7096436462","https://openalex.org/W4310171577","https://openalex.org/W2982162412","https://openalex.org/W3004335876"],"abstract_inverted_index":{"BACKGROUND:":[0],"Basal":[1],"cell":[2],"carcinoma":[3],"(BCC)":[4],"is":[5,28,144],"the":[6,21,39,53,62,68,80,102,108],"most":[7],"common":[8],"skin":[9],"cancer.":[10],"Recently,":[11],"there":[12],"has":[13],"been":[14],"renewed":[15],"interest":[16],"in":[17,20,38,61,110,137],"various":[18],"immunotherapies":[19],"treatment":[22,40,63,104,150],"of":[23,34,41,47,57,64,76,84,91,115,122,130,151],"BCC.":[24,43,65,152],"The":[25,45,94],"current":[26,149],"study":[27,49],"a":[29,119],"randomized,":[30],"open-label,":[31],"placebo-controlled":[32],"trial":[33],"intralesional":[35,58],"Candida":[36,59,81,131],"antigen":[37,60,132],"nodular":[42,141],"OBJECTIVE:":[44],"objective":[46],"this":[48],"was":[50,98],"to":[51,100,113,134,146],"evaluate":[52],"safety":[54],"and":[55,140],"efficacy":[56],"RESULTS:":[66],"In":[67,79],"control":[69],"group,":[70,82],"no":[71],"patients":[72,87],"had":[73,88],"complete":[74,89],"clearing":[75,90,138],"their":[77,92],"tumor.":[78,93],"10":[83],"17":[85],"(56%)":[86],"Fisher":[95],"exact":[96],"test":[97],"used":[99],"compare":[101],"two":[103],"groups.":[105],"This":[106],"showed":[107],"difference":[109],"clearance":[111],"rates":[112],"be":[114,135],"borderline":[116],"significance,":[117],"with":[118,127],"p":[120],"value":[121],".105.":[123],"CONCLUSION:":[124],"Although":[125],"immunotherapy":[126],"repeated":[128],"injections":[129],"appears":[133],"effective":[136],"superficial":[139],"BCCs,":[142],"it":[143],"unlikely":[145],"alter":[147],"our":[148]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}